| UniProt: | P16684 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10715 | ||
| Length: | 241 (231) | ||
| Sequences: | 3972 | ||
| Seq/Len: | 17.19 |
| PHNF
Paralog alert: 0.83 [within 20: 0.08] - ratio of genomes with paralogs Cluster includes: FRLR MNGR PHNF YEGW YIDP YIHL |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 30_R | 33_D | 4.254 | 1.00 | |
| 195_E | 229_L | 3.286 | 1.00 | |
| 191_A | 207_L | 3.169 | 1.00 | |
| 24_E | 44_R | 3.026 | 1.00 | |
| 20_K | 45_F | 2.859 | 1.00 | |
| 22_E | 62_K | 2.78 | 1.00 | |
| 192_Q | 195_E | 2.686 | 1.00 | |
| 68_R | 71_V | 2.635 | 1.00 | |
| 17_I | 47_V | 2.499 | 1.00 | |
| 104_E | 137_R | 2.451 | 1.00 | |
| 190_R | 206_P | 2.363 | 1.00 | |
| 56_I | 65_V | 2.298 | 1.00 | |
| 18_A | 58_Q | 2.216 | 1.00 | |
| 34_Y | 74_L | 2.19 | 1.00 | |
| 117_V | 149_Y | 2.184 | 1.00 | |
| 65_V | 73_V | 2.173 | 1.00 | |
| 18_A | 62_K | 2.107 | 1.00 | |
| 133_R | 147_D | 2.067 | 1.00 | |
| 102_T | 137_R | 2.062 | 1.00 | |
| 23_Q | 27_Q | 2.013 | 1.00 | |
| 114_S | 117_V | 1.979 | 1.00 | |
| 131_H | 147_D | 1.967 | 1.00 | |
| 124_T | 127_E | 1.954 | 1.00 | |
| 60_V | 65_V | 1.908 | 1.00 | |
| 133_R | 194_K | 1.887 | 1.00 | |
| 71_V | 74_L | 1.881 | 1.00 | |
| 102_T | 140_G | 1.803 | 1.00 | |
| 22_E | 64_W | 1.778 | 1.00 | |
| 38_E | 49_R | 1.732 | 1.00 | |
| 145_L | 195_E | 1.729 | 1.00 | |
| 185_R | 236_E | 1.708 | 1.00 | |
| 106_L | 135_L | 1.687 | 1.00 | |
| 141_V | 234_M | 1.663 | 1.00 | |
| 13_R | 16_E | 1.656 | 1.00 | |
| 189_R | 209_C | 1.639 | 1.00 | |
| 110_L | 128_N | 1.634 | 1.00 | |
| 99_S | 139_N | 1.609 | 1.00 | |
| 107_L | 133_R | 1.601 | 1.00 | |
| 56_I | 60_V | 1.598 | 1.00 | |
| 35_L | 65_V | 1.598 | 1.00 | |
| 187_S | 236_E | 1.598 | 1.00 | |
| 185_R | 238_T | 1.595 | 1.00 | |
| 66_Q | 76_L | 1.58 | 1.00 | |
| 20_K | 24_E | 1.573 | 1.00 | |
| 187_S | 209_C | 1.573 | 1.00 | |
| 18_A | 22_E | 1.545 | 1.00 | |
| 111_R | 131_H | 1.545 | 1.00 | |
| 191_A | 204_M | 1.527 | 1.00 | |
| 60_V | 67_R | 1.526 | 1.00 | |
| 103_S | 136_R | 1.523 | 1.00 | |
| 201_I | 207_L | 1.514 | 1.00 | |
| 110_L | 152_D | 1.512 | 1.00 | |
| 184_T | 212_T | 1.471 | 1.00 | |
| 177_I | 216_R | 1.465 | 1.00 | |
| 111_R | 117_V | 1.462 | 1.00 | |
| 188_A | 208_L | 1.456 | 1.00 | |
| 145_L | 198_R | 1.438 | 1.00 | |
| 218_G | 221_S | 1.436 | 1.00 | |
| 118_A | 123_I | 1.431 | 1.00 | |
| 169_D | 173_E | 1.415 | 1.00 | |
| 113_A | 129_V | 1.413 | 1.00 | |
| 54_R | 57_D | 1.411 | 1.00 | |
| 17_I | 52_L | 1.403 | 0.99 | |
| 191_A | 205_S | 1.402 | 0.99 | |
| 107_L | 131_H | 1.399 | 0.99 | |
| 216_R | 221_S | 1.385 | 0.99 | |
| 38_E | 53_R | 1.363 | 0.99 | |
| 123_I | 127_E | 1.359 | 0.99 | |
| 183_Q | 238_T | 1.355 | 0.99 | |
| 189_R | 195_E | 1.346 | 0.99 | |
| 121_L | 129_V | 1.345 | 0.99 | |
| 54_R | 58_Q | 1.33 | 0.99 | |
| 24_E | 29_Y | 1.323 | 0.99 | |
| 22_E | 26_R | 1.32 | 0.99 | |
| 213_L | 222_P | 1.311 | 0.99 | |
| 17_I | 20_K | 1.307 | 0.99 | |
| 168_H | 224_E | 1.299 | 0.99 | |
| 216_R | 223_A | 1.296 | 0.99 | |
| 109_V | 131_H | 1.294 | 0.99 | |
| 57_D | 61_E | 1.293 | 0.99 | |
| 168_H | 214_N | 1.283 | 0.99 | |
| 67_R | 73_V | 1.282 | 0.99 | |
| 113_A | 118_A | 1.282 | 0.99 | |
| 191_A | 201_I | 1.279 | 0.99 | |
| 209_C | 227_V | 1.267 | 0.99 | |
| 207_L | 229_L | 1.264 | 0.99 | |
| 121_L | 222_P | 1.26 | 0.99 | |
| 202_P | 205_S | 1.233 | 0.98 | |
| 17_I | 45_F | 1.222 | 0.98 | |
| 127_E | 153_L | 1.218 | 0.98 | |
| 94_L | 138_V | 1.217 | 0.98 | |
| 104_E | 135_L | 1.171 | 0.98 | |
| 137_R | 140_G | 1.165 | 0.97 | |
| 47_V | 52_L | 1.161 | 0.97 | |
| 24_E | 45_F | 1.159 | 0.97 | |
| 172_R | 178_A | 1.157 | 0.97 | |
| 196_C | 204_M | 1.147 | 0.97 | |
| 14_Y | 58_Q | 1.147 | 0.97 | |
| 113_A | 127_E | 1.144 | 0.97 | |
| 21_L | 29_Y | 1.139 | 0.97 | |
| 150_F | 167_L | 1.135 | 0.97 | |
| 189_R | 207_L | 1.113 | 0.96 | |
| 211_R | 227_V | 1.087 | 0.96 | |
| 113_A | 123_I | 1.075 | 0.95 | |
| 37_A | 40_Q | 1.074 | 0.95 | |
| 190_R | 205_S | 1.073 | 0.95 | |
| 90_F | 94_L | 1.072 | 0.95 | |
| 123_I | 129_V | 1.067 | 0.95 | |
| 108_S | 130_I | 1.062 | 0.95 | |
| 57_D | 67_R | 1.061 | 0.95 | |
| 183_Q | 240_E | 1.053 | 0.95 | |
| 113_A | 126_G | 1.049 | 0.94 | |
| 25_L | 75_V | 1.048 | 0.94 | |
| 118_A | 125_E | 1.042 | 0.94 | |
| 41_L | 52_L | 1.042 | 0.94 | |
| 15_Q | 19_A | 1.029 | 0.94 | |
| 142_A | 199_L | 1.024 | 0.93 | |
| 147_D | 227_V | 1.022 | 0.93 | |
| 148_H | 224_E | 1.014 | 0.93 | |
| 193_A | 203_N | 1.011 | 0.93 | |
| 31_C | 77_M | 1.009 | 0.93 | |
| 58_Q | 61_E | 1.007 | 0.93 | |
| 112_P | 128_N | 1.005 | 0.93 | |
| 170_F | 175_T | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2wv0A | 10 | 0.9876 | 100 | 0.096 | Contact Map | 0.897 |
| 2ra5A | 1 | 0.9834 | 100 | 0.125 | Contact Map | 0.702 |
| 3f8mA | 2 | 0.9751 | 100 | 0.139 | Contact Map | 0.757 |
| 3edpA | 2 | 0.9627 | 100 | 0.15 | Contact Map | 0.701 |
| 3bwgA | 3 | 0.9585 | 100 | 0.161 | Contact Map | 0.857 |
| 3eetA | 2 | 0.9627 | 100 | 0.175 | Contact Map | 0.739 |
| 3f8lA | 4 | 0.7884 | 100 | 0.384 | Contact Map | 0.787 |
| 2fa1A | 2 | 0.6598 | 100 | 0.48 | Contact Map | 0.739 |
| 3hfiA | 1 | 0.6722 | 100 | 0.489 | Contact Map | 0.779 |
| 2ikkA | 2 | 0.6888 | 100 | 0.493 | Contact Map | 0.891 |
Sequence Conservation (Image Generated using WebLogo v3)