| UniProt: | P45544 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12913 | ||
| Length: | 243 (234) | ||
| Sequences: | 3963 | ||
| Seq/Len: | 16.94 |
| FRLR
Paralog alert: 0.83 [within 20: 0.08] - ratio of genomes with paralogs Cluster includes: FRLR MNGR PHNF YEGW YIDP YIHL |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 30_Q | 33_Q | 4.526 | 1.00 | |
| 195_Q | 228_F | 3.226 | 1.00 | |
| 191_A | 207_L | 3.163 | 1.00 | |
| 23_D | 44_Q | 3.082 | 1.00 | |
| 23_D | 28_V | 2.952 | 1.00 | |
| 19_R | 45_Y | 2.918 | 1.00 | |
| 21_L | 62_D | 2.737 | 1.00 | |
| 68_W | 71_K | 2.675 | 1.00 | |
| 192_T | 195_Q | 2.642 | 1.00 | |
| 16_V | 47_V | 2.536 | 1.00 | |
| 104_K | 136_Y | 2.487 | 1.00 | |
| 190_A | 206_P | 2.389 | 1.00 | |
| 56_I | 65_L | 2.311 | 1.00 | |
| 34_Q | 74_F | 2.211 | 1.00 | |
| 65_L | 73_T | 2.184 | 1.00 | |
| 17_R | 58_D | 2.138 | 1.00 | |
| 116_F | 148_W | 2.123 | 1.00 | |
| 17_R | 62_D | 2.114 | 1.00 | |
| 102_K | 136_Y | 2.072 | 1.00 | |
| 132_C | 146_S | 2.059 | 1.00 | |
| 22_D | 26_Q | 2.045 | 1.00 | |
| 113_A | 116_F | 2.012 | 1.00 | |
| 60_V | 65_L | 1.971 | 1.00 | |
| 130_H | 146_S | 1.956 | 1.00 | |
| 123_P | 126_S | 1.949 | 1.00 | |
| 71_K | 74_F | 1.907 | 1.00 | |
| 132_C | 194_P | 1.898 | 1.00 | |
| 21_L | 64_V | 1.786 | 1.00 | |
| 144_I | 195_Q | 1.754 | 1.00 | |
| 185_T | 235_T | 1.746 | 1.00 | |
| 102_K | 139_K | 1.745 | 1.00 | |
| 38_E | 49_R | 1.712 | 1.00 | |
| 99_K | 138_D | 1.695 | 1.00 | |
| 126_S | 152_S | 1.691 | 1.00 | |
| 183_K | 239_D | 1.687 | 1.00 | |
| 140_E | 233_R | 1.665 | 1.00 | |
| 12_L | 15_T | 1.614 | 1.00 | |
| 107_E | 132_C | 1.606 | 1.00 | |
| 106_I | 134_V | 1.603 | 1.00 | |
| 56_I | 60_V | 1.594 | 1.00 | |
| 35_I | 65_L | 1.592 | 1.00 | |
| 187_D | 235_T | 1.589 | 1.00 | |
| 189_F | 209_R | 1.582 | 1.00 | |
| 109_E | 127_E | 1.579 | 1.00 | |
| 187_D | 209_R | 1.574 | 1.00 | |
| 184_K | 212_K | 1.541 | 1.00 | |
| 17_R | 21_L | 1.536 | 1.00 | |
| 66_I | 76_Q | 1.531 | 1.00 | |
| 19_R | 23_D | 1.519 | 1.00 | |
| 103_E | 135_M | 1.515 | 1.00 | |
| 191_A | 204_G | 1.511 | 1.00 | |
| 201_C | 207_L | 1.505 | 1.00 | |
| 110_R | 116_F | 1.5 | 1.00 | |
| 109_E | 151_L | 1.475 | 1.00 | |
| 188_I | 208_F | 1.472 | 1.00 | |
| 60_V | 67_R | 1.466 | 1.00 | |
| 185_T | 237_T | 1.461 | 1.00 | |
| 107_E | 130_H | 1.438 | 1.00 | |
| 112_S | 128_V | 1.431 | 1.00 | |
| 144_I | 198_W | 1.43 | 1.00 | |
| 110_R | 130_H | 1.419 | 1.00 | |
| 117_C | 122_I | 1.411 | 1.00 | |
| 191_A | 205_E | 1.408 | 1.00 | |
| 177_T | 216_D | 1.382 | 0.99 | |
| 122_I | 126_S | 1.38 | 0.99 | |
| 112_S | 117_C | 1.379 | 0.99 | |
| 169_Q | 173_E | 1.377 | 0.99 | |
| 54_K | 57_S | 1.347 | 0.99 | |
| 16_V | 52_I | 1.346 | 0.99 | |
| 216_D | 220_K | 1.339 | 0.99 | |
| 189_F | 195_Q | 1.337 | 0.99 | |
| 38_E | 53_R | 1.333 | 0.99 | |
| 54_K | 58_D | 1.327 | 0.99 | |
| 213_I | 221_P | 1.32 | 0.99 | |
| 120_L | 128_V | 1.316 | 0.99 | |
| 16_V | 19_R | 1.308 | 0.99 | |
| 168_Y | 223_H | 1.308 | 0.99 | |
| 168_Y | 214_A | 1.305 | 0.99 | |
| 120_L | 221_P | 1.302 | 0.99 | |
| 23_D | 29_Y | 1.283 | 0.99 | |
| 16_V | 45_Y | 1.281 | 0.99 | |
| 67_R | 73_T | 1.277 | 0.99 | |
| 57_S | 61_A | 1.275 | 0.99 | |
| 191_A | 201_C | 1.273 | 0.99 | |
| 21_L | 25_A | 1.268 | 0.99 | |
| 94_G | 137_L | 1.267 | 0.99 | |
| 108_Q | 130_H | 1.265 | 0.99 | |
| 216_D | 222_V | 1.265 | 0.99 | |
| 207_L | 228_F | 1.256 | 0.99 | |
| 202_E | 205_E | 1.255 | 0.99 | |
| 209_R | 226_E | 1.254 | 0.99 | |
| 154_Y | 171_F | 1.222 | 0.98 | |
| 152_S | 220_K | 1.188 | 0.98 | |
| 47_V | 52_I | 1.185 | 0.98 | |
| 183_K | 237_T | 1.182 | 0.98 | |
| 172_Q | 178_R | 1.173 | 0.98 | |
| 189_F | 207_L | 1.172 | 0.98 | |
| 136_Y | 139_K | 1.172 | 0.98 | |
| 13_Y | 58_D | 1.163 | 0.97 | |
| 104_K | 134_V | 1.154 | 0.97 | |
| 181_S | 239_D | 1.149 | 0.97 | |
| 112_S | 126_S | 1.145 | 0.97 | |
| 149_I | 167_T | 1.145 | 0.97 | |
| 23_D | 45_Y | 1.128 | 0.97 | |
| 122_I | 128_V | 1.123 | 0.97 | |
| 190_A | 205_E | 1.115 | 0.96 | |
| 24_I | 75_V | 1.108 | 0.96 | |
| 196_A | 204_G | 1.106 | 0.96 | |
| 112_S | 122_I | 1.073 | 0.95 | |
| 31_A | 77_S | 1.067 | 0.95 | |
| 14_A | 18_Q | 1.065 | 0.95 | |
| 211_S | 226_E | 1.058 | 0.95 | |
| 90_F | 94_G | 1.053 | 0.95 | |
| 57_S | 67_R | 1.038 | 0.94 | |
| 141_P | 199_L | 1.033 | 0.94 | |
| 147_S | 223_H | 1.029 | 0.94 | |
| 37_T | 40_E | 1.022 | 0.93 | |
| 41_L | 52_I | 1.014 | 0.93 | |
| 29_Y | 33_Q | 1.008 | 0.93 | |
| 134_V | 141_P | 1.006 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2wv0A | 10 | 0.9918 | 100 | 0.096 | Contact Map | 0.885 |
| 3f8mA | 2 | 0.9753 | 100 | 0.121 | Contact Map | 0.762 |
| 2ra5A | 1 | 0.9877 | 100 | 0.123 | Contact Map | 0.674 |
| 3edpA | 2 | 0.9547 | 100 | 0.142 | Contact Map | 0.689 |
| 3bwgA | 3 | 0.963 | 100 | 0.151 | Contact Map | 0.842 |
| 3eetA | 2 | 0.9918 | 100 | 0.16 | Contact Map | 0.749 |
| 3f8lA | 4 | 0.7901 | 100 | 0.376 | Contact Map | 0.788 |
| 3hfiA | 1 | 0.679 | 100 | 0.479 | Contact Map | 0.781 |
| 2ikkA | 2 | 0.6955 | 100 | 0.486 | Contact Map | 0.881 |
| 3cnvA | 4 | 0.642 | 100 | 0.492 | Contact Map | 0.823 |
Sequence Conservation (Image Generated using WebLogo v3)