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YAHA - Cyclic di-GMP phosphodiesterase YahA
UniProt: P21514 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11236
Length: 362 (346)
Sequences: 1154
Seq/Len: 3.34
YAHA
Paralog alert: 0.71 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ADRB CSRD DOSP GMR RTN YAHA YCGF YCGG YDIV YHJH YHJK YJCC YLAB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
132_A 338_L 3.517 1.00
140_C 352_F 3.432 1.00
173_T 205_C 3.42 1.00
321_V 338_L 3.318 1.00
344_S 347_V 3.29 1.00
148_H 152_G 3.068 1.00
323_T 326_Q 2.866 1.00
72_D 76_W 2.812 1.00
131_C 134_T 2.737 1.00
286_K 290_Q 2.689 1.00
253_H 280_D 2.647 1.00
126_I 183_I 2.498 1.00
149_P 152_G 2.469 1.00
310_R 336_H 2.411 1.00
124_P 175_Q 2.327 1.00
216_L 255_H 2.294 1.00
76_W 79_I 2.257 1.00
201_V 211_F 2.25 1.00
174_R 214_E 2.16 1.00
163_A 172_M 2.144 1.00
63_L 66_K 2.121 1.00
232_E 283_K 2.055 1.00
148_H 151_T 2.036 1.00
141_E 200_N 2.004 1.00
341_Y 346_P 1.986 1.00
249_F 259_F 1.908 1.00
126_I 142_V 1.891 1.00
144_V 176_L 1.884 0.99
164_E 169_I 1.871 0.99
260_A 281_F 1.84 0.99
125_W 348_P 1.799 0.99
324_Q 328_D 1.774 0.99
58_H 61_K 1.736 0.99
121_E 148_H 1.733 0.99
321_V 330_M 1.705 0.99
315_S 336_H 1.702 0.99
275_Q 298_S 1.697 0.99
112_A 148_H 1.688 0.99
286_K 320_G 1.682 0.99
121_E 146_W 1.673 0.99
183_I 187_V 1.67 0.98
318_A 330_M 1.659 0.98
230_V 281_F 1.651 0.98
258_T 280_D 1.62 0.98
249_F 278_P 1.598 0.98
160_I 169_I 1.591 0.98
306_V 335_V 1.591 0.98
211_F 215_C 1.571 0.98
143_L 263_D 1.553 0.97
285_D 319_E 1.551 0.97
175_Q 179_Q 1.512 0.97
318_A 335_V 1.497 0.96
127_Q 339_Q 1.495 0.96
234_T 263_D 1.488 0.96
295_D 298_S 1.482 0.96
132_A 321_V 1.477 0.96
71_S 74_T 1.475 0.96
160_I 234_T 1.47 0.96
200_N 262_D 1.436 0.95
130_F 343_Y 1.433 0.95
129_V 281_F 1.429 0.95
263_D 319_E 1.422 0.95
148_H 154_I 1.417 0.95
327_A 338_L 1.409 0.94
127_Q 322_E 1.408 0.94
124_P 176_L 1.394 0.94
281_F 317_V 1.383 0.94
199_I 229_L 1.368 0.93
329_L 333_K 1.366 0.93
200_N 232_E 1.366 0.93
156_P 159_F 1.336 0.92
230_V 260_A 1.336 0.92
129_V 337_F 1.309 0.91
184_L 224_N 1.306 0.91
163_A 169_I 1.305 0.91
75_F 79_I 1.297 0.91
143_L 262_D 1.293 0.90
177_M 199_I 1.284 0.90
188_K 228_K 1.282 0.90
123_K 147_E 1.28 0.90
144_V 172_M 1.268 0.89
225_D 228_K 1.253 0.89
200_N 319_E 1.244 0.88
143_L 232_E 1.24 0.88
200_N 283_K 1.234 0.88
284_I 289_V 1.231 0.87
219_V 257_I 1.23 0.87
282_I 309_A 1.221 0.87
146_W 152_G 1.22 0.87
262_D 283_K 1.218 0.87
292_A 329_L 1.216 0.86
143_L 200_N 1.212 0.86
163_A 167_G 1.208 0.86
127_Q 200_N 1.208 0.86
348_P 351_K 1.203 0.86
124_P 144_V 1.202 0.86
147_E 153_I 1.199 0.85
141_E 283_K 1.198 0.85
55_T 58_H 1.198 0.85
178_K 218_L 1.191 0.85
127_Q 262_D 1.189 0.85
200_N 341_Y 1.181 0.84
264_F 267_G 1.18 0.84
144_V 175_Q 1.177 0.84
129_V 230_V 1.176 0.84
283_K 322_E 1.173 0.84
121_E 149_P 1.173 0.84
235_E 265_G 1.163 0.83
234_T 288_F 1.161 0.83
113_I 163_A 1.152 0.82
120_H 179_Q 1.149 0.82
178_K 222_L 1.149 0.82
141_E 232_E 1.148 0.82
200_N 339_Q 1.142 0.81
52_S 76_W 1.139 0.81
283_K 339_Q 1.138 0.81
181_A 218_L 1.138 0.81
288_F 309_A 1.136 0.81
318_A 321_V 1.131 0.81
72_D 79_I 1.126 0.80
49_R 52_S 1.12 0.80
180_T 199_I 1.119 0.80
232_E 339_Q 1.116 0.79
235_E 285_D 1.111 0.79
141_E 262_D 1.109 0.79
71_S 79_I 1.108 0.79
177_M 215_C 1.106 0.78
306_V 316_I 1.104 0.78
142_V 197_I 1.103 0.78
266_T 288_F 1.101 0.78
72_D 75_F 1.098 0.78
235_E 283_K 1.09 0.77
67_L 74_T 1.09 0.77
309_A 316_I 1.079 0.76
338_L 343_Y 1.078 0.76
229_L 257_I 1.077 0.76
122_F 175_Q 1.076 0.76
267_G 270_T 1.074 0.76
71_S 75_F 1.069 0.75
286_K 319_E 1.067 0.75
234_T 267_G 1.064 0.75
181_A 326_Q 1.052 0.73
330_M 335_V 1.052 0.73
122_F 144_V 1.052 0.73
293_S 323_T 1.05 0.73
127_Q 143_L 1.048 0.73
327_A 343_Y 1.047 0.73
322_E 341_Y 1.047 0.73
341_Y 345_P 1.046 0.73
173_T 230_V 1.042 0.72
293_S 325_E 1.035 0.72
145_R 283_K 1.034 0.72
127_Q 232_E 1.031 0.71
301_I 308_L 1.028 0.71
263_D 266_T 1.028 0.71
262_D 339_Q 1.026 0.71
263_D 341_Y 1.025 0.71
293_S 326_Q 1.023 0.70
71_S 76_W 1.021 0.70
235_E 263_D 1.019 0.70
141_E 339_Q 1.014 0.69
218_L 222_L 1.007 0.69
112_A 146_W 1.007 0.69
292_A 302_V 1.006 0.69
127_Q 283_K 1.004 0.68
14_G 72_D 1.003 0.68
128_P 344_S 1.001 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hvbA20.9531000.212Contact Map0.652
3pjxA10.91441000.227Contact Map0.599
4hjfA10.88121000.228Contact Map0.631
4hu4A20.78731000.299Contact Map0.649
3gfzA20.87571000.328Contact Map0.619
2r6oA20.75971000.342Contact Map0.723
3sy8A40.93651000.348Contact Map0.727
3s83A10.70441000.38Contact Map0.639
3hv8A10.72381000.384Contact Map0.651
4fojA10.71271000.384Contact Map0.666
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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