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OPENSEQ.org
YHBE - Uncharacterized inner membrane transporter YhbE
UniProt: P0AA73 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11499
Length: 321 (288)
Sequences: 13618
Seq/Len: 47.28
YHBE
Paralog alert: 0.84 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: EAMA RHTA YDDG YEDA YHBE YICL YIJE YTFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
92_S 164_G 3.348 1.00
11_L 238_E 2.705 1.00
131_G 293_G 2.655 1.00
238_E 242_R 2.533 1.00
47_S 196_T 2.439 1.00
88_L 166_G 2.417 1.00
20_G 258_F 2.349 1.00
25_A 224_F 2.346 1.00
91_S 163_F 2.283 1.00
100_A 161_V 2.228 1.00
263_S 277_P 2.18 1.00
40_F 203_F 2.124 1.00
115_A 176_V 2.103 1.00
111_G 168_A 2.078 1.00
102_Q 259_T 2.072 1.00
226_G 230_L 2.068 1.00
162_I 166_G 2.05 1.00
238_E 241_A 2.041 1.00
45_M 226_G 1.996 1.00
47_S 199_T 1.961 1.00
27_K 277_P 1.958 1.00
12_A 239_A 1.947 1.00
216_H 220_A 1.922 1.00
122_E 179_K 1.917 1.00
44_L 199_T 1.904 1.00
112_M 249_S 1.841 1.00
26_M 90_S 1.817 1.00
20_G 262_F 1.811 1.00
113_M 132_A 1.793 1.00
117_V 124_M 1.786 1.00
116_S 120_L 1.778 1.00
17_I 258_F 1.773 1.00
88_L 163_F 1.759 1.00
116_S 122_E 1.697 1.00
51_G 192_F 1.692 1.00
101_S 164_G 1.691 1.00
280_N 283_G 1.627 1.00
107_L 111_G 1.622 1.00
88_L 170_V 1.599 1.00
125_R 128_Q 1.576 1.00
115_A 173_S 1.573 1.00
281_L 285_L 1.57 1.00
200_I 204_P 1.565 1.00
244_Q 247_Q 1.561 1.00
186_A 189_Q 1.552 1.00
96_L 161_V 1.539 1.00
21_A 224_F 1.527 1.00
295_M 299_I 1.516 1.00
40_F 199_T 1.513 1.00
111_G 169_T 1.491 1.00
258_F 262_F 1.488 1.00
133_L 137_S 1.485 1.00
33_M 218_Q 1.465 1.00
135_L 253_T 1.449 1.00
96_L 100_A 1.439 1.00
215_S 218_Q 1.438 1.00
98_P 263_S 1.437 1.00
52_A 55_A 1.43 1.00
48_I 52_A 1.395 0.99
288_F 292_A 1.388 0.99
38_I 225_C 1.381 0.99
10_L 14_T 1.379 0.99
18_C 227_L 1.378 0.99
29_V 38_I 1.378 0.99
47_S 192_F 1.374 0.99
11_L 235_A 1.37 0.99
96_L 160_G 1.37 0.99
141_M 289_V 1.365 0.99
73_I 197_L 1.36 0.99
284_Y 288_F 1.342 0.99
279_L 284_Y 1.337 0.99
91_S 95_Y 1.317 0.99
95_Y 159_W 1.315 0.99
217_W 220_A 1.306 0.99
15_T 239_A 1.294 0.99
32_V 218_Q 1.292 0.99
99_T 260_L 1.29 0.99
67_R 70_R 1.282 0.99
129_V 133_L 1.281 0.99
216_H 219_L 1.276 0.99
103_V 287_A 1.273 0.99
126_S 130_V 1.272 0.99
24_I 262_F 1.264 0.99
115_A 119_I 1.252 0.99
21_A 262_F 1.251 0.99
172_V 176_V 1.243 0.98
111_G 172_V 1.243 0.98
49_G 230_L 1.238 0.98
40_F 44_L 1.235 0.98
142_F 286_G 1.229 0.98
93_L 101_S 1.228 0.98
180_V 184_R 1.228 0.98
131_G 297_S 1.226 0.98
98_P 275_A 1.213 0.98
124_M 129_V 1.212 0.98
178_Q 237_A 1.202 0.98
40_F 206_A 1.199 0.98
141_M 282_L 1.196 0.98
84_G 170_V 1.193 0.98
112_M 245_A 1.188 0.98
138_G 286_G 1.177 0.98
46_A 195_Y 1.175 0.98
15_T 19_W 1.173 0.98
51_G 55_A 1.17 0.97
25_A 221_C 1.17 0.97
223_I 226_G 1.169 0.97
122_E 128_Q 1.168 0.97
34_E 37_T 1.162 0.97
110_V 135_L 1.148 0.97
107_L 139_L 1.147 0.97
220_A 224_F 1.141 0.97
39_V 202_L 1.14 0.97
257_L 287_A 1.14 0.97
91_S 94_Q 1.138 0.97
97_S 100_A 1.137 0.97
179_K 245_A 1.136 0.97
9_I 251_I 1.135 0.97
117_V 123_K 1.134 0.97
29_V 221_C 1.131 0.97
158_T 162_I 1.131 0.97
104_I 164_G 1.13 0.97
264_D 279_L 1.128 0.97
219_L 223_I 1.124 0.97
104_I 168_A 1.124 0.97
95_Y 160_G 1.122 0.97
89_F 93_L 1.122 0.97
240_M 248_V 1.116 0.96
120_L 176_V 1.112 0.96
112_M 175_G 1.109 0.96
68_K 184_R 1.107 0.96
19_W 232_G 1.104 0.96
115_A 169_T 1.103 0.96
19_W 236_L 1.102 0.96
240_M 244_Q 1.099 0.96
262_F 266_L 1.098 0.96
115_A 172_V 1.085 0.96
18_C 235_A 1.083 0.96
49_G 226_G 1.079 0.95
204_P 207_K 1.075 0.95
15_T 235_A 1.073 0.95
77_V 201_A 1.072 0.95
52_A 56_V 1.066 0.95
28_Q 221_C 1.064 0.95
118_F 121_K 1.064 0.95
115_A 118_F 1.059 0.95
179_K 244_Q 1.056 0.95
254_L 258_F 1.056 0.95
126_S 129_V 1.054 0.95
98_P 277_P 1.054 0.95
138_G 290_V 1.052 0.95
180_V 183_R 1.049 0.94
36_P 87_I 1.047 0.94
104_I 165_V 1.047 0.94
131_G 296_Y 1.043 0.94
137_S 141_M 1.043 0.94
168_A 172_V 1.042 0.94
72_L 75_L 1.04 0.94
76_A 197_L 1.037 0.94
29_V 218_Q 1.036 0.94
243_W 248_V 1.036 0.94
27_K 31_E 1.035 0.94
7_I 242_R 1.03 0.94
201_A 204_P 1.03 0.94
227_L 231_V 1.028 0.94
50_L 230_L 1.019 0.93
32_V 215_S 1.005 0.93
16_A 20_G 1.005 0.93
224_F 227_L 1.003 0.93
83_F 201_A 1 0.92
103_V 140_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.376998.70.816Contact Map0.011
3b5dA20.336497.90.854Contact Map0.051
4j05A20.953317.10.951Contact Map0.198
3wdoA10.92217.50.958Contact Map0.214
2cfqA10.59196.90.959Contact Map0.318
1pw4A10.93464.40.962Contact Map0.15
1w8xP10.14333.90.964Contact Map0.19
2gfpA20.71653.60.964Contact Map0.154
2kv5A10.10282.90.966Contact Map0
4ldsA20.5672.90.966Contact Map0.28
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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