| UniProt: | P37646 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12252 | ||
| Length: | 255 (239) | ||
| Sequences: | 12067 | ||
| Seq/Len: | 50.49 |
| YHJH
Paralog alert: 0.89 [within 20: 0.46] - ratio of genomes with paralogs Cluster includes: ADRB CSRD DOSP GMR RTN YAHA YCGF YCGG YDIV YHJH YHJK YJCC YLAB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 47_V | 248_L | 3.949 | 1.00 | |
| 40_T | 234_A | 3.545 | 1.00 | |
| 182_R | 186_V | 3.313 | 1.00 | |
| 150_C | 176_D | 3.106 | 1.00 | |
| 240_S | 243_A | 3.074 | 1.00 | |
| 58_N | 61_Q | 2.91 | 1.00 | |
| 131_R | 177_Y | 2.893 | 1.00 | |
| 225_D | 229_S | 2.599 | 1.00 | |
| 31_A | 54_T | 2.577 | 1.00 | |
| 220_P | 224_R | 2.566 | 1.00 | |
| 206_N | 232_F | 2.479 | 1.00 | |
| 156_W | 177_Y | 2.268 | 1.00 | |
| 223_W | 239_L | 2.237 | 1.00 | |
| 217_V | 234_A | 2.204 | 1.00 | |
| 171_S | 194_G | 2.181 | 1.00 | |
| 55_H | 61_Q | 2.14 | 1.00 | |
| 199_S | 207_R | 2.125 | 1.00 | |
| 219_T | 222_E | 2.081 | 1.00 | |
| 223_W | 234_A | 2.07 | 1.00 | |
| 82_K | 110_T | 2.033 | 1.00 | |
| 121_L | 152_F | 2.001 | 1.00 | |
| 37_I | 233_A | 1.994 | 1.00 | |
| 182_R | 216_G | 1.965 | 1.00 | |
| 33_T | 244_P | 1.948 | 1.00 | |
| 57_L | 61_Q | 1.882 | 1.00 | |
| 131_R | 156_W | 1.812 | 1.00 | |
| 7_Q | 67_R | 1.812 | 1.00 | |
| 80_V | 84_Q | 1.805 | 1.00 | |
| 146_F | 155_L | 1.803 | 1.00 | |
| 38_Y | 239_L | 1.802 | 1.00 | |
| 31_A | 62_R | 1.801 | 1.00 | |
| 195_R | 225_D | 1.796 | 1.00 | |
| 54_T | 62_R | 1.794 | 1.00 | |
| 37_I | 177_Y | 1.764 | 1.00 | |
| 55_H | 58_N | 1.747 | 1.00 | |
| 177_Y | 213_I | 1.736 | 1.00 | |
| 95_F | 129_W | 1.733 | 1.00 | |
| 34_W | 90_Q | 1.733 | 1.00 | |
| 123_Q | 127_L | 1.726 | 1.00 | |
| 189_R | 221_E | 1.702 | 1.00 | |
| 154_P | 176_D | 1.69 | 1.00 | |
| 237_W | 242_P | 1.656 | 1.00 | |
| 220_P | 238_F | 1.643 | 1.00 | |
| 223_W | 227_Q | 1.643 | 1.00 | |
| 92_A | 96_I | 1.639 | 1.00 | |
| 91_K | 94_F | 1.627 | 1.00 | |
| 14_A | 55_H | 1.614 | 1.00 | |
| 199_S | 229_S | 1.602 | 1.00 | |
| 33_T | 62_R | 1.592 | 1.00 | |
| 37_I | 131_R | 1.578 | 1.00 | |
| 178_I | 205_M | 1.569 | 1.00 | |
| 223_W | 238_F | 1.568 | 1.00 | |
| 244_P | 247_T | 1.566 | 1.00 | |
| 214_V | 231_A | 1.561 | 1.00 | |
| 101_L | 154_P | 1.541 | 1.00 | |
| 202_L | 229_S | 1.537 | 1.00 | |
| 211_G | 232_F | 1.476 | 1.00 | |
| 189_R | 195_R | 1.476 | 1.00 | |
| 211_G | 233_A | 1.473 | 1.00 | |
| 87_L | 91_K | 1.47 | 1.00 | |
| 45_M | 233_A | 1.47 | 1.00 | |
| 189_R | 222_E | 1.397 | 0.99 | |
| 106_I | 132_F | 1.389 | 0.99 | |
| 157_L | 175_Y | 1.377 | 0.99 | |
| 37_I | 46_A | 1.367 | 0.99 | |
| 202_L | 231_A | 1.365 | 0.99 | |
| 101_L | 131_R | 1.363 | 0.99 | |
| 188_L | 225_D | 1.319 | 0.99 | |
| 90_Q | 245_I | 1.319 | 0.99 | |
| 131_R | 154_P | 1.313 | 0.99 | |
| 199_S | 203_H | 1.304 | 0.99 | |
| 82_K | 85_I | 1.27 | 0.99 | |
| 171_S | 187_M | 1.251 | 0.99 | |
| 32_Y | 51_T | 1.233 | 0.98 | |
| 188_L | 198_F | 1.228 | 0.98 | |
| 90_Q | 94_F | 1.216 | 0.98 | |
| 234_A | 239_L | 1.215 | 0.98 | |
| 189_R | 225_D | 1.202 | 0.98 | |
| 91_K | 95_F | 1.186 | 0.98 | |
| 106_I | 116_Q | 1.173 | 0.98 | |
| 103_S | 131_R | 1.169 | 0.97 | |
| 39_Q | 43_R | 1.163 | 0.97 | |
| 205_M | 212_V | 1.155 | 0.97 | |
| 224_R | 227_Q | 1.153 | 0.97 | |
| 83_E | 119_K | 1.147 | 0.97 | |
| 175_Y | 210_R | 1.147 | 0.97 | |
| 177_Y | 211_G | 1.139 | 0.97 | |
| 189_R | 219_T | 1.134 | 0.97 | |
| 224_R | 228_N | 1.132 | 0.97 | |
| 147_A | 151_E | 1.132 | 0.97 | |
| 191_S | 194_G | 1.13 | 0.97 | |
| 58_N | 67_R | 1.118 | 0.96 | |
| 247_T | 250_T | 1.117 | 0.96 | |
| 37_I | 103_S | 1.11 | 0.96 | |
| 24_F | 51_T | 1.106 | 0.96 | |
| 159_D | 215_E | 1.099 | 0.96 | |
| 49_L | 102_A | 1.079 | 0.95 | |
| 196_T | 207_R | 1.063 | 0.95 | |
| 143_D | 147_A | 1.061 | 0.95 | |
| 121_L | 148_S | 1.052 | 0.95 | |
| 18_S | 24_F | 1.05 | 0.94 | |
| 108_G | 137_H | 1.046 | 0.94 | |
| 143_D | 172_E | 1.045 | 0.94 | |
| 119_K | 123_Q | 1.041 | 0.94 | |
| 44_L | 251_A | 1.035 | 0.94 | |
| 34_W | 49_L | 1.034 | 0.94 | |
| 200_Q | 207_R | 1.033 | 0.94 | |
| 82_K | 86_D | 1.032 | 0.94 | |
| 32_Y | 49_L | 1.028 | 0.94 | |
| 42_G | 227_Q | 1.023 | 0.93 | |
| 17_E | 21_E | 1.021 | 0.93 | |
| 202_L | 212_V | 1.017 | 0.93 | |
| 145_T | 148_S | 1.013 | 0.93 | |
| 122_R | 126_R | 1.01 | 0.93 | |
| 39_Q | 45_M | 1.009 | 0.93 | |
| 32_Y | 84_Q | 1.006 | 0.93 | |
| 73_T | 78_M | 1.005 | 0.93 | |
| 94_F | 245_I | 1.003 | 0.93 | |
| 243_A | 247_T | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4hjfA | 1 | 0.9686 | 100 | -0.014 | Contact Map | 0.599 |
| 4hu4A | 2 | 0.9686 | 100 | -0.008 | Contact Map | 0.755 |
| 2r6oA | 2 | 0.9686 | 100 | 0.019 | Contact Map | 0.769 |
| 3sy8A | 4 | 0.9686 | 100 | 0.042 | Contact Map | 0.789 |
| 3hvbA | 2 | 0.9647 | 100 | 0.044 | Contact Map | 0.676 |
| 3pjxA | 1 | 0.9176 | 100 | 0.049 | Contact Map | 0.674 |
| 3s83A | 1 | 0.9373 | 100 | 0.062 | Contact Map | 0.638 |
| 4fojA | 1 | 0.949 | 100 | 0.067 | Contact Map | 0.646 |
| 3hv8A | 1 | 0.9647 | 100 | 0.073 | Contact Map | 0.681 |
| 2basA | 2 | 0.9529 | 100 | 0.094 | Contact Map | 0.694 |
Sequence Conservation (Image Generated using WebLogo v3)