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OPENSEQ.org
WBBK - Putative glycosyltransferase WbbK
UniProt: P37751 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11985
Length: 372 (364)
Sequences: 18379
Seq/Len: 50.49
WBBK
Paralog alert: 0.87 [within 20: 0.44] - ratio of genomes with paralogs
Cluster includes: GLGA RFAB RFAG WBBK WCAC WCAI WCAL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
202_F 274_S 4.521 1.00
230_K 257_H 3.767 1.00
240_N 244_K 3.452 1.00
149_A 171_I 3.284 1.00
5_I 36_S 3.243 1.00
218_S 246_I 3.045 1.00
277_V 293_A 2.596 1.00
222_K 330_V 2.55 1.00
222_K 327_D 2.534 1.00
158_K 162_I 2.462 1.00
90_I 107_Y 2.429 1.00
38_I 86_A 2.397 1.00
304_D 309_R 2.359 1.00
220_A 231_F 2.302 1.00
38_I 57_I 2.293 1.00
218_S 326_D 2.288 1.00
226_Q 334_I 2.273 1.00
203_Y 213_Y 2.257 1.00
236_S 240_N 2.233 1.00
322_D 328_M 2.216 1.00
304_D 322_D 2.196 1.00
312_L 318_K 2.183 1.00
224_K 255_N 2.15 1.00
200_T 232_L 2.13 1.00
7_V 86_A 2.128 1.00
90_I 368_I 2.103 1.00
201_I 276_I 2.04 1.00
199_L 337_K 2.015 1.00
319_A 332_L 2.004 1.00
200_T 273_I 1.998 1.00
325_N 328_M 1.993 1.00
212_N 215_L 1.991 1.00
38_I 84_L 1.982 1.00
155_F 158_K 1.953 1.00
313_G 316_E 1.946 1.00
247_I 258_F 1.931 1.00
106_V 147_N 1.926 1.00
232_L 259_L 1.918 1.00
7_V 40_L 1.914 1.00
302_A 320_F 1.912 1.00
201_I 333_I 1.897 1.00
234_T 270_C 1.891 1.00
332_L 335_D 1.881 1.00
335_D 342_K 1.861 1.00
216_I 278_C 1.858 1.00
247_I 252_G 1.853 1.00
339_G 342_K 1.833 1.00
326_D 330_V 1.822 1.00
246_I 250_A 1.781 1.00
198_E 230_K 1.778 1.00
204_P 267_I 1.776 1.00
248_S 253_L 1.773 1.00
155_F 310_E 1.771 1.00
239_E 242_Y 1.76 1.00
28_A 31_N 1.755 1.00
223_L 334_I 1.749 1.00
212_N 282_R 1.748 1.00
262_L 266_K 1.745 1.00
262_L 270_C 1.732 1.00
277_V 298_K 1.73 1.00
155_F 159_E 1.729 1.00
266_K 269_H 1.719 1.00
245_Y 249_L 1.711 1.00
6_V 35_V 1.709 1.00
4_S 35_V 1.7 1.00
158_K 172_V 1.699 1.00
328_M 332_L 1.689 1.00
199_L 275_D 1.673 1.00
221_R 250_A 1.671 1.00
274_S 298_K 1.645 1.00
335_D 339_G 1.642 1.00
158_K 170_I 1.642 1.00
313_G 317_K 1.639 1.00
155_F 172_V 1.601 1.00
216_I 231_F 1.58 1.00
166_S 169_N 1.566 1.00
263_D 266_K 1.551 1.00
290_L 308_T 1.541 1.00
152_V 170_I 1.541 1.00
38_I 55_K 1.535 1.00
334_I 338_K 1.528 1.00
319_A 335_D 1.522 1.00
219_A 329_L 1.52 1.00
232_L 257_H 1.517 1.00
200_T 230_K 1.517 1.00
207_P 233_L 1.516 1.00
214_E 282_R 1.472 1.00
214_E 246_I 1.465 1.00
23_K 27_A 1.459 1.00
220_A 229_I 1.458 1.00
321_F 332_L 1.455 1.00
302_A 308_T 1.437 1.00
91_C 104_R 1.432 1.00
246_I 249_L 1.432 1.00
302_A 312_L 1.43 1.00
201_I 278_C 1.418 1.00
340_N 343_K 1.412 1.00
210_F 283_L 1.401 0.99
33_E 362_D 1.36 0.99
8_V 29_T 1.352 0.99
5_I 38_I 1.347 0.99
109_H 288_L 1.324 0.99
286_W 291_S 1.323 0.99
204_P 271_Y 1.321 0.99
223_L 229_I 1.318 0.99
328_M 331_K 1.317 0.99
180_S 296_R 1.308 0.99
153_Q 175_P 1.307 0.99
8_V 92_L 1.306 0.99
159_E 162_I 1.306 0.99
222_K 326_D 1.302 0.99
322_D 325_N 1.3 0.99
234_T 259_L 1.29 0.99
203_Y 216_I 1.28 0.99
151_F 173_S 1.269 0.99
279_F 289_P 1.267 0.99
8_V 26_L 1.266 0.99
303_S 321_F 1.255 0.99
159_E 163_K 1.252 0.99
162_I 167_I 1.25 0.99
180_S 268_D 1.241 0.98
36_S 55_K 1.239 0.98
200_T 275_D 1.235 0.98
21_I 288_L 1.227 0.98
215_L 326_D 1.22 0.98
103_K 148_T 1.219 0.98
109_H 153_Q 1.209 0.98
301_L 321_F 1.205 0.98
293_A 298_K 1.203 0.98
202_F 271_Y 1.202 0.98
267_I 271_Y 1.2 0.98
268_D 296_R 1.197 0.98
199_L 276_I 1.196 0.98
152_V 158_K 1.187 0.98
223_L 333_I 1.179 0.98
241_A 244_K 1.169 0.97
30_N 34_N 1.169 0.97
312_L 317_K 1.16 0.97
35_V 365_V 1.149 0.97
306_P 309_R 1.148 0.97
276_I 336_F 1.146 0.97
359_V 363_E 1.143 0.97
152_V 161_F 1.134 0.97
294_K 300_V 1.128 0.97
290_L 311_T 1.126 0.97
214_E 218_S 1.124 0.97
222_K 225_E 1.123 0.97
244_K 248_S 1.118 0.96
16_G 19_F 1.111 0.96
22_L 92_L 1.11 0.96
26_L 39_A 1.109 0.96
213_Y 233_L 1.105 0.96
259_L 262_L 1.105 0.96
152_V 157_M 1.098 0.96
8_V 90_I 1.096 0.96
232_L 270_C 1.096 0.96
174_R 310_E 1.093 0.96
24_K 27_A 1.093 0.96
202_F 234_T 1.087 0.96
92_L 109_H 1.085 0.96
271_Y 296_R 1.085 0.96
276_I 333_I 1.085 0.96
201_I 220_A 1.076 0.95
215_L 282_R 1.074 0.95
208_R 238_T 1.072 0.95
204_P 234_T 1.071 0.95
278_C 333_I 1.071 0.95
259_L 270_C 1.057 0.95
206_V 210_F 1.056 0.95
264_K 267_I 1.054 0.95
191_Q 269_H 1.054 0.95
234_T 262_L 1.052 0.95
294_K 317_K 1.051 0.94
21_I 109_H 1.046 0.94
282_R 324_N 1.046 0.94
319_A 342_K 1.039 0.94
200_T 274_S 1.039 0.94
301_L 332_L 1.039 0.94
281_S 284_E 1.033 0.94
28_A 33_E 1.031 0.94
349_N 353_R 1.031 0.94
221_R 224_K 1.03 0.94
272_N 296_R 1.028 0.94
331_K 335_D 1.026 0.94
219_A 330_V 1.022 0.93
5_I 86_A 1.021 0.93
279_F 290_L 1.019 0.93
215_L 329_L 1.019 0.93
314_S 332_L 1.017 0.93
202_F 270_C 1.016 0.93
33_E 365_V 1.016 0.93
307_F 310_E 1.015 0.93
321_F 329_L 1.013 0.93
232_L 274_S 1.012 0.93
277_V 289_P 1.01 0.93
271_Y 289_P 1.007 0.93
287_G 308_T 1.007 0.93
153_Q 157_M 1.006 0.93
217_I 247_I 1.006 0.93
350_F 354_N 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r60A10.99461000.122Contact Map0.698
3c48A20.97581000.149Contact Map0.822
1rzuA20.97311000.163Contact Map0.728
3froA30.97311000.166Contact Map0.782
2qzsA10.97311000.169Contact Map0.732
2x6qA20.93281000.183Contact Map0.771
3okpA10.93281000.187Contact Map0.78
3s28A80.98121000.197Contact Map0.601
2jjmA120.95161000.199Contact Map0.793
2gekA10.92471000.2Contact Map0.731
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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