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WCAC - Putative colanic acid biosynthesis glycosyl transferase WcaC
UniProt: P71237 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13571
Length: 405 (393)
Sequences: 11774
Seq/Len: 29.96
WCAC
Paralog alert: 0.79 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: GLGA RFAB RFAG WBBK WCAC WCAI WCAL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
245_A 307_M 4.778 1.00
273_E 289_V 4.168 1.00
2_N 32_A 3.535 1.00
99_H 402_Y 3.521 1.00
265_M 274_L 3.128 1.00
241_K 273_E 2.982 1.00
29_Q 396_E 2.866 1.00
267_A 359_L 2.786 1.00
279_K 283_F 2.751 1.00
34_H 95_P 2.748 1.00
193_Q 215_R 2.739 1.00
354_S 360_Q 2.683 1.00
31_L 399_V 2.545 1.00
337_H 342_R 2.515 1.00
310_L 326_A 2.512 1.00
337_H 354_S 2.476 1.00
267_A 362_V 2.461 1.00
3_I 31_L 2.329 1.00
357_E 360_Q 2.289 1.00
99_H 132_T 2.284 1.00
263_R 358_V 2.281 1.00
345_L 350_G 2.255 1.00
335_A 352_T 2.242 1.00
34_H 93_A 2.237 1.00
202_A 206_N 2.235 1.00
4_L 36_V 2.207 1.00
257_T 260_Q 2.178 1.00
243_K 275_H 2.163 1.00
261_L 311_V 2.161 1.00
393_Q 397_E 2.16 1.00
277_F 303_A 2.159 1.00
242_P 373_I 2.13 1.00
358_V 362_V 2.126 1.00
351_K 364_L 2.111 1.00
29_Q 399_V 2.095 1.00
246_V 258_N 2.069 1.00
269_G 287_N 2.042 1.00
275_H 291_H 2.035 1.00
244_I 309_A 2.012 1.00
294_E 303_A 1.981 1.00
261_L 274_L 1.979 1.00
25_R 28_Q 1.975 1.00
382_S 385_S 1.967 1.00
25_R 395_L 1.919 1.00
131_W 187_M 1.91 1.00
215_R 404_N 1.905 1.00
199_Q 202_A 1.891 1.00
1_M 31_L 1.867 1.00
4_L 95_P 1.865 1.00
310_L 331_V 1.839 1.00
199_Q 203_D 1.837 1.00
268_L 370_A 1.813 1.00
397_E 400_N 1.812 1.00
360_Q 364_L 1.797 1.00
323_L 341_A 1.792 1.00
371_Q 375_G 1.749 1.00
5_Q 26_A 1.739 1.00
257_T 315_R 1.731 1.00
5_Q 101_H 1.729 1.00
202_A 216_I 1.717 1.00
243_K 273_E 1.711 1.00
244_I 369_I 1.703 1.00
243_K 306_Q 1.698 1.00
353_V 364_L 1.676 1.00
251_L 276_T 1.662 1.00
220_G 391_G 1.661 1.00
364_L 371_Q 1.657 1.00
25_R 392_Q 1.654 1.00
193_Q 401_F 1.64 1.00
22_L 398_Y 1.63 1.00
354_S 357_E 1.614 1.00
382_S 386_R 1.597 1.00
199_Q 343_E 1.588 1.00
268_L 272_I 1.576 1.00
202_A 214_C 1.575 1.00
370_A 374_F 1.573 1.00
195_I 398_Y 1.572 1.00
265_M 272_I 1.557 1.00
255_G 316_V 1.552 1.00
277_F 291_H 1.543 1.00
393_Q 396_E 1.541 1.00
351_K 371_Q 1.526 1.00
259_Q 315_R 1.509 1.00
20_L 24_Q 1.503 1.00
378_L 382_S 1.492 1.00
217_I 401_F 1.477 1.00
275_H 289_V 1.47 1.00
399_V 403_Q 1.463 1.00
380_E 384_R 1.446 1.00
335_A 341_A 1.443 1.00
360_Q 363_Q 1.442 1.00
242_P 308_D 1.442 1.00
196_S 214_C 1.441 1.00
100_F 129_L 1.436 1.00
5_Q 23_H 1.429 1.00
264_E 361_L 1.429 1.00
13_G 16_A 1.426 1.00
18_V 134_H 1.423 1.00
260_Q 356_E 1.418 1.00
27_L 30_G 1.414 1.00
247_V 277_F 1.391 0.99
195_I 401_F 1.391 0.99
314_S 317_D 1.39 0.99
345_L 349_G 1.377 0.99
258_N 276_T 1.375 0.99
244_I 311_V 1.371 0.99
199_Q 216_I 1.366 0.99
217_I 398_Y 1.361 0.99
193_Q 404_N 1.354 0.99
210_G 213_R 1.35 0.99
203_D 206_N 1.35 0.99
242_P 309_A 1.348 0.99
134_H 321_L 1.348 0.99
197_P 219_N 1.346 0.99
101_H 134_H 1.329 0.99
319_Y 324_C 1.329 0.99
339_D 342_R 1.324 0.99
23_H 35_F 1.324 0.99
307_M 331_V 1.319 0.99
381_F 384_R 1.313 0.99
259_Q 263_R 1.311 0.99
326_A 331_V 1.307 0.99
196_S 202_A 1.304 0.99
299_K 302_S 1.3 0.99
346_Q 349_G 1.297 0.99
19_A 101_H 1.293 0.99
390_S 393_Q 1.292 0.99
218_N 389_Y 1.285 0.99
267_A 358_V 1.283 0.99
348_S 384_R 1.282 0.99
226_E 329_I 1.271 0.99
379_A 383_Q 1.269 0.99
335_A 345_L 1.268 0.99
247_V 300_L 1.266 0.99
218_N 343_E 1.249 0.99
277_F 294_E 1.246 0.98
381_F 385_S 1.245 0.98
336_T 353_V 1.245 0.98
304_L 322_I 1.244 0.98
330_G 386_R 1.231 0.98
294_E 299_K 1.226 0.98
100_F 131_W 1.222 0.98
295_T 299_K 1.219 0.98
23_H 27_L 1.218 0.98
222_D 225_T 1.218 0.98
97_V 402_Y 1.206 0.98
309_A 334_I 1.205 0.98
245_A 304_L 1.2 0.98
334_I 353_V 1.196 0.98
18_V 321_L 1.188 0.98
27_L 33_S 1.187 0.98
243_K 308_D 1.184 0.98
312_F 322_I 1.183 0.98
247_V 304_L 1.182 0.98
291_H 294_E 1.179 0.98
396_E 400_N 1.168 0.97
195_I 217_I 1.166 0.97
2_N 34_H 1.166 0.97
29_Q 395_L 1.165 0.97
135_D 255_G 1.163 0.97
5_Q 33_S 1.163 0.97
315_R 356_E 1.162 0.97
309_A 369_I 1.16 0.97
260_Q 358_V 1.16 0.97
222_D 226_E 1.157 0.97
323_L 344_V 1.154 0.97
268_L 369_I 1.149 0.97
264_E 362_V 1.148 0.97
244_I 265_M 1.145 0.97
353_V 360_Q 1.143 0.97
238_T 241_K 1.142 0.97
18_V 219_N 1.136 0.97
310_L 322_I 1.133 0.97
226_E 301_M 1.13 0.97
223_M 390_S 1.126 0.97
29_Q 392_Q 1.114 0.96
253_Y 281_S 1.112 0.96
392_Q 396_E 1.11 0.96
275_H 303_A 1.11 0.96
340_A 343_E 1.11 0.96
260_Q 315_R 1.107 0.96
274_L 288_V 1.107 0.96
391_G 394_M 1.105 0.96
372_A 375_G 1.102 0.96
132_T 402_Y 1.101 0.96
317_D 320_P 1.101 0.96
372_A 378_L 1.099 0.96
300_L 304_L 1.092 0.96
4_L 89_I 1.078 0.95
223_M 328_S 1.072 0.95
400_N 403_Q 1.072 0.95
25_R 29_Q 1.066 0.95
311_V 369_I 1.062 0.95
323_L 333_V 1.061 0.95
215_R 397_E 1.055 0.95
380_E 383_Q 1.054 0.95
291_H 303_A 1.051 0.94
218_N 397_E 1.049 0.94
275_H 307_M 1.047 0.94
320_P 323_L 1.046 0.94
245_A 303_A 1.044 0.94
220_G 394_M 1.04 0.94
256_K 314_S 1.04 0.94
353_V 361_L 1.038 0.94
18_V 101_H 1.035 0.94
394_M 397_E 1.029 0.94
243_K 307_M 1.028 0.94
280_F 283_F 1.026 0.94
2_N 95_P 1.017 0.93
320_P 341_A 1.013 0.93
244_I 274_L 1.013 0.93
23_H 33_S 1.013 0.93
234_P 302_S 1.001 0.92
7_N 15_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1rzuA20.9211000.204Contact Map0.72
2qzsA10.91851000.215Contact Map0.74
2r60A10.89881000.222Contact Map0.684
3c48A20.87411000.253Contact Map0.797
2gekA10.8421000.256Contact Map0.731
2x6qA20.83211000.26Contact Map0.766
2x0dA20.84941000.261Contact Map0.606
3froA30.89141000.262Contact Map0.802
3s28A80.91111000.264Contact Map0.567
3okpA10.83951000.273Contact Map0.738
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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