| UniProt: | P13669 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11109 | ||
| Length: | 240 (234) | ||
| Sequences: | 3964 | ||
| Seq/Len: | 16.94 |
| MNGR
Paralog alert: 0.83 [within 20: 0.08] - ratio of genomes with paralogs Cluster includes: FRLR MNGR PHNF YEGW YIDP YIHL |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 24_K | 27_D | 4.446 | 1.00 | |
| 189_M | 222_A | 3.198 | 1.00 | |
| 185_P | 201_I | 3.109 | 1.00 | |
| 17_Q | 38_E | 3.033 | 1.00 | |
| 17_Q | 22_E | 2.968 | 1.00 | |
| 13_R | 39_F | 2.869 | 1.00 | |
| 15_R | 56_Q | 2.742 | 1.00 | |
| 62_I | 65_S | 2.642 | 1.00 | |
| 186_T | 189_M | 2.63 | 1.00 | |
| 10_I | 41_V | 2.477 | 1.00 | |
| 98_E | 131_Y | 2.438 | 1.00 | |
| 184_M | 200_P | 2.425 | 1.00 | |
| 50_L | 59_L | 2.29 | 1.00 | |
| 28_A | 68_Y | 2.214 | 1.00 | |
| 111_L | 143_W | 2.211 | 1.00 | |
| 59_L | 67_T | 2.187 | 1.00 | |
| 11_A | 52_Q | 2.159 | 1.00 | |
| 11_A | 56_Q | 2.107 | 1.00 | |
| 96_H | 131_Y | 2.078 | 1.00 | |
| 127_K | 141_E | 2.046 | 1.00 | |
| 16_E | 20_R | 2.025 | 1.00 | |
| 125_H | 141_E | 1.957 | 1.00 | |
| 108_D | 111_L | 1.953 | 1.00 | |
| 177_E | 233_I | 1.934 | 1.00 | |
| 65_S | 68_Y | 1.93 | 1.00 | |
| 54_V | 59_L | 1.926 | 1.00 | |
| 118_T | 121_D | 1.903 | 1.00 | |
| 127_K | 188_E | 1.868 | 1.00 | |
| 15_R | 58_I | 1.747 | 1.00 | |
| 139_L | 189_M | 1.739 | 1.00 | |
| 96_H | 134_Q | 1.721 | 1.00 | |
| 179_E | 229_K | 1.704 | 1.00 | |
| 32_E | 43_R | 1.694 | 1.00 | |
| 100_L | 129_V | 1.671 | 1.00 | |
| 135_K | 227_D | 1.664 | 1.00 | |
| 93_V | 133_K | 1.658 | 1.00 | |
| 6_L | 9_Q | 1.615 | 1.00 | |
| 50_L | 54_V | 1.602 | 1.00 | |
| 183_L | 203_E | 1.592 | 1.00 | |
| 121_D | 147_A | 1.589 | 1.00 | |
| 181_I | 203_E | 1.581 | 1.00 | |
| 29_L | 59_L | 1.578 | 1.00 | |
| 181_I | 229_K | 1.562 | 1.00 | |
| 179_E | 231_T | 1.559 | 1.00 | |
| 13_R | 17_Q | 1.549 | 1.00 | |
| 104_V | 122_R | 1.545 | 1.00 | |
| 105_I | 125_H | 1.543 | 1.00 | |
| 101_I | 127_K | 1.535 | 1.00 | |
| 11_A | 15_R | 1.509 | 1.00 | |
| 185_P | 198_T | 1.5 | 1.00 | |
| 104_V | 146_L | 1.498 | 1.00 | |
| 105_I | 111_L | 1.482 | 1.00 | |
| 195_I | 201_I | 1.479 | 1.00 | |
| 54_V | 61_S | 1.478 | 1.00 | |
| 97_S | 130_R | 1.473 | 1.00 | |
| 178_Q | 206_S | 1.442 | 1.00 | |
| 182_P | 202_L | 1.439 | 1.00 | |
| 107_A | 123_V | 1.436 | 1.00 | |
| 60_E | 70_K | 1.433 | 1.00 | |
| 175_R | 233_I | 1.423 | 1.00 | |
| 101_I | 125_H | 1.4 | 0.99 | |
| 139_L | 192_L | 1.399 | 0.99 | |
| 112_Q | 117_I | 1.386 | 0.99 | |
| 177_E | 231_T | 1.377 | 0.99 | |
| 10_I | 46_V | 1.372 | 0.99 | |
| 210_L | 214_R | 1.372 | 0.99 | |
| 10_I | 13_R | 1.367 | 0.99 | |
| 185_P | 199_K | 1.367 | 0.99 | |
| 183_L | 189_M | 1.361 | 0.99 | |
| 48_Q | 51_R | 1.358 | 0.99 | |
| 115_L | 123_V | 1.348 | 0.99 | |
| 17_Q | 23_L | 1.347 | 0.99 | |
| 163_H | 167_E | 1.343 | 0.99 | |
| 171_M | 210_L | 1.339 | 0.99 | |
| 117_I | 121_D | 1.333 | 0.99 | |
| 32_E | 47_R | 1.332 | 0.99 | |
| 48_Q | 52_Q | 1.321 | 0.99 | |
| 102_F | 153_T | 1.313 | 0.99 | |
| 162_Y | 217_E | 1.293 | 0.99 | |
| 107_A | 112_Q | 1.288 | 0.99 | |
| 207_R | 215_V | 1.287 | 0.99 | |
| 210_L | 216_F | 1.285 | 0.99 | |
| 149_F | 165_I | 1.278 | 0.99 | |
| 61_S | 67_T | 1.277 | 0.99 | |
| 51_R | 55_E | 1.277 | 0.99 | |
| 185_P | 195_I | 1.269 | 0.99 | |
| 203_E | 220_R | 1.267 | 0.99 | |
| 10_I | 39_F | 1.265 | 0.99 | |
| 201_I | 222_A | 1.26 | 0.99 | |
| 162_Y | 208_G | 1.254 | 0.99 | |
| 103_E | 125_H | 1.253 | 0.99 | |
| 196_S | 199_K | 1.252 | 0.99 | |
| 88_L | 132_R | 1.248 | 0.99 | |
| 15_R | 19_A | 1.246 | 0.98 | |
| 115_L | 215_V | 1.21 | 0.98 | |
| 147_A | 214_R | 1.204 | 0.98 | |
| 17_Q | 39_F | 1.177 | 0.98 | |
| 7_Y | 52_Q | 1.173 | 0.98 | |
| 166_E | 172_V | 1.171 | 0.98 | |
| 131_Y | 134_Q | 1.167 | 0.97 | |
| 144_M | 161_K | 1.163 | 0.97 | |
| 190_S | 198_T | 1.148 | 0.97 | |
| 41_V | 46_V | 1.138 | 0.97 | |
| 107_A | 121_D | 1.119 | 0.96 | |
| 183_L | 201_I | 1.109 | 0.96 | |
| 98_E | 129_V | 1.106 | 0.96 | |
| 117_I | 123_V | 1.096 | 0.96 | |
| 107_A | 117_I | 1.086 | 0.96 | |
| 18_I | 69_V | 1.079 | 0.95 | |
| 184_M | 199_K | 1.076 | 0.95 | |
| 8_R | 12_D | 1.065 | 0.95 | |
| 25_P | 71_E | 1.056 | 0.95 | |
| 84_F | 88_L | 1.055 | 0.95 | |
| 205_V | 220_R | 1.045 | 0.94 | |
| 142_T | 217_E | 1.032 | 0.94 | |
| 51_R | 61_S | 1.029 | 0.94 | |
| 23_L | 27_D | 1.028 | 0.94 | |
| 136_P | 193_L | 1.012 | 0.93 | |
| 102_F | 124_W | 1.01 | 0.93 | |
| 35_L | 46_V | 1.009 | 0.93 | |
| 166_E | 236_R | 1.005 | 0.93 | |
| 73_R | 181_I | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2wv0A | 10 | 0.9917 | 100 | 0.104 | Contact Map | 0.877 |
| 3f8mA | 2 | 0.9792 | 100 | 0.127 | Contact Map | 0.763 |
| 3edpA | 2 | 0.9542 | 100 | 0.138 | Contact Map | 0.685 |
| 2ra5A | 1 | 0.9792 | 100 | 0.139 | Contact Map | 0.659 |
| 3eetA | 2 | 0.975 | 100 | 0.146 | Contact Map | 0.732 |
| 3bwgA | 3 | 0.9875 | 100 | 0.16 | Contact Map | 0.836 |
| 3f8lA | 4 | 0.8167 | 100 | 0.37 | Contact Map | 0.783 |
| 3hfiA | 1 | 0.7 | 100 | 0.481 | Contact Map | 0.771 |
| 2ikkA | 2 | 0.7042 | 100 | 0.485 | Contact Map | 0.879 |
| 2fa1A | 2 | 0.6625 | 100 | 0.492 | Contact Map | 0.715 |
Sequence Conservation (Image Generated using WebLogo v3)