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OPENSEQ.org
YDJH - Uncharacterized sugar kinase YdjH
UniProt: P77493 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13484
Length: 315 (308)
Sequences: 9689
Seq/Len: 31.46
YDJH
Paralog alert: 0.85 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: FRLD K1PF K6PF2 KDGK PSUK RBSK YDJH YEGV YEII YIHV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_H 268_A 2.996 1.00
275_N 278_E 2.942 1.00
235_I 280_A 2.735 1.00
74_L 89_Q 2.688 1.00
51_I 56_H 2.63 1.00
5_D 135_K 2.58 1.00
138_S 168_C 2.574 1.00
71_Q 89_Q 2.574 1.00
66_K 91_V 2.509 1.00
59_A 83_D 2.394 1.00
233_C 262_F 2.37 1.00
53_R 80_E 2.35 1.00
269_A 274_K 2.332 1.00
168_C 267_I 2.328 1.00
5_D 57_R 2.281 1.00
158_T 189_Y 2.224 1.00
7_I 134_A 2.182 1.00
302_N 305_L 2.172 1.00
228_T 234_F 2.157 1.00
274_K 278_E 2.068 1.00
269_A 282_F 2.052 1.00
261_N 286_T 2.048 1.00
157_F 167_I 2.043 1.00
217_L 236_K 2.038 1.00
8_C 48_A 2.031 1.00
191_D 222_K 2.028 1.00
303_R 307_E 1.956 1.00
63_R 125_D 1.942 1.00
197_F 228_T 1.925 1.00
75_D 79_K 1.909 1.00
293_S 305_L 1.892 1.00
277_R 281_R 1.884 1.00
155_E 158_T 1.849 1.00
50_I 264_S 1.848 1.00
63_R 90_D 1.844 1.00
265_G 286_T 1.802 1.00
266_F 279_C 1.799 1.00
6_V 51_I 1.774 1.00
66_K 71_Q 1.754 1.00
242_M 277_R 1.747 1.00
166_I 191_D 1.726 1.00
49_T 80_E 1.721 1.00
160_A 165_M 1.703 1.00
272_E 303_R 1.702 1.00
78_R 84_I 1.678 1.00
194_F 263_A 1.675 1.00
228_T 243_K 1.672 1.00
287_A 291_V 1.65 1.00
233_C 284_N 1.646 1.00
254_D 295_G 1.646 1.00
159_Q 163_R 1.62 1.00
225_V 266_F 1.608 1.00
76_H 79_K 1.592 1.00
154_T 185_E 1.583 1.00
12_A 62_S 1.578 1.00
190_V 193_L 1.575 1.00
40_T 73_I 1.571 1.00
71_Q 75_D 1.566 1.00
258_A 291_V 1.56 1.00
161_K 191_D 1.559 1.00
132_S 163_R 1.55 1.00
51_I 268_A 1.546 1.00
74_L 78_R 1.545 1.00
136_L 267_I 1.534 1.00
154_T 158_T 1.533 1.00
266_F 283_A 1.529 1.00
215_C 218_A 1.502 1.00
155_E 159_Q 1.501 1.00
74_L 87_L 1.493 1.00
38_M 72_F 1.48 1.00
244_V 280_A 1.469 1.00
159_Q 162_A 1.459 1.00
213_A 236_K 1.455 1.00
265_G 282_F 1.446 1.00
192_Y 223_T 1.435 1.00
136_L 166_I 1.434 1.00
200_A 226_I 1.434 1.00
266_F 270_L 1.431 1.00
247_V 285_A 1.427 1.00
122_N 125_D 1.421 1.00
66_K 89_Q 1.418 1.00
201_K 207_E 1.408 1.00
158_T 162_A 1.396 0.99
208_T 211_E 1.387 0.99
265_G 283_A 1.386 0.99
237_R 240_M 1.371 0.99
214_D 218_A 1.364 0.99
166_I 222_K 1.359 0.99
250_I 292_L 1.355 0.99
235_I 242_M 1.352 0.99
66_K 92_S 1.35 0.99
233_C 280_A 1.348 0.99
223_T 266_F 1.338 0.99
228_T 231_D 1.319 0.99
210_D 214_D 1.314 0.99
223_T 237_R 1.311 0.99
52_S 82_I 1.311 0.99
278_E 281_R 1.311 0.99
234_F 243_K 1.31 0.99
247_V 281_R 1.302 0.99
136_L 168_C 1.288 0.99
45_I 77_C 1.276 0.99
51_I 264_S 1.276 0.99
210_D 241_T 1.274 0.99
223_T 276_L 1.273 0.99
64_I 70_G 1.265 0.99
217_L 238_G 1.254 0.99
197_F 231_D 1.248 0.99
235_I 276_L 1.243 0.98
213_A 226_I 1.24 0.98
194_F 227_K 1.228 0.98
75_D 78_R 1.227 0.98
269_A 279_C 1.226 0.98
284_N 287_A 1.219 0.98
12_A 73_I 1.212 0.98
54_L 265_G 1.209 0.98
16_I 36_I 1.207 0.98
76_H 80_E 1.206 0.98
49_T 53_R 1.202 0.98
161_K 189_Y 1.197 0.98
51_I 58_T 1.197 0.98
170_D 227_K 1.192 0.98
211_E 214_D 1.191 0.98
244_V 284_N 1.182 0.98
56_H 271_L 1.173 0.98
289_I 293_S 1.172 0.98
305_L 308_Q 1.171 0.98
187_L 190_V 1.17 0.97
68_A 71_Q 1.169 0.97
252_A 291_V 1.156 0.97
268_A 272_E 1.153 0.97
64_I 74_L 1.149 0.97
304_K 308_Q 1.144 0.97
166_I 192_Y 1.138 0.97
48_A 58_T 1.137 0.97
228_T 232_G 1.137 0.97
227_K 262_F 1.136 0.97
57_R 83_D 1.127 0.97
196_N 199_E 1.125 0.97
7_I 61_M 1.115 0.96
70_G 95_T 1.114 0.96
287_A 290_S 1.114 0.96
72_F 75_D 1.103 0.96
40_T 76_H 1.1 0.96
215_C 219_C 1.099 0.96
304_K 307_E 1.098 0.96
289_I 292_L 1.094 0.96
50_I 261_N 1.089 0.96
171_M 195_P 1.085 0.96
194_F 266_F 1.083 0.96
127_D 155_E 1.079 0.95
137_L 160_A 1.078 0.95
223_T 270_L 1.076 0.95
266_F 276_L 1.075 0.95
12_A 60_L 1.051 0.94
64_I 87_L 1.05 0.94
9_I 137_L 1.049 0.94
71_Q 74_L 1.048 0.94
282_F 306_V 1.046 0.94
192_Y 266_F 1.041 0.94
5_D 59_A 1.04 0.94
52_S 57_R 1.039 0.94
169_A 190_V 1.038 0.94
200_A 212_I 1.037 0.94
270_L 279_C 1.028 0.94
147_L 151_K 1.027 0.94
206_K 215_C 1.027 0.94
206_K 211_E 1.023 0.93
123_I 155_E 1.015 0.93
59_A 86_S 1.011 0.93
261_N 300_V 1.01 0.93
14_V 72_F 1.009 0.93
279_C 283_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3h49A20.99681000.131Contact Map0.842
3iq0A20.98411000.154Contact Map0.857
2rbcA10.95871000.158Contact Map0.771
3ljsA20.97781000.158Contact Map0.742
3pl2A40.97461000.164Contact Map0.848
4du5A40.96511000.166Contact Map0.808
3hj6A20.96511000.17Contact Map0.53
4k8kA20.9811000.172Contact Map0.786
3vasA20.96831000.176Contact Map0.73
1tyyA20.95241000.179Contact Map0.767
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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