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OPENSEQ.org
TYRR - Transcriptional regulatory protein TyrR
UniProt: P07604 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11042
Length: 513 (441)
Sequences: 2183
Seq/Len: 4.95
TYRR
Paralog alert: 0.71 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
345_E 349_K 3.694 1.00
235_D 371_R 3.612 1.00
387_R 420_K 3.441 1.00
288_E 322_R 3.437 1.00
279_A 325_E 3.221 1.00
346_L 351_M 3.137 1.00
264_A 309_A 3.08 1.00
403_L 407_L 3.015 1.00
469_E 500_K 2.898 1.00
292_G 332_D 2.785 1.00
208_A 213_M 2.758 1.00
296_L 338_A 2.698 1.00
268_E 306_R 2.685 1.00
241_D 313_R 2.631 1.00
341_K 346_L 2.586 1.00
470_R 474_T 2.524 1.00
480_Y 489_R 2.471 1.00
492_V 497_I 2.47 1.00
316_N 420_K 2.462 1.00
381_T 399_L 2.461 1.00
222_K 431_D 2.445 1.00
342_N 345_E 2.405 1.00
286_F 321_R 2.392 1.00
228_A 424_Y 2.263 1.00
412_W 422_A 2.202 1.00
97_D 101_K 2.182 1.00
385_V 427_L 2.154 1.00
253_R 332_D 2.126 1.00
278_H 282_G 2.107 1.00
480_Y 486_L 2.072 1.00
378_M 408_T 2.067 1.00
319_T 328_E 2.052 1.00
210_S 375_Q 2.05 1.00
220_A 243_F 2.04 1.00
320_F 331_V 2.036 1.00
378_M 404_N 2.028 1.00
315_L 335_V 2.028 1.00
228_A 428_T 2.021 1.00
295_V 335_V 2.019 1.00
476_L 486_L 2.011 1.00
301_G 339_T 2.006 1.00
399_L 423_I 1.948 1.00
319_T 330_H 1.946 1.00
400_A 436_R 1.923 1.00
287_F 295_V 1.919 1.00
216_V 365_L 1.918 1.00
272_E 310_K 1.896 1.00
479_N 489_R 1.896 1.00
484_R 494_H 1.894 1.00
123_H 127_Q 1.888 1.00
378_M 381_T 1.87 1.00
374_P 411_A 1.866 1.00
238_T 367_L 1.841 1.00
485_K 488_K 1.838 1.00
403_L 437_P 1.835 1.00
321_R 328_E 1.834 1.00
287_F 314_F 1.829 1.00
203_F 246_A 1.819 1.00
228_A 392_Q 1.819 1.00
410_Y 413_P 1.776 1.00
206_I 213_M 1.767 1.00
472_V 476_L 1.766 1.00
227_S 253_R 1.722 1.00
325_E 329_V 1.714 1.00
384_F 423_I 1.712 1.00
94_L 102_V 1.686 0.99
469_E 473_L 1.665 0.99
101_K 124_T 1.665 0.99
380_L 384_F 1.664 0.99
483_T 494_H 1.655 0.99
203_F 220_A 1.645 0.99
256_K 292_G 1.64 0.99
345_E 348_Q 1.623 0.99
91_E 183_R 1.618 0.99
314_F 320_F 1.612 0.99
473_L 501_L 1.592 0.99
216_V 220_A 1.587 0.99
110_C 117_L 1.587 0.99
287_F 333_V 1.584 0.99
377_I 381_T 1.583 0.99
216_V 243_F 1.582 0.99
337_C 360_L 1.581 0.99
381_T 423_I 1.579 0.99
384_F 388_F 1.579 0.99
168_D 172_Q 1.566 0.99
466_S 503_E 1.564 0.99
465_T 468_F 1.563 0.99
374_P 377_I 1.559 0.99
223_L 363_L 1.556 0.99
403_L 435_L 1.544 0.99
400_A 403_L 1.536 0.99
116_K 119_R 1.532 0.99
335_V 360_L 1.523 0.99
220_A 365_L 1.522 0.99
496_A 499_N 1.51 0.99
229_P 337_C 1.508 0.99
105_A 120_L 1.505 0.99
494_H 498_A 1.501 0.98
278_H 283_K 1.497 0.98
482_S 494_H 1.495 0.98
209_V 379_P 1.481 0.98
235_D 369_P 1.476 0.98
213_M 216_V 1.459 0.98
500_K 504_Y 1.452 0.98
201_S 245_Y 1.448 0.98
495_T 498_A 1.444 0.98
247_C 336_I 1.443 0.98
291_N 332_D 1.443 0.98
302_E 341_K 1.443 0.98
206_I 243_F 1.442 0.98
464_I 472_V 1.437 0.98
388_F 423_I 1.437 0.98
343_L 352_F 1.436 0.98
473_L 497_I 1.419 0.98
212_K 372_D 1.413 0.98
226_L 428_T 1.409 0.97
245_Y 260_A 1.389 0.97
217_V 243_F 1.386 0.97
389_A 395_P 1.383 0.97
322_R 329_V 1.376 0.97
243_F 367_L 1.37 0.97
405_T 409_R 1.364 0.97
232_I 365_L 1.362 0.97
233_T 366_N 1.36 0.97
207_V 383_L 1.357 0.97
87_E 107_P 1.356 0.97
348_Q 354_E 1.349 0.96
301_G 341_K 1.343 0.96
279_A 322_R 1.343 0.96
468_F 472_V 1.343 0.96
406_V 437_P 1.33 0.96
402_D 437_P 1.318 0.96
501_L 504_Y 1.309 0.96
262_N 265_S 1.308 0.96
392_Q 428_T 1.303 0.95
137_W 140_S 1.302 0.95
279_A 282_G 1.299 0.95
273_S 338_A 1.295 0.95
435_L 440_I 1.294 0.95
476_L 480_Y 1.288 0.95
253_R 333_V 1.284 0.95
291_N 333_V 1.264 0.94
271_V 307_M 1.261 0.94
96_V 178_A 1.26 0.94
206_I 242_L 1.26 0.94
493_S 496_A 1.255 0.94
92_P 112_L 1.25 0.94
320_F 330_H 1.245 0.94
232_I 244_A 1.244 0.94
245_Y 249_Q 1.239 0.94
399_L 404_N 1.239 0.94
410_Y 418_Q 1.237 0.93
430_L 439_D 1.237 0.93
388_F 427_L 1.234 0.93
286_F 289_Q 1.215 0.93
289_Q 325_E 1.205 0.92
443_P 446_D 1.202 0.92
231_L 337_C 1.197 0.92
383_L 387_R 1.195 0.92
322_R 325_E 1.191 0.92
92_P 106_N 1.184 0.91
477_Y 486_L 1.184 0.91
465_T 469_E 1.181 0.91
486_L 489_R 1.175 0.91
107_P 111_Q 1.174 0.91
288_E 329_V 1.165 0.91
230_L 247_C 1.162 0.90
286_F 498_A 1.162 0.90
477_Y 501_L 1.147 0.90
436_R 439_D 1.147 0.90
398_K 434_E 1.146 0.90
473_L 486_L 1.142 0.89
476_L 489_R 1.141 0.89
292_G 333_V 1.14 0.89
381_T 404_N 1.136 0.89
460_S 463_E 1.13 0.89
208_A 217_V 1.127 0.88
233_T 344_V 1.121 0.88
115_Q 120_L 1.114 0.88
284_K 322_R 1.114 0.88
404_N 408_T 1.113 0.88
283_K 326_D 1.113 0.88
210_S 213_M 1.112 0.88
475_Q 479_N 1.109 0.87
389_A 396_R 1.103 0.87
268_E 304_S 1.102 0.87
228_A 362_V 1.102 0.87
108_A 111_Q 1.094 0.86
482_S 498_A 1.087 0.86
361_N 425_R 1.084 0.86
295_V 314_F 1.081 0.86
298_D 313_R 1.079 0.85
370_L 419_L 1.076 0.85
244_A 258_Y 1.074 0.85
391_E 424_Y 1.071 0.85
287_F 320_F 1.068 0.85
473_L 477_Y 1.063 0.84
232_I 367_L 1.063 0.84
295_V 331_V 1.062 0.84
389_A 427_L 1.056 0.84
422_A 426_A 1.052 0.83
232_I 243_F 1.051 0.83
461_L 464_I 1.051 0.83
270_A 273_S 1.049 0.83
494_H 497_I 1.039 0.82
220_A 247_C 1.037 0.82
483_T 498_A 1.036 0.82
346_L 349_K 1.033 0.82
258_Y 293_G 1.031 0.82
221_Q 250_A 1.024 0.81
274_E 343_L 1.02 0.81
274_E 352_F 1.019 0.81
271_V 303_M 1.018 0.81
464_I 468_F 1.013 0.80
374_P 378_M 1.012 0.80
274_E 278_H 1.01 0.80
484_R 498_A 1.009 0.80
227_S 391_E 1.006 0.79
213_M 217_V 1.004 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l4uA10.79531000.378Contact Map0.65
1ny5A20.73681000.491Contact Map0.716
1ojlA60.5771000.508Contact Map0.757
3dzdA20.67451000.523Contact Map0.686
4fwgA10.82461000.693Contact Map0.321
2bjvA10.5011000.704Contact Map0.616
1hqcA20.541000.73Contact Map0.465
1in4A10.56731000.738Contact Map0.478
1r6bX10.83821000.743Contact Map0.391
1qvrA30.81091000.744Contact Map0.295
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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