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OPENSEQ.org
GLDA - Glycerol dehydrogenase
UniProt: P0A9S5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11904
Length: 367 (343)
Sequences: 4703
Seq/Len: 13.71
GLDA
Paralog alert: 0.76 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ADH2 AROB EUTG FUCO GLDA YBDH YQHD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
323_R 349_Y 4.095 1.00
327_E 345_P 3.951 1.00
215_E 302_A 3.878 1.00
78_G 82_T 3.677 1.00
319_P 353_L 3.509 1.00
216_K 226_V 2.805 1.00
71_N 133_D 2.791 1.00
256_V 352_L 2.787 1.00
46_S 50_K 2.688 1.00
205_L 208_N 2.619 1.00
322_M 349_Y 2.534 1.00
315_K 320_A 2.529 1.00
76_L 103_L 2.502 1.00
213_E 232_R 2.437 1.00
220_A 223_Q 2.387 1.00
172_A 210_L 2.373 1.00
46_S 49_E 2.313 1.00
173_L 207_Y 2.301 1.00
349_Y 353_L 2.287 1.00
16_D 155_K 2.276 1.00
15_A 155_K 2.275 1.00
344_T 347_Q 2.271 1.00
308_T 311_Q 2.206 1.00
298_A 302_A 2.165 1.00
31_R 58_V 2.158 1.00
97_L 113_I 2.148 1.00
315_K 321_K 2.142 1.00
326_A 349_Y 2.133 1.00
32_W 87_A 2.121 1.00
325_V 352_L 2.107 1.00
167_A 273_E 2.09 1.00
20_R 23_E 2.09 1.00
176_W 206_C 2.087 1.00
80_A 109_V 1.925 1.00
88_I 100_A 1.913 1.00
63_P 75_R 1.899 1.00
75_R 78_G 1.845 1.00
345_P 349_Y 1.82 1.00
257_H 274_K 1.809 1.00
152_V 234_I 1.796 1.00
350_A 354_V 1.756 1.00
17_V 20_R 1.721 1.00
49_E 53_K 1.696 1.00
35_V 103_L 1.694 1.00
295_T 298_A 1.679 1.00
37_D 40_V 1.678 1.00
39_F 43_F 1.668 1.00
301_H 307_I 1.653 1.00
326_A 345_P 1.648 1.00
228_P 232_R 1.647 1.00
350_A 353_L 1.634 1.00
53_K 59_V 1.632 1.00
47_T 155_K 1.598 1.00
30_E 86_G 1.588 1.00
216_K 220_A 1.582 1.00
22_G 51_S 1.582 1.00
50_K 54_D 1.563 1.00
162_A 166_A 1.555 1.00
165_L 217_A 1.546 1.00
60_E 83_A 1.543 1.00
169_I 214_G 1.531 1.00
32_W 89_L 1.522 1.00
158_A 227_T 1.496 1.00
65_G 72_E 1.495 1.00
165_L 230_L 1.491 1.00
269_Y 274_K 1.485 1.00
294_E 298_A 1.469 1.00
132_T 135_G 1.464 1.00
72_E 75_R 1.462 1.00
323_R 345_P 1.443 1.00
79_I 83_A 1.437 1.00
80_A 85_C 1.43 1.00
347_Q 350_A 1.404 0.99
73_I 130_I 1.404 0.99
327_E 331_A 1.402 0.99
38_K 42_G 1.401 0.99
60_E 79_I 1.401 0.99
216_K 228_P 1.399 0.99
25_L 87_A 1.375 0.99
90_G 100_A 1.364 0.99
73_I 99_T 1.363 0.99
215_E 219_L 1.354 0.99
31_R 84_Q 1.342 0.99
24_Y 27_P 1.338 0.99
157_V 234_I 1.329 0.99
219_L 302_A 1.329 0.99
324_I 327_E 1.327 0.99
210_L 233_V 1.326 0.99
69_S 72_E 1.325 0.99
213_E 216_K 1.321 0.99
74_D 78_G 1.312 0.99
216_K 223_Q 1.311 0.99
19_N 47_T 1.31 0.99
87_A 112_A 1.31 0.99
90_G 111_V 1.309 0.99
321_K 324_I 1.308 0.99
277_F 312_L 1.306 0.99
16_D 153_D 1.296 0.99
256_V 348_V 1.293 0.99
204_E 283_L 1.288 0.99
79_I 82_T 1.282 0.99
10_K 24_Y 1.273 0.99
15_A 158_A 1.271 0.99
170_G 300_S 1.271 0.99
324_I 328_A 1.268 0.99
322_M 353_L 1.268 0.99
220_A 226_V 1.264 0.99
218_M 304_G 1.26 0.99
290_V 294_E 1.26 0.99
48_V 91_I 1.248 0.99
138_D 142_L 1.244 0.98
200_L 203_A 1.24 0.98
155_K 158_A 1.237 0.98
163_R 273_E 1.234 0.98
112_A 149_M 1.234 0.98
70_Q 74_D 1.225 0.98
41_L 62_A 1.217 0.98
162_A 218_M 1.216 0.98
160_A 164_L 1.215 0.98
104_A 108_G 1.211 0.98
346_D 349_Y 1.202 0.98
88_I 104_A 1.189 0.98
90_G 97_L 1.179 0.98
33_L 85_C 1.179 0.98
50_K 53_K 1.167 0.97
12_I 24_Y 1.167 0.97
65_G 69_S 1.165 0.97
118_A 165_L 1.164 0.97
60_E 85_C 1.16 0.97
211_L 284_V 1.157 0.97
201_A 205_L 1.156 0.97
179_A 244_G 1.156 0.97
170_G 305_L 1.151 0.97
38_K 62_A 1.147 0.97
100_A 111_V 1.14 0.97
25_L 112_A 1.138 0.97
323_R 327_E 1.137 0.97
212_E 232_R 1.127 0.97
205_L 209_T 1.127 0.97
78_G 81_E 1.124 0.97
179_A 203_A 1.12 0.96
252_A 343_A 1.114 0.96
31_R 60_E 1.112 0.96
169_I 233_V 1.107 0.96
67_E 268_H 1.1 0.96
176_W 241_S 1.098 0.96
277_F 280_L 1.091 0.96
31_R 83_A 1.09 0.96
157_V 230_L 1.089 0.96
154_T 231_E 1.083 0.96
163_R 167_A 1.08 0.95
204_E 208_N 1.076 0.95
330_C 345_P 1.073 0.95
80_A 103_L 1.073 0.95
40_V 43_F 1.072 0.95
38_K 63_P 1.07 0.95
218_M 303_V 1.069 0.95
97_L 115_P 1.069 0.95
26_K 55_A 1.066 0.95
139_R 142_L 1.063 0.95
206_C 241_S 1.062 0.95
162_A 219_L 1.055 0.95
53_K 58_V 1.053 0.95
15_A 231_E 1.051 0.94
21_L 114_A 1.05 0.94
12_I 20_R 1.048 0.94
177_F 207_Y 1.041 0.94
11_Y 239_Y 1.041 0.94
49_E 59_V 1.04 0.94
346_D 350_A 1.038 0.94
35_V 64_F 1.035 0.94
306_P 312_L 1.032 0.94
77_R 106_F 1.025 0.93
39_F 42_G 1.023 0.93
33_L 79_I 1.02 0.93
257_H 261_T 1.017 0.93
297_A 301_H 1.016 0.93
35_V 96_T 1.012 0.93
69_S 268_H 1.011 0.93
70_Q 133_D 1.003 0.93
90_G 113_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ta9A20.99731000.191Contact Map0.673
1jq5A10.99731000.193Contact Map0.679
3uhjA80.98641000.194Contact Map0.694
3ox4A40.91281000.204Contact Map0.848
3bfjA200.91281000.205Contact Map0.84
1kq3A10.98911000.208Contact Map0.659
1rrmA20.91551000.21Contact Map0.795
4fr2A10.9211000.217Contact Map0.543
1vljA20.91831000.221Contact Map0.759
1oj7A40.90741000.233Contact Map0.737
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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