May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YEGD - Uncharacterized chaperone protein YegD
UniProt: P36928 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12200
Length: 450 (419)
Sequences: 1258
Seq/Len: 3.00
YEGD
Paralog alert: 0.65 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: DNAK HSCA HSCC MREB YEGD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
417_K 421_E 3.069 1.00
108_S 253_N 2.909 1.00
128_D 182_R 2.702 1.00
342_E 346_I 2.682 1.00
382_L 414_L 2.546 1.00
154_I 180_A 2.465 1.00
12_C 137_I 2.41 1.00
128_D 132_A 2.407 1.00
409_S 412_S 2.353 1.00
132_A 135_L 2.305 1.00
9_T 219_G 2.182 1.00
138_R 142_Q 2.153 1.00
86_V 132_A 2.128 1.00
110_K 219_G 2.118 1.00
155_G 441_L 2.078 1.00
3_I 14_V 1.985 1.00
225_L 392_A 1.981 1.00
418_A 421_E 1.965 1.00
374_L 412_S 1.965 1.00
173_Q 177_E 1.945 1.00
219_G 222_D 1.942 0.99
193_E 222_D 1.909 0.99
7_Y 130_V 1.896 0.99
151_Q 186_R 1.836 0.99
194_P 222_D 1.805 0.99
15_A 442_A 1.79 0.99
155_G 158_I 1.779 0.99
259_L 369_I 1.778 0.99
386_L 422_Q 1.775 0.99
390_Q 422_Q 1.755 0.99
193_E 220_T 1.722 0.99
371_Q 375_E 1.721 0.99
216_I 221_T 1.714 0.98
218_G 222_D 1.708 0.98
89_G 110_K 1.701 0.98
194_P 220_T 1.697 0.98
5_F 152_A 1.684 0.98
210_R 227_L 1.671 0.98
391_L 395_N 1.668 0.98
337_L 384_R 1.655 0.98
10_A 218_G 1.647 0.98
18_R 23_H 1.616 0.98
373_G 376_S 1.611 0.97
156_R 190_F 1.604 0.97
318_E 321_K 1.598 0.97
15_A 438_T 1.592 0.97
118_L 123_V 1.56 0.97
371_Q 413_P 1.498 0.96
406_T 436_S 1.488 0.95
131_C 182_R 1.484 0.95
7_Y 173_Q 1.48 0.95
110_K 220_T 1.476 0.95
193_E 219_G 1.469 0.95
376_S 379_S 1.45 0.94
201_Y 209_K 1.449 0.94
264_L 341_A 1.443 0.94
5_F 154_I 1.435 0.94
214_V 385_I 1.432 0.94
216_I 415_I 1.424 0.94
177_E 181_K 1.423 0.94
414_L 417_K 1.417 0.94
212_L 223_C 1.411 0.93
13_S 438_T 1.397 0.93
110_K 193_E 1.393 0.93
378_L 381_P 1.375 0.92
369_I 374_L 1.369 0.92
2_F 445_A 1.365 0.92
9_T 194_P 1.364 0.92
372_R 376_S 1.359 0.92
387_E 390_Q 1.346 0.91
36_S 219_G 1.346 0.91
374_L 410_A 1.345 0.91
152_A 183_A 1.34 0.91
36_S 110_K 1.336 0.91
113_L 130_V 1.33 0.90
130_V 173_Q 1.328 0.90
387_E 391_L 1.327 0.90
222_D 247_G 1.323 0.90
158_I 194_P 1.316 0.90
24_L 27_M 1.313 0.90
374_L 409_S 1.309 0.89
106_V 109_P 1.302 0.89
109_P 133_M 1.291 0.89
255_L 412_S 1.282 0.88
194_P 218_G 1.281 0.88
392_A 396_A 1.266 0.87
193_E 197_A 1.264 0.87
196_A 256_D 1.256 0.87
194_P 197_A 1.253 0.87
274_T 280_L 1.251 0.86
355_R 366_A 1.247 0.86
225_L 396_A 1.245 0.86
259_L 341_A 1.243 0.86
151_Q 187_D 1.235 0.85
126_F 130_V 1.234 0.85
193_E 218_G 1.234 0.85
258_A 380_Q 1.233 0.85
40_A 132_A 1.229 0.85
3_I 185_F 1.229 0.85
219_G 406_T 1.225 0.85
198_G 247_G 1.22 0.85
378_L 412_S 1.219 0.84
348_L 371_Q 1.219 0.84
6_D 9_T 1.208 0.84
39_C 103_V 1.203 0.83
349_S 413_P 1.197 0.83
159_N 247_G 1.194 0.83
39_C 87_Q 1.193 0.83
432_D 435_G 1.193 0.83
418_A 422_Q 1.185 0.82
197_A 247_G 1.185 0.82
138_R 185_F 1.183 0.82
194_P 219_G 1.178 0.82
214_V 221_T 1.175 0.81
7_Y 134_M 1.175 0.81
135_L 139_Q 1.174 0.81
216_I 385_I 1.171 0.81
197_A 220_T 1.168 0.81
113_L 173_Q 1.167 0.81
27_M 34_L 1.159 0.80
136_H 140_Q 1.157 0.80
370_S 373_G 1.157 0.80
160_F 176_L 1.155 0.80
336_R 358_L 1.155 0.80
230_P 238_R 1.154 0.80
344_C 354_T 1.152 0.80
201_Y 409_S 1.149 0.79
9_T 12_C 1.148 0.79
311_D 322_V 1.146 0.79
209_K 401_D 1.145 0.79
299_D 302_S 1.143 0.79
13_S 33_L 1.142 0.79
197_A 437_V 1.141 0.79
171_Q 178_R 1.136 0.78
273_E 279_A 1.132 0.78
386_L 418_A 1.13 0.78
404_Y 431_G 1.129 0.78
220_T 256_D 1.127 0.77
11_N 108_S 1.127 0.77
111_S 216_I 1.118 0.77
9_T 441_L 1.116 0.77
106_V 129_L 1.114 0.76
327_K 331_Q 1.113 0.76
158_I 222_D 1.113 0.76
215_D 219_G 1.112 0.76
319_P 374_L 1.109 0.76
255_L 374_L 1.106 0.76
372_R 375_E 1.106 0.76
355_R 368_L 1.101 0.75
406_T 441_L 1.098 0.75
191_Q 199_L 1.098 0.75
216_I 255_L 1.097 0.75
267_L 367_T 1.091 0.74
215_D 220_T 1.086 0.74
114_G 172_A 1.085 0.74
383_T 387_E 1.084 0.74
9_T 222_D 1.077 0.73
220_T 247_G 1.077 0.73
114_G 254_D 1.074 0.73
243_L 398_E 1.07 0.72
130_V 437_V 1.068 0.72
194_P 256_D 1.068 0.72
189_V 444_W 1.066 0.72
25_L 190_F 1.064 0.72
100_P 371_Q 1.064 0.72
158_I 220_T 1.06 0.71
258_A 261_F 1.058 0.71
110_K 222_D 1.058 0.71
134_M 220_T 1.047 0.70
111_S 254_D 1.046 0.70
247_G 406_T 1.042 0.69
206_Q 230_P 1.041 0.69
328_V 333_L 1.04 0.69
14_V 137_I 1.04 0.69
378_L 382_L 1.039 0.69
9_T 220_T 1.037 0.69
3_I 214_V 1.035 0.69
194_P 213_V 1.034 0.68
119_K 122_Q 1.031 0.68
110_K 218_G 1.031 0.68
197_A 222_D 1.028 0.68
158_I 173_Q 1.027 0.68
433_D 443_R 1.027 0.68
178_R 182_R 1.022 0.67
388_Q 392_A 1.02 0.67
212_L 225_L 1.019 0.67
283_L 315_D 1.014 0.66
113_L 190_F 1.014 0.66
59_D 80_D 1.012 0.66
4_G 438_T 1.01 0.66
424_P 427_P 1.01 0.66
348_L 412_S 1.01 0.66
172_A 342_E 1.009 0.66
399_K 417_K 1.008 0.66
185_F 391_L 1.007 0.65
371_Q 374_L 1.005 0.65
124_A 132_A 1.004 0.65
138_R 152_A 1.003 0.65
9_T 110_K 1.002 0.65
139_Q 394_D 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4jneA20.76441000.301Contact Map0.598
3d2fA20.75331000.301Contact Map0.565
1yuwA10.75331000.337Contact Map0.521
4fl9A10.75331000.337Contact Map0.54
2v7yA10.75111000.348Contact Map0.551
3i33A10.75331000.382Contact Map0.564
4j8fA10.75331000.392Contact Map0.572
3qfuA10.75111000.396Contact Map0.536
4gniA20.75331000.398Contact Map0.549
1jceA10.68671000.572Contact Map0.467
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.1337 seconds.