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OPENSEQ.org
FUCO - Lactaldehyde reductase
UniProt: P0A9S1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10351
Length: 382 (379)
Sequences: 4778
Seq/Len: 12.61
FUCO
Paralog alert: 0.77 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ADH2 AROB EUTG FUCO GLDA YBDH YQHD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
350_P 375_V 3.766 1.00
229_R 332_D 3.705 1.00
354_Q 371_L 3.594 1.00
289_R 327_F 3.564 1.00
81_G 85_N 3.535 1.00
230_G 235_D 3.427 1.00
346_K 379_H 3.143 1.00
74_T 156_E 2.87 1.00
264_M 378_Y 2.686 1.00
48_A 52_D 2.682 1.00
219_K 222_E 2.589 1.00
227_A 241_E 2.566 1.00
79_G 106_I 2.466 1.00
196_A 224_I 2.385 1.00
349_I 375_V 2.371 1.00
345_R 348_D 2.317 1.00
375_V 379_H 2.28 1.00
200_A 220_A 2.255 1.00
182_D 236_K 2.239 1.00
16_G 179_D 2.237 1.00
15_R 179_D 2.228 1.00
338_H 341_D 2.219 1.00
66_G 78_E 2.201 1.00
48_A 51_T 2.182 1.00
176_I 243_A 2.177 1.00
370_T 373_D 2.169 1.00
197_L 221_I 2.169 1.00
20_A 23_D 2.119 1.00
100_Q 136_A 2.1 1.00
33_A 90_Y 2.1 1.00
328_A 332_D 2.056 1.00
352_L 378_Y 2.014 1.00
189_K 239_G 1.989 1.00
353_A 375_V 1.977 1.00
68_V 75_V 1.961 1.00
376_E 380_T 1.949 1.00
191_A 278_V 1.945 1.00
32_K 60_A 1.943 1.00
291_N 365_N 1.936 1.00
289_R 380_T 1.927 1.00
214_D 298_K 1.877 1.00
282_I 342_V 1.861 1.00
265_A 279_A 1.851 1.00
91_L 103_C 1.817 1.00
30_Y 90_Y 1.809 1.00
83_F 132_V 1.794 1.00
40_T 44_C 1.786 1.00
371_L 375_V 1.754 1.00
78_E 81_G 1.75 1.00
314_S 317_E 1.71 1.00
289_R 320_N 1.706 1.00
286_H 381_A 1.696 1.00
221_I 302_I 1.64 1.00
225_A 306_M 1.638 1.00
331_R 337_P 1.618 1.00
51_T 55_D 1.606 1.00
224_I 242_M 1.605 1.00
230_G 234_G 1.598 1.00
17_A 20_A 1.589 1.00
193_G 228_L 1.588 1.00
22_T 53_K 1.586 1.00
325_A 328_A 1.583 1.00
186_P 190_A 1.577 1.00
49_K 179_D 1.539 1.00
353_A 371_L 1.535 1.00
181_M 239_G 1.531 1.00
237_D 241_E 1.529 1.00
303_A 322_A 1.528 1.00
189_K 231_S 1.511 1.00
376_E 379_H 1.507 1.00
75_V 78_E 1.506 1.00
324_E 328_A 1.504 1.00
155_D 158_K 1.503 1.00
55_D 61_W 1.499 1.00
15_R 236_K 1.475 1.00
62_A 86_S 1.471 1.00
52_D 56_A 1.463 1.00
33_A 92_I 1.447 1.00
229_R 233_A 1.442 1.00
36_V 106_I 1.437 1.00
230_G 237_D 1.432 1.00
235_D 238_A 1.421 1.00
264_M 374_I 1.409 1.00
181_M 243_A 1.406 0.99
76_V 153_I 1.405 0.99
31_Q 89_D 1.403 0.99
62_A 82_V 1.4 0.99
193_G 242_M 1.393 0.99
320_N 324_E 1.383 0.99
263_G 362_T 1.374 0.99
373_D 376_E 1.37 0.99
264_M 283_L 1.368 0.99
116_A 120_S 1.363 0.99
340_R 382_W 1.352 0.99
297_E 315_L 1.349 0.99
36_V 67_V 1.341 0.99
350_P 371_L 1.339 0.99
76_V 102_T 1.339 0.99
274_T 279_A 1.337 0.99
25_V 90_Y 1.337 0.99
227_A 230_G 1.336 0.99
83_F 88_A 1.334 0.99
39_K 43_Q 1.33 0.99
93_A 103_C 1.326 0.99
24_E 27_R 1.299 0.99
233_A 332_D 1.299 0.99
93_A 134_I 1.282 0.99
42_V 65_D 1.273 0.99
292_A 319_R 1.269 0.99
351_A 354_Q 1.262 0.99
62_A 88_A 1.259 0.99
90_Y 135_L 1.259 0.99
82_V 86_S 1.248 0.99
232_V 334_G 1.244 0.98
72_T 75_V 1.243 0.98
141_A 189_K 1.242 0.98
19_G 49_K 1.238 0.98
194_V 330_N 1.235 0.98
16_G 177_D 1.233 0.98
354_Q 358_D 1.232 0.98
116_A 121_L 1.227 0.98
68_V 72_T 1.219 0.98
184_M 188_L 1.218 0.98
351_A 355_A 1.215 0.98
179_D 236_K 1.212 0.98
93_A 100_Q 1.208 0.98
218_I 301_D 1.208 0.98
50_V 94_I 1.206 0.98
290_Y 373_D 1.206 0.98
32_K 87_G 1.201 0.98
107_G 131_S 1.2 0.98
187_A 278_V 1.197 0.98
214_D 217_H 1.18 0.98
82_V 85_N 1.175 0.98
51_T 61_W 1.172 0.98
220_A 249_A 1.17 0.97
293_D 367_R 1.17 0.97
15_R 182_D 1.167 0.97
288_M 326_V 1.162 0.97
203_G 252_G 1.157 0.97
135_L 173_V 1.155 0.97
292_A 320_N 1.148 0.97
77_K 81_G 1.146 0.97
186_P 232_V 1.146 0.97
179_D 182_D 1.139 0.97
11_A 247_Y 1.138 0.97
271_F 351_A 1.137 0.97
103_C 134_I 1.132 0.97
286_H 380_T 1.13 0.97
73_I 77_K 1.129 0.97
81_G 84_Q 1.127 0.97
226_G 241_E 1.127 0.97
34_L 88_A 1.127 0.97
296_G 316_E 1.12 0.96
227_A 238_A 1.104 0.96
55_D 60_A 1.099 0.96
186_P 233_A 1.098 0.96
200_A 249_A 1.094 0.96
80_L 109_I 1.088 0.96
201_I 221_I 1.087 0.96
12_W 24_E 1.086 0.96
15_R 240_E 1.083 0.96
203_G 214_D 1.081 0.95
349_I 379_H 1.077 0.95
203_G 217_H 1.077 0.95
215_A 219_K 1.071 0.95
190_A 232_V 1.07 0.95
194_V 335_I 1.068 0.95
253_F 258_L 1.068 0.95
218_I 305_V 1.063 0.95
83_F 110_S 1.06 0.95
77_K 117_D 1.057 0.95
348_D 351_A 1.057 0.95
350_P 354_Q 1.056 0.95
70_N 273_N 1.051 0.94
286_H 289_R 1.047 0.94
39_K 65_D 1.047 0.94
300_R 318_A 1.042 0.94
227_A 237_D 1.037 0.94
10_T 24_E 1.036 0.94
91_L 107_G 1.035 0.94
261_V 280_N 1.033 0.94
302_I 322_A 1.022 0.93
260_L 369_A 1.02 0.93
230_G 238_A 1.02 0.93
93_A 136_A 1.019 0.93
178_A 240_E 1.018 0.93
141_A 243_A 1.011 0.93
357_L 371_L 1.011 0.93
198_T 284_L 1.01 0.93
52_D 55_D 1.009 0.93
372_E 375_V 1.005 0.93
218_I 222_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bfjA200.99481000.091Contact Map0.85
1rrmA211000.093Contact Map0.794
3ox4A40.99481000.093Contact Map0.869
4fr2A10.99481000.104Contact Map0.594
1vljA20.98691000.125Contact Map0.743
1oj7A40.98431000.142Contact Map0.719
3zdrA10.98431000.142Contact Map0.815
1o2dA20.93461000.174Contact Map0.725
3iv7A20.89271000.204Contact Map0.807
3hl0A20.89271000.209Contact Map0.747
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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