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OPENSEQ.org
INSK - Putative transposase InsK for insertion sequence element IS150
UniProt: P19769 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG40011
Length: 283 (276)
Sequences: 3915
Seq/Len: 14.18
INSK
Paralog alert: 0.71 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: INSD1 INSD2 INSD3 INSD4 INSD5 INSD6 INSD8 INSF1 INSF2 INSF3 INSF4 INSF5 INSK INSO1 INSO2 YAGA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
69_R 273_E 3.026 1.00
122_N 125_W 2.685 1.00
46_R 70_E 2.6 1.00
143_P 227_F 2.55 1.00
47_I 63_V 2.542 1.00
44_K 86_L 2.528 1.00
171_D 201_I 2.464 1.00
269_L 277_Q 2.41 1.00
255_E 259_S 2.386 1.00
126_V 223_V 2.324 1.00
120_R 123_E 2.323 1.00
44_K 85_T 2.221 1.00
151_E 272_I 2.153 1.00
270_T 273_E 2.124 1.00
241_S 245_E 2.073 1.00
23_P 26_T 2.071 1.00
240_F 249_A 2.063 1.00
119_T 123_E 2.051 1.00
75_N 78_A 2.04 1.00
259_S 272_I 2.034 1.00
156_S 172_Q 1.977 1.00
46_R 49_E 1.957 1.00
65_L 268_G 1.909 1.00
131_E 138_K 1.784 1.00
230_L 250_V 1.752 1.00
127_T 187_S 1.748 1.00
150_N 263_S 1.745 1.00
242_N 245_E 1.732 1.00
233_E 261_R 1.722 1.00
66_S 262_I 1.704 1.00
141_L 230_L 1.7 1.00
50_I 63_V 1.691 1.00
199_Q 209_Q 1.67 1.00
64_T 68_H 1.669 1.00
142_S 193_Y 1.663 1.00
156_S 168_N 1.654 1.00
125_W 144_V 1.634 1.00
266_L 270_T 1.623 1.00
58_Y 62_R 1.617 1.00
125_W 173_A 1.614 1.00
154_S 169_M 1.593 1.00
64_T 79_V 1.584 1.00
246_L 250_V 1.584 1.00
143_P 223_V 1.582 1.00
228_G 232_S 1.572 1.00
127_T 185_L 1.554 1.00
74_I 79_V 1.554 1.00
161_P 192_Q 1.553 1.00
126_V 147_L 1.542 1.00
269_L 274_Y 1.54 1.00
60_Y 80_Q 1.523 1.00
118_A 124_K 1.515 1.00
151_E 275_R 1.514 1.00
234_C 240_F 1.49 1.00
234_C 249_A 1.487 1.00
213_R 219_D 1.486 1.00
129_V 192_Q 1.474 1.00
264_L 268_G 1.452 1.00
44_K 82_L 1.45 1.00
163_M 167_E 1.45 1.00
78_A 81_R 1.442 1.00
12_P 15_E 1.432 1.00
183_P 207_I 1.428 1.00
3_V 7_L 1.42 1.00
47_I 82_L 1.41 1.00
25_S 28_Y 1.41 1.00
225_C 228_G 1.404 0.99
134_V 137_R 1.397 0.99
145_I 152_V 1.375 0.99
125_W 183_P 1.37 0.99
69_R 262_I 1.369 0.99
51_Y 88_L 1.359 0.99
60_Y 76_H 1.359 0.99
147_L 222_V 1.349 0.99
112_L 124_K 1.347 0.99
66_S 70_E 1.345 0.99
43_V 74_I 1.335 0.99
53_E 260_R 1.325 0.99
141_L 155_Y 1.324 0.99
127_T 193_Y 1.319 0.99
50_I 66_S 1.31 0.99
62_R 233_E 1.306 0.99
130_T 231_K 1.304 0.99
185_L 198_Y 1.296 0.99
14_D 24_R 1.295 0.99
46_R 72_K 1.28 0.99
126_V 222_V 1.279 0.99
218_L 221_A 1.266 0.99
189_Q 214_K 1.263 0.99
258_N 261_R 1.25 0.99
200_N 204_E 1.241 0.98
212_S 219_D 1.234 0.98
115_D 124_K 1.228 0.98
174_F 205_H 1.216 0.98
201_I 205_H 1.214 0.98
174_F 207_I 1.207 0.98
62_R 264_L 1.207 0.98
80_Q 84_G 1.202 0.98
255_E 260_R 1.2 0.98
149_N 275_R 1.199 0.98
202_L 207_I 1.192 0.98
100_Y 103_E 1.192 0.98
213_R 216_N 1.188 0.98
266_L 274_Y 1.188 0.98
82_L 86_L 1.177 0.98
202_L 209_Q 1.167 0.97
139_L 243_I 1.166 0.97
158_S 165_M 1.155 0.97
187_S 209_Q 1.149 0.97
142_S 169_M 1.144 0.97
48_S 86_L 1.138 0.97
159_E 243_I 1.135 0.97
22_I 26_T 1.133 0.97
212_S 220_N 1.132 0.97
161_P 191_W 1.132 0.97
257_Y 263_S 1.128 0.97
131_E 140_Y 1.124 0.97
110_N 212_S 1.124 0.97
97_Y 100_Y 1.123 0.97
132_F 250_V 1.121 0.97
266_L 271_P 1.118 0.96
44_K 48_S 1.116 0.96
263_S 266_L 1.108 0.96
124_K 147_L 1.107 0.96
152_V 254_I 1.107 0.96
145_I 223_V 1.102 0.96
189_Q 211_M 1.099 0.96
64_T 76_H 1.098 0.96
51_Y 56_G 1.097 0.96
141_L 157_L 1.089 0.96
54_N 256_Y 1.088 0.96
152_V 226_F 1.084 0.96
191_W 195_M 1.081 0.95
17_L 27_F 1.073 0.95
131_E 161_P 1.067 0.95
186_H 219_D 1.05 0.94
186_H 210_S 1.048 0.94
148_F 278_T 1.048 0.94
225_C 229_T 1.047 0.94
247_K 251_T 1.037 0.94
144_V 173_A 1.028 0.94
29_Y 33_A 1.021 0.93
120_R 148_F 1.021 0.93
122_N 177_L 1.011 0.93
5_N 8_R 1.011 0.93
14_D 18_R 1.007 0.93
144_V 169_M 1.005 0.93
270_T 274_Y 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fcyA20.98231000.396Contact Map0.471
3hotA20.95761000.511Contact Map0.609
1bcoA10.62191000.528Contact Map0.517
4fw1A20.59361000.572Contact Map0.683
3av9A20.63251000.573Contact Map0.443
3oymA20.92231000.576Contact Map0.574
3kksA20.53361000.584Contact Map0.596
3l3uA20.56181000.586Contact Map0.641
1c6vA40.56181000.588Contact Map0.711
1ex4A20.56181000.594Contact Map0.602
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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