| UniProt: | P14375 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10482 | ||
| Length: | 441 (435) | ||
| Sequences: | 5239 | ||
| Seq/Len: | 12.04 |
| ZRAR
Paralog alert: 0.77 [within 20: 0.19] - ratio of genomes with paralogs Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 288_E | 293_R | 3.997 | 1.00 | |
| 214_E | 224_R | 3.913 | 1.00 | |
| 170_D | 313_R | 3.677 | 1.00 | |
| 199_A | 251_V | 3.229 | 1.00 | |
| 417_T | 427_Q | 3.211 | 1.00 | |
| 287_A | 291_A | 2.996 | 1.00 | |
| 230_V | 264_R | 2.98 | 1.00 | |
| 228_R | 263_Q | 2.927 | 1.00 | |
| 33_A | 50_F | 2.812 | 1.00 | |
| 284_D | 287_A | 2.758 | 1.00 | |
| 155_I | 178_V | 2.721 | 1.00 | |
| 262_V | 273_V | 2.58 | 1.00 | |
| 261_E | 272_S | 2.486 | 1.00 | |
| 261_E | 270_I | 2.455 | 1.00 | |
| 63_D | 66_A | 2.439 | 1.00 | |
| 409_V | 413_A | 2.393 | 1.00 | |
| 203_E | 248_M | 2.371 | 1.00 | |
| 329_R | 362_E | 2.364 | 1.00 | |
| 423_E | 426_R | 2.334 | 1.00 | |
| 37_S | 40_Q | 2.321 | 1.00 | |
| 320_P | 346_M | 2.316 | 1.00 | |
| 229_F | 256_A | 2.314 | 1.00 | |
| 18_C | 36_N | 2.286 | 1.00 | |
| 417_T | 424_A | 2.285 | 1.00 | |
| 341_F | 365_V | 2.276 | 1.00 | |
| 283_R | 288_E | 2.259 | 1.00 | |
| 38_G | 62_M | 2.255 | 1.00 | |
| 407_K | 411_L | 2.24 | 1.00 | |
| 214_E | 267_S | 2.142 | 1.00 | |
| 323_A | 341_F | 2.141 | 1.00 | |
| 342_T | 378_S | 2.126 | 1.00 | |
| 9_L | 35_A | 2.121 | 1.00 | |
| 11_V | 41_A | 2.073 | 1.00 | |
| 238_F | 280_A | 2.07 | 1.00 | |
| 257_I | 277_L | 2.049 | 1.00 | |
| 18_C | 34_L | 2.049 | 1.00 | |
| 354_W | 364_A | 2.035 | 1.00 | |
| 288_E | 291_A | 2.027 | 1.00 | |
| 258_Q | 362_E | 2.023 | 1.00 | |
| 320_P | 350_I | 2.002 | 1.00 | |
| 287_A | 290_N | 1.976 | 1.00 | |
| 214_E | 264_R | 1.956 | 1.00 | |
| 263_Q | 270_I | 1.935 | 1.00 | |
| 101_L | 120_A | 1.932 | 1.00 | |
| 69_K | 98_T | 1.895 | 1.00 | |
| 36_N | 40_Q | 1.893 | 1.00 | |
| 130_E | 134_V | 1.887 | 1.00 | |
| 178_V | 309_V | 1.869 | 1.00 | |
| 416_K | 427_Q | 1.838 | 1.00 | |
| 244_D | 283_R | 1.804 | 1.00 | |
| 151_L | 307_I | 1.799 | 1.00 | |
| 168_H | 308_E | 1.765 | 1.00 | |
| 352_Y | 355_P | 1.763 | 1.00 | |
| 157_L | 373_T | 1.746 | 1.00 | |
| 188_R | 274_D | 1.733 | 1.00 | |
| 233_D | 273_V | 1.725 | 1.00 | |
| 342_T | 345_A | 1.721 | 1.00 | |
| 234_G | 274_D | 1.702 | 1.00 | |
| 39_R | 61_E | 1.694 | 1.00 | |
| 225_R | 268_N | 1.633 | 1.00 | |
| 7_D | 31_N | 1.628 | 1.00 | |
| 233_D | 274_D | 1.626 | 1.00 | |
| 22_Q | 34_L | 1.613 | 1.00 | |
| 256_A | 262_V | 1.603 | 1.00 | |
| 344_Q | 379_E | 1.6 | 1.00 | |
| 413_A | 417_T | 1.595 | 1.00 | |
| 52_L | 117_L | 1.592 | 1.00 | |
| 70_E | 73_A | 1.588 | 1.00 | |
| 377_I | 382_L | 1.584 | 1.00 | |
| 316_R | 320_P | 1.575 | 1.00 | |
| 316_R | 353_D | 1.573 | 1.00 | |
| 151_L | 309_V | 1.568 | 1.00 | |
| 54_L | 117_L | 1.566 | 1.00 | |
| 144_K | 321_L | 1.566 | 1.00 | |
| 213_H | 218_F | 1.563 | 1.00 | |
| 324_G | 346_M | 1.56 | 1.00 | |
| 279_A | 302_L | 1.553 | 1.00 | |
| 145_S | 317_E | 1.546 | 1.00 | |
| 176_E | 255_R | 1.535 | 1.00 | |
| 406_E | 438_K | 1.521 | 1.00 | |
| 433_K | 437_A | 1.516 | 1.00 | |
| 325_H | 329_R | 1.514 | 1.00 | |
| 323_A | 365_V | 1.488 | 1.00 | |
| 55_C | 67_T | 1.487 | 1.00 | |
| 173_T | 309_V | 1.487 | 1.00 | |
| 267_S | 271_I | 1.486 | 1.00 | |
| 168_H | 306_A | 1.485 | 1.00 | |
| 207_E | 252_R | 1.48 | 1.00 | |
| 156_A | 185_S | 1.471 | 1.00 | |
| 346_M | 350_I | 1.463 | 1.00 | |
| 308_E | 314_Q | 1.457 | 1.00 | |
| 243_G | 281_T | 1.456 | 1.00 | |
| 345_A | 349_L | 1.455 | 1.00 | |
| 42_L | 70_E | 1.45 | 1.00 | |
| 46_R | 74_L | 1.441 | 1.00 | |
| 45_V | 71_I | 1.44 | 1.00 | |
| 59_M | 62_M | 1.423 | 1.00 | |
| 244_D | 282_H | 1.421 | 1.00 | |
| 226_E | 230_V | 1.42 | 1.00 | |
| 33_A | 44_Q | 1.416 | 1.00 | |
| 35_A | 41_A | 1.414 | 1.00 | |
| 152_L | 155_I | 1.413 | 1.00 | |
| 413_A | 428_L | 1.412 | 1.00 | |
| 413_A | 427_Q | 1.409 | 1.00 | |
| 213_H | 217_A | 1.403 | 0.99 | |
| 55_C | 82_I | 1.402 | 0.99 | |
| 81_L | 116_T | 1.401 | 0.99 | |
| 35_A | 44_Q | 1.4 | 0.99 | |
| 345_A | 379_E | 1.396 | 0.99 | |
| 22_Q | 26_R | 1.378 | 0.99 | |
| 322_L | 326_F | 1.378 | 0.99 | |
| 285_L | 294_F | 1.378 | 0.99 | |
| 148_M | 152_L | 1.376 | 0.99 | |
| 229_F | 237_L | 1.375 | 0.99 | |
| 53_V | 71_I | 1.369 | 0.99 | |
| 316_R | 319_I | 1.367 | 0.99 | |
| 340_G | 376_Y | 1.361 | 0.99 | |
| 434_T | 438_K | 1.357 | 0.99 | |
| 352_Y | 360_E | 1.353 | 0.99 | |
| 170_D | 311_S | 1.353 | 0.99 | |
| 37_S | 61_E | 1.351 | 0.99 | |
| 150_H | 153_S | 1.349 | 0.99 | |
| 89_V | 93_V | 1.348 | 0.99 | |
| 70_E | 74_L | 1.34 | 0.99 | |
| 206_L | 249_M | 1.34 | 0.99 | |
| 163_A | 334_N | 1.324 | 0.99 | |
| 129_A | 134_V | 1.324 | 0.99 | |
| 75_N | 78_I | 1.321 | 0.99 | |
| 8_I | 30_Y | 1.314 | 0.99 | |
| 143_G | 152_L | 1.314 | 0.99 | |
| 213_H | 265_V | 1.307 | 0.99 | |
| 277_L | 302_L | 1.294 | 0.99 | |
| 330_F | 369_V | 1.291 | 0.99 | |
| 420_N | 423_E | 1.291 | 0.99 | |
| 333_R | 366_E | 1.28 | 0.99 | |
| 163_A | 366_E | 1.279 | 0.99 | |
| 345_A | 377_I | 1.275 | 0.99 | |
| 28_W | 114_Q | 1.271 | 0.99 | |
| 264_R | 267_S | 1.264 | 0.99 | |
| 167_I | 278_I | 1.253 | 0.99 | |
| 327_L | 341_F | 1.25 | 0.99 | |
| 433_K | 436_L | 1.25 | 0.99 | |
| 203_E | 246_S | 1.25 | 0.99 | |
| 422_T | 426_R | 1.237 | 0.98 | |
| 218_F | 221_A | 1.231 | 0.98 | |
| 411_L | 415_E | 1.229 | 0.98 | |
| 348_L | 379_E | 1.226 | 0.98 | |
| 153_S | 156_A | 1.223 | 0.98 | |
| 12_D | 59_M | 1.223 | 0.98 | |
| 435_L | 438_K | 1.221 | 0.98 | |
| 410_I | 435_L | 1.221 | 0.98 | |
| 431_T | 434_T | 1.216 | 0.98 | |
| 327_L | 369_V | 1.216 | 0.98 | |
| 230_V | 271_I | 1.215 | 0.98 | |
| 424_A | 427_Q | 1.214 | 0.98 | |
| 44_Q | 50_F | 1.212 | 0.98 | |
| 437_A | 441_R | 1.206 | 0.98 | |
| 317_E | 350_I | 1.199 | 0.98 | |
| 38_G | 67_T | 1.197 | 0.98 | |
| 341_F | 346_M | 1.196 | 0.98 | |
| 262_V | 272_S | 1.195 | 0.98 | |
| 141_M | 178_V | 1.189 | 0.98 | |
| 91_T | 103_Y | 1.181 | 0.98 | |
| 431_T | 437_A | 1.179 | 0.98 | |
| 54_L | 113_L | 1.178 | 0.98 | |
| 71_I | 80_V | 1.175 | 0.98 | |
| 143_G | 155_I | 1.174 | 0.98 | |
| 421_K | 436_L | 1.174 | 0.98 | |
| 155_I | 181_A | 1.173 | 0.98 | |
| 53_V | 78_I | 1.171 | 0.98 | |
| 367_R | 371_L | 1.169 | 0.97 | |
| 143_G | 178_V | 1.161 | 0.97 | |
| 191_K | 234_G | 1.158 | 0.97 | |
| 38_G | 59_M | 1.157 | 0.97 | |
| 378_S | 381_E | 1.156 | 0.97 | |
| 65_I | 95_A | 1.149 | 0.97 | |
| 412_A | 416_K | 1.144 | 0.97 | |
| 141_M | 152_L | 1.144 | 0.97 | |
| 326_F | 330_F | 1.136 | 0.97 | |
| 58_R | 86_Y | 1.131 | 0.97 | |
| 126_S | 130_E | 1.128 | 0.97 | |
| 403_V | 441_R | 1.127 | 0.97 | |
| 410_I | 428_L | 1.126 | 0.97 | |
| 158_V | 305_V | 1.124 | 0.97 | |
| 24_L | 110_F | 1.115 | 0.96 | |
| 166_L | 279_A | 1.114 | 0.96 | |
| 94_E | 98_T | 1.113 | 0.96 | |
| 167_I | 178_V | 1.11 | 0.96 | |
| 10_V | 32_V | 1.108 | 0.96 | |
| 162_E | 188_R | 1.105 | 0.96 | |
| 217_A | 265_V | 1.099 | 0.96 | |
| 42_L | 62_M | 1.098 | 0.96 | |
| 324_G | 328_Q | 1.097 | 0.96 | |
| 7_D | 33_A | 1.095 | 0.96 | |
| 209_E | 225_R | 1.091 | 0.96 | |
| 420_N | 432_R | 1.088 | 0.96 | |
| 229_F | 275_V | 1.084 | 0.96 | |
| 326_F | 365_V | 1.082 | 0.96 | |
| 197_N | 244_D | 1.082 | 0.96 | |
| 12_D | 18_C | 1.079 | 0.95 | |
| 342_T | 376_Y | 1.079 | 0.95 | |
| 68_L | 82_I | 1.079 | 0.95 | |
| 206_L | 210_L | 1.078 | 0.95 | |
| 319_I | 349_L | 1.074 | 0.95 | |
| 68_L | 80_V | 1.072 | 0.95 | |
| 208_S | 218_F | 1.072 | 0.95 | |
| 260_R | 272_S | 1.067 | 0.95 | |
| 290_N | 296_Q | 1.066 | 0.95 | |
| 208_S | 213_H | 1.064 | 0.95 | |
| 33_A | 48_Q | 1.062 | 0.95 | |
| 38_G | 42_L | 1.059 | 0.95 | |
| 264_R | 271_I | 1.059 | 0.95 | |
| 237_L | 277_L | 1.058 | 0.95 | |
| 347_D | 351_H | 1.054 | 0.95 | |
| 316_R | 350_I | 1.051 | 0.94 | |
| 320_P | 323_A | 1.049 | 0.94 | |
| 422_T | 432_R | 1.048 | 0.94 | |
| 423_E | 427_Q | 1.048 | 0.94 | |
| 55_C | 80_V | 1.048 | 0.94 | |
| 243_G | 285_L | 1.047 | 0.94 | |
| 181_A | 185_S | 1.043 | 0.94 | |
| 11_V | 67_T | 1.042 | 0.94 | |
| 176_E | 195_T | 1.041 | 0.94 | |
| 13_D | 106_K | 1.037 | 0.94 | |
| 30_Y | 118_E | 1.029 | 0.94 | |
| 143_G | 148_M | 1.026 | 0.94 | |
| 421_K | 439_L | 1.025 | 0.93 | |
| 28_W | 118_E | 1.023 | 0.93 | |
| 405_V | 409_V | 1.023 | 0.93 | |
| 141_M | 177_L | 1.019 | 0.93 | |
| 154_E | 371_L | 1.016 | 0.93 | |
| 143_G | 321_L | 1.015 | 0.93 | |
| 372_L | 381_E | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4l4uA | 1 | 0.9887 | 100 | 0.093 | Contact Map | 0.731 |
| 1ny5A | 2 | 0.8685 | 100 | 0.215 | Contact Map | 0.794 |
| 3dzdA | 2 | 0.8345 | 100 | 0.255 | Contact Map | 0.78 |
| 1ojlA | 6 | 0.6893 | 100 | 0.427 | Contact Map | 0.768 |
| 4fwgA | 1 | 0.9274 | 100 | 0.641 | Contact Map | 0.368 |
| 1r6bX | 1 | 0.8957 | 100 | 0.653 | Contact Map | 0.338 |
| 2bjvA | 1 | 0.5986 | 100 | 0.659 | Contact Map | 0.678 |
| 1qvrA | 3 | 0.8866 | 100 | 0.671 | Contact Map | 0.298 |
| 3pxiA | 3 | 0.8662 | 100 | 0.7 | Contact Map | 0.372 |
| 1hqcA | 2 | 0.6054 | 100 | 0.704 | Contact Map | 0.466 |
Sequence Conservation (Image Generated using WebLogo v3)