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OPENSEQ.org
YDDG - Aromatic amino acid exporter YddG
UniProt: P46136 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12713
Length: 293 (277)
Sequences: 12958
Seq/Len: 46.78
YDDG
Paralog alert: 0.84 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: EAMA RHTA YDDG YEDA YHBE YICL YIJE YTFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
82_S 162_A 3.586 1.00
125_G 282_G 2.649 1.00
235_V 239_H 2.516 1.00
18_S 255_L 2.496 1.00
9_I 235_V 2.431 1.00
23_L 221_S 2.354 1.00
94_E 159_Y 2.306 1.00
78_C 164_I 2.28 1.00
105_L 166_A 2.233 1.00
260_A 266_A 2.177 1.00
96_G 256_S 2.174 1.00
81_L 161_L 2.143 1.00
235_V 238_L 2.128 1.00
109_F 174_T 2.113 1.00
160_F 164_I 2.072 1.00
43_L 223_A 2.068 1.00
223_A 227_G 2.052 1.00
25_R 266_A 2.05 1.00
213_T 217_I 1.999 1.00
116_Q 177_N 1.998 1.00
10_G 236_G 1.985 1.00
106_T 246_A 1.95 1.00
18_S 259_L 1.872 1.00
24_I 80_A 1.866 1.00
111_I 118_T 1.843 1.00
15_V 255_L 1.835 1.00
107_I 126_L 1.828 1.00
78_C 161_L 1.8 1.00
45_G 191_L 1.79 1.00
86_A 91_Q 1.768 1.00
110_A 114_N 1.746 1.00
95_V 162_A 1.728 1.00
19_T 221_S 1.674 1.00
259_L 263_L 1.633 1.00
78_C 168_I 1.633 1.00
101_L 105_L 1.626 1.00
110_A 116_Q 1.599 1.00
109_F 171_A 1.588 1.00
269_S 272_F 1.577 1.00
86_A 159_Y 1.569 1.00
270_F 274_Q 1.558 1.00
60_I 182_G 1.544 1.00
127_L 131_V 1.501 1.00
31_L 215_V 1.5 1.00
105_L 167_F 1.491 1.00
45_G 194_G 1.49 1.00
119_N 122_I 1.489 1.00
129_A 250_Y 1.489 1.00
255_L 259_L 1.482 1.00
16_L 224_F 1.48 1.00
241_N 244_I 1.47 1.00
273_W 277_L 1.469 1.00
36_G 222_A 1.464 1.00
86_A 158_S 1.464 1.00
86_A 94_E 1.451 1.00
46_L 50_F 1.444 1.00
214_P 217_I 1.421 1.00
92_A 260_A 1.42 1.00
170_A 174_T 1.414 1.00
19_T 259_L 1.402 0.99
27_V 36_G 1.4 0.99
118_T 123_V 1.382 0.99
212_S 215_V 1.375 0.99
22_G 259_L 1.356 0.99
120_W 124_P 1.339 0.99
135_W 278_M 1.336 0.99
277_L 281_G 1.324 0.99
220_I 223_A 1.32 0.99
135_W 271_S 1.319 0.99
93_I 257_S 1.314 0.99
13_A 236_G 1.309 0.99
23_L 218_K 1.303 0.99
105_L 170_A 1.298 0.99
268_L 273_W 1.296 0.99
38_A 42_S 1.29 0.99
97_M 276_A 1.287 0.99
74_S 168_I 1.252 0.99
47_L 227_G 1.252 0.99
176_T 234_N 1.249 0.99
81_L 85_Y 1.241 0.98
195_A 199_V 1.237 0.98
136_V 275_G 1.236 0.98
116_Q 122_I 1.229 0.98
125_G 286_C 1.212 0.98
83_L 95_V 1.212 0.98
213_T 216_M 1.208 0.98
62_K 66_L 1.207 0.98
237_I 241_N 1.206 0.98
123_V 127_L 1.203 0.98
98_V 166_A 1.199 0.98
224_F 228_F 1.198 0.98
254_V 276_A 1.192 0.98
109_F 113_F 1.188 0.98
32_G 35_G 1.182 0.98
81_L 84_G 1.18 0.98
30_G 215_V 1.179 0.98
101_L 133_V 1.179 0.98
85_Y 157_L 1.171 0.98
91_Q 94_E 1.169 0.97
22_G 263_L 1.163 0.97
9_I 232_A 1.163 0.97
177_N 242_V 1.162 0.97
38_A 198_W 1.159 0.97
106_T 173_C 1.157 0.97
8_L 12_I 1.152 0.97
166_A 170_A 1.147 0.97
98_V 163_F 1.143 0.97
34_V 77_I 1.14 0.97
38_A 194_G 1.134 0.97
13_A 17_W 1.134 0.97
26_G 218_K 1.133 0.97
42_S 194_G 1.133 0.97
92_A 264_L 1.132 0.97
261_A 268_L 1.128 0.97
104_S 129_A 1.126 0.97
216_M 220_I 1.126 0.97
199_V 202_F 1.123 0.97
7_T 248_G 1.118 0.96
111_I 117_K 1.117 0.96
132_G 279_V 1.116 0.96
132_G 275_G 1.113 0.96
98_V 162_A 1.113 0.96
284_L 288_L 1.112 0.96
240_G 245_M 1.109 0.96
85_Y 158_S 1.109 0.96
47_L 223_A 1.102 0.96
106_T 242_V 1.102 0.96
109_F 167_F 1.099 0.96
92_A 266_A 1.096 0.96
17_W 233_W 1.095 0.96
22_G 260_A 1.095 0.96
251_F 255_L 1.092 0.96
177_N 241_N 1.088 0.96
217_I 221_S 1.084 0.96
156_P 160_F 1.082 0.96
221_S 224_F 1.078 0.95
17_W 229_A 1.073 0.95
27_V 218_K 1.07 0.95
59_Q 62_K 1.067 0.95
178_K 182_G 1.065 0.95
48_L 227_G 1.061 0.95
27_V 215_V 1.048 0.94
79_L 83_L 1.045 0.94
14_I 255_L 1.04 0.94
169_W 173_C 1.037 0.94
106_T 174_T 1.036 0.94
13_A 232_A 1.032 0.94
109_F 170_A 1.03 0.94
82_S 95_V 1.027 0.94
112_L 115_G 1.026 0.94
178_K 181_R 1.025 0.93
120_W 123_V 1.025 0.93
97_M 134_C 1.024 0.93
14_I 18_S 1.02 0.93
109_F 112_L 1.018 0.93
257_S 268_L 1.018 0.93
131_V 135_W 1.016 0.93
85_Y 161_L 1.013 0.93
25_R 29_E 1.013 0.93
50_F 53_G 1.009 0.93
114_N 174_T 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.361898.70.776Contact Map0.012
3b5dA20.37297.90.822Contact Map0.11
4hg6A10.21167.90.949Contact Map0.019
3j01B10.184330.958Contact Map0.043
2kluA10.12631.60.964Contact Map0.42
1b4gA10.05121.50.964Contact Map0
2l9uA20.102410.968Contact Map0.414
2ksfA10.351510.968Contact Map0.206
3wdoA10.9420.90.969Contact Map0.195
4il6R10.1160.90.969Contact Map0.529
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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