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OPENSEQ.org
YICL - Uncharacterized inner membrane transporter YicL
UniProt: P31437 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11688
Length: 307 (290)
Sequences: 14179
Seq/Len: 48.89
YICL
Paralog alert: 0.87 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: EAMA RHTA YDDG YEDA YHBE YICL YIJE YTFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
93_T 162_G 3.322 1.00
132_A 285_S 2.646 1.00
238_K 242_L 2.519 1.00
48_G 194_L 2.516 1.00
10_N 238_K 2.492 1.00
89_T 164_A 2.357 1.00
19_G 258_S 2.287 1.00
24_C 223_Y 2.25 1.00
263_S 269_I 2.192 1.00
92_L 161_W 2.182 1.00
101_T 159_L 2.166 1.00
41_M 201_L 2.096 1.00
112_I 166_A 2.068 1.00
116_W 174_T 2.062 1.00
238_K 241_Q 2.059 1.00
103_T 259_S 2.044 1.00
160_F 164_A 2.033 1.00
11_V 239_G 1.982 1.00
48_G 197_G 1.945 1.00
46_F 225_V 1.944 1.00
215_G 219_L 1.912 1.00
45_I 197_G 1.908 1.00
26_Q 269_I 1.9 1.00
123_S 177_S 1.891 1.00
113_I 249_S 1.884 1.00
19_G 262_L 1.846 1.00
225_V 230_S 1.826 1.00
16_V 258_S 1.819 1.00
118_S 125_P 1.782 1.00
25_A 91_L 1.78 1.00
68_N 71_D 1.77 1.00
71_D 182_R 1.767 1.00
114_V 133_I 1.75 1.00
108_L 112_I 1.746 1.00
89_T 161_W 1.709 1.00
117_F 121_R 1.7 1.00
117_F 123_S 1.665 1.00
102_A 162_G 1.66 1.00
52_L 190_G 1.65 1.00
272_T 275_D 1.6 1.00
97_S 159_L 1.597 1.00
20_S 223_Y 1.583 1.00
184_G 187_P 1.575 1.00
41_M 197_G 1.569 1.00
126_G 129_V 1.559 1.00
244_G 247_K 1.553 1.00
273_L 277_L 1.523 1.00
134_L 138_V 1.497 1.00
262_L 266_L 1.496 1.00
258_S 262_L 1.495 1.00
116_W 171_F 1.493 1.00
89_T 168_A 1.462 1.00
97_S 101_T 1.452 1.00
49_L 53_T 1.451 1.00
99_A 263_S 1.432 1.00
280_L 284_S 1.43 1.00
136_S 253_C 1.421 1.00
214_N 217_L 1.404 0.99
10_N 235_L 1.392 0.99
34_M 217_L 1.387 0.99
127_I 131_C 1.377 0.99
76_L 195_I 1.373 0.99
112_I 167_F 1.368 0.99
142_L 281_L 1.355 0.99
53_T 56_F 1.351 0.99
130_F 134_L 1.344 0.99
216_S 219_L 1.343 0.99
271_F 276_W 1.333 0.99
276_W 280_L 1.333 0.99
97_S 158_A 1.327 0.99
198_L 202_P 1.324 0.99
48_G 190_G 1.324 0.99
28_I 39_L 1.324 0.99
92_L 96_K 1.32 0.99
96_K 157_A 1.318 0.99
9_L 13_I 1.314 0.99
17_L 227_I 1.313 0.99
39_L 224_L 1.308 0.99
104_V 279_T 1.304 0.99
14_A 239_G 1.303 0.99
100_A 260_A 1.302 0.99
50_I 230_S 1.299 0.99
69_H 73_I 1.288 0.99
142_L 274_P 1.281 0.99
85_T 168_A 1.278 0.99
287_I 291_M 1.271 0.99
112_I 170_A 1.267 0.99
132_A 289_I 1.264 0.99
116_W 120_V 1.256 0.99
35_S 38_F 1.245 0.98
73_I 77_I 1.228 0.98
113_I 245_G 1.227 0.98
94_I 102_A 1.226 0.98
23_V 262_L 1.221 0.98
99_A 267_L 1.212 0.98
222_F 225_V 1.209 0.98
202_P 205_A 1.203 0.98
98_N 101_T 1.197 0.98
52_L 56_F 1.196 0.98
125_P 130_F 1.193 0.98
41_M 204_Y 1.191 0.98
215_G 218_I 1.188 0.98
20_S 262_L 1.174 0.98
219_L 223_Y 1.174 0.98
30_E 33_Q 1.173 0.98
113_I 173_T 1.172 0.98
178_T 182_R 1.169 0.97
24_C 220_A 1.167 0.97
123_S 129_V 1.167 0.97
143_L 278_G 1.166 0.97
176_P 237_L 1.163 0.97
128_L 288_L 1.159 0.97
6_K 242_L 1.154 0.97
47_A 193_M 1.14 0.97
105_L 166_A 1.137 0.97
60_D 184_G 1.136 0.97
99_A 269_I 1.134 0.97
92_L 95_E 1.134 0.97
170_A 174_T 1.132 0.97
240_A 244_G 1.123 0.97
166_A 170_A 1.117 0.96
51_L 230_S 1.117 0.96
41_M 45_I 1.116 0.96
8_M 251_L 1.112 0.96
118_S 124_R 1.111 0.96
156_P 160_F 1.109 0.96
227_I 231_L 1.108 0.96
177_S 245_G 1.106 0.96
113_I 174_T 1.104 0.96
18_W 236_Y 1.102 0.96
139_G 278_G 1.101 0.96
121_R 174_T 1.094 0.96
108_L 140_T 1.093 0.96
27_Y 220_A 1.091 0.96
70_K 73_I 1.089 0.96
111_T 136_S 1.088 0.96
14_A 235_L 1.087 0.96
53_T 57_V 1.086 0.96
257_L 279_T 1.085 0.96
40_T 200_L 1.085 0.96
132_A 288_L 1.082 0.96
240_A 248_A 1.081 0.95
264_L 271_F 1.081 0.95
116_W 170_A 1.079 0.95
105_L 163_I 1.077 0.95
119_L 122_K 1.072 0.95
50_I 226_V 1.07 0.95
17_L 235_L 1.069 0.95
199_I 202_P 1.068 0.95
218_I 222_F 1.064 0.95
50_I 225_V 1.061 0.95
105_L 162_G 1.06 0.95
14_A 18_W 1.056 0.95
18_W 232_T 1.052 0.95
33_Q 217_L 1.05 0.94
169_A 173_T 1.044 0.94
96_K 161_W 1.04 0.94
26_Q 30_E 1.04 0.94
90_F 94_I 1.04 0.94
127_I 130_F 1.04 0.94
28_I 220_A 1.038 0.94
96_K 158_A 1.036 0.94
116_W 119_L 1.034 0.94
15_A 19_G 1.022 0.93
139_G 282_I 1.018 0.93
80_V 199_I 1.016 0.93
104_V 141_F 1.009 0.93
116_W 167_F 1.008 0.93
254_A 258_S 1.004 0.93
77_I 175_Y 1.002 0.92
70_K 74_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.384499.10.768Contact Map0.011
3b5dA20.35598.30.817Contact Map0.055
2kluA10.156413.10.948Contact Map0.499
3j01B10.21177.90.953Contact Map0.043
2xutA30.79155.40.957Contact Map0.181
4he8J20.54075.20.957Contact Map0.222
2cfqA10.59934.80.958Contact Map0.4
3m73A10.58314.70.958Contact Map0.315
4j05A20.97394.30.959Contact Map0.201
2gfpA20.74274.20.959Contact Map0.165
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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