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OPENSEQ.org
YHJK - Protein YhjK
UniProt: P37649 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12256
Length: 662 (651)
Sequences: 705
Seq/Len: 1.08
YHJK
Paralog alert: 0.82 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ADRB CSRD DOSP GMR RTN YAHA YCGF YCGG YDIV YHJH YHJK YJCC YLAB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
476_G 507_Q 3.697 1.00
443_A 654_F 3.399 1.00
623_V 640_A 2.863 1.00
612_Q 638_G 2.841 1.00
308_S 311_M 2.788 1.00
591_K 595_E 2.64 1.00
626_E 630_D 2.355 0.99
646_A 649_L 2.348 0.99
555_R 585_D 2.345 0.99
486_L 490_W 2.341 0.99
253_K 293_E 2.245 0.98
289_E 385_F 2.227 0.98
503_L 513_M 2.186 0.98
240_E 244_R 2.106 0.97
256_L 322_A 2.098 0.97
363_G 383_A 2.064 0.97
284_A 318_G 2.06 0.97
452_P 455_S 2.02 0.96
533_L 559_V 1.959 0.95
629_R 640_A 1.955 0.95
537_E 567_G 1.944 0.95
215_D 218_G 1.903 0.94
444_E 502_N 1.889 0.94
591_K 622_G 1.88 0.94
276_T 385_F 1.862 0.94
466_I 475_V 1.848 0.93
486_L 651_I 1.842 0.93
7_L 11_Q 1.795 0.92
253_K 381_I 1.75 0.91
477_H 516_D 1.737 0.90
631_W 635_A 1.73 0.90
320_D 381_I 1.726 0.90
274_I 384_A 1.691 0.88
451_Q 455_S 1.69 0.88
463_I 472_M 1.675 0.88
284_A 292_R 1.674 0.88
334_A 338_G 1.667 0.87
430_Q 624_E 1.664 0.87
537_E 590_D 1.662 0.87
276_T 319_Y 1.644 0.86
284_A 293_E 1.634 0.86
276_T 289_E 1.625 0.86
6_S 11_Q 1.622 0.85
434_E 437_S 1.619 0.85
276_T 285_G 1.612 0.85
289_E 381_I 1.608 0.85
363_G 380_A 1.586 0.84
435_M 640_A 1.585 0.84
276_T 388_R 1.558 0.82
7_L 10_K 1.557 0.82
273_M 362_I 1.549 0.82
577_Q 600_D 1.541 0.81
567_G 590_D 1.538 0.81
385_F 388_R 1.538 0.81
415_D 451_Q 1.534 0.81
481_E 523_R 1.523 0.80
408_K 461_G 1.516 0.80
620_A 632_L 1.511 0.79
502_N 641_Q 1.508 0.79
299_L 587_L 1.506 0.79
502_N 564_D 1.502 0.79
372_T 375_Q 1.501 0.79
280_L 289_E 1.476 0.77
278_E 319_Y 1.469 0.77
280_L 292_R 1.468 0.77
361_S 388_R 1.467 0.77
280_L 388_R 1.465 0.76
247_V 293_E 1.46 0.76
274_I 380_A 1.456 0.76
449_I 637_V 1.454 0.76
490_W 651_I 1.452 0.76
319_Y 388_R 1.448 0.75
625_T 628_Q 1.445 0.75
463_I 466_I 1.431 0.74
504_S 621_E 1.428 0.74
466_I 472_M 1.423 0.73
612_Q 615_N 1.421 0.73
413_E 476_G 1.419 0.73
468_C 507_Q 1.419 0.73
289_E 388_R 1.402 0.72
276_T 320_D 1.393 0.71
426_A 450_Q 1.392 0.71
430_Q 641_Q 1.392 0.71
429_L 486_L 1.39 0.71
289_E 361_S 1.389 0.71
6_S 10_K 1.383 0.70
275_I 377_Y 1.381 0.70
276_T 317_S 1.376 0.70
562_A 586_V 1.374 0.70
409_R 500_S 1.371 0.69
501_V 531_L 1.359 0.68
274_I 381_I 1.356 0.68
513_M 517_M 1.353 0.68
618_M 622_G 1.349 0.68
60_A 69_A 1.348 0.68
281_R 361_S 1.347 0.67
430_Q 564_D 1.345 0.67
572_G 575_Q 1.342 0.67
280_L 284_A 1.337 0.67
73_L 85_A 1.336 0.67
285_G 385_F 1.329 0.66
459_P 562_A 1.328 0.66
446_L 590_D 1.319 0.65
444_E 641_Q 1.316 0.65
245_F 315_Q 1.315 0.65
193_L 227_N 1.311 0.64
480_L 501_V 1.31 0.64
278_E 317_S 1.305 0.64
276_T 361_S 1.304 0.64
481_E 524_Y 1.303 0.64
293_E 319_Y 1.301 0.64
499_L 563_L 1.301 0.64
427_I 478_W 1.285 0.62
534_E 588_K 1.285 0.62
338_G 364_V 1.283 0.62
467_E 472_M 1.281 0.62
251_P 380_A 1.274 0.61
361_S 385_F 1.274 0.61
277_C 318_G 1.274 0.61
278_E 361_S 1.269 0.61
243_M 503_L 1.269 0.61
491_Q 530_T 1.267 0.60
412_E 451_Q 1.262 0.60
281_R 317_S 1.258 0.60
278_E 388_R 1.258 0.60
251_P 255_L 1.255 0.59
466_I 504_S 1.25 0.59
255_L 259_M 1.249 0.59
303_L 643_F 1.248 0.59
216_E 220_L 1.24 0.58
643_F 648_P 1.236 0.58
493_R 655_E 1.235 0.58
278_E 385_F 1.233 0.57
541_I 563_L 1.225 0.57
624_E 641_Q 1.225 0.57
560_R 585_D 1.225 0.57
432_Q 586_V 1.223 0.56
565_D 621_E 1.221 0.56
285_G 317_S 1.218 0.56
289_E 317_S 1.217 0.56
185_P 216_E 1.217 0.56
413_E 507_Q 1.217 0.56
432_Q 619_I 1.214 0.56
532_I 586_V 1.212 0.55
361_S 381_I 1.21 0.55
277_C 289_E 1.208 0.55
224_Y 227_N 1.207 0.55
628_Q 631_W 1.205 0.55
557_A 593_F 1.201 0.54
293_E 318_G 1.2 0.54
325_A 337_L 1.197 0.54
317_S 385_F 1.196 0.54
216_E 227_N 1.196 0.54
288_K 381_I 1.192 0.54
374_E 381_I 1.189 0.53
503_L 613_S 1.188 0.53
536_T 565_D 1.187 0.53
417_L 471_L 1.187 0.53
292_R 319_Y 1.184 0.53
247_V 284_A 1.182 0.53
5_R 9_I 1.18 0.52
587_L 611_A 1.177 0.52
429_L 445_V 1.175 0.52
424_Q 452_P 1.174 0.52
54_R 72_I 1.173 0.52
319_Y 381_I 1.172 0.52
482_E 485_R 1.168 0.51
278_E 320_D 1.165 0.51
650_P 653_I 1.164 0.51
467_E 624_E 1.163 0.51
572_G 641_Q 1.163 0.51
588_K 641_Q 1.163 0.51
500_S 532_I 1.159 0.50
260_L 499_L 1.157 0.50
448_R 567_G 1.157 0.50
589_I 596_G 1.154 0.50
281_R 319_Y 1.153 0.50
192_E 224_Y 1.152 0.50
502_N 536_T 1.152 0.50
308_S 337_L 1.151 0.50
281_R 289_E 1.15 0.50
253_K 284_A 1.149 0.49
281_R 292_R 1.148 0.49
520_L 524_Y 1.147 0.49
179_N 183_L 1.147 0.49
480_L 533_L 1.146 0.49
43_A 47_E 1.146 0.49
566_F 606_A 1.144 0.49
61_I 92_Q 1.144 0.49
448_R 621_E 1.141 0.49
281_R 388_R 1.14 0.49
560_R 596_G 1.138 0.48
280_L 565_D 1.137 0.48
361_S 393_N 1.135 0.48
592_M 618_M 1.133 0.48
446_L 564_D 1.132 0.48
5_R 10_K 1.132 0.48
280_L 285_G 1.132 0.48
567_G 622_G 1.129 0.48
523_R 529_G 1.129 0.48
275_I 295_L 1.127 0.47
551_L 561_V 1.126 0.47
260_L 363_G 1.126 0.47
6_S 9_I 1.124 0.47
253_K 317_S 1.123 0.47
317_S 388_R 1.118 0.47
55_E 78_P 1.117 0.46
274_I 322_A 1.117 0.46
5_R 8_T 1.117 0.46
624_E 643_F 1.116 0.46
67_P 73_L 1.116 0.46
380_A 383_A 1.116 0.46
449_I 459_P 1.115 0.46
479_V 502_N 1.114 0.46
292_R 318_G 1.108 0.46
242_A 277_C 1.108 0.46
381_I 385_F 1.106 0.45
359_H 391_G 1.105 0.45
430_Q 446_L 1.102 0.45
498_P 530_T 1.102 0.45
491_Q 496_M 1.101 0.45
467_E 502_N 1.099 0.45
472_M 536_T 1.098 0.45
564_D 641_Q 1.095 0.44
468_C 476_G 1.091 0.44
608_I 638_G 1.089 0.44
8_T 11_Q 1.089 0.44
216_E 221_V 1.087 0.44
303_L 307_L 1.086 0.44
462_L 571_A 1.085 0.43
89_L 94_Q 1.084 0.43
276_T 281_R 1.084 0.43
281_R 285_G 1.082 0.43
292_R 388_R 1.081 0.43
532_I 562_A 1.081 0.43
277_C 317_S 1.08 0.43
360_C 566_F 1.08 0.43
358_P 377_Y 1.078 0.43
484_C 531_L 1.077 0.43
285_G 320_D 1.077 0.43
367_F 370_D 1.077 0.43
620_A 637_V 1.075 0.43
272_L 538_S 1.075 0.43
446_L 467_E 1.073 0.42
428_W 650_P 1.073 0.42
617_Q 638_G 1.07 0.42
563_L 611_A 1.068 0.42
276_T 381_I 1.067 0.42
502_N 621_E 1.067 0.42
322_A 399_D 1.065 0.42
306_V 341_V 1.065 0.42
365_A 380_A 1.063 0.41
270_T 384_A 1.062 0.41
399_D 488_A 1.06 0.41
273_M 338_G 1.058 0.41
591_K 621_E 1.056 0.41
167_S 263_V 1.056 0.41
317_S 381_I 1.054 0.41
193_L 223_S 1.054 0.41
448_R 642_G 1.053 0.40
377_Y 555_R 1.052 0.40
107_P 186_L 1.051 0.40
484_C 520_L 1.05 0.40
611_A 618_M 1.049 0.40
76_I 85_A 1.048 0.40
446_L 641_Q 1.046 0.40
484_C 524_Y 1.045 0.40
213_Q 218_G 1.042 0.39
416_I 419_A 1.042 0.39
162_I 165_L 1.04 0.39
180_R 196_I 1.04 0.39
507_Q 513_M 1.038 0.39
293_E 381_I 1.038 0.39
479_V 483_S 1.036 0.39
231_L 234_H 1.036 0.39
444_E 564_D 1.035 0.39
507_Q 533_L 1.035 0.39
311_M 325_A 1.033 0.39
472_M 621_E 1.033 0.39
459_P 536_T 1.03 0.38
182_I 249_D 1.03 0.38
429_L 483_S 1.029 0.38
40_Y 44_T 1.029 0.38
238_Q 241_N 1.027 0.38
566_F 593_F 1.025 0.38
316_I 440_L 1.025 0.38
361_S 391_G 1.024 0.38
377_Y 522_T 1.022 0.38
233_R 585_D 1.022 0.38
292_R 381_I 1.02 0.38
85_A 102_P 1.019 0.37
281_R 385_F 1.019 0.37
500_S 521_L 1.018 0.37
323_V 391_G 1.018 0.37
270_T 466_I 1.017 0.37
52_S 56_P 1.016 0.37
459_P 565_D 1.014 0.37
588_K 642_G 1.012 0.37
378_S 483_S 1.012 0.37
280_L 319_Y 1.012 0.37
442_S 532_I 1.012 0.37
253_K 315_Q 1.01 0.37
444_E 621_E 1.009 0.37
444_E 448_R 1.007 0.36
462_L 576_L 1.006 0.36
284_A 381_I 1.005 0.36
471_L 539_R 1.005 0.36
238_Q 601_S 1.005 0.36
542_D 587_L 1.004 0.36
335_I 501_V 1.004 0.36
172_V 184_H 1.003 0.36
168_L 535_V 1.002 0.36
604_I 623_V 1.001 0.36
189_I 221_V 1.001 0.36
589_I 594_V 1 0.36
280_L 317_S 1 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hvbA20.64651000.417Contact Map0.46
3pjxA10.63141000.427Contact Map0.348
3gfzA20.57851000.517Contact Map0.288
4hjfA10.48341000.549Contact Map0.477
4hu4A20.4291000.59Contact Map0.469
2r6oA20.41391000.616Contact Map0.54
3sy8A40.57551000.627Contact Map0.496
3hv8A10.40031000.635Contact Map0.462
4fojA10.39121000.636Contact Map0.47
3s83A10.37761000.643Contact Map0.489
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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