May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YEII - Uncharacterized sugar kinase YeiI
UniProt: P33020 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12028
Length: 362 (303)
Sequences: 7820
Seq/Len: 25.81
YEII
Paralog alert: 0.83 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: FRLD K1PF K6PF2 KDGK PSUK RBSK YDJH YEGV YEII YIHV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
324_S 327_D 3.084 1.00
108_R 317_Y 2.926 1.00
118_D 143_H 2.786 1.00
59_Y 189_G 2.737 1.00
284_C 329_A 2.707 1.00
103_L 108_R 2.638 1.00
126_L 141_R 2.587 1.00
123_E 141_R 2.548 1.00
61_V 188_A 2.533 1.00
215_F 316_V 2.441 1.00
111_H 135_N 2.374 1.00
282_V 311_F 2.323 1.00
105_L 132_A 2.308 1.00
207_T 233_H 2.281 1.00
59_Y 109_D 2.206 1.00
115_V 177_L 2.203 1.00
266_H 285_S 2.177 1.00
323_Y 327_D 2.169 1.00
310_G 335_C 2.153 1.00
277_L 283_Y 2.122 1.00
318_S 323_Y 2.078 1.00
206_F 214_V 2.069 1.00
351_S 354_N 2.042 1.00
235_H 271_Q 2.041 1.00
254_S 257_D 2.019 1.00
62_V 100_A 2.012 1.00
314_G 335_C 1.971 1.00
318_S 331_F 1.932 1.00
127_E 131_R 1.896 1.00
352_A 356_L 1.893 1.00
102_N 313_A 1.881 1.00
115_V 142_L 1.802 1.00
315_L 328_S 1.795 1.00
292_F 326_R 1.786 1.00
241_L 277_L 1.778 1.00
326_R 330_R 1.758 1.00
60_C 103_L 1.726 1.00
204_W 207_T 1.716 1.00
238_K 312_M 1.684 1.00
342_S 354_N 1.683 1.00
66_I 114_S 1.669 1.00
192_L 215_F 1.668 1.00
130_R 136_V 1.667 1.00
213_P 235_H 1.664 1.00
315_L 332_A 1.632 1.00
92_A 125_L 1.625 1.00
264_A 267_Q 1.624 1.00
101_H 132_A 1.621 1.00
209_A 212_I 1.616 1.00
118_D 123_E 1.599 1.00
128_E 131_R 1.592 1.00
336_A 340_R 1.583 1.00
277_L 293_L 1.563 1.00
297_P 334_A 1.553 1.00
244_L 275_V 1.551 1.00
126_L 130_R 1.521 1.00
236_T 272_Q 1.515 1.00
274_F 315_L 1.504 1.00
126_L 139_C 1.489 1.00
103_L 313_A 1.477 1.00
190_V 316_V 1.474 1.00
123_E 127_E 1.471 1.00
294_L 329_A 1.471 1.00
217_D 276_Y 1.467 1.00
282_V 333_V 1.459 1.00
272_Q 286_E 1.448 1.00
204_W 208_L 1.446 1.00
286_E 289_G 1.444 1.00
315_L 319_F 1.442 1.00
103_L 317_Y 1.428 1.00
299_H 341_A 1.425 1.00
213_P 271_Q 1.405 0.99
203_E 229_H 1.399 0.99
303_D 344_S 1.393 0.99
203_E 207_T 1.393 0.99
263_N 267_Q 1.392 0.99
284_C 292_F 1.383 0.99
234_I 237_L 1.381 0.99
262_V 285_S 1.381 0.99
297_P 330_R 1.374 0.99
257_D 260_T 1.368 0.99
321_E 352_A 1.365 0.99
116_I 122_G 1.364 0.99
216_V 234_I 1.362 0.99
307_A 340_R 1.355 0.99
118_D 141_R 1.35 0.99
245_E 251_A 1.349 0.99
327_D 330_R 1.348 0.99
90_C 124_M 1.347 0.99
118_D 144_G 1.326 0.99
68_M 124_M 1.323 0.99
190_V 215_F 1.31 0.99
213_P 236_T 1.305 0.99
259_N 263_N 1.304 0.99
314_G 332_A 1.297 0.99
104_A 134_V 1.29 0.99
314_G 331_F 1.286 0.99
66_I 125_L 1.285 0.99
218_T 239_P 1.283 0.99
283_Y 293_L 1.277 0.99
282_V 329_A 1.273 0.99
174_T 177_L 1.266 0.99
259_N 291_Q 1.265 0.99
186_R 210_D 1.263 0.99
286_E 290_E 1.253 0.99
241_L 280_E 1.252 0.99
63_V 191_V 1.249 0.99
103_L 110_V 1.247 0.99
276_Y 311_F 1.24 0.98
70_I 88_I 1.239 0.98
338_I 342_S 1.236 0.98
272_Q 325_F 1.234 0.98
301_T 340_R 1.23 0.98
277_L 280_E 1.227 0.98
190_V 213_P 1.222 0.98
228_K 268_Q 1.215 0.98
317_Y 321_E 1.194 0.98
179_N 204_W 1.184 0.98
250_Q 264_A 1.168 0.97
294_L 333_V 1.162 0.97
250_Q 260_T 1.16 0.97
299_H 340_R 1.151 0.97
127_E 130_R 1.149 0.97
284_C 325_F 1.149 0.97
106_L 314_G 1.147 0.97
331_F 355_A 1.143 0.97
97_R 129_T 1.138 0.97
193_A 214_V 1.136 0.97
231_L 234_I 1.13 0.97
264_A 268_Q 1.127 0.97
100_A 110_V 1.122 0.97
108_R 320_L 1.12 0.96
315_L 325_F 1.117 0.96
109_D 135_N 1.117 0.96
354_N 357_S 1.116 0.96
145_Q 172_Q 1.116 0.96
263_N 285_S 1.109 0.96
318_S 328_S 1.105 0.96
260_T 263_N 1.102 0.96
75_D 156_R 1.101 0.96
67_N 148_S 1.101 0.96
238_K 276_Y 1.099 0.96
122_G 147_T 1.091 0.96
92_A 128_E 1.089 0.96
244_L 261_A 1.086 0.96
330_R 334_A 1.078 0.95
175_P 204_W 1.074 0.95
338_I 341_A 1.066 0.95
116_I 141_R 1.062 0.95
59_Y 111_H 1.061 0.95
128_E 132_A 1.06 0.95
193_A 206_F 1.057 0.95
101_H 105_L 1.046 0.94
353_D 357_S 1.044 0.94
117_G 147_T 1.037 0.94
319_F 328_S 1.037 0.94
236_T 315_L 1.036 0.94
272_Q 315_L 1.036 0.94
336_A 339_S 1.034 0.94
328_S 332_A 1.034 0.94
185_L 212_I 1.03 0.94
262_V 275_V 1.028 0.94
116_I 126_L 1.02 0.93
66_I 112_L 1.008 0.93
272_Q 284_C 1.002 0.92
299_H 337_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rbcA10.8951000.417Contact Map0.772
3kzhA20.85361000.425Contact Map0.72
2fv7A20.89781000.434Contact Map0.816
1rkdA10.84251000.438Contact Map0.832
3ry7A10.8261000.441Contact Map0.756
2nwhA10.83981000.442Contact Map0.679
1vm7A20.84251000.444Contact Map0.843
3ikhA40.78451000.465Contact Map0.647
3vasA20.8951000.465Contact Map0.731
3ljsA20.8261000.472Contact Map0.75
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0486 seconds.