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OPENSEQ.org
HSCC - Chaperone protein HscC
UniProt: P77319 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13653
Length: 556 (545)
Sequences: 3668
Seq/Len: 6.73
HSCC
Paralog alert: 0.43 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DNAK HSCA HSCC MREB YEGD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
116_D 143_N 5.559 1.00
209_M 274_P 4.44 1.00
198_D 278_R 4.237 1.00
210_L 263_F 3.827 1.00
314_R 318_R 3.764 1.00
317_V 323_L 3.547 1.00
476_A 480_E 3.155 1.00
171_F 279_L 3.066 1.00
71_L 204_E 3.014 1.00
406_T 427_D 3.01 1.00
526_T 530_A 2.933 1.00
536_D 539_R 2.929 1.00
116_D 145_V 2.896 1.00
182_V 286_A 2.882 1.00
363_S 379_P 2.868 1.00
408_N 422_L 2.79 1.00
32_N 39_T 2.719 1.00
530_A 533_Q 2.709 1.00
519_E 523_R 2.705 1.00
217_R 267_E 2.656 1.00
248_L 262_E 2.643 1.00
214_V 261_C 2.592 1.00
507_E 529_D 2.525 1.00
194_A 286_A 2.501 1.00
83_R 86_S 2.462 1.00
522_G 526_T 2.422 1.00
456_L 462_V 2.406 1.00
267_E 270_D 2.384 1.00
379_P 382_E 2.381 1.00
515_G 519_E 2.378 1.00
169_L 180_V 2.377 1.00
7_A 145_V 2.372 1.00
410_Y 422_L 2.318 1.00
104_E 108_E 2.308 1.00
527_D 546_R 2.235 1.00
313_Q 326_Q 2.231 1.00
481_E 485_R 2.229 1.00
18_L 29_L 2.173 1.00
306_A 309_M 2.172 1.00
378_S 395_Y 2.16 1.00
329_D 332_T 2.138 1.00
217_R 221_A 2.131 1.00
276_L 311_L 2.122 1.00
208_H 212_D 2.092 1.00
280_R 319_L 2.089 1.00
357_T 386_T 2.023 1.00
293_K 296_Q 2.023 1.00
315_I 318_R 2.023 1.00
173_L 206_F 1.992 1.00
543_V 546_R 1.985 1.00
545_R 549_D 1.982 1.00
214_V 237_V 1.978 1.00
281_V 285_Q 1.969 1.00
36_E 55_K 1.95 1.00
103_K 107_E 1.94 1.00
539_R 543_V 1.936 1.00
365_G 377_F 1.921 1.00
272_W 309_M 1.895 1.00
541_D 545_R 1.88 1.00
169_L 182_V 1.874 1.00
480_E 484_T 1.867 1.00
515_G 522_G 1.845 1.00
273_L 277_N 1.84 1.00
268_L 309_M 1.828 1.00
67_K 85_G 1.798 1.00
20_A 335_A 1.766 1.00
281_V 284_E 1.763 1.00
524_V 546_R 1.756 1.00
491_I 495_D 1.715 1.00
377_F 410_Y 1.707 1.00
524_V 527_D 1.706 1.00
523_R 527_D 1.705 1.00
66_D 227_E 1.694 1.00
527_D 543_V 1.693 1.00
120_S 338_A 1.691 1.00
20_A 339_A 1.689 1.00
211_V 234_Y 1.686 1.00
534_S 539_R 1.683 1.00
51_I 97_L 1.681 1.00
487_S 490_K 1.672 1.00
360_C 445_Y 1.665 1.00
182_V 297_I 1.659 1.00
223_T 257_E 1.658 1.00
268_L 306_A 1.656 1.00
506_L 551_L 1.647 1.00
484_T 488_A 1.641 1.00
93_E 97_L 1.641 1.00
284_E 288_R 1.636 1.00
499_N 528_F 1.632 1.00
392_V 442_R 1.624 1.00
416_K 419_N 1.622 1.00
102_L 105_D 1.62 1.00
8_I 19_I 1.609 1.00
285_Q 288_R 1.606 1.00
486_L 489_L 1.604 1.00
408_N 425_S 1.6 1.00
206_F 275_L 1.592 1.00
379_P 415_H 1.551 0.99
314_R 317_V 1.551 0.99
484_T 487_S 1.548 0.99
517_E 520_E 1.548 0.99
209_M 272_W 1.546 0.99
250_I 495_D 1.541 0.99
368_V 378_S 1.523 0.99
503_K 529_D 1.52 0.99
214_V 263_F 1.505 0.99
210_L 237_V 1.501 0.99
528_F 543_V 1.498 0.99
138_E 143_N 1.498 0.99
23_K 28_Q 1.495 0.99
272_W 276_L 1.492 0.99
131_K 135_L 1.482 0.99
518_R 522_G 1.481 0.99
539_R 542_E 1.471 0.99
97_L 100_R 1.464 0.99
166_T 299_S 1.462 0.99
284_E 319_L 1.452 0.99
507_E 511_A 1.451 0.99
138_E 476_A 1.439 0.99
422_L 425_S 1.438 0.99
83_R 88_T 1.437 0.99
265_E 269_E 1.436 0.99
438_S 458_E 1.426 0.99
18_L 38_L 1.424 0.99
392_V 440_D 1.422 0.99
269_E 314_R 1.418 0.99
524_V 550_Y 1.418 0.99
530_A 534_S 1.417 0.99
72_F 95_S 1.415 0.99
521_I 550_Y 1.414 0.99
173_L 178_F 1.404 0.99
503_K 528_F 1.397 0.99
196_A 285_Q 1.387 0.99
537_M 541_D 1.38 0.98
492_Y 495_D 1.372 0.98
7_A 342_A 1.371 0.98
406_T 425_S 1.369 0.98
101_S 105_D 1.367 0.98
238_E 242_C 1.363 0.98
89_F 94_L 1.359 0.98
280_R 315_I 1.357 0.98
167_R 292_L 1.345 0.98
516_D 519_E 1.332 0.98
493_P 496_M 1.329 0.98
311_L 314_R 1.324 0.98
74_R 205_D 1.322 0.98
287_L 294_P 1.322 0.98
410_Y 417_V 1.321 0.98
267_E 271_L 1.318 0.98
45_M 97_L 1.309 0.98
80_T 84_L 1.299 0.97
538_A 541_D 1.296 0.97
72_F 98_V 1.287 0.97
60_R 64_H 1.28 0.97
11_D 14_T 1.275 0.97
236_C 240_A 1.274 0.97
493_P 497_L 1.269 0.97
95_S 133_T 1.267 0.97
193_H 292_L 1.264 0.97
308_Q 331_S 1.261 0.97
30_I 109_F 1.256 0.97
485_R 488_A 1.256 0.97
546_R 549_D 1.256 0.97
72_F 82_W 1.252 0.97
29_L 336_L 1.247 0.97
502_F 506_L 1.239 0.96
119_I 144_A 1.238 0.96
270_D 273_L 1.237 0.96
119_I 137_A 1.234 0.96
489_L 492_Y 1.232 0.96
538_A 542_E 1.221 0.96
276_L 315_I 1.218 0.96
44_S 60_R 1.214 0.96
523_R 526_T 1.211 0.96
213_E 263_F 1.203 0.96
12_L 133_T 1.201 0.95
212_D 216_K 1.198 0.95
287_L 292_L 1.195 0.95
280_R 284_E 1.175 0.95
45_M 89_F 1.175 0.95
285_Q 289_D 1.172 0.95
514_L 517_E 1.17 0.95
542_E 546_R 1.169 0.95
519_E 522_G 1.152 0.94
316_A 324_P 1.151 0.94
373_V 398_M 1.145 0.94
167_R 193_H 1.144 0.94
87_D 93_E 1.137 0.93
169_L 283_I 1.131 0.93
211_V 237_V 1.129 0.93
206_F 309_M 1.126 0.93
299_S 325_Y 1.125 0.93
515_G 518_R 1.124 0.93
8_I 114_I 1.12 0.93
149_N 152_T 1.119 0.93
37_Y 332_T 1.112 0.92
390_S 442_R 1.112 0.92
285_Q 383_R 1.111 0.92
92_P 135_L 1.108 0.92
69_A 94_L 1.106 0.92
284_E 294_P 1.104 0.92
531_A 539_R 1.102 0.92
492_Y 496_M 1.099 0.92
475_S 478_Q 1.098 0.92
137_A 147_L 1.096 0.92
529_D 533_Q 1.092 0.91
526_T 533_Q 1.088 0.91
289_D 383_R 1.088 0.91
213_E 261_C 1.085 0.91
528_F 540_V 1.075 0.91
12_L 99_L 1.074 0.91
213_E 267_E 1.072 0.90
500_R 504_A 1.069 0.90
217_R 261_C 1.065 0.90
272_W 311_L 1.064 0.90
17_S 102_L 1.06 0.90
404_S 427_D 1.058 0.90
264_Y 267_E 1.055 0.89
236_C 249_H 1.046 0.89
105_D 108_E 1.043 0.89
534_S 540_V 1.042 0.89
424_E 467_I 1.04 0.89
516_D 520_E 1.039 0.89
506_L 525_I 1.036 0.88
269_E 272_W 1.032 0.88
478_Q 481_E 1.032 0.88
27_A 336_L 1.032 0.88
385_T 389_V 1.031 0.88
520_E 524_V 1.03 0.88
135_L 138_E 1.03 0.88
103_K 142_L 1.028 0.88
509_L 513_A 1.028 0.88
292_L 297_I 1.028 0.88
520_E 550_Y 1.025 0.88
325_Y 333_I 1.024 0.88
542_E 545_R 1.023 0.87
169_L 320_F 1.023 0.87
20_A 29_L 1.022 0.87
513_A 521_I 1.021 0.87
531_A 540_V 1.019 0.87
33_K 105_D 1.014 0.87
12_L 95_S 1.014 0.87
9_G 13_G 1.014 0.87
45_M 94_L 1.013 0.87
43_I 94_L 1.01 0.87
531_A 534_S 1.009 0.87
196_A 289_D 1.008 0.86
214_V 259_R 1.005 0.86
106_A 110_L 1.004 0.86
283_I 319_L 1.004 0.86
506_L 521_I 1.003 0.86
213_E 217_R 1.002 0.86
214_V 233_L 1.001 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4jneA20.9731000.166Contact Map0.831
3d2fA20.97661000.181Contact Map0.688
4fl9A10.91911000.216Contact Map0.773
1yuwA10.91911000.216Contact Map0.753
2v7yA10.88851000.239Contact Map0.761
3i33A10.62231000.477Contact Map0.77
3qfuA10.61871000.484Contact Map0.723
4j8fA10.90831000.488Contact Map0.769
4gniA20.63131000.494Contact Map0.701
1jceA10.58091000.656Contact Map0.529
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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