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OPENSEQ.org
UBIH - 2-octaprenyl-6-methoxyphenol hydroxylase
UniProt: P25534 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11324
Length: 392 (385)
Sequences: 10321
Seq/Len: 26.81
UBIH
Paralog alert: 0.83 [within 20: 0.33] - ratio of genomes with paralogs
Cluster includes: CBRA FIXC UBIF UBIH VISC YDIS YGCN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_H 128_H 4.401 1.00
34_A 132_R 4.032 1.00
11_A 302_G 3.736 1.00
333_Q 337_Q 3.593 1.00
2_S 156_R 3.551 1.00
2_S 28_P 3.395 1.00
4_I 155_G 3.367 1.00
15_L 159_V 3.264 1.00
4_I 145_V 3.108 1.00
160_A 168_L 2.836 1.00
132_R 148_E 2.731 1.00
133_V 145_V 2.689 1.00
118_L 121_K 2.67 1.00
4_I 32_I 2.611 1.00
68_S 117_A 2.606 1.00
14_T 303_M 2.603 1.00
135_N 171_A 2.599 1.00
144_E 154_T 2.583 1.00
131_D 149_S 2.547 1.00
113_Q 117_A 2.502 1.00
32_I 153_L 2.45 1.00
22_L 314_T 2.426 1.00
18_A 310_A 2.424 1.00
135_N 146_T 2.341 1.00
11_A 284_V 2.338 1.00
238_S 241_K 2.329 1.00
136_V 158_L 2.302 1.00
1_M 30_H 2.29 1.00
137_A 144_E 2.245 1.00
146_T 152_T 2.241 1.00
277_I 330_C 2.218 1.00
32_I 147_L 2.12 1.00
144_E 152_T 2.114 1.00
161_A 284_V 2.09 1.00
5_I 15_L 2.065 1.00
17_L 118_L 2.061 1.00
312_T 335_R 2.027 1.00
16_A 31_L 2.024 1.00
3_V 27_L 1.994 1.00
28_P 126_T 1.993 1.00
162_D 166_S 1.981 1.00
139_T 154_T 1.972 1.00
160_A 283_L 1.949 1.00
61_A 66_W 1.948 1.00
157_V 329_L 1.941 1.00
142_H 154_T 1.934 1.00
2_S 30_H 1.922 1.00
147_L 153_L 1.922 1.00
56_T 300_N 1.908 1.00
4_I 153_L 1.906 1.00
275_R 278_T 1.899 1.00
119_L 125_V 1.888 1.00
128_H 131_D 1.887 1.00
131_D 147_L 1.878 1.00
308_S 312_T 1.864 1.00
137_A 146_T 1.824 1.00
244_R 248_S 1.822 1.00
3_V 19_I 1.818 1.00
15_L 19_I 1.816 1.00
134_A 148_E 1.795 1.00
311_E 335_R 1.778 1.00
20_S 125_V 1.758 1.00
172_C 281_T 1.752 1.00
306_V 310_A 1.75 1.00
36_A 130_P 1.742 1.00
68_S 118_L 1.728 1.00
118_L 122_A 1.71 1.00
30_H 153_L 1.703 1.00
277_I 282_V 1.695 1.00
15_L 306_V 1.67 1.00
337_Q 341_E 1.666 1.00
312_T 328_V 1.631 1.00
276_S 340_R 1.627 1.00
167_A 171_A 1.612 1.00
27_L 314_T 1.611 1.00
138_R 278_T 1.606 1.00
56_T 303_M 1.595 1.00
68_S 121_K 1.595 1.00
305_D 336_R 1.589 1.00
59_Q 307_M 1.589 1.00
18_A 63_I 1.588 1.00
10_M 299_F 1.587 1.00
191_A 258_T 1.584 1.00
308_S 335_R 1.578 1.00
139_T 144_E 1.57 1.00
68_S 71_D 1.569 1.00
62_R 307_M 1.569 1.00
143_V 158_L 1.565 1.00
139_T 142_H 1.551 1.00
275_R 333_Q 1.539 1.00
145_V 158_L 1.52 1.00
5_I 29_V 1.505 1.00
276_S 333_Q 1.499 1.00
304_R 339_D 1.497 1.00
155_G 158_L 1.492 1.00
6_V 158_L 1.489 1.00
128_H 151_E 1.484 1.00
312_T 331_R 1.481 1.00
284_V 332_Y 1.473 1.00
15_L 284_V 1.465 1.00
4_I 30_H 1.459 1.00
131_D 151_E 1.459 1.00
72_C 110_N 1.456 1.00
8_G 13_A 1.443 1.00
17_L 119_L 1.438 1.00
289_Q 305_D 1.435 1.00
67_Q 70_A 1.431 1.00
67_Q 71_D 1.429 1.00
143_V 280_R 1.427 1.00
282_V 309_L 1.423 1.00
166_S 169_A 1.418 1.00
174_V 273_A 1.414 1.00
133_V 168_L 1.402 0.99
133_V 136_V 1.396 0.99
32_I 128_H 1.377 0.99
17_L 63_I 1.375 0.99
240_E 244_R 1.367 0.99
14_T 18_A 1.358 0.99
159_V 282_V 1.35 0.99
5_I 16_A 1.328 0.99
8_G 33_E 1.328 0.99
6_V 168_L 1.327 0.99
167_A 170_T 1.324 0.99
117_A 120_R 1.323 0.99
164_T 290_T 1.314 0.99
6_V 133_V 1.311 0.99
116_F 129_C 1.3 0.99
66_W 70_A 1.29 0.99
17_L 21_R 1.289 0.99
138_R 280_R 1.286 0.99
159_V 284_V 1.276 0.99
243_C 247_Q 1.275 0.99
116_F 127_L 1.248 0.99
17_L 122_A 1.233 0.98
1_M 4_I 1.218 0.98
277_I 329_L 1.211 0.98
277_I 326_Y 1.21 0.98
72_C 114_R 1.21 0.98
14_T 63_I 1.206 0.98
128_H 153_L 1.204 0.98
21_R 118_L 1.2 0.98
2_S 27_L 1.191 0.98
69_L 114_R 1.166 0.97
145_V 155_G 1.166 0.97
60_L 65_V 1.162 0.97
283_L 287_A 1.159 0.97
244_R 247_Q 1.151 0.97
50_I 299_F 1.145 0.97
308_S 311_E 1.137 0.97
134_A 146_T 1.136 0.97
282_V 332_Y 1.13 0.97
29_V 125_V 1.128 0.97
157_V 282_V 1.123 0.97
277_I 333_Q 1.118 0.96
291_L 301_L 1.106 0.96
316_A 331_R 1.097 0.96
271_T 290_T 1.095 0.96
315_Q 331_R 1.081 0.95
312_T 315_Q 1.08 0.95
31_L 127_L 1.075 0.95
138_R 143_V 1.075 0.95
330_C 334_Q 1.071 0.95
245_E 248_S 1.064 0.95
19_I 27_L 1.064 0.95
137_A 152_T 1.062 0.95
230_R 233_E 1.06 0.95
32_I 131_D 1.056 0.95
61_A 70_A 1.052 0.95
65_V 118_L 1.048 0.94
291_L 344_I 1.038 0.94
88_G 91_T 1.038 0.94
55_G 304_R 1.025 0.93
33_E 129_C 1.022 0.93
69_L 111_V 1.022 0.93
159_V 309_L 1.022 0.93
10_M 303_M 1.021 0.93
241_K 244_R 1.018 0.93
160_A 281_T 1.017 0.93
16_A 29_V 1.016 0.93
168_L 281_T 1.015 0.93
110_N 113_Q 1.013 0.93
175_D 274_A 1.012 0.93
50_I 108_L 1.011 0.93
136_V 171_A 1.007 0.93
147_L 151_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4n9xA10.99231000.198Contact Map0.707
2qa2A10.94391000.256Contact Map0.767
4k22A20.91581000.258Contact Map0.757
2qa1A10.94391000.265Contact Map0.804
4k2xA20.95151000.273Contact Map0.801
3fmwA30.95411000.274Contact Map0.716
4k5sA10.95411000.275Contact Map0.809
2x3nA10.95151000.286Contact Map0.776
1k0iA10.95921000.297Contact Map0.716
1pn0A40.96431000.3Contact Map0.777
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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