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OPENSEQ.org
MREB - Rod shape-determining protein MreB
UniProt: P0A9X4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10608
Length: 347 (327)
Sequences: 6361
Seq/Len: 19.45
MREB
Paralog alert: 0.79 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: DNAK HSCA HSCC MREB YEGD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
109_R 136_R 5.204 1.00
197_A 262_E 4.159 1.00
186_S 266_G 3.975 1.00
308_M 314_P 3.612 1.00
305_R 309_E 3.492 1.00
164_V 267_I 3.415 1.00
175_V 274_A 3.012 1.00
205_N 255_E 2.979 1.00
198_I 251_L 2.964 1.00
203_R 211_G 2.916 1.00
255_E 258_E 2.748 1.00
320_D 323_T 2.617 1.00
109_R 138_V 2.603 1.00
216_E 220_H 2.531 1.00
268_V 310_E 2.487 1.00
227_P 250_T 2.419 1.00
272_M 310_E 2.338 1.00
196_E 200_N 2.323 1.00
112_V 130_A 2.311 1.00
217_R 221_E 2.273 1.00
304_D 317_V 2.264 1.00
261_Q 265_T 2.227 1.00
162_M 173_V 2.207 1.00
20_A 168_G 2.179 1.00
306_L 309_E 2.118 1.00
264_L 302_N 2.114 1.00
159_T 289_R 2.057 1.00
297_G 300_L 2.047 1.00
283_A 286_I 2.035 1.00
260_L 300_L 1.974 1.00
202_V 215_A 1.958 1.00
131_Q 136_R 1.956 1.00
269_S 273_V 1.938 1.00
162_M 175_V 1.936 1.00
194_F 263_P 1.919 1.00
12_D 138_V 1.869 1.00
273_V 277_Q 1.833 1.00
194_F 260_L 1.818 1.00
256_I 300_L 1.79 1.00
269_S 272_M 1.783 1.00
268_V 306_L 1.778 1.00
62_M 66_T 1.767 1.00
260_L 264_L 1.754 1.00
175_V 278_C 1.688 1.00
166_I 194_F 1.685 1.00
272_M 276_E 1.685 1.00
95_I 99_H 1.681 1.00
253_S 257_L 1.665 1.00
299_L 322_L 1.665 1.00
113_C 329_G 1.629 1.00
305_R 308_M 1.624 1.00
13_L 24_I 1.619 1.00
198_I 215_A 1.617 1.00
124_R 128_E 1.611 1.00
252_N 255_E 1.606 1.00
25_Y 326_A 1.594 1.00
166_I 171_T 1.576 1.00
19_T 169_G 1.561 1.00
199_I 215_A 1.556 1.00
25_Y 330_G 1.55 1.00
197_A 260_L 1.545 1.00
264_L 306_L 1.541 1.00
91_L 94_F 1.518 1.00
302_N 305_R 1.506 1.00
175_V 287_S 1.48 1.00
273_V 276_E 1.471 1.00
233_E 250_T 1.469 1.00
160_G 282_L 1.463 1.00
89_K 93_H 1.461 1.00
201_Y 205_N 1.454 1.00
307_L 315_V 1.452 1.00
256_I 297_G 1.452 1.00
199_I 212_E 1.448 1.00
141_I 332_A 1.436 1.00
128_E 131_Q 1.432 1.00
268_V 272_M 1.431 1.00
306_L 310_E 1.428 1.00
197_A 263_P 1.415 1.00
17_L 126_I 1.407 0.99
93_H 96_K 1.403 0.99
255_E 259_A 1.379 0.99
66_T 69_N 1.374 0.99
202_V 249_F 1.374 0.99
62_M 65_R 1.368 0.99
258_E 261_Q 1.36 0.99
257_L 305_R 1.36 0.99
89_K 92_Q 1.339 0.99
237_R 243_E 1.329 0.99
204_R 211_G 1.328 0.99
66_T 70_I 1.32 0.99
160_G 177_S 1.312 0.99
95_I 98_V 1.311 0.99
16_D 19_T 1.311 0.99
293_L 307_L 1.308 0.99
120_Q 124_R 1.308 0.99
194_F 264_L 1.301 0.99
194_F 300_L 1.286 0.99
265_T 269_S 1.261 0.99
323_T 327_R 1.256 0.99
200_N 204_R 1.252 0.99
194_F 256_I 1.246 0.98
57_H 61_Q 1.242 0.98
87_T 91_L 1.227 0.98
271_V 307_L 1.222 0.98
275_L 284_S 1.22 0.98
294_T 324_C 1.219 0.98
171_T 267_I 1.203 0.98
142_E 145_M 1.193 0.98
31_I 34_N 1.191 0.98
22_T 37_S 1.19 0.98
12_D 109_R 1.18 0.98
320_D 327_R 1.179 0.98
265_T 268_V 1.161 0.97
191_G 297_G 1.16 0.97
91_L 95_I 1.16 0.97
201_Y 255_E 1.154 0.97
302_N 306_L 1.153 0.97
289_R 316_V 1.151 0.97
261_Q 302_N 1.144 0.97
27_K 30_G 1.142 0.97
82_A 85_F 1.14 0.97
165_D 172_E 1.135 0.97
291_M 311_T 1.122 0.97
23_L 31_I 1.119 0.96
282_L 286_I 1.119 0.96
201_Y 259_A 1.116 0.96
189_I 193_R 1.113 0.96
253_S 301_R 1.111 0.96
14_S 326_A 1.107 0.96
53_A 93_H 1.103 0.96
316_V 324_C 1.097 0.96
88_E 91_L 1.096 0.96
92_Q 96_K 1.093 0.96
151_A 324_C 1.09 0.96
169_G 172_E 1.081 0.95
261_Q 306_L 1.081 0.95
141_I 146_A 1.074 0.95
275_L 282_L 1.073 0.95
164_V 171_T 1.066 0.95
235_E 248_G 1.064 0.95
111_L 332_A 1.061 0.95
23_L 326_A 1.06 0.95
260_L 302_N 1.054 0.95
197_A 200_N 1.054 0.95
68_G 77_K 1.05 0.94
40_A 62_M 1.047 0.94
237_R 244_G 1.046 0.94
260_L 263_P 1.044 0.94
198_I 256_I 1.043 0.94
114_V 126_I 1.041 0.94
143_E 172_E 1.036 0.94
293_L 298_A 1.032 0.94
162_M 271_V 1.03 0.94
214_T 218_I 1.03 0.94
114_V 140_L 1.028 0.94
119_T 122_E 1.02 0.93
10_S 109_R 1.015 0.93
123_R 142_E 1.015 0.93
214_T 217_R 1.015 0.93
62_M 69_N 1.01 0.93
165_D 169_G 1.008 0.93
87_T 90_M 1.002 0.92
12_D 333_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3d2fA20.93081000.239Contact Map0.677
4jneA20.93371000.247Contact Map0.828
4fl9A10.93371000.282Contact Map0.779
1yuwA10.93371000.282Contact Map0.747
2v7yA10.93371000.286Contact Map0.813
1jceA10.96251000.309Contact Map0.645
3i33A10.9281000.332Contact Map0.768
3qfuA10.92221000.335Contact Map0.749
4j8fA10.94521000.342Contact Map0.781
4gniA20.94241000.352Contact Map0.712
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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