May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
PRPR - Propionate catabolism operon regulatory protein
UniProt: P77743 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13600
Length: 528 (508)
Sequences: 693
Seq/Len: 1.36
PRPR
Paralog alert: 0.66 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
247_E 399_R 5.179 1.00
316_E 350_R 3.325 1.00
374_D 379_R 3.262 1.00
299_E 353_G 2.901 1.00
314_L 349_T 2.881 1.00
504_F 514_Y 2.878 1.00
284_G 337_T 2.773 1.00
232_I 255_A 2.711 1.00
415_V 452_R 2.632 1.00
324_F 366_A 2.579 1.00
343_L 363_V 2.544 1.00
503_K 514_Y 2.485 1.00
344_E 452_R 2.416 1.00
288_E 334_P 2.405 1.00
504_F 511_A 2.381 0.99
220_G 225_M 2.256 0.99
320_G 360_D 2.244 0.99
247_E 397_P 2.239 0.99
444_W 454_M 2.165 0.99
510_A 513_N 2.136 0.99
299_E 310_G 2.076 0.98
240_A 456_E 1.981 0.97
442_Y 445_P 1.897 0.96
374_D 377_Q 1.889 0.96
250_T 395_L 1.889 0.96
349_T 356_P 1.86 0.96
500_A 511_A 1.789 0.94
300_E 309_G 1.783 0.94
298_Y 303_F 1.741 0.93
243_L 367_T 1.736 0.93
442_Y 450_E 1.692 0.92
369_C 374_D 1.686 0.92
399_R 442_Y 1.674 0.91
253_E 341_R 1.643 0.90
291_L 335_L 1.643 0.90
243_L 365_S 1.642 0.90
299_E 350_R 1.641 0.90
520_T 524_R 1.623 0.90
234_L 463_S 1.615 0.89
228_V 393_L 1.591 0.88
293_A 303_F 1.576 0.88
412_F 455_M 1.565 0.87
244_I 256_A 1.559 0.87
353_G 357_V 1.556 0.87
394_Q 400_E 1.546 0.86
373_E 377_Q 1.544 0.86
338_R 368_H 1.525 0.85
330_E 369_C 1.523 0.85
247_E 250_T 1.519 0.85
303_F 306_S 1.51 0.85
370_N 373_E 1.508 0.85
92_D 189_A 1.497 0.84
286_I 351_V 1.492 0.84
520_T 523_W 1.485 0.83
500_A 504_F 1.473 0.83
301_G 324_F 1.468 0.82
241_A 365_S 1.42 0.79
409_A 413_L 1.415 0.79
409_A 455_M 1.406 0.78
416_S 459_A 1.406 0.78
273_K 360_D 1.398 0.78
69_G 72_G 1.392 0.77
288_E 343_L 1.389 0.77
287_A 302_A 1.386 0.77
238_S 460_L 1.385 0.77
229_R 255_A 1.381 0.77
365_S 388_L 1.377 0.76
316_E 357_V 1.363 0.75
293_A 298_Y 1.354 0.75
293_A 301_G 1.349 0.74
518_S 524_R 1.348 0.74
282_N 342_V 1.335 0.73
293_A 306_S 1.331 0.73
294_E 366_A 1.331 0.73
92_D 519_R 1.326 0.72
283_C 344_E 1.323 0.72
413_L 459_A 1.321 0.72
406_L 440_L 1.319 0.72
329_G 367_T 1.313 0.71
254_L 363_V 1.311 0.71
218_M 254_L 1.31 0.71
326_D 341_R 1.309 0.71
326_D 449_R 1.306 0.71
330_E 368_H 1.305 0.71
286_I 420_L 1.305 0.71
228_V 255_A 1.299 0.70
253_E 282_N 1.291 0.70
395_L 509_T 1.29 0.69
311_R 354_H 1.282 0.69
497_P 525_R 1.279 0.69
285_A 315_F 1.279 0.69
371_L 380_F 1.269 0.68
500_A 515_L 1.264 0.67
507_D 519_R 1.254 0.66
304_T 366_A 1.251 0.66
507_D 513_N 1.25 0.66
402_V 405_I 1.247 0.66
326_D 387_R 1.246 0.66
428_L 439_L 1.238 0.65
292_E 338_R 1.235 0.65
287_A 293_A 1.235 0.65
225_M 228_V 1.232 0.64
321_G 336_Q 1.226 0.64
83_V 186_F 1.22 0.63
279_V 421_S 1.219 0.63
365_S 378_G 1.205 0.62
351_V 419_A 1.205 0.62
292_E 386_Y 1.202 0.62
515_L 521_T 1.2 0.61
342_V 348_V 1.2 0.61
361_V 452_R 1.198 0.61
373_E 376_Q 1.196 0.61
327_E 387_R 1.188 0.60
188_D 191_D 1.187 0.60
346_K 361_V 1.185 0.60
220_G 229_R 1.183 0.60
340_L 387_R 1.183 0.60
232_I 393_L 1.182 0.60
290_L 303_F 1.182 0.60
292_E 383_D 1.182 0.60
301_G 366_A 1.179 0.59
16_T 19_V 1.179 0.59
294_E 318_A 1.177 0.59
512_A 522_F 1.177 0.59
425_S 428_L 1.177 0.59
450_E 458_L 1.162 0.58
294_E 301_G 1.162 0.58
253_E 345_E 1.16 0.57
281_V 525_R 1.158 0.57
64_A 84_I 1.15 0.56
319_H 360_D 1.142 0.56
294_E 340_L 1.142 0.56
285_A 324_F 1.136 0.55
282_N 285_A 1.134 0.55
346_K 493_R 1.132 0.55
290_L 293_A 1.132 0.55
315_F 361_V 1.129 0.54
294_E 380_F 1.119 0.53
416_S 456_E 1.118 0.53
81_V 343_L 1.117 0.53
444_W 458_L 1.116 0.53
153_T 189_A 1.114 0.53
235_Y 391_L 1.114 0.53
294_E 324_F 1.114 0.53
142_R 168_E 1.114 0.53
508_K 526_L 1.113 0.53
287_A 351_V 1.108 0.52
303_F 366_A 1.107 0.52
279_V 346_K 1.107 0.52
339_L 515_L 1.107 0.52
350_R 353_G 1.103 0.52
288_E 450_E 1.102 0.52
323_L 333_L 1.099 0.51
290_L 301_G 1.097 0.51
298_Y 366_A 1.096 0.51
327_E 449_R 1.096 0.51
387_R 449_R 1.093 0.51
242_V 359_V 1.092 0.51
240_A 393_L 1.091 0.51
310_G 350_R 1.091 0.51
402_V 406_L 1.09 0.50
293_A 368_H 1.089 0.50
253_E 340_L 1.087 0.50
350_R 357_V 1.086 0.50
218_M 229_R 1.085 0.50
406_L 436_E 1.083 0.50
348_V 358_P 1.08 0.49
299_E 316_E 1.079 0.49
315_F 342_V 1.077 0.49
347_E 356_P 1.075 0.49
498_Q 502_E 1.073 0.49
344_E 386_Y 1.07 0.48
301_G 306_S 1.068 0.48
290_L 302_A 1.067 0.48
341_R 449_R 1.065 0.48
65_I 69_G 1.064 0.48
521_T 524_R 1.063 0.48
290_L 304_T 1.063 0.48
288_E 332_P 1.063 0.48
317_I 368_H 1.062 0.48
328_I 371_L 1.06 0.47
243_L 412_F 1.059 0.47
294_E 326_D 1.058 0.47
515_L 518_S 1.057 0.47
293_A 366_A 1.055 0.47
15_W 26_F 1.054 0.47
317_I 353_G 1.054 0.47
299_E 357_V 1.053 0.47
509_T 517_I 1.047 0.46
509_T 513_N 1.046 0.46
56_K 350_R 1.043 0.46
401_R 408_L 1.042 0.46
395_L 454_M 1.042 0.46
328_I 364_I 1.042 0.46
294_E 449_R 1.039 0.45
287_A 292_E 1.038 0.45
219_L 254_L 1.038 0.45
298_Y 306_S 1.036 0.45
508_K 515_L 1.035 0.45
122_F 126_F 1.032 0.45
450_E 457_R 1.03 0.44
519_R 524_R 1.027 0.44
294_E 303_F 1.026 0.44
298_Y 311_R 1.025 0.44
372_E 377_Q 1.024 0.44
391_L 461_F 1.024 0.44
22_L 25_L 1.023 0.44
500_A 514_Y 1.022 0.44
324_F 449_R 1.022 0.44
518_S 523_W 1.022 0.44
283_C 288_E 1.021 0.44
178_S 185_A 1.018 0.43
29_I 129_R 1.017 0.43
98_A 101_G 1.014 0.43
81_V 186_F 1.014 0.43
42_I 49_A 1.012 0.43
508_K 518_S 1.011 0.43
71_N 90_G 1.01 0.42
336_Q 384_L 1.01 0.42
75_L 454_M 1.01 0.42
499_Q 503_K 1.01 0.42
17_V 23_F 1.009 0.42
323_L 368_H 1.008 0.42
288_E 520_T 1.005 0.42
294_E 341_R 1.005 0.42
507_D 510_A 1.004 0.42
327_E 352_G 1.003 0.42
24_E 29_I 1.002 0.42
375_M 500_A 1.002 0.42
303_F 324_F 1.002 0.42
301_G 449_R 1.001 0.42
383_D 387_R 1 0.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l4uA10.81821000.386Contact Map0.428
1ny5A20.72161000.48Contact Map0.474
3dzdA20.68561000.518Contact Map0.467
1ojlA60.55871000.546Contact Map0.473
4fwgA10.83521000.715Contact Map0.213
2bjvA10.49431000.737Contact Map0.431
1hqcA20.50951000.759Contact Map0.303
1r6bX10.86171000.767Contact Map0.22
2pjuA40.42231000.767Contact Map0.295
1in4A10.53411000.767Contact Map0.306
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.7698 seconds.