| UniProt: | Q47718 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | |||
| Length: | 198 (187) | ||
| Sequences: | 3280 | ||
| Seq/Len: | 17.54 |
| INSO2
Paralog alert: 0.68 [within 20: 0.16] - ratio of genomes with paralogs Cluster includes: INSD1 INSD2 INSD3 INSD4 INSD5 INSD6 INSD8 INSF1 INSF2 INSF3 INSF4 INSF5 INSK INSO1 INSO2 YAGA |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 32_R | 74_L | 3.233 | 1.00 | |
| 35_V | 51_I | 3.066 | 1.00 | |
| 108_E | 111_Q | 2.704 | 1.00 | |
| 34_Q | 58_R | 2.548 | 1.00 | |
| 119_Y | 126_W | 2.423 | 1.00 | |
| 110_N | 113_W | 2.376 | 1.00 | |
| 32_R | 73_E | 2.294 | 1.00 | |
| 28_R | 66_L | 2.266 | 1.00 | |
| 38_L | 51_I | 2.252 | 1.00 | |
| 63_G | 66_L | 2.249 | 1.00 | |
| 46_A | 50_S | 2.1 | 1.00 | |
| 144_A | 156_K | 2.096 | 1.00 | |
| 34_Q | 37_E | 2.082 | 1.00 | |
| 142_G | 157_A | 2.045 | 1.00 | |
| 106_V | 112_V | 2.031 | 1.00 | |
| 38_L | 54_M | 2.02 | 1.00 | |
| 159_E | 189_Y | 2.017 | 1.00 | |
| 48_A | 68_G | 1.996 | 1.00 | |
| 62_M | 67_A | 1.991 | 1.00 | |
| 115_G | 173_F | 1.921 | 1.00 | |
| 52_A | 56_T | 1.919 | 1.00 | |
| 114_C | 135_L | 1.906 | 1.00 | |
| 144_A | 160_M | 1.875 | 1.00 | |
| 113_W | 171_V | 1.846 | 1.00 | |
| 115_G | 175_A | 1.798 | 1.00 | |
| 39_H | 76_L | 1.776 | 1.00 | |
| 151_S | 155_M | 1.772 | 1.00 | |
| 129_L | 143_W | 1.759 | 1.00 | |
| 107_T | 111_Q | 1.743 | 1.00 | |
| 32_R | 70_L | 1.737 | 1.00 | |
| 100_L | 112_V | 1.712 | 1.00 | |
| 113_W | 161_A | 1.676 | 1.00 | |
| 31_L | 62_M | 1.666 | 1.00 | |
| 122_T | 125_R | 1.663 | 1.00 | |
| 66_L | 69_R | 1.652 | 1.00 | |
| 130_A | 181_I | 1.636 | 1.00 | |
| 133_L | 140_P | 1.596 | 1.00 | |
| 34_Q | 60_Y | 1.563 | 1.00 | |
| 112_V | 135_L | 1.561 | 1.00 | |
| 48_A | 64_R | 1.558 | 1.00 | |
| 110_N | 165_R | 1.507 | 1.00 | |
| 56_T | 61_Q | 1.471 | 1.00 | |
| 103_Q | 112_V | 1.463 | 1.00 | |
| 28_R | 69_R | 1.459 | 1.00 | |
| 120_I | 129_L | 1.458 | 1.00 | |
| 54_M | 58_R | 1.441 | 1.00 | |
| 115_G | 130_A | 1.439 | 1.00 | |
| 70_L | 74_L | 1.436 | 1.00 | |
| 24_P | 28_R | 1.427 | 1.00 | |
| 146_S | 150_D | 1.385 | 0.99 | |
| 54_M | 57_R | 1.352 | 0.99 | |
| 179_V | 182_R | 1.339 | 0.99 | |
| 130_A | 157_A | 1.328 | 0.99 | |
| 146_S | 153_L | 1.307 | 0.99 | |
| 37_E | 41_I | 1.293 | 0.99 | |
| 88_R | 91_H | 1.272 | 0.99 | |
| 68_G | 72_K | 1.265 | 0.99 | |
| 183_A | 186_S | 1.264 | 0.99 | |
| 13_S | 16_L | 1.263 | 0.99 | |
| 182_R | 186_S | 1.256 | 0.99 | |
| 52_A | 67_A | 1.256 | 0.99 | |
| 52_A | 64_R | 1.256 | 0.99 | |
| 155_M | 159_E | 1.253 | 0.99 | |
| 149_P | 179_V | 1.247 | 0.99 | |
| 42_S | 45_S | 1.243 | 0.98 | |
| 113_W | 132_V | 1.221 | 0.98 | |
| 179_V | 183_A | 1.211 | 0.98 | |
| 39_H | 44_G | 1.189 | 0.98 | |
| 17_R | 20_R | 1.146 | 0.97 | |
| 36_L | 74_L | 1.122 | 0.97 | |
| 121_W | 126_W | 1.111 | 0.96 | |
| 100_L | 135_L | 1.104 | 0.96 | |
| 130_A | 153_L | 1.099 | 0.96 | |
| 149_P | 180_I | 1.081 | 0.95 | |
| 119_Y | 128_Y | 1.08 | 0.95 | |
| 131_V | 140_P | 1.072 | 0.95 | |
| 117_V | 180_I | 1.071 | 0.95 | |
| 27_R | 66_L | 1.061 | 0.95 | |
| 184_G | 188_S | 1.047 | 0.94 | |
| 90_G | 93_H | 1.046 | 0.94 | |
| 50_S | 54_M | 1.045 | 0.94 | |
| 63_G | 69_R | 1.043 | 0.94 | |
| 36_L | 40_G | 1.037 | 0.94 | |
| 28_R | 31_L | 1.034 | 0.94 | |
| 49_R | 68_G | 1.03 | 0.94 | |
| 188_S | 192_D | 1.012 | 0.93 | |
| 173_F | 186_S | 1.004 | 0.93 | |
| 186_S | 190_C | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4fcyA | 2 | 0.9798 | 99.9 | 0.567 | Contact Map | 0.581 |
| 3hotA | 2 | 0.9596 | 99.9 | 0.59 | Contact Map | 0.592 |
| 1bcoA | 1 | 0.5253 | 99.8 | 0.65 | Contact Map | 0.646 |
| 3oymA | 2 | 0.9242 | 99.8 | 0.663 | Contact Map | 0.524 |
| 4fw1A | 2 | 0.4798 | 99.7 | 0.686 | Contact Map | 0.733 |
| 1cxqA | 1 | 0.4848 | 99.6 | 0.697 | Contact Map | 0.471 |
| 3av9A | 2 | 0.5505 | 99.6 | 0.706 | Contact Map | 0.468 |
| 2x78A | 3 | 0.4899 | 99.6 | 0.713 | Contact Map | 0.6 |
| 4fw2A | 2 | 0.7222 | 99.6 | 0.716 | Contact Map | 0.644 |
| 1ex4A | 2 | 0.4495 | 99.6 | 0.717 | Contact Map | 0.509 |
Sequence Conservation (Image Generated using WebLogo v3)