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OPENSEQ.org
YQHD - Alcohol dehydrogenase YqhD
UniProt: Q46856 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13014
Length: 387 (384)
Sequences: 4775
Seq/Len: 12.43
YQHD
Paralog alert: 0.77 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ADH2 AROB EUTG FUCO GLDA YBDH YQHD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
354_P 380_R 3.844 1.00
229_P 336_Q 3.798 1.00
358_K 376_L 3.733 1.00
294_N 331_R 3.66 1.00
79_K 83_E 3.658 1.00
230_K 237_N 3.497 1.00
234_E 237_N 3.251 1.00
350_G 384_E 3.228 1.00
72_E 155_K 2.955 1.00
269_L 383_Y 2.78 1.00
219_G 222_L 2.688 1.00
48_D 52_D 2.679 1.00
77_A 104_I 2.551 1.00
227_D 243_N 2.484 1.00
195_A 224_L 2.436 1.00
353_I 380_R 2.383 1.00
380_R 384_E 2.336 1.00
17_G 178_V 2.323 1.00
199_T 220_I 2.323 1.00
349_D 352_S 2.309 1.00
196_F 221_L 2.228 1.00
64_G 76_N 2.222 1.00
48_D 51_L 2.221 1.00
175_L 245_M 2.219 1.00
181_Y 238_Y 2.204 1.00
342_H 345_D 2.191 1.00
375_T 378_V 2.155 1.00
21_G 24_E 2.152 1.00
16_K 178_V 2.142 1.00
357_L 380_R 2.103 1.00
332_N 336_Q 2.102 1.00
98_L 135_C 2.09 1.00
381_R 385_A 2.061 1.00
356_L 383_Y 2.042 1.00
66_E 73_T 2.035 1.00
190_N 283_Q 2.034 1.00
294_N 385_A 1.985 1.00
287_I 346_Y 1.933 1.00
296_K 370_E 1.929 1.00
188_V 241_R 1.922 1.00
89_L 101_T 1.89 1.00
270_G 284_T 1.859 1.00
376_L 380_R 1.831 1.00
214_D 303_K 1.821 1.00
81_V 131_I 1.78 1.00
40_S 44_T 1.768 1.00
291_A 386_A 1.756 1.00
32_V 36_Y 1.743 1.00
76_N 79_K 1.733 1.00
32_V 88_F 1.71 1.00
329_A 332_N 1.663 1.00
31_R 58_D 1.658 1.00
18_A 21_G 1.653 1.00
294_N 324_D 1.627 1.00
221_L 307_Y 1.617 1.00
23_R 53_A 1.617 1.00
357_L 376_L 1.607 1.00
75_M 115_D 1.6 1.00
230_K 234_E 1.581 1.00
192_V 228_G 1.571 1.00
335_E 341_T 1.567 1.00
185_P 189_A 1.548 1.00
112_E 119_I 1.526 1.00
229_P 233_K 1.523 1.00
324_D 328_A 1.516 1.00
381_R 384_E 1.507 1.00
237_N 240_V 1.498 1.00
328_A 332_N 1.497 1.00
49_Q 178_V 1.492 1.00
73_T 76_N 1.483 1.00
308_A 326_A 1.483 1.00
230_K 239_D 1.471 1.00
180_T 245_M 1.467 1.00
35_T 65_I 1.455 1.00
224_L 244_V 1.451 1.00
60_L 84_Q 1.45 1.00
26_I 88_F 1.448 1.00
188_V 231_A 1.443 1.00
180_T 241_R 1.442 1.00
33_L 36_Y 1.44 1.00
239_D 243_N 1.435 1.00
269_L 288_V 1.429 1.00
39_G 43_K 1.422 1.00
51_L 55_K 1.422 1.00
74_L 152_I 1.417 1.00
188_V 235_P 1.413 1.00
60_L 80_L 1.407 0.99
16_K 238_Y 1.392 0.99
279_L 284_T 1.388 0.99
112_E 118_H 1.386 0.99
318_S 321_E 1.386 0.99
268_M 367_Q 1.385 0.99
154_R 157_T 1.385 0.99
192_V 244_V 1.378 0.99
354_P 376_L 1.375 0.99
80_L 84_Q 1.374 0.99
74_L 100_G 1.371 0.99
378_V 381_R 1.362 0.99
269_L 379_S 1.357 0.99
81_V 86_V 1.357 0.99
32_V 37_G 1.344 0.99
344_S 387_R 1.341 0.99
88_F 134_G 1.34 0.99
91_A 101_T 1.338 0.99
358_K 362_E 1.334 0.99
302_A 319_D 1.326 0.99
42_K 63_G 1.323 0.99
20_A 49_Q 1.321 0.99
227_D 230_K 1.32 0.99
91_A 133_M 1.294 0.99
233_K 336_Q 1.284 0.99
78_V 107_A 1.284 0.99
25_Q 28_H 1.282 0.99
66_E 70_A 1.266 0.99
55_K 59_V 1.263 0.99
60_L 86_V 1.259 0.99
193_V 334_F 1.257 0.99
232_L 338_G 1.249 0.99
218_E 306_Q 1.242 0.98
51_L 59_V 1.239 0.98
70_A 73_T 1.236 0.98
140_P 188_V 1.235 0.98
183_L 187_Q 1.233 0.98
186_R 283_Q 1.228 0.98
80_L 83_E 1.227 0.98
355_A 359_K 1.227 0.98
123_G 126_E 1.22 0.98
295_E 378_V 1.208 0.98
214_D 217_A 1.208 0.98
293_W 330_T 1.205 0.98
105_A 130_A 1.204 0.98
355_A 358_K 1.2 0.98
220_I 251_A 1.198 0.98
12_I 249_T 1.196 0.98
202_Q 254_G 1.19 0.98
255_L 260_V 1.178 0.98
50_V 92_V 1.172 0.98
17_G 176_D 1.172 0.98
79_K 82_R 1.17 0.97
91_A 98_L 1.17 0.97
11_R 25_Q 1.166 0.97
297_R 323_I 1.161 0.97
291_A 385_A 1.16 0.97
301_R 320_D 1.157 0.97
71_Y 75_M 1.153 0.97
199_T 251_A 1.148 0.97
16_K 181_Y 1.147 0.97
13_L 25_Q 1.139 0.97
178_V 238_Y 1.139 0.97
75_M 79_K 1.138 0.97
226_E 243_N 1.13 0.97
68_N 278_G 1.129 0.97
101_T 133_M 1.126 0.97
22_L 136_V 1.122 0.97
185_P 233_K 1.121 0.97
185_P 232_L 1.117 0.96
134_G 172_F 1.115 0.96
193_V 339_V 1.114 0.96
377_D 380_R 1.108 0.96
297_R 324_D 1.102 0.96
16_K 242_A 1.099 0.96
178_V 181_Y 1.096 0.96
200_V 221_L 1.093 0.96
227_D 240_V 1.093 0.96
352_S 355_A 1.091 0.96
298_D 372_H 1.091 0.96
33_L 86_V 1.091 0.96
197_V 289_L 1.09 0.96
353_I 384_E 1.089 0.96
32_V 90_L 1.086 0.96
35_T 104_I 1.085 0.96
227_D 239_D 1.082 0.96
81_V 108_A 1.072 0.95
215_R 219_G 1.066 0.95
202_Q 214_D 1.063 0.95
276_M 355_A 1.062 0.95
91_A 135_C 1.059 0.95
235_P 241_R 1.059 0.95
89_L 105_A 1.058 0.95
26_I 134_G 1.052 0.95
202_Q 217_A 1.052 0.95
189_A 232_L 1.051 0.94
177_P 242_A 1.048 0.94
266_T 285_L 1.047 0.94
270_G 274_T 1.042 0.94
307_Y 326_A 1.038 0.94
204_V 293_W 1.038 0.94
218_E 222_L 1.037 0.94
309_E 322_R 1.035 0.94
140_P 245_M 1.033 0.94
66_E 76_N 1.031 0.94
291_A 294_N 1.029 0.94
230_K 240_V 1.028 0.94
31_R 85_K 1.019 0.93
265_A 374_I 1.012 0.93
225_I 312_W 1.002 0.92
361_E 376_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1oj7A40.99741000.099Contact Map0.702
1vljA20.98711000.102Contact Map0.742
3bfjA200.97161000.112Contact Map0.828
3ox4A40.97161000.113Contact Map0.845
4fr2A10.97161000.126Contact Map0.582
1rrmA20.9691000.126Contact Map0.787
3zdrA10.97671000.147Contact Map0.79
1o2dA20.91991000.178Contact Map0.691
3hl0A20.88371000.208Contact Map0.737
3jzdA40.89151000.213Contact Map0.721
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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