May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
DOSP - Oxygen sensor protein DosP
UniProt: P76129 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13792
Length: 799 (775)
Sequences: 1156
Seq/Len: 1.49
DOSP
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ADRB CSRD DOSP GMR RTN YAHA YCGF YCGG YDIV YHJH YHJK YJCC YLAB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
575_I 787_I 4.83 1.00
779_S 782_L 4.363 1.00
442_K 445_Q 3.938 1.00
721_K 725_D 3.843 1.00
756_V 773_I 3.407 1.00
608_G 640_H 3.322 1.00
613_A 656_A 3.267 1.00
393_Y 446_Y 3.213 1.00
441_L 447_L 3.063 1.00
636_L 646_L 2.981 1.00
710_V 733_I 2.908 1.00
567_A 773_I 2.869 1.00
634_V 664_L 2.848 1.00
653_A 657_W 2.798 1.00
390_L 456_V 2.797 1.00
389_N 446_Y 2.78 1.00
47_Y 96_K 2.769 1.00
129_M 132_K 2.765 1.00
559_L 610_W 2.745 1.00
504_N 507_Y 2.71 1.00
540_E 593_R 2.614 1.00
618_Q 622_W 2.61 1.00
374_Q 378_F 2.588 1.00
688_R 715_T 2.563 1.00
51_E 96_K 2.558 1.00
776_Y 781_P 2.524 1.00
547_A 583_D 2.437 1.00
392_N 446_Y 2.377 1.00
583_D 587_G 2.371 1.00
389_N 393_Y 2.285 0.99
560_V 783_P 2.278 0.99
614_E 617_R 2.266 0.99
175_E 217_R 2.263 0.99
638_A 671_S 2.244 0.99
471_A 497_I 2.235 0.99
561_Y 618_Q 2.183 0.99
745_Q 771_R 2.126 0.99
584_P 587_G 2.122 0.99
684_I 694_L 2.098 0.99
651_S 690_M 2.081 0.99
759_K 763_E 2.076 0.99
595_I 669_T 2.071 0.98
556_Q 583_D 2.07 0.98
171_Y 217_R 2.051 0.98
171_Y 175_E 2.027 0.98
583_D 586_H 2.017 0.98
566_F 569_T 2.007 0.98
654_M 659_I 1.999 0.98
558_K 582_H 1.998 0.98
513_H 517_D 1.989 0.98
128_E 132_K 1.976 0.98
408_L 516_M 1.974 0.98
564_Q 665_T 1.966 0.98
138_L 141_A 1.957 0.98
665_T 716_E 1.936 0.97
620_A 624_S 1.92 0.97
248_I 252_R 1.909 0.97
619_L 659_I 1.846 0.96
764_M 768_I 1.845 0.96
579_A 607_I 1.836 0.96
618_Q 784_A 1.833 0.96
165_F 176_A 1.832 0.96
47_Y 51_E 1.826 0.96
452_G 513_H 1.803 0.96
389_N 392_N 1.781 0.95
779_S 790_W 1.771 0.95
95_K 99_S 1.762 0.95
423_Y 513_H 1.755 0.95
150_I 158_I 1.749 0.95
557_L 579_A 1.744 0.94
451_E 513_H 1.728 0.94
199_Q 203_W 1.724 0.94
612_I 634_V 1.721 0.94
390_L 458_V 1.711 0.94
650_V 687_L 1.706 0.94
616_C 664_L 1.703 0.93
710_V 726_R 1.693 0.93
407_Y 471_A 1.681 0.93
148_P 168_M 1.666 0.92
408_L 456_V 1.665 0.92
409_I 493_L 1.663 0.92
138_L 142_V 1.655 0.92
623_R 663_Q 1.651 0.92
598_A 607_I 1.645 0.92
616_C 653_A 1.632 0.91
456_V 516_M 1.623 0.91
132_K 135_T 1.617 0.91
165_F 169_F 1.615 0.91
419_D 513_H 1.61 0.91
454_Q 513_H 1.601 0.90
517_D 520_R 1.579 0.90
559_L 579_A 1.572 0.89
558_K 588_H 1.567 0.89
169_F 176_A 1.566 0.89
135_T 138_L 1.564 0.89
415_Q 517_D 1.563 0.89
595_I 604_I 1.555 0.89
782_L 790_W 1.533 0.88
664_L 692_V 1.529 0.87
547_A 586_H 1.526 0.87
633_S 665_T 1.526 0.87
92_Q 102_W 1.525 0.87
34_V 38_N 1.525 0.87
152_L 158_I 1.521 0.87
407_Y 495_I 1.52 0.87
753_A 770_C 1.518 0.87
142_V 149_V 1.517 0.87
659_I 664_L 1.513 0.87
62_P 65_L 1.51 0.87
646_L 650_V 1.509 0.86
750_T 771_R 1.506 0.86
467_I 471_A 1.497 0.86
366_E 369_R 1.489 0.85
423_Y 452_G 1.486 0.85
420_S 542_L 1.485 0.85
152_L 169_F 1.485 0.85
413_H 524_G 1.473 0.85
762_F 766_R 1.471 0.85
488_P 550_E 1.447 0.83
131_Q 135_T 1.447 0.83
693_G 715_T 1.445 0.83
161_C 171_Y 1.442 0.83
609_R 649_Q 1.441 0.83
214_L 224_I 1.44 0.83
783_P 786_E 1.438 0.83
590_P 596_P 1.434 0.82
582_H 588_H 1.433 0.82
622_W 784_A 1.429 0.82
142_V 160_Q 1.421 0.82
720_D 754_E 1.414 0.81
428_Q 485_D 1.413 0.81
518_Y 521_K 1.406 0.81
161_C 165_F 1.401 0.80
38_N 120_A 1.4 0.80
408_L 513_H 1.398 0.80
151_V 165_F 1.394 0.80
442_K 473_E 1.394 0.80
762_F 773_I 1.392 0.80
125_A 129_M 1.391 0.80
762_F 778_F 1.389 0.80
736_L 743_I 1.382 0.79
734_L 764_M 1.376 0.79
452_G 517_D 1.373 0.78
545_G 549_K 1.373 0.78
91_L 105_F 1.371 0.78
410_G 517_D 1.367 0.78
641_F 684_I 1.352 0.77
32_D 38_N 1.348 0.77
607_I 611_V 1.345 0.76
520_R 523_G 1.344 0.76
564_Q 574_G 1.343 0.76
216_T 220_E 1.34 0.76
550_E 556_Q 1.339 0.76
61_I 64_D 1.33 0.75
415_Q 513_H 1.33 0.75
378_F 389_N 1.33 0.75
376_I 513_H 1.329 0.75
492_T 525_N 1.328 0.75
95_K 101_I 1.326 0.75
451_E 517_D 1.324 0.75
203_W 206_A 1.314 0.74
572_L 790_W 1.313 0.74
419_D 454_Q 1.309 0.74
161_C 169_F 1.309 0.74
564_Q 716_E 1.307 0.74
150_I 165_F 1.3 0.73
242_V 245_F 1.3 0.73
419_D 517_D 1.297 0.73
415_Q 419_D 1.297 0.73
579_A 588_H 1.295 0.73
410_G 451_E 1.294 0.72
741_T 768_I 1.291 0.72
544_L 597_L 1.29 0.72
762_F 777_F 1.288 0.72
213_L 223_W 1.287 0.72
38_N 41_A 1.286 0.72
225_K 246_S 1.284 0.72
38_N 42_E 1.284 0.72
669_T 754_E 1.284 0.72
37_F 42_E 1.282 0.71
432_E 435_N 1.279 0.71
741_T 771_R 1.276 0.71
153_D 157_H 1.274 0.71
216_T 222_I 1.272 0.71
408_L 419_D 1.268 0.70
233_D 237_H 1.268 0.70
410_G 415_Q 1.267 0.70
650_V 692_V 1.266 0.70
150_I 162_N 1.266 0.70
161_C 166_T 1.264 0.70
111_S 114_G 1.26 0.70
350_R 353_D 1.255 0.69
145_L 149_V 1.253 0.69
40_A 43_K 1.253 0.69
519_I 523_G 1.239 0.68
555_N 614_E 1.237 0.68
419_D 442_K 1.237 0.68
738_E 746_S 1.234 0.67
149_V 162_N 1.232 0.67
705_G 723_F 1.229 0.67
214_L 222_I 1.227 0.67
38_N 91_L 1.225 0.66
211_E 217_R 1.223 0.66
394_L 505_R 1.221 0.66
166_T 169_F 1.22 0.66
417_V 429_A 1.218 0.66
166_T 176_A 1.218 0.66
28_I 34_V 1.218 0.66
151_V 162_N 1.21 0.65
646_L 712_L 1.21 0.65
91_L 120_A 1.208 0.65
579_A 611_V 1.206 0.65
716_E 772_V 1.203 0.64
385_P 389_N 1.202 0.64
459_S 470_I 1.201 0.64
623_R 660_D 1.201 0.64
104_R 123_R 1.199 0.64
577_A 632_L 1.199 0.64
376_I 419_D 1.199 0.64
423_Y 517_D 1.197 0.64
45_W 93_L 1.195 0.64
158_I 181_P 1.193 0.63
613_A 657_W 1.192 0.63
602_G 747_L 1.192 0.63
29_N 33_E 1.186 0.63
129_M 135_T 1.185 0.63
160_Q 230_P 1.185 0.63
199_Q 202_L 1.182 0.62
252_R 255_R 1.182 0.62
375_L 564_Q 1.181 0.62
37_F 52_V 1.181 0.62
214_L 217_R 1.177 0.62
616_C 657_W 1.175 0.62
429_A 491_L 1.162 0.60
411_V 452_G 1.159 0.60
738_E 768_I 1.159 0.60
741_T 770_C 1.155 0.60
595_I 599_E 1.154 0.60
604_I 669_T 1.143 0.59
27_L 38_N 1.142 0.58
502_G 511_T 1.136 0.58
565_I 778_F 1.135 0.58
410_G 423_Y 1.13 0.57
619_L 632_L 1.127 0.57
618_Q 788_P 1.126 0.57
564_Q 772_V 1.123 0.57
64_D 92_Q 1.119 0.56
376_I 517_D 1.118 0.56
598_A 604_I 1.117 0.56
727_C 764_M 1.116 0.56
615_A 634_V 1.116 0.56
211_E 252_R 1.114 0.56
719_I 740_I 1.114 0.56
158_I 243_M 1.112 0.55
94_E 100_K 1.111 0.55
581_W 587_G 1.11 0.55
372_I 375_L 1.108 0.55
442_K 517_D 1.103 0.54
158_I 162_N 1.102 0.54
233_D 236_A 1.102 0.54
429_A 482_I 1.101 0.54
419_D 452_G 1.1 0.54
410_G 454_Q 1.1 0.54
214_L 228_I 1.099 0.54
125_A 132_K 1.099 0.54
478_V 493_L 1.097 0.54
432_E 482_I 1.097 0.54
669_T 723_F 1.096 0.54
415_Q 452_G 1.096 0.54
165_F 171_Y 1.095 0.54
581_W 755_G 1.092 0.53
706_L 755_G 1.092 0.53
450_I 513_H 1.088 0.53
595_I 598_A 1.087 0.53
451_E 454_Q 1.087 0.53
586_H 589_V 1.087 0.53
598_A 669_T 1.084 0.53
428_Q 431_L 1.08 0.52
560_V 588_H 1.079 0.52
152_L 181_P 1.077 0.52
28_I 57_I 1.077 0.52
641_F 672_M 1.075 0.52
614_E 618_Q 1.074 0.51
162_N 165_F 1.07 0.51
412_D 523_G 1.07 0.51
612_I 650_V 1.07 0.51
34_V 52_V 1.063 0.50
696_V 714_V 1.063 0.50
612_I 664_L 1.062 0.50
410_G 419_D 1.062 0.50
517_D 524_G 1.061 0.50
69_H 72_Y 1.061 0.50
511_T 535_N 1.061 0.50
739_A 746_S 1.061 0.50
634_V 692_V 1.06 0.50
598_A 602_G 1.06 0.50
728_L 764_M 1.059 0.50
145_L 148_P 1.058 0.50
567_A 756_V 1.057 0.50
92_Q 100_K 1.056 0.50
442_K 470_I 1.056 0.50
41_A 45_W 1.054 0.49
601_I 604_I 1.053 0.49
559_L 615_A 1.051 0.49
710_V 730_E 1.049 0.49
170_G 175_E 1.049 0.49
599_E 669_T 1.049 0.49
721_K 752_V 1.049 0.49
150_I 243_M 1.048 0.49
668_I 694_L 1.047 0.49
610_W 618_Q 1.043 0.48
613_A 653_A 1.043 0.48
38_N 105_F 1.043 0.48
152_L 161_C 1.042 0.48
198_L 203_W 1.04 0.48
412_D 494_S 1.039 0.48
646_L 694_L 1.039 0.48
48_K 51_E 1.035 0.47
135_T 139_I 1.035 0.47
548_L 557_L 1.03 0.47
28_I 38_N 1.028 0.47
669_T 720_D 1.028 0.47
47_Y 101_I 1.028 0.47
101_I 126_S 1.028 0.47
684_I 713_P 1.025 0.46
38_N 46_G 1.024 0.46
236_A 243_M 1.023 0.46
415_Q 423_Y 1.023 0.46
393_Y 442_K 1.021 0.46
419_D 423_Y 1.021 0.46
162_N 213_L 1.02 0.46
409_I 544_L 1.018 0.46
633_S 716_E 1.015 0.45
198_L 202_L 1.015 0.45
622_W 788_P 1.015 0.45
95_K 98_G 1.014 0.45
674_M 680_I 1.014 0.45
599_E 604_I 1.012 0.45
147_R 246_S 1.012 0.45
638_A 668_I 1.01 0.45
556_Q 581_W 1.01 0.45
38_N 52_V 1.01 0.45
213_L 230_P 1.01 0.45
558_K 785_E 1.009 0.45
369_R 373_E 1.009 0.45
717_I 749_L 1.008 0.45
374_Q 383_G 1.008 0.45
561_Y 622_W 1.008 0.45
425_W 489_F 1.005 0.44
702_G 754_E 1.005 0.44
684_I 714_V 1.005 0.44
653_A 656_A 1.004 0.44
478_V 482_I 1.004 0.44
610_W 614_E 1.004 0.44
759_K 777_F 1.003 0.44
411_V 493_L 1.001 0.44
548_L 551_A 1 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hvbA20.53691000.487Contact Map0.579
3pjxA10.52571000.501Contact Map0.45
3gfzA20.48811000.562Contact Map0.408
4hjfA10.40681000.598Contact Map0.559
4hu4A20.36551000.625Contact Map0.603
2r6oA20.35291000.664Contact Map0.714
3sy8A40.48441000.669Contact Map0.657
3hv8A10.33421000.686Contact Map0.566
4fojA10.32791000.687Contact Map0.562
3s83A10.32171000.691Contact Map0.586
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0609 seconds.