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OPENSEQ.org
RIMK - Ribosomal protein S6 modification protein
UniProt: P0C0U4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10852
Length: 300 (287)
Sequences: 13489
Seq/Len: 47.00
RIMK
Paralog alert: 0.95 [within 20: 0.52] - ratio of genomes with paralogs
Cluster includes: ACCC DDLA DDLB GSHB PUR2 PURK PURT RIMK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
116_V 178_E 4.158 1.00
231_E 235_K 3.835 1.00
156_T 159_A 3.532 1.00
131_D 157_R 3.478 1.00
2_K 28_L 3.162 1.00
78_R 95_A 3.098 1.00
127_S 161_E 2.929 1.00
234_I 238_R 2.665 1.00
78_R 82_M 2.648 1.00
118_G 132_M 2.562 1.00
107_L 236_A 2.532 1.00
122_S 125_D 2.499 1.00
109_R 239_T 2.471 1.00
136_A 157_R 2.47 1.00
107_L 258_V 2.231 1.00
181_K 253_N 2.167 1.00
227_P 231_E 2.116 1.00
155_E 159_A 2.115 1.00
157_R 161_E 1.934 1.00
235_K 238_R 1.933 1.00
186_C 202_E 1.906 1.00
221_S 273_T 1.898 1.00
228_Q 231_E 1.885 1.00
70_T 98_R 1.883 1.00
105_Q 109_R 1.88 1.00
79_Q 83_L 1.86 1.00
112_I 258_V 1.846 1.00
4_A 32_L 1.837 1.00
153_L 179_Y 1.832 1.00
103_S 107_L 1.794 1.00
161_E 165_D 1.79 1.00
61_V 85_S 1.778 1.00
101_L 119_I 1.77 1.00
128_D 132_M 1.758 1.00
24_Q 280_G 1.75 1.00
280_G 284_R 1.743 1.00
155_E 181_K 1.735 1.00
102_R 105_Q 1.698 1.00
99_D 143_V 1.663 1.00
25_R 284_R 1.657 1.00
22_A 29_V 1.656 1.00
113_D 232_I 1.656 1.00
284_R 289_H 1.648 1.00
108_A 116_V 1.646 1.00
277_D 280_G 1.634 1.00
129_L 132_M 1.624 1.00
81_E 91_S 1.619 1.00
193_V 285_W 1.613 1.00
127_S 157_R 1.602 1.00
188_I 251_R 1.601 1.00
95_A 102_R 1.601 1.00
105_Q 108_A 1.594 1.00
192_V 237_A 1.577 1.00
130_I 136_A 1.57 1.00
123_P 127_S 1.56 1.00
139_V 153_L 1.555 1.00
104_M 177_Q 1.549 1.00
92_V 96_R 1.507 1.00
190_C 229_E 1.489 1.00
232_I 256_P 1.484 1.00
4_A 58_F 1.459 1.00
101_L 105_Q 1.455 1.00
78_R 92_V 1.45 1.00
265_P 278_I 1.448 1.00
127_S 131_D 1.436 1.00
227_P 230_R 1.432 1.00
125_D 128_D 1.43 1.00
96_R 102_R 1.427 1.00
136_A 156_T 1.423 1.00
178_E 257_L 1.419 1.00
80_F 87_P 1.414 1.00
79_Q 82_M 1.399 0.99
123_P 165_D 1.393 0.99
143_V 173_H 1.391 0.99
97_A 261_V 1.39 0.99
3_I 27_H 1.385 0.99
120_A 129_L 1.365 0.99
206_K 210_F 1.365 0.99
129_L 133_V 1.352 0.99
118_G 129_L 1.35 0.99
28_L 44_A 1.333 0.99
128_D 131_D 1.332 0.99
61_V 80_F 1.328 0.99
247_V 261_V 1.326 0.99
168_R 172_A 1.321 0.99
121_H 125_D 1.307 0.99
121_H 173_H 1.306 0.99
139_V 179_Y 1.301 0.99
152_V 166_A 1.299 0.99
124_D 128_D 1.29 0.99
96_R 106_L 1.29 0.99
252_A 255_G 1.289 0.99
27_H 283_I 1.289 0.99
2_K 30_E 1.28 0.99
80_F 85_S 1.276 0.99
193_V 244_V 1.264 0.99
180_I 257_L 1.257 0.99
136_A 160_A 1.255 0.99
116_V 132_M 1.253 0.99
54_K 83_L 1.251 0.99
21_A 280_G 1.251 0.99
21_A 24_Q 1.247 0.99
235_K 239_T 1.243 0.98
230_R 234_I 1.243 0.98
162_S 165_D 1.242 0.98
106_L 110_Q 1.235 0.98
162_S 166_A 1.232 0.98
251_R 256_P 1.23 0.98
21_A 277_D 1.23 0.98
283_I 287_E 1.228 0.98
19_R 29_V 1.222 0.98
30_E 58_F 1.216 0.98
192_V 233_A 1.212 0.98
25_R 280_G 1.2 0.98
144_E 171_N 1.199 0.98
228_Q 232_I 1.181 0.98
123_P 161_E 1.179 0.98
104_M 114_L 1.173 0.98
108_A 114_L 1.171 0.98
190_C 230_R 1.165 0.97
250_L 259_M 1.16 0.97
193_V 281_K 1.159 0.97
231_E 234_I 1.154 0.97
281_K 284_R 1.145 0.97
186_C 251_R 1.141 0.97
101_L 143_V 1.139 0.97
229_E 256_P 1.122 0.97
130_I 138_L 1.118 0.96
196_E 238_R 1.117 0.96
106_L 239_T 1.115 0.96
23_I 43_P 1.101 0.96
190_C 200_A 1.097 0.96
164_I 168_R 1.096 0.96
20_E 24_Q 1.094 0.96
130_I 160_A 1.09 0.96
133_V 138_L 1.09 0.96
237_A 245_A 1.089 0.96
154_A 163_V 1.084 0.96
106_L 109_R 1.079 0.95
105_Q 117_T 1.077 0.95
86_Y 287_E 1.073 0.95
138_L 176_V 1.073 0.95
123_P 164_I 1.072 0.95
190_C 233_A 1.069 0.95
126_T 164_I 1.064 0.95
110_Q 239_T 1.063 0.95
116_V 133_V 1.062 0.95
78_R 91_S 1.062 0.95
81_E 87_P 1.056 0.95
27_H 287_E 1.054 0.95
92_V 95_A 1.05 0.94
228_Q 255_G 1.047 0.94
228_Q 235_K 1.041 0.94
139_V 151_V 1.04 0.94
124_D 127_S 1.035 0.94
252_A 257_L 1.034 0.94
194_G 197_V 1.027 0.94
22_A 283_I 1.019 0.93
236_A 239_T 1.005 0.93
232_I 249_I 1.005 0.93
180_I 259_M 1.005 0.93
159_A 162_S 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4iwxA111000.224Contact Map0.5
3vpbA40.92331000.253Contact Map0.78
3vpdA20.92331000.284Contact Map0.75
3r5xA40.941000.302Contact Map0.673
4fu0A20.981000.313Contact Map0.637
1iowA10.91331000.316Contact Map0.638
3se7A60.961000.316Contact Map0.655
1ehiA20.98331000.32Contact Map0.674
3tqtA20.98331000.322Contact Map0.681
3e5nA10.98331000.323Contact Map0.584
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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