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OPENSEQ.org
YBDH - Uncharacterized oxidoreductase YbdH
UniProt: P45579 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12692
Length: 362 (348)
Sequences: 5278
Seq/Len: 15.17
YBDH
Paralog alert: 0.78 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ADH2 AROB EUTG FUCO GLDA YBDH YQHD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
325_D 351_R 4.137 1.00
329_A 347_P 3.993 1.00
214_E 304_R 3.765 1.00
81_A 85_D 3.584 1.00
51_T 55_P 2.825 1.00
321_Q 355_K 2.808 1.00
259_V 354_F 2.808 1.00
74_S 135_D 2.68 1.00
324_I 351_R 2.679 1.00
317_D 322_A 2.588 1.00
219_D 222_N 2.553 1.00
51_T 54_P 2.538 1.00
20_G 157_E 2.521 1.00
79_L 105_L 2.483 1.00
19_P 157_E 2.435 1.00
346_T 349_T 2.37 1.00
174_T 209_L 2.313 1.00
37_A 89_V 2.312 1.00
24_H 27_D 2.297 1.00
310_T 313_E 2.296 1.00
204_A 207_D 2.27 1.00
90_V 102_A 2.26 1.00
317_D 323_E 2.219 1.00
99_L 115_A 2.209 1.00
300_G 304_R 2.209 1.00
327_V 354_F 2.208 1.00
169_A 276_T 2.197 1.00
36_R 63_K 2.189 1.00
328_I 351_R 2.17 1.00
215_Q 222_N 2.154 1.00
175_L 206_R 2.091 1.00
54_P 58_G 1.99 1.00
78_Q 81_A 1.979 1.00
215_Q 225_L 1.965 1.00
347_P 351_R 1.944 1.00
351_R 355_K 1.934 1.00
178_W 205_I 1.899 1.00
260_H 277_K 1.887 1.00
44_R 48_A 1.852 1.00
34_L 89_V 1.837 1.00
83_S 111_L 1.818 1.00
42_G 45_A 1.814 1.00
26_H 56_A 1.81 1.00
164_Q 168_L 1.8 1.00
303_Q 309_T 1.795 1.00
154_V 238_A 1.793 1.00
75_D 78_Q 1.757 1.00
40_I 105_L 1.748 1.00
165_Q 276_T 1.716 1.00
328_I 347_P 1.714 1.00
21_S 24_H 1.703 1.00
215_Q 219_D 1.678 1.00
55_P 59_L 1.675 1.00
296_A 300_G 1.67 1.00
52_K 157_E 1.64 1.00
76_V 101_T 1.615 1.00
212_S 231_D 1.611 1.00
92_G 102_A 1.599 1.00
58_G 64_H 1.595 1.00
297_Q 300_G 1.557 1.00
325_D 347_P 1.556 1.00
167_L 216_A 1.555 1.00
65_I 82_E 1.54 1.00
134_N 137_G 1.539 1.00
352_A 356_K 1.527 1.00
272_F 277_K 1.526 1.00
29_F 89_V 1.519 1.00
65_I 87_R 1.518 1.00
37_A 91_I 1.51 1.00
349_T 352_A 1.489 1.00
23_N 52_K 1.478 1.00
28_F 31_D 1.474 1.00
329_A 333_R 1.456 1.00
43_K 47_A 1.455 1.00
171_I 213_S 1.45 1.00
212_S 215_Q 1.432 1.00
326_K 330_H 1.408 1.00
20_G 155_E 1.395 0.99
83_S 87_R 1.38 0.99
19_P 160_L 1.373 0.99
157_E 160_L 1.372 0.99
323_E 326_K 1.369 0.99
172_G 302_Y 1.366 0.99
326_K 329_A 1.357 0.99
77_Q 81_A 1.356 0.99
159_I 238_A 1.349 0.99
76_V 132_W 1.338 0.99
53_L 93_V 1.326 0.99
214_E 218_S 1.323 0.99
218_S 304_R 1.322 0.99
352_A 355_K 1.312 0.99
199_I 202_A 1.31 0.99
36_R 86_D 1.303 0.99
89_V 114_V 1.301 0.99
167_L 229_F 1.301 0.99
15_Y 242_M 1.301 0.99
14_N 28_F 1.291 0.99
55_P 58_G 1.291 0.99
114_V 151_M 1.29 0.99
92_G 113_F 1.286 0.99
200_N 204_A 1.281 0.99
82_E 85_D 1.278 0.99
162_A 166_Y 1.278 0.99
259_V 350_L 1.274 0.99
348_D 351_R 1.267 0.99
46_I 68_R 1.267 0.99
106_A 110_G 1.259 0.99
160_L 223_Q 1.25 0.99
178_W 244_G 1.234 0.98
54_P 64_H 1.232 0.98
217_L 306_H 1.228 0.98
38_V 82_E 1.226 0.98
38_V 83_S 1.215 0.98
36_R 65_I 1.207 0.98
73_E 77_Q 1.203 0.98
280_Y 314_L 1.201 0.98
210_L 287_A 1.198 0.98
172_G 307_L 1.197 0.98
299_T 303_Q 1.188 0.98
38_V 87_R 1.188 0.98
72_S 75_D 1.173 0.98
164_Q 217_L 1.173 0.98
325_D 329_A 1.168 0.97
255_A 345_L 1.168 0.97
92_G 99_L 1.166 0.97
348_D 352_A 1.166 0.97
292_D 296_A 1.16 0.97
227_Q 231_D 1.155 0.97
260_H 264_T 1.152 0.97
45_A 48_A 1.144 0.97
40_I 102_A 1.142 0.97
171_I 237_I 1.138 0.97
332_L 347_P 1.127 0.97
120_A 167_L 1.117 0.96
80_A 108_R 1.113 0.96
90_V 106_A 1.111 0.96
324_I 355_K 1.111 0.96
25_L 116_V 1.108 0.96
25_L 53_L 1.106 0.96
207_D 211_N 1.104 0.96
16_F 28_F 1.101 0.96
81_A 84_G 1.101 0.96
35_S 88_S 1.096 0.96
30_T 60_P 1.092 0.96
99_L 117_P 1.09 0.96
293_D 296_A 1.087 0.96
19_P 230_C 1.08 0.95
181_A 247_G 1.076 0.95
42_G 48_A 1.068 0.95
44_R 47_A 1.068 0.95
181_A 202_A 1.066 0.95
52_K 55_P 1.064 0.95
70_H 271_K 1.063 0.95
140_L 144_I 1.055 0.95
58_G 63_K 1.055 0.95
308_P 314_L 1.047 0.94
29_F 114_V 1.043 0.94
165_Q 169_A 1.042 0.94
102_A 113_F 1.038 0.94
283_L 287_A 1.033 0.94
43_K 68_R 1.033 0.94
39_W 64_H 1.031 0.94
24_H 28_F 1.031 0.94
99_L 124_A 1.029 0.94
256_A 278_V 1.028 0.94
204_A 208_V 1.022 0.93
112_P 150_F 1.02 0.93
58_G 61_G 1.018 0.93
220_Q 223_Q 1.016 0.93
16_F 24_H 1.013 0.93
212_S 236_I 1.01 0.93
92_G 115_A 1.01 0.93
164_Q 218_S 1.008 0.93
141_H 144_I 1.004 0.93
200_N 207_D 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jq5A10.97511000.158Contact Map0.693
3bfjA200.92541000.161Contact Map0.84
3uhjA80.98071000.161Contact Map0.708
3ox4A40.91991000.165Contact Map0.856
1kq3A10.98341000.167Contact Map0.66
1ta9A20.98621000.168Contact Map0.683
1rrmA20.92271000.175Contact Map0.797
4fr2A10.93651000.179Contact Map0.54
1vljA20.93371000.18Contact Map0.766
3zdrA10.92541000.194Contact Map0.801
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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