| UniProt: | Q06065 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11668 | ||
| Length: | 461 (453) | ||
| Sequences: | 5474 | ||
| Seq/Len: | 12.08 |
| ATOC
Paralog alert: 0.75 [within 20: 0.18] - ratio of genomes with paralogs Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 292_M | 297_T | 4.011 | 1.00 | |
| 218_E | 228_L | 3.961 | 1.00 | |
| 174_E | 317_R | 3.804 | 1.00 | |
| 429_Q | 439_M | 3.305 | 1.00 | |
| 203_A | 255_A | 3.239 | 1.00 | |
| 232_L | 267_E | 3.151 | 1.00 | |
| 234_E | 268_R | 3.103 | 1.00 | |
| 291_A | 295_E | 3.054 | 1.00 | |
| 288_D | 291_A | 2.84 | 1.00 | |
| 159_T | 182_I | 2.804 | 1.00 | |
| 32_H | 49_P | 2.742 | 1.00 | |
| 266_F | 277_V | 2.599 | 1.00 | |
| 265_E | 274_T | 2.522 | 1.00 | |
| 265_E | 276_K | 2.51 | 1.00 | |
| 207_E | 252_V | 2.493 | 1.00 | |
| 62_D | 65_K | 2.479 | 1.00 | |
| 333_K | 366_S | 2.428 | 1.00 | |
| 345_I | 369_I | 2.402 | 1.00 | |
| 421_I | 425_V | 2.385 | 1.00 | |
| 429_Q | 436_T | 2.377 | 1.00 | |
| 435_R | 438_L | 2.34 | 1.00 | |
| 287_R | 292_M | 2.334 | 1.00 | |
| 324_S | 350_M | 2.32 | 1.00 | |
| 36_N | 39_T | 2.319 | 1.00 | |
| 233_F | 260_I | 2.315 | 1.00 | |
| 17_R | 35_N | 2.237 | 1.00 | |
| 37_G | 61_M | 2.227 | 1.00 | |
| 419_K | 423_M | 2.225 | 1.00 | |
| 327_A | 345_I | 2.214 | 1.00 | |
| 242_L | 284_A | 2.205 | 1.00 | |
| 346_D | 382_F | 2.195 | 1.00 | |
| 218_E | 271_G | 2.125 | 1.00 | |
| 10_V | 40_A | 2.112 | 1.00 | |
| 261_L | 281_I | 2.089 | 1.00 | |
| 8_L | 34_A | 2.084 | 1.00 | |
| 358_W | 368_V | 2.069 | 1.00 | |
| 218_E | 268_R | 2.057 | 1.00 | |
| 262_Q | 366_S | 2.05 | 1.00 | |
| 324_S | 354_T | 2.045 | 1.00 | |
| 291_A | 294_K | 2.024 | 1.00 | |
| 17_R | 33_C | 2.023 | 1.00 | |
| 267_E | 274_T | 1.992 | 1.00 | |
| 292_M | 295_E | 1.956 | 1.00 | |
| 248_E | 287_R | 1.907 | 1.00 | |
| 100_F | 119_A | 1.903 | 1.00 | |
| 182_I | 313_L | 1.884 | 1.00 | |
| 428_Q | 439_M | 1.875 | 1.00 | |
| 161_K | 377_S | 1.845 | 1.00 | |
| 35_N | 39_T | 1.842 | 1.00 | |
| 68_K | 97_C | 1.811 | 1.00 | |
| 129_I | 132_L | 1.801 | 1.00 | |
| 155_I | 311_L | 1.791 | 1.00 | |
| 260_I | 266_F | 1.79 | 1.00 | |
| 237_N | 277_V | 1.756 | 1.00 | |
| 192_R | 278_D | 1.751 | 1.00 | |
| 356_W | 359_P | 1.751 | 1.00 | |
| 172_S | 312_I | 1.75 | 1.00 | |
| 229_R | 272_H | 1.716 | 1.00 | |
| 346_D | 349_A | 1.691 | 1.00 | |
| 418_E | 450_K | 1.682 | 1.00 | |
| 177_T | 313_L | 1.682 | 1.00 | |
| 237_N | 278_D | 1.678 | 1.00 | |
| 283_A | 306_L | 1.677 | 1.00 | |
| 180_E | 259_R | 1.668 | 1.00 | |
| 238_E | 278_D | 1.668 | 1.00 | |
| 38_R | 60_E | 1.661 | 1.00 | |
| 320_R | 357_S | 1.65 | 1.00 | |
| 381_I | 386_L | 1.646 | 1.00 | |
| 425_V | 429_Q | 1.634 | 1.00 | |
| 51_V | 116_V | 1.623 | 1.00 | |
| 148_N | 325_L | 1.61 | 1.00 | |
| 349_A | 353_L | 1.603 | 1.00 | |
| 69_E | 72_S | 1.587 | 1.00 | |
| 217_H | 222_F | 1.581 | 1.00 | |
| 6_R | 30_E | 1.58 | 1.00 | |
| 128_E | 133_H | 1.579 | 1.00 | |
| 21_S | 33_C | 1.571 | 1.00 | |
| 271_G | 275_I | 1.569 | 1.00 | |
| 149_S | 321_E | 1.567 | 1.00 | |
| 329_H | 333_K | 1.566 | 1.00 | |
| 247_G | 285_T | 1.56 | 1.00 | |
| 348_M | 383_S | 1.552 | 1.00 | |
| 155_I | 313_L | 1.53 | 1.00 | |
| 445_R | 449_Y | 1.525 | 1.00 | |
| 320_R | 324_S | 1.525 | 1.00 | |
| 54_M | 66_A | 1.523 | 1.00 | |
| 350_M | 354_T | 1.52 | 1.00 | |
| 312_I | 318_D | 1.513 | 1.00 | |
| 53_L | 116_V | 1.511 | 1.00 | |
| 327_A | 369_I | 1.511 | 1.00 | |
| 289_L | 298_F | 1.499 | 1.00 | |
| 248_E | 286_N | 1.499 | 1.00 | |
| 328_N | 350_M | 1.499 | 1.00 | |
| 211_E | 256_K | 1.49 | 1.00 | |
| 58_M | 61_M | 1.47 | 1.00 | |
| 128_E | 132_L | 1.454 | 1.00 | |
| 44_F | 70_M | 1.45 | 1.00 | |
| 425_V | 440_L | 1.44 | 1.00 | |
| 326_L | 330_F | 1.436 | 1.00 | |
| 349_A | 383_S | 1.434 | 1.00 | |
| 160_A | 189_N | 1.431 | 1.00 | |
| 233_F | 241_L | 1.428 | 1.00 | |
| 210_L | 253_L | 1.427 | 1.00 | |
| 172_S | 310_H | 1.426 | 1.00 | |
| 52_V | 70_M | 1.421 | 1.00 | |
| 425_V | 439_M | 1.42 | 1.00 | |
| 344_D | 380_I | 1.41 | 1.00 | |
| 152_M | 156_C | 1.406 | 0.99 | |
| 156_C | 159_T | 1.406 | 0.99 | |
| 217_H | 221_A | 1.401 | 0.99 | |
| 230_Q | 234_E | 1.397 | 0.99 | |
| 80_I | 115_I | 1.392 | 0.99 | |
| 54_M | 81_L | 1.387 | 0.99 | |
| 446_A | 450_K | 1.386 | 0.99 | |
| 45_A | 73_H | 1.386 | 0.99 | |
| 32_H | 43_L | 1.377 | 0.99 | |
| 422_I | 447_L | 1.374 | 0.99 | |
| 356_W | 364_E | 1.37 | 0.99 | |
| 41_L | 69_E | 1.368 | 0.99 | |
| 334_F | 373_V | 1.362 | 0.99 | |
| 167_A | 370_E | 1.362 | 0.99 | |
| 320_R | 323_I | 1.361 | 0.99 | |
| 21_S | 25_A | 1.36 | 0.99 | |
| 34_A | 40_A | 1.359 | 0.99 | |
| 167_A | 338_N | 1.356 | 0.99 | |
| 34_A | 43_L | 1.35 | 0.99 | |
| 349_A | 381_I | 1.34 | 0.99 | |
| 434_T | 438_L | 1.338 | 0.99 | |
| 174_E | 315_P | 1.336 | 0.99 | |
| 74_E | 77_T | 1.326 | 0.99 | |
| 36_N | 60_E | 1.325 | 0.99 | |
| 147_T | 156_C | 1.315 | 0.99 | |
| 281_I | 306_L | 1.308 | 0.99 | |
| 88_V | 92_V | 1.303 | 0.99 | |
| 443_S | 446_A | 1.301 | 0.99 | |
| 7_I | 29_F | 1.299 | 0.99 | |
| 69_E | 73_H | 1.294 | 0.99 | |
| 266_F | 276_K | 1.291 | 0.99 | |
| 217_H | 269_I | 1.29 | 0.99 | |
| 331_L | 373_V | 1.288 | 0.99 | |
| 154_D | 157_K | 1.278 | 0.99 | |
| 268_R | 271_G | 1.274 | 0.99 | |
| 449_Y | 453_E | 1.272 | 0.99 | |
| 423_M | 427_E | 1.272 | 0.99 | |
| 337_E | 370_E | 1.26 | 0.99 | |
| 195_G | 238_E | 1.258 | 0.99 | |
| 436_T | 439_M | 1.254 | 0.99 | |
| 331_L | 345_I | 1.252 | 0.99 | |
| 432_N | 444_R | 1.252 | 0.99 | |
| 207_E | 250_P | 1.247 | 0.99 | |
| 171_I | 282_I | 1.246 | 0.98 | |
| 70_M | 79_V | 1.245 | 0.98 | |
| 345_I | 350_M | 1.244 | 0.98 | |
| 157_K | 160_A | 1.243 | 0.98 | |
| 324_S | 327_A | 1.241 | 0.98 | |
| 330_F | 334_F | 1.24 | 0.98 | |
| 147_T | 152_M | 1.239 | 0.98 | |
| 222_F | 225_A | 1.237 | 0.98 | |
| 432_N | 435_R | 1.237 | 0.98 | |
| 352_L | 383_S | 1.236 | 0.98 | |
| 433_R | 448_M | 1.235 | 0.98 | |
| 145_I | 182_I | 1.233 | 0.98 | |
| 382_F | 385_D | 1.228 | 0.98 | |
| 11_D | 58_M | 1.212 | 0.98 | |
| 159_T | 185_A | 1.209 | 0.98 | |
| 27_Q | 113_N | 1.208 | 0.98 | |
| 43_L | 49_P | 1.205 | 0.98 | |
| 434_T | 444_R | 1.201 | 0.98 | |
| 371_R | 375_M | 1.187 | 0.98 | |
| 415_K | 453_E | 1.187 | 0.98 | |
| 445_R | 448_M | 1.184 | 0.98 | |
| 9_I | 31_T | 1.18 | 0.98 | |
| 443_S | 449_Y | 1.18 | 0.98 | |
| 147_T | 159_T | 1.179 | 0.98 | |
| 346_D | 380_I | 1.173 | 0.98 | |
| 234_E | 275_I | 1.163 | 0.97 | |
| 147_T | 182_I | 1.162 | 0.97 | |
| 37_G | 58_M | 1.16 | 0.97 | |
| 162_I | 309_I | 1.158 | 0.97 | |
| 422_I | 440_L | 1.146 | 0.97 | |
| 241_L | 281_I | 1.146 | 0.97 | |
| 321_E | 354_T | 1.144 | 0.97 | |
| 155_I | 182_I | 1.143 | 0.97 | |
| 52_V | 77_T | 1.142 | 0.97 | |
| 213_E | 229_R | 1.141 | 0.97 | |
| 212_S | 217_H | 1.134 | 0.97 | |
| 233_F | 279_I | 1.125 | 0.97 | |
| 166_Q | 192_R | 1.123 | 0.97 | |
| 57_R | 85_Y | 1.122 | 0.97 | |
| 424_E | 428_Q | 1.121 | 0.97 | |
| 268_R | 275_I | 1.12 | 0.96 | |
| 264_R | 276_K | 1.116 | 0.96 | |
| 64_I | 94_A | 1.113 | 0.96 | |
| 147_T | 325_L | 1.112 | 0.96 | |
| 37_G | 66_A | 1.111 | 0.96 | |
| 53_L | 112_L | 1.11 | 0.96 | |
| 330_F | 369_I | 1.109 | 0.96 | |
| 23_A | 109_L | 1.108 | 0.96 | |
| 90_T | 102_Y | 1.106 | 0.96 | |
| 185_A | 189_N | 1.098 | 0.96 | |
| 67_L | 81_L | 1.098 | 0.96 | |
| 294_K | 300_E | 1.096 | 0.96 | |
| 145_I | 181_L | 1.093 | 0.96 | |
| 145_I | 156_C | 1.091 | 0.96 | |
| 125_M | 129_I | 1.091 | 0.96 | |
| 210_L | 214_L | 1.09 | 0.96 | |
| 41_L | 61_M | 1.081 | 0.95 | |
| 320_R | 354_T | 1.078 | 0.95 | |
| 417_V | 421_I | 1.075 | 0.95 | |
| 67_L | 79_V | 1.074 | 0.95 | |
| 170_L | 283_A | 1.073 | 0.95 | |
| 159_T | 186_I | 1.073 | 0.95 | |
| 11_D | 17_R | 1.072 | 0.95 | |
| 247_G | 289_L | 1.071 | 0.95 | |
| 447_L | 450_K | 1.069 | 0.95 | |
| 433_R | 451_L | 1.069 | 0.95 | |
| 37_G | 41_L | 1.067 | 0.95 | |
| 158_D | 375_M | 1.066 | 0.95 | |
| 290_Q | 294_K | 1.064 | 0.95 | |
| 323_I | 353_L | 1.058 | 0.95 | |
| 328_N | 332_Q | 1.056 | 0.95 | |
| 221_A | 269_I | 1.054 | 0.95 | |
| 93_E | 97_C | 1.051 | 0.94 | |
| 334_F | 369_I | 1.051 | 0.94 | |
| 10_V | 66_A | 1.05 | 0.94 | |
| 171_I | 182_I | 1.049 | 0.94 | |
| 351_S | 355_A | 1.048 | 0.94 | |
| 54_M | 79_V | 1.044 | 0.94 | |
| 201_N | 249_M | 1.04 | 0.94 | |
| 180_E | 199_K | 1.04 | 0.94 | |
| 6_R | 32_H | 1.039 | 0.94 | |
| 12_D | 105_K | 1.039 | 0.94 | |
| 421_I | 440_L | 1.036 | 0.94 | |
| 51_V | 120_L | 1.032 | 0.94 | |
| 234_E | 266_F | 1.029 | 0.94 | |
| 32_H | 47_I | 1.026 | 0.94 | |
| 376_N | 385_D | 1.023 | 0.93 | |
| 146_L | 329_H | 1.019 | 0.93 | |
| 201_N | 248_E | 1.014 | 0.93 | |
| 435_R | 439_M | 1.011 | 0.93 | |
| 235_R | 271_G | 1.009 | 0.93 | |
| 210_L | 249_M | 1.004 | 0.93 | |
| 212_S | 222_F | 1.003 | 0.93 | |
| 442_I | 446_A | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4l4uA | 1 | 0.9588 | 100 | 0.114 | Contact Map | 0.73 |
| 1ny5A | 2 | 0.8395 | 100 | 0.242 | Contact Map | 0.79 |
| 3dzdA | 2 | 0.7983 | 100 | 0.284 | Contact Map | 0.778 |
| 1ojlA | 6 | 0.6594 | 100 | 0.447 | Contact Map | 0.766 |
| 4fwgA | 1 | 0.9089 | 100 | 0.652 | Contact Map | 0.368 |
| 1r6bX | 1 | 0.872 | 100 | 0.665 | Contact Map | 0.344 |
| 2bjvA | 1 | 0.5727 | 100 | 0.672 | Contact Map | 0.667 |
| 1qvrA | 3 | 0.8568 | 100 | 0.683 | Contact Map | 0.309 |
| 1hqcA | 2 | 0.5987 | 100 | 0.708 | Contact Map | 0.475 |
| 3pxiA | 3 | 0.8351 | 100 | 0.712 | Contact Map | 0.378 |
Sequence Conservation (Image Generated using WebLogo v3)