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OPENSEQ.org
YAGA - Uncharacterized protein YagA
UniProt: P37007 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12338
Length: 384 (361)
Sequences: 2053
Seq/Len: 5.69
YAGA
Paralog alert: 0.44 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: INSD1 INSD2 INSD3 INSD4 INSD5 INSD6 INSD8 INSF1 INSF2 INSF3 INSF4 INSF5 INSK INSO1 INSO2 YAGA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
110_F 114_H 3.018 1.00
161_H 182_E 2.966 1.00
237_R 243_T 2.881 1.00
142_N 145_W 2.535 1.00
249_R 252_R 2.461 1.00
171_R 287_H 2.451 1.00
236_S 244_Q 2.435 1.00
343_F 368_V 2.342 1.00
177_A 193_S 2.315 1.00
323_K 347_R 2.301 1.00
168_D 246_K 2.289 1.00
143_R 202_D 2.282 1.00
191_L 206_M 2.256 1.00
112_T 115_N 2.225 1.00
146_Q 245_G 2.223 1.00
226_L 231_I 2.172 1.00
145_W 194_V 2.169 1.00
332_V 352_E 2.12 1.00
332_V 350_L 2.08 1.00
226_L 233_V 2.077 1.00
293_A 298_R 2.032 1.00
145_W 165_L 2.023 1.00
321_V 347_R 2.016 1.00
266_D 269_E 2.011 1.00
30_I 45_Y 1.999 1.00
271_Q 275_D 1.979 1.00
360_E 367_K 1.961 1.00
164_T 247_L 1.957 1.00
249_R 253_S 1.88 1.00
252_R 256_A 1.857 1.00
293_A 301_P 1.847 1.00
182_E 211_P 1.833 1.00
150_K 255_K 1.828 1.00
34_C 44_G 1.801 1.00
178_H 274_F 1.777 1.00
144_L 203_R 1.766 1.00
111_S 115_N 1.744 1.00
30_I 48_L 1.742 1.00
362_W 367_K 1.739 1.00
78_T 116_L 1.728 1.00
93_A 117_M 1.717 1.00
149_F 211_P 1.7 1.00
149_F 163_L 1.677 1.00
81_L 96_I 1.676 1.00
97_K 101_E 1.664 1.00
164_T 251_H 1.663 1.00
208_N 238_P 1.638 1.00
32_S 36_R 1.636 0.99
174_L 193_S 1.622 0.99
43_T 47_W 1.609 0.99
209_G 212_W 1.608 0.99
28_A 36_R 1.6 0.99
367_K 370_V 1.593 0.99
294_V 297_S 1.573 0.99
41_P 45_Y 1.572 0.99
358_S 370_V 1.566 0.99
240_H 243_T 1.535 0.99
324_V 330_L 1.533 0.99
178_H 271_Q 1.527 0.99
143_R 203_R 1.526 0.99
109_A 115_N 1.524 0.99
319_V 349_G 1.504 0.99
111_S 114_H 1.503 0.99
32_S 35_R 1.497 0.99
37_F 44_G 1.489 0.99
322_R 348_V 1.485 0.99
140_A 143_R 1.48 0.99
279_T 283_L 1.478 0.99
140_A 202_D 1.47 0.99
181_D 186_T 1.465 0.99
205_T 243_T 1.457 0.99
31_R 41_P 1.456 0.99
174_L 177_A 1.455 0.99
49_Q 53_Q 1.451 0.99
97_K 113_V 1.398 0.98
203_R 234_G 1.397 0.98
324_V 344_R 1.373 0.98
146_Q 168_D 1.368 0.98
39_I 44_G 1.35 0.97
75_D 79_A 1.347 0.97
19_F 44_G 1.338 0.97
160_C 270_L 1.337 0.97
331_S 336_S 1.337 0.97
42_A 45_Y 1.325 0.97
179_C 190_Q 1.325 0.97
206_M 235_H 1.325 0.97
171_R 295_P 1.322 0.97
147_M 212_W 1.321 0.97
54_E 58_G 1.319 0.97
173_S 250_F 1.316 0.97
330_L 350_L 1.315 0.97
180_T 267_S 1.313 0.97
172_F 299_Y 1.31 0.97
348_V 361_V 1.299 0.96
179_C 189_Q 1.299 0.96
324_V 348_V 1.297 0.96
165_L 190_Q 1.286 0.96
144_L 205_T 1.283 0.96
171_R 290_L 1.279 0.96
163_L 190_Q 1.273 0.96
296_G 300_Q 1.265 0.96
269_E 272_R 1.264 0.96
257_E 285_R 1.26 0.96
169_H 302_S 1.259 0.96
172_F 296_G 1.251 0.95
170_S 302_S 1.248 0.95
33_L 37_F 1.246 0.95
82_R 116_L 1.243 0.95
210_S 266_D 1.24 0.95
85_H 117_M 1.237 0.95
176_L 278_R 1.226 0.95
322_R 350_L 1.225 0.95
205_T 244_Q 1.221 0.94
146_Q 244_Q 1.213 0.94
147_M 206_M 1.212 0.94
165_L 194_V 1.204 0.94
187_V 209_G 1.204 0.94
287_H 290_L 1.201 0.94
258_V 274_F 1.2 0.94
42_A 49_Q 1.199 0.94
257_E 277_W 1.192 0.93
150_K 251_H 1.191 0.93
147_M 165_L 1.187 0.93
206_M 233_V 1.186 0.93
283_L 296_G 1.185 0.93
187_V 212_W 1.182 0.93
40_S 43_T 1.181 0.93
258_V 273_A 1.18 0.93
191_L 195_F 1.178 0.93
244_Q 247_L 1.171 0.93
164_T 250_F 1.17 0.93
141_P 169_H 1.161 0.92
331_S 334_G 1.158 0.92
92_G 95_K 1.147 0.92
197_R 279_T 1.144 0.92
265_A 269_E 1.139 0.91
350_L 361_V 1.139 0.91
144_L 168_D 1.134 0.91
31_R 40_S 1.131 0.91
139_D 143_R 1.13 0.91
236_S 239_Y 1.126 0.91
171_R 289_A 1.124 0.91
176_L 274_F 1.118 0.90
96_I 113_V 1.111 0.90
31_R 35_R 1.109 0.90
330_L 337_L 1.104 0.90
286_P 290_L 1.101 0.89
300_Q 304_R 1.101 0.89
169_H 298_R 1.101 0.89
18_E 21_L 1.096 0.89
12_T 15_L 1.087 0.89
194_V 198_Y 1.078 0.88
236_S 243_T 1.077 0.88
171_R 246_K 1.076 0.88
114_H 118_A 1.074 0.88
43_T 46_K 1.074 0.88
208_N 235_H 1.073 0.88
203_R 232_R 1.071 0.88
178_H 270_L 1.07 0.87
18_E 22_F 1.056 0.87
286_P 294_V 1.051 0.86
166_L 247_L 1.051 0.86
95_K 257_E 1.049 0.86
166_L 250_F 1.046 0.86
368_V 371_I 1.042 0.86
98_R 280_V 1.039 0.85
321_V 349_G 1.039 0.85
163_L 179_C 1.037 0.85
237_R 241_P 1.036 0.85
149_F 182_E 1.034 0.85
183_R 353_M 1.033 0.85
357_G 372_D 1.031 0.85
93_A 96_I 1.03 0.85
244_Q 251_H 1.026 0.84
33_L 44_G 1.026 0.84
165_L 204_M 1.021 0.84
192_V 196_E 1.015 0.83
146_Q 246_K 1.013 0.83
149_F 190_Q 1.012 0.83
149_F 161_H 1.009 0.83
174_L 197_R 1.008 0.83
255_K 259_L 1.005 0.83
195_F 231_I 1.005 0.83
287_H 295_P 1.005 0.83
290_L 295_P 1.004 0.83
269_E 273_A 1.002 0.82
110_F 118_A 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fcyA20.99221000.377Contact Map0.487
1bcoA10.66151000.554Contact Map0.52
3hotA20.7371000.662Contact Map0.594
4fw1A20.546999.90.704Contact Map0.676
1c6vA40.427199.90.718Contact Map0.719
3kksA20.395899.90.721Contact Map0.604
2x78A30.515699.90.722Contact Map0.572
3av9A20.468899.90.723Contact Map0.487
3l3uA20.424599.90.723Contact Map0.604
1cxqA10.406299.90.732Contact Map0.693
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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