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OPENSEQ.org
PURK - N5-carboxyaminoimidazole ribonucleotide synthase
UniProt: P09029 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10796
Length: 355 (341)
Sequences: 10587
Seq/Len: 31.05
PURK
Paralog alert: 0.88 [within 20: 0.77] - ratio of genomes with paralogs
Cluster includes: ACCC DDLA DDLB GSHB PUR2 PURK PURT RIMK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
111_D 137_N 4.442 1.00
136_A 139_T 3.463 1.00
3_Q 26_A 3.236 1.00
59_T 75_P 3.231 1.00
211_S 215_Q 3.195 1.00
102_E 105_E 3.069 1.00
107_P 141_Q 3.049 1.00
89_K 216_E 3.014 1.00
208_E 212_A 2.952 1.00
96_P 154_Q 2.93 1.00
59_T 63_A 2.928 1.00
200_A 204_A 2.772 1.00
322_D 327_R 2.698 1.00
2_K 44_S 2.689 1.00
205_Q 208_E 2.589 1.00
324_D 327_R 2.554 1.00
98_Q 112_R 2.553 1.00
115_E 137_N 2.528 1.00
199_N 202_Q 2.3 1.00
4_V 67_A 2.244 1.00
135_R 139_T 2.21 1.00
87_F 213_I 2.19 1.00
264_R 269_L 2.175 1.00
85_Q 89_K 2.133 1.00
60_R 64_R 2.091 1.00
194_A 253_G 2.078 1.00
135_R 157_N 2.041 1.00
108_A 112_R 2.04 1.00
323_S 327_R 2.032 1.00
41_F 64_R 2 1.00
141_Q 145_E 1.985 1.00
204_A 208_E 1.976 1.00
75_P 82_T 1.929 1.00
137_N 141_Q 1.851 1.00
22_P 260_E 1.833 1.00
37_A 64_R 1.832 1.00
204_A 207_E 1.804 1.00
164_L 206_A 1.804 1.00
107_P 137_N 1.792 1.00
170_F 220_V 1.786 1.00
4_V 20_G 1.777 1.00
55_E 78_A 1.763 1.00
37_A 41_F 1.753 1.00
82_T 85_Q 1.727 1.00
3_Q 28_W 1.726 1.00
283_I 332_L 1.726 1.00
261_L 272_P 1.722 1.00
157_N 231_P 1.717 1.00
101_A 105_E 1.715 1.00
209_M 234_L 1.711 1.00
260_E 264_R 1.689 1.00
109_V 112_R 1.686 1.00
62_L 71_R 1.681 1.00
33_D 60_R 1.677 1.00
133_R 155_G 1.667 1.00
167_A 265_A 1.637 1.00
243_V 258_Q 1.621 1.00
19_A 260_E 1.618 1.00
104_S 108_A 1.608 1.00
255_S 275_V 1.6 1.00
108_A 111_D 1.583 1.00
20_G 27_V 1.579 1.00
212_A 215_Q 1.577 1.00
60_R 63_A 1.574 1.00
86_L 216_E 1.552 1.00
286_I 313_R 1.55 1.00
70_N 73_V 1.549 1.00
105_E 108_A 1.535 1.00
34_A 60_R 1.517 1.00
122_R 149_E 1.501 1.00
295_L 328_L 1.499 1.00
103_R 107_P 1.498 1.00
81_L 85_Q 1.492 1.00
166_G 210_L 1.491 1.00
255_S 277_N 1.488 1.00
167_A 261_L 1.487 1.00
252_N 319_N 1.48 1.00
85_Q 88_D 1.475 1.00
86_L 90_L 1.471 1.00
202_Q 205_Q 1.471 1.00
109_V 113_L 1.47 1.00
5_C 30_V 1.466 1.00
154_Q 235_L 1.466 1.00
230_T 233_G 1.453 1.00
61_E 66_P 1.443 1.00
77_I 239_L 1.442 1.00
175_V 273_Q 1.427 1.00
84_K 153_E 1.426 1.00
168_R 174_T 1.425 1.00
35_E 38_A 1.414 1.00
205_Q 233_G 1.406 0.99
70_N 220_V 1.404 0.99
33_D 37_A 1.4 0.99
38_A 41_F 1.399 0.99
87_F 236_I 1.395 0.99
207_E 211_S 1.392 0.99
202_Q 229_V 1.386 0.99
46_I 61_E 1.383 0.99
98_Q 109_V 1.38 0.99
100_L 109_V 1.38 0.99
6_V 17_R 1.375 0.99
103_R 141_Q 1.368 0.99
107_P 111_D 1.363 0.99
72_D 76_I 1.352 0.99
59_T 72_D 1.342 0.99
76_I 86_L 1.34 0.99
115_E 136_A 1.327 0.99
40_P 46_I 1.327 0.99
326_S 330_A 1.324 0.99
104_S 107_P 1.324 0.99
174_T 211_S 1.312 0.99
167_A 222_V 1.3 0.99
110_F 115_E 1.297 0.99
81_L 99_L 1.284 0.99
4_V 25_I 1.276 0.99
173_S 215_Q 1.269 0.99
283_I 317_H 1.252 0.99
79_D 122_R 1.239 0.98
334_A 338_L 1.237 0.98
166_G 214_M 1.234 0.98
201_Q 205_Q 1.233 0.98
164_L 210_L 1.218 0.98
198_A 202_Q 1.216 0.98
92_L 236_I 1.212 0.98
322_D 331_T 1.207 0.98
25_I 267_T 1.206 0.98
86_L 89_K 1.199 0.98
300_V 320_L 1.198 0.98
103_R 145_E 1.194 0.98
88_D 94_T 1.193 0.98
15_M 18_Q 1.19 0.98
85_Q 97_W 1.189 0.98
88_D 96_P 1.186 0.98
90_L 216_E 1.185 0.98
252_N 321_T 1.179 0.98
4_V 263_L 1.177 0.98
96_P 112_R 1.172 0.98
101_A 149_E 1.169 0.97
62_L 70_N 1.162 0.97
117_A 152_V 1.156 0.97
110_F 140_E 1.156 0.97
118_I 133_R 1.156 0.97
251_Q 319_N 1.153 0.97
110_F 117_A 1.146 0.97
83_Q 87_F 1.131 0.97
103_R 144_A 1.125 0.97
142_L 146_C 1.122 0.97
76_I 82_T 1.122 0.97
70_N 218_G 1.121 0.97
106_W 144_A 1.111 0.96
210_L 225_M 1.105 0.96
39_V 43_Q 1.103 0.96
138_E 142_L 1.097 0.96
327_R 331_T 1.095 0.96
201_Q 204_A 1.095 0.96
99_L 149_E 1.092 0.96
16_L 47_T 1.087 0.96
40_P 61_E 1.087 0.96
318_L 339_L 1.087 0.96
59_T 71_R 1.086 0.96
229_V 234_L 1.072 0.95
115_E 140_E 1.07 0.95
119_V 150_C 1.069 0.95
156_I 237_N 1.064 0.95
36_P 61_E 1.063 0.95
84_K 94_T 1.059 0.95
144_A 150_C 1.052 0.95
93_P 209_M 1.052 0.95
292_Y 304_W 1.051 0.94
106_W 140_E 1.049 0.94
72_D 75_P 1.044 0.94
105_E 109_V 1.043 0.94
113_L 117_A 1.04 0.94
200_A 203_Q 1.032 0.94
162_V 229_V 1.026 0.94
169_G 173_S 1.009 0.93
281_V 328_L 1.009 0.93
329_T 333_E 1.008 0.93
213_I 239_L 1.005 0.93
62_L 220_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ethA20.98871000.225Contact Map0.557
4mamA20.97751000.269Contact Map0.697
4e4tA20.96341000.272Contact Map0.605
3orqA20.94651000.281Contact Map0.686
2dwcA20.99151000.283Contact Map0.758
3ax6A40.97181000.285Contact Map0.814
3aw8A20.97181000.287Contact Map0.693
3q2oA20.97461000.291Contact Map0.661
1kjqA20.95771000.297Contact Map0.779
3k5iA40.96341000.3Contact Map0.73
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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