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OPENSEQ.org
VISC - Protein VisC
UniProt: P25535 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11333
Length: 400 (388)
Sequences: 10099
Seq/Len: 26.03
VISC
Paralog alert: 0.82 [within 20: 0.32] - ratio of genomes with paralogs
Cluster includes: CBRA FIXC UBIF UBIH VISC YDIS YGCN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_A 130_L 4.429 1.00
34_Q 134_E 4.034 1.00
14_V 305_G 3.665 1.00
336_E 340_K 3.606 1.00
5_D 158_R 3.511 1.00
7_A 157_A 3.386 1.00
5_D 28_R 3.365 1.00
18_V 161_I 3.325 1.00
7_A 147_L 3.242 1.00
162_G 170_L 2.759 1.00
137_Q 173_K 2.714 1.00
135_L 147_L 2.699 1.00
120_K 123_Q 2.693 1.00
134_E 150_K 2.69 1.00
69_D 119_N 2.617 1.00
17_A 306_F 2.581 1.00
133_A 151_D 2.556 1.00
146_F 156_T 2.555 1.00
7_A 32_L 2.548 1.00
115_Y 119_N 2.504 1.00
21_G 313_I 2.433 1.00
137_Q 148_T 2.424 1.00
4_V 30_A 2.424 1.00
32_L 155_L 2.422 1.00
25_S 317_K 2.392 1.00
14_V 287_V 2.378 1.00
148_T 154_M 2.299 1.00
138_V 160_V 2.267 1.00
139_A 146_F 2.256 1.00
241_S 244_E 2.235 1.00
280_A 333_R 2.137 1.00
163_A 287_V 2.134 1.00
19_A 31_V 2.1 1.00
6_V 27_L 2.092 1.00
315_E 338_S 2.077 1.00
8_I 18_V 2.074 1.00
32_L 149_L 2.072 1.00
121_A 127_I 2.049 1.00
20_C 120_K 2.044 1.00
149_L 155_L 2.003 1.00
28_R 128_T 1.985 1.00
62_T 67_W 1.977 1.00
146_F 154_M 1.973 1.00
141_G 156_T 1.968 1.00
162_G 286_L 1.938 1.00
133_A 149_L 1.923 1.00
136_Q 150_K 1.908 1.00
144_E 156_T 1.905 1.00
164_D 168_S 1.901 1.00
247_R 251_I 1.885 1.00
5_D 30_A 1.88 1.00
159_L 332_L 1.878 1.00
57_S 303_N 1.873 1.00
309_A 313_I 1.871 1.00
130_L 133_A 1.846 1.00
139_A 148_T 1.844 1.00
7_A 155_L 1.834 1.00
278_Q 281_S 1.831 1.00
23_Q 127_I 1.805 1.00
69_D 120_K 1.798 1.00
311_E 315_E 1.784 1.00
174_A 284_L 1.781 1.00
18_V 22_L 1.778 1.00
36_V 132_P 1.751 1.00
314_A 338_S 1.746 1.00
6_V 22_L 1.737 1.00
130_L 153_S 1.726 1.00
120_K 124_S 1.725 1.00
18_V 309_A 1.707 1.00
315_E 331_Y 1.686 1.00
340_K 344_A 1.675 1.00
145_T 160_V 1.674 1.00
30_A 155_L 1.673 1.00
279_F 343_A 1.668 1.00
169_W 173_K 1.663 1.00
280_A 285_A 1.624 1.00
133_A 153_S 1.608 1.00
140_W 281_S 1.602 1.00
141_G 144_E 1.59 1.00
279_F 336_E 1.585 1.00
27_L 317_K 1.581 1.00
57_S 306_F 1.58 1.00
307_M 342_S 1.575 1.00
278_Q 336_E 1.574 1.00
311_E 338_S 1.574 1.00
147_L 160_V 1.569 1.00
69_D 123_Q 1.566 1.00
63_R 310_A 1.555 1.00
60_L 310_A 1.555 1.00
21_G 64_L 1.551 1.00
141_G 146_F 1.545 1.00
287_V 335_Y 1.532 1.00
315_E 334_R 1.523 1.00
8_I 29_V 1.521 1.00
308_D 339_R 1.509 1.00
157_A 160_V 1.502 1.00
9_V 160_V 1.494 1.00
18_V 287_V 1.488 1.00
7_A 30_A 1.488 1.00
13_M 302_V 1.486 1.00
176_I 276_A 1.484 1.00
145_T 283_R 1.444 1.00
20_C 121_A 1.434 1.00
20_C 64_L 1.432 1.00
69_D 73_R 1.419 1.00
193_R 261_K 1.41 1.00
292_H 308_D 1.393 0.99
11_G 16_L 1.389 0.99
20_C 124_S 1.377 0.99
119_N 122_H 1.371 0.99
11_G 33_E 1.369 0.99
246_N 250_N 1.369 0.99
135_L 138_V 1.367 0.99
17_A 21_G 1.364 0.99
285_A 312_L 1.364 0.99
135_L 170_L 1.363 0.99
161_I 285_A 1.359 0.99
74_R 112_V 1.348 0.99
9_V 170_L 1.344 0.99
9_V 135_L 1.328 0.99
20_C 24_G 1.326 0.99
168_S 171_R 1.321 0.99
32_L 130_L 1.32 0.99
118_W 131_A 1.319 0.99
8_I 19_A 1.316 0.99
243_D 247_R 1.297 0.99
140_W 283_R 1.275 0.99
149_L 153_S 1.274 0.99
17_A 64_L 1.273 0.99
169_W 172_N 1.269 0.99
4_V 7_A 1.253 0.99
166_A 293_T 1.252 0.99
130_L 155_L 1.252 0.99
140_W 145_T 1.234 0.98
51_S 302_V 1.234 0.98
161_I 287_V 1.229 0.98
29_V 127_I 1.228 0.98
118_W 129_L 1.218 0.98
68_Q 73_R 1.212 0.98
177_P 277_R 1.209 0.98
274_R 293_T 1.205 0.98
147_L 157_A 1.196 0.98
280_A 329_Y 1.185 0.98
61_L 66_V 1.181 0.98
24_G 120_K 1.18 0.98
68_Q 72_S 1.17 0.97
70_I 116_A 1.162 0.97
280_A 332_L 1.156 0.97
159_L 285_A 1.156 0.97
294_I 347_L 1.155 0.97
280_A 336_E 1.154 0.97
5_D 27_L 1.153 0.97
136_Q 148_T 1.146 0.97
286_L 290_A 1.124 0.97
311_E 314_A 1.107 0.96
319_L 334_R 1.103 0.96
242_E 266_R 1.101 0.96
33_E 131_A 1.1 0.96
74_R 116_A 1.1 0.96
56_A 300_Q 1.092 0.96
138_V 174_A 1.089 0.96
285_A 335_Y 1.089 0.96
67_W 72_S 1.086 0.96
24_G 124_S 1.081 0.95
170_L 284_L 1.078 0.95
333_R 337_R 1.075 0.95
318_R 334_R 1.074 0.95
19_A 29_V 1.073 0.95
294_I 304_L 1.073 0.95
56_A 307_M 1.073 0.95
233_E 236_R 1.07 0.95
112_V 115_Y 1.07 0.95
31_V 129_L 1.065 0.95
63_R 314_A 1.064 0.95
248_A 251_I 1.056 0.95
344_A 348_A 1.053 0.95
70_I 113_I 1.053 0.95
315_E 318_R 1.052 0.95
66_V 120_K 1.04 0.94
32_L 133_A 1.039 0.94
51_S 110_N 1.035 0.94
244_E 247_R 1.031 0.94
22_L 27_L 1.028 0.94
251_I 254_D 1.02 0.93
247_R 250_N 1.02 0.93
162_G 284_L 1.014 0.93
13_M 306_F 1.01 0.93
121_A 126_D 1.005 0.93
363_A 367_L 1.003 0.93
4_V 28_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4n9xA10.99751000.21Contact Map0.7
4k22A20.911000.279Contact Map0.746
2qa2A10.9451000.291Contact Map0.761
2qa1A10.9451000.301Contact Map0.798
2x3nA10.951000.306Contact Map0.773
4k2xA20.95251000.308Contact Map0.8
3fmwA30.95751000.311Contact Map0.699
4k5sA10.95751000.316Contact Map0.803
1pn0A40.961000.318Contact Map0.774
1k0iA10.95251000.328Contact Map0.699
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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