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OPENSEQ.org
KDGK - 2-dehydro-3-deoxygluconokinase
UniProt: P37647 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12253
Length: 309 (295)
Sequences: 9568
Seq/Len: 32.43
KDGK
Paralog alert: 0.85 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: FRLD K1PF K6PF2 KDGK PSUK RBSK YDJH YEGV YEII YIHV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
279_S 282_D 2.912 1.00
46_L 272_A 2.892 1.00
236_V 284_A 2.687 1.00
4_K 129_D 2.658 1.00
64_L 79_R 2.644 1.00
132_Y 164_I 2.571 1.00
61_Q 79_R 2.531 1.00
56_T 81_E 2.47 1.00
37_I 46_L 2.445 1.00
6_A 128_F 2.437 1.00
39_R 70_E 2.362 1.00
49_H 73_D 2.352 1.00
164_I 271_L 2.339 1.00
273_V 278_G 2.288 1.00
154_R 190_C 2.28 1.00
234_C 266_F 2.272 1.00
4_K 47_T 2.133 1.00
229_R 235_L 2.09 1.00
273_V 286_R 2.058 1.00
218_H 237_S 2.028 1.00
153_L 163_V 2.019 1.00
265_S 290_T 2.016 1.00
278_G 282_D 1.978 1.00
192_D 223_K 1.906 1.00
65_D 69_G 1.886 1.00
36_Y 268_A 1.855 1.00
281_E 285_K 1.84 1.00
7_V 34_S 1.834 1.00
151_S 154_R 1.83 1.00
269_G 290_T 1.802 1.00
53_A 80_M 1.777 1.00
156_C 161_G 1.774 1.00
198_L 229_R 1.759 1.00
56_T 61_Q 1.754 1.00
35_V 70_E 1.752 1.00
270_Y 283_A 1.751 1.00
162_K 192_D 1.732 1.00
150_L 186_Q 1.728 1.00
244_V 281_E 1.723 1.00
5_I 37_I 1.71 1.00
122_C 155_E 1.696 1.00
68_H 74_T 1.694 1.00
249_V 289_L 1.68 1.00
37_I 272_A 1.67 1.00
229_R 245_D 1.65 1.00
258_D 299_G 1.649 1.00
155_E 159_N 1.649 1.00
291_A 295_I 1.643 1.00
64_L 68_H 1.612 1.00
226_V 270_Y 1.587 1.00
66_A 69_G 1.585 1.00
234_C 288_H 1.583 1.00
126_A 159_N 1.579 1.00
151_S 155_E 1.576 1.00
11_C 52_T 1.57 1.00
150_L 154_R 1.552 1.00
157_R 192_D 1.55 1.00
195_F 267_S 1.529 1.00
130_Y 271_L 1.527 1.00
262_A 295_I 1.525 1.00
26_F 63_M 1.513 1.00
209_P 212_D 1.509 1.00
61_Q 65_D 1.507 1.00
214_I 237_S 1.485 1.00
130_Y 162_K 1.484 1.00
53_A 117_Q 1.479 1.00
191_T 194_A 1.477 1.00
24_R 62_Q 1.473 1.00
270_Y 287_G 1.464 1.00
154_R 158_A 1.457 1.00
246_V 284_A 1.452 1.00
64_L 77_T 1.448 1.00
155_E 158_A 1.436 1.00
270_Y 274_R 1.422 1.00
269_G 286_R 1.417 1.00
193_I 224_E 1.398 0.99
216_R 219_N 1.397 0.99
201_E 227_V 1.393 0.99
130_Y 164_I 1.389 0.99
162_K 223_K 1.38 0.99
215_A 219_N 1.378 0.99
269_G 287_G 1.361 0.99
235_L 245_D 1.36 0.99
249_V 285_K 1.356 0.99
56_T 79_R 1.355 0.99
37_I 268_A 1.352 0.99
38_A 72_V 1.339 0.99
236_V 244_V 1.337 0.99
166_D 228_K 1.332 0.99
54_L 60_S 1.31 0.99
251_L 296_Q 1.297 0.99
293_T 297_Y 1.282 0.99
224_E 270_Y 1.28 0.99
229_R 232_D 1.28 0.99
11_C 63_M 1.277 0.99
114_E 117_Q 1.276 0.99
234_C 284_A 1.262 0.99
282_D 285_K 1.252 0.99
211_E 215_A 1.244 0.98
31_L 67_W 1.227 0.98
272_A 276_T 1.226 0.98
8_I 131_L 1.223 0.98
185_Q 220_A 1.222 0.98
165_F 191_T 1.221 0.98
35_V 39_R 1.221 0.98
15_L 22_V 1.221 0.98
224_E 280_A 1.221 0.98
198_L 232_D 1.216 0.98
40_Q 269_G 1.206 0.98
66_A 70_E 1.201 0.98
37_I 48_V 1.196 0.98
211_E 243_L 1.192 0.98
65_D 68_H 1.192 0.98
122_C 158_A 1.182 0.98
157_R 190_C 1.182 0.98
188_L 191_T 1.173 0.98
236_V 280_A 1.167 0.97
251_L 295_I 1.167 0.97
197_T 200_D 1.161 0.97
123_E 126_A 1.159 0.97
288_H 291_A 1.159 0.97
56_T 82_N 1.158 0.97
293_T 296_Q 1.157 0.97
131_L 156_C 1.148 0.97
47_T 73_D 1.148 0.97
34_S 48_V 1.145 0.97
6_A 51_V 1.141 0.97
256_V 295_I 1.141 0.97
133_L 163_V 1.137 0.97
195_F 228_K 1.136 0.97
246_V 288_H 1.131 0.97
122_C 159_N 1.129 0.97
273_V 283_A 1.127 0.97
54_L 77_T 1.125 0.97
202_D 208_Q 1.125 0.97
46_L 275_L 1.122 0.97
167_N 196_L 1.121 0.97
154_R 186_Q 1.114 0.96
54_L 64_L 1.114 0.96
224_E 238_I 1.114 0.96
119_A 151_S 1.109 0.96
36_Y 265_S 1.107 0.96
162_K 193_I 1.105 0.96
214_I 227_V 1.096 0.96
62_Q 65_D 1.087 0.96
143_P 147_E 1.081 0.95
229_R 233_S 1.068 0.95
270_Y 280_A 1.062 0.95
291_A 294_V 1.057 0.95
26_F 66_A 1.055 0.95
249_V 292_S 1.047 0.94
11_C 50_Y 1.046 0.94
4_K 49_H 1.044 0.94
132_Y 271_L 1.04 0.94
57_D 85_P 1.036 0.94
216_R 220_A 1.033 0.94
131_L 161_G 1.032 0.94
228_K 266_F 1.031 0.94
212_D 215_A 1.03 0.94
40_Q 290_T 1.024 0.93
224_E 274_R 1.019 0.93
61_Q 64_L 1.019 0.93
58_S 61_Q 1.014 0.93
238_I 242_G 1.013 0.93
274_R 283_A 1.013 0.93
285_K 289_L 1.009 0.93
198_L 202_D 1 0.92
54_L 79_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lhxA211000.172Contact Map0.807
4e69A20.96441000.18Contact Map0.71
3ljsA20.94821000.191Contact Map0.736
4du5A40.95151000.196Contact Map0.797
3iq0A20.9451000.202Contact Map0.839
3pl2A40.94821000.204Contact Map0.849
3hj6A20.93851000.209Contact Map0.52
1tyyA20.94171000.21Contact Map0.786
2rbcA10.89641000.212Contact Map0.773
2v78A30.93531000.216Contact Map0.834
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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