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OPENSEQ.org
HSCA - Chaperone protein HscA
UniProt: P0A6Z1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12130
Length: 616 (585)
Sequences: 3361
Seq/Len: 5.75
HSCA
Paralog alert: 0.41 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DNAK HSCA HSCC MREB YEGD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
151_G 178_H 5.544 1.00
233_D 310_R 4.569 1.00
244_L 306_P 4.531 1.00
245_L 295_I 4.028 1.00
349_G 355_P 3.639 1.00
346_E 350_E 3.453 1.00
206_Y 311_T 3.41 1.00
84_S 239_D 3.339 1.00
217_I 318_A 3.337 1.00
250_R 258_R 3.275 1.00
229_A 318_A 3.058 1.00
506_D 510_A 3.021 1.00
46_D 53_L 3.006 1.00
395_S 407_K 2.975 1.00
544_H 570_S 2.908 1.00
436_H 450_S 2.833 1.00
434_S 455_A 2.831 1.00
283_S 294_E 2.811 1.00
519_Y 522_Q 2.61 1.00
151_G 180_L 2.571 1.00
361_D 364_K 2.546 1.00
577_D 580_A 2.485 1.00
249_I 293_G 2.469 1.00
21_A 180_L 2.458 1.00
407_K 410_P 2.447 1.00
204_A 215_I 2.431 1.00
560_Q 564_D 2.429 1.00
252_Q 299_Q 2.429 1.00
438_M 450_S 2.405 1.00
345_R 358_T 2.346 1.00
517_M 520_A 2.324 1.00
299_Q 302_E 2.303 1.00
536_A 569_L 2.239 1.00
312_L 351_F 2.215 1.00
241_F 307_L 2.201 1.00
64_H 132_D 2.201 1.00
138_A 142_T 2.192 1.00
338_S 341_V 2.191 1.00
524_V 528_M 2.186 1.00
308_V 343_L 2.157 1.00
300_F 338_S 2.155 1.00
304_I 341_V 2.132 1.00
50_R 68_Y 2.127 1.00
249_I 271_A 2.123 1.00
204_A 217_I 2.106 1.00
521_E 525_K 2.062 1.00
139_A 143_E 2.053 1.00
22_A 33_V 2.051 1.00
556_A 560_Q 2.046 1.00
568_H 584_A 2.029 1.00
300_F 341_V 2.028 1.00
397_G 405_V 1.955 1.00
511_S 515_D 1.948 1.00
389_L 414_T 1.938 1.00
486_M 493_E 1.929 1.00
118_E 121_A 1.924 1.00
208_L 241_F 1.918 1.00
246_A 268_L 1.913 1.00
567_A 571_E 1.904 1.00
543_L 592_T 1.893 1.00
406_E 423_F 1.878 1.00
32_L 43_T 1.856 1.00
313_L 317_R 1.818 1.00
173_R 506_D 1.814 1.00
347_R 350_E 1.805 1.00
571_E 574_Q 1.805 1.00
558_E 598_R 1.785 1.00
578_V 582_E 1.784 1.00
584_A 587_N 1.783 1.00
243_H 247_D 1.751 1.00
555_S 558_E 1.74 1.00
79_A 106_Q 1.733 1.00
304_I 308_V 1.733 1.00
79_A 261_N 1.706 1.00
106_Q 118_E 1.702 1.00
563_D 567_A 1.694 1.00
32_L 52_L 1.686 1.00
137_L 140_R 1.677 1.00
285_T 292_Q 1.666 1.00
325_E 328_E 1.666 1.00
245_L 271_A 1.666 1.00
444_L 530_A 1.658 1.00
586_K 590_K 1.652 1.00
594_D 597_A 1.619 0.99
582_E 586_K 1.614 0.99
514_K 518_S 1.609 0.99
434_S 453_R 1.603 0.99
118_E 123_L 1.601 0.99
540_L 570_S 1.601 0.99
173_R 178_H 1.586 0.99
551_A 559_R 1.585 0.99
436_H 453_R 1.577 0.99
515_D 518_S 1.57 0.99
305_A 309_K 1.567 0.99
37_R 42_E 1.56 0.99
420_A 470_R 1.558 0.99
392_I 475_V 1.552 0.99
85_V 130_S 1.55 0.99
313_L 316_R 1.542 0.99
44_L 144_A 1.538 0.99
94_A 109_A 1.538 0.99
166_Q 170_D 1.537 0.99
316_R 320_K 1.533 0.99
514_K 517_M 1.532 0.99
21_A 374_A 1.527 0.99
589_D 593_Q 1.527 0.99
565_A 587_N 1.526 0.99
58_H 73_N 1.509 0.99
115_P 119_T 1.507 0.99
73_N 77_D 1.506 0.99
201_G 331_E 1.495 0.99
510_A 514_K 1.493 0.99
299_Q 303_L 1.484 0.99
308_V 347_R 1.478 0.99
540_L 569_L 1.469 0.99
420_A 472_T 1.469 0.99
217_I 329_V 1.468 0.99
301_N 346_E 1.443 0.98
155_T 370_A 1.442 0.98
248_Y 299_Q 1.442 0.98
228_L 324_V 1.442 0.98
405_V 438_M 1.44 0.98
532_Q 582_E 1.434 0.98
34_A 371_A 1.431 0.98
59_Y 132_D 1.43 0.98
407_K 443_E 1.43 0.98
208_L 213_F 1.426 0.98
580_A 584_A 1.421 0.98
302_E 305_A 1.419 0.98
444_L 447_D 1.415 0.98
317_R 320_K 1.41 0.98
312_L 316_R 1.405 0.98
124_L 129_V 1.4 0.98
202_V 324_V 1.396 0.98
270_A 274_A 1.387 0.98
593_Q 596_A 1.386 0.98
316_R 351_F 1.381 0.98
272_I 276_I 1.371 0.98
83_S 104_P 1.371 0.98
304_I 343_L 1.37 0.98
34_A 367_A 1.37 0.98
438_M 445_V 1.362 0.98
575_G 580_A 1.362 0.98
85_V 117_I 1.361 0.98
128_R 132_D 1.359 0.98
564_D 568_H 1.359 0.98
468_H 488_K 1.357 0.97
520_A 524_V 1.354 0.97
348_V 356_P 1.352 0.97
331_E 357_L 1.349 0.97
136_A 140_R 1.343 0.97
51_H 364_K 1.343 0.97
317_R 411_R 1.33 0.97
43_T 368_I 1.329 0.97
297_R 301_N 1.328 0.97
245_L 248_Y 1.317 0.97
340_R 363_D 1.314 0.97
170_D 173_R 1.314 0.97
583_Q 587_N 1.311 0.97
251_E 258_R 1.304 0.97
130_S 168_T 1.304 0.97
592_T 596_A 1.297 0.96
572_V 584_A 1.294 0.96
565_A 568_H 1.275 0.96
248_Y 303_L 1.268 0.96
521_E 524_V 1.267 0.96
59_Y 124_L 1.262 0.96
248_Y 295_I 1.262 0.96
547_L 563_D 1.258 0.96
172_A 182_L 1.25 0.95
204_A 315_C 1.25 0.95
535_E 585_I 1.247 0.95
346_E 349_G 1.238 0.95
25_D 28_T 1.235 0.95
77_D 80_N 1.235 0.95
533_K 573_A 1.222 0.95
97_Q 101_P 1.217 0.94
45_A 144_A 1.215 0.94
154_I 179_V 1.209 0.94
312_L 347_R 1.205 0.94
559_R 563_D 1.201 0.94
249_I 295_I 1.201 0.94
85_V 129_V 1.193 0.94
87_R 240_D 1.191 0.94
244_L 304_I 1.19 0.94
319_L 324_V 1.189 0.94
22_A 149_L 1.188 0.93
266_E 270_A 1.188 0.93
585_I 589_D 1.187 0.93
249_I 267_L 1.186 0.93
401_M 426_F 1.183 0.93
26_L 168_T 1.182 0.93
202_V 228_L 1.182 0.93
85_V 133_I 1.182 0.93
505_T 508_E 1.182 0.93
41_A 368_I 1.181 0.93
532_Q 585_I 1.18 0.93
23_G 27_G 1.178 0.93
132_D 135_K 1.174 0.93
450_S 453_R 1.172 0.93
556_A 559_R 1.167 0.93
295_I 300_F 1.161 0.92
400_T 406_E 1.159 0.92
319_L 329_V 1.158 0.92
534_V 541_E 1.157 0.92
399_E 403_G 1.155 0.92
249_I 286_V 1.154 0.92
528_M 578_V 1.153 0.92
47_H 140_R 1.152 0.92
241_F 308_V 1.139 0.91
286_V 295_I 1.138 0.91
317_R 321_D 1.138 0.91
460_P 489_S 1.137 0.91
556_A 563_D 1.134 0.91
462_L 487_E 1.132 0.91
565_A 591_Q 1.13 0.91
82_I 129_V 1.128 0.91
274_A 284_V 1.125 0.91
324_V 329_V 1.124 0.91
127_V 170_D 1.123 0.91
540_L 566_A 1.121 0.91
241_F 341_V 1.12 0.91
97_Q 100_Y 1.118 0.90
413_T 417_V 1.117 0.90
568_H 587_N 1.11 0.90
558_E 561_V 1.104 0.90
542_S 546_A 1.103 0.90
572_V 581_I 1.102 0.90
94_A 113_G 1.101 0.90
319_L 326_A 1.101 0.90
579_D 582_E 1.099 0.89
138_A 177_L 1.097 0.89
110_S 116_M 1.097 0.89
250_R 267_L 1.093 0.89
208_L 307_L 1.091 0.89
59_Y 129_V 1.088 0.89
231_G 317_R 1.085 0.89
61_Q 120_A 1.084 0.89
569_L 584_A 1.079 0.88
357_L 365_V 1.078 0.88
315_C 348_V 1.075 0.88
557_A 561_V 1.074 0.88
321_D 411_R 1.074 0.88
58_H 65_S 1.068 0.88
82_I 119_T 1.067 0.87
28_T 211_G 1.066 0.87
36_V 41_A 1.065 0.87
22_A 152_V 1.064 0.87
26_L 134_L 1.063 0.87
508_E 511_S 1.063 0.87
343_L 346_E 1.061 0.87
246_A 271_A 1.061 0.87
213_F 311_T 1.058 0.87
594_D 598_R 1.058 0.87
248_Y 293_G 1.052 0.86
343_L 347_R 1.052 0.86
537_A 541_E 1.046 0.86
543_L 566_A 1.044 0.86
248_Y 252_Q 1.044 0.86
202_V 219_R 1.043 0.86
172_A 179_V 1.043 0.86
218_L 227_V 1.041 0.86
314_A 318_A 1.033 0.85
93_L 97_Q 1.032 0.85
80_N 120_A 1.031 0.85
77_D 81_T 1.03 0.85
184_N 390_D 1.03 0.85
51_H 361_D 1.029 0.85
315_C 351_F 1.029 0.85
296_S 299_Q 1.026 0.85
580_A 583_Q 1.024 0.84
316_R 326_A 1.023 0.84
233_D 313_L 1.023 0.84
406_E 421_Q 1.021 0.84
154_I 172_A 1.019 0.84
565_A 569_L 1.019 0.84
544_H 548_A 1.018 0.84
395_S 441_E 1.016 0.84
252_Q 293_G 1.01 0.83
562_I 591_Q 1.009 0.83
548_A 551_A 1.007 0.83
586_K 589_D 1.006 0.83
570_S 574_Q 1.006 0.83
82_I 85_V 1.004 0.83
527_R 531_E 1.003 0.83
387_L 477_A 1.001 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3d2fA20.96921000.196Contact Map0.689
4jneA20.95131000.204Contact Map0.81
1yuwA10.86361000.275Contact Map0.738
4fl9A10.86361000.275Contact Map0.751
2v7yA10.80361000.326Contact Map0.73
3qfuA10.60881000.535Contact Map0.735
3i33A10.60231000.537Contact Map0.757
4gniA20.61361000.546Contact Map0.689
4j8fA10.86041000.548Contact Map0.75
1jceA10.52271000.704Contact Map0.521
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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