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OPENSEQ.org
PUR2 - Phosphoribosylamine--glycine ligase
UniProt: P15640 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10792
Length: 429 (421)
Sequences: 8343
Seq/Len: 19.82
PUR2
Paralog alert: 0.86 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: ACCC DDLA DDLB GSHB PUR2 PURK PURT RIMK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
136_R 161_L 4.283 1.00
58_D 62_N 3.609 1.00
160_T 163_E 3.572 1.00
82_D 100_Q 3.501 1.00
253_W 257_K 3.465 1.00
127_E 130_P 3.176 1.00
3_V 92_F 2.97 1.00
393_T 396_E 2.918 1.00
2_K 26_E 2.858 1.00
52_D 55_A 2.847 1.00
246_R 250_R 2.738 1.00
82_D 86_A 2.705 1.00
132_L 165_E 2.622 1.00
159_M 163_E 2.545 1.00
391_G 396_E 2.527 1.00
61_Q 87_A 2.467 1.00
159_M 191_D 2.387 1.00
77_V 103_G 2.379 1.00
241_D 245_Q 2.362 1.00
179_D 183_R 2.351 1.00
83_T 87_A 2.299 1.00
392_H 396_E 2.286 1.00
140_A 161_L 2.217 1.00
334_V 401_A 2.172 1.00
219_G 223_T 2.17 1.00
234_S 302_R 2.132 1.00
5_V 16_A 2.131 1.00
44_Q 59_F 2.111 1.00
121_E 188_E 2.111 1.00
240_T 243_V 2.092 1.00
246_R 281_N 2.074 1.00
313_A 318_K 2.063 1.00
291_F 307_L 2.006 1.00
112_L 258_G 2 1.00
110_D 114_R 1.993 1.00
172_L 182_H 1.992 1.00
85_R 96_A 1.973 1.00
44_Q 63_E 1.968 1.00
191_D 278_K 1.951 1.00
133_A 137_E 1.939 1.00
310_L 320_D 1.899 1.00
123_Q 137_E 1.877 1.00
22_S 309_E 1.867 1.00
165_E 169_H 1.859 1.00
95_T 98_A 1.853 1.00
350_V 376_Q 1.85 1.00
57_L 87_A 1.828 1.00
304_K 325_E 1.819 1.00
20_A 27_T 1.801 1.00
257_K 260_A 1.799 1.00
200_M 314_A 1.779 1.00
245_Q 253_W 1.778 1.00
157_V 189_F 1.769 1.00
204_E 260_A 1.758 1.00
126_T 130_P 1.756 1.00
197_F 247_T 1.755 1.00
107_F 110_D 1.738 1.00
82_D 97_G 1.726 1.00
102_E 287_F 1.696 1.00
95_T 267_T 1.69 1.00
366_H 369_T 1.679 1.00
245_Q 249_E 1.672 1.00
53_I 83_T 1.67 1.00
68_T 89_L 1.669 1.00
309_E 313_A 1.664 1.00
18_K 21_Q 1.663 1.00
54_P 83_T 1.661 1.00
60_A 68_T 1.654 1.00
57_L 61_Q 1.639 1.00
84_F 89_L 1.621 1.00
3_V 20_A 1.619 1.00
362_G 389_A 1.602 1.00
128_V 165_E 1.595 1.00
84_F 91_I 1.59 1.00
336_M 413_C 1.571 1.00
37_T 43_L 1.57 1.00
134_Y 137_E 1.564 1.00
2_K 42_A 1.563 1.00
304_K 327_D 1.562 1.00
218_V 414_F 1.541 1.00
83_T 86_A 1.54 1.00
110_D 113_A 1.54 1.00
68_T 84_F 1.539 1.00
132_L 161_L 1.535 1.00
30_V 46_V 1.534 1.00
277_D 281_N 1.534 1.00
243_V 246_R 1.533 1.00
117_I 284_V 1.529 1.00
111_F 115_H 1.519 1.00
100_Q 107_F 1.519 1.00
29_F 36_G 1.513 1.00
200_M 269_F 1.507 1.00
143_V 157_V 1.507 1.00
188_E 283_K 1.497 1.00
128_V 132_L 1.486 1.00
277_D 280_G 1.485 1.00
130_P 133_A 1.483 1.00
2_K 28_V 1.48 1.00
90_K 316_E 1.479 1.00
249_E 253_W 1.474 1.00
21_Q 41_P 1.47 1.00
101_L 111_F 1.468 1.00
3_V 25_V 1.463 1.00
55_A 58_D 1.463 1.00
113_A 123_Q 1.461 1.00
129_E 133_A 1.452 1.00
114_R 261_A 1.45 1.00
147_D 183_R 1.449 1.00
26_E 42_A 1.428 1.00
92_F 312_L 1.422 1.00
134_Y 138_K 1.421 1.00
106_A 124_N 1.421 1.00
333_G 386_C 1.415 1.00
220_D 417_K 1.411 1.00
243_V 276_I 1.41 1.00
395_A 399_K 1.405 0.99
161_L 165_E 1.404 0.99
346_R 349_D 1.402 0.99
85_R 267_T 1.401 0.99
59_F 63_E 1.393 0.99
144_I 184_I 1.392 0.99
97_G 101_L 1.381 0.99
133_A 136_R 1.377 0.99
132_L 136_R 1.368 0.99
341_Y 383_R 1.366 0.99
104_S 147_D 1.344 0.99
403_A 407_D 1.335 0.99
250_R 254_P 1.333 0.99
3_V 312_L 1.331 0.99
200_M 310_L 1.323 0.99
361_G 400_R 1.303 0.99
22_S 306_D 1.292 0.99
27_T 42_A 1.281 0.99
332_L 398_Q 1.279 0.99
13_H 39_L 1.274 0.99
59_F 65_I 1.271 0.99
135_L 164_A 1.268 0.99
245_Q 248_M 1.266 0.99
58_D 61_Q 1.265 0.99
128_V 168_V 1.26 0.99
391_G 400_R 1.259 0.99
110_D 122_Y 1.255 0.99
256_V 260_A 1.248 0.99
85_R 95_T 1.236 0.98
299_I 388_T 1.232 0.98
296_T 299_I 1.231 0.98
129_E 132_L 1.23 0.98
108_T 112_L 1.228 0.98
148_G 179_D 1.225 0.98
387_V 408_I 1.221 0.98
106_A 110_D 1.214 0.98
242_D 245_Q 1.2 0.98
130_P 134_Y 1.199 0.98
128_V 169_H 1.198 0.98
111_F 258_G 1.197 0.98
242_D 246_R 1.195 0.98
254_P 282_P 1.193 0.98
31_A 43_L 1.191 0.98
125_F 134_Y 1.19 0.98
143_V 189_F 1.188 0.98
396_E 400_R 1.181 0.98
239_V 243_V 1.18 0.98
135_L 140_A 1.178 0.98
16_A 39_L 1.174 0.98
114_R 262_E 1.162 0.97
332_L 420_G 1.161 0.97
42_A 63_E 1.16 0.97
29_F 40_E 1.157 0.97
97_G 100_Q 1.154 0.97
101_L 107_F 1.154 0.97
140_A 160_T 1.154 0.97
238_V 276_I 1.15 0.97
112_L 284_V 1.148 0.97
131_A 164_A 1.148 0.97
135_L 168_V 1.146 0.97
106_A 147_D 1.144 0.97
205_H 208_P 1.143 0.97
60_A 84_F 1.136 0.97
60_A 89_L 1.134 0.97
332_L 397_A 1.127 0.97
201_V 205_H 1.126 0.97
57_L 83_T 1.126 0.97
293_D 296_T 1.125 0.97
197_F 248_M 1.119 0.96
82_D 96_A 1.114 0.96
362_G 404_L 1.114 0.96
136_R 165_E 1.112 0.96
255_T 287_F 1.11 0.96
257_K 261_A 1.11 0.96
140_A 164_A 1.109 0.96
166_A 169_H 1.104 0.96
19_A 69_I 1.095 0.96
124_N 183_R 1.091 0.96
379_T 382_G 1.086 0.96
301_L 390_L 1.084 0.96
240_T 280_G 1.084 0.96
142_I 186_I 1.081 0.95
398_Q 402_Y 1.08 0.95
18_K 309_E 1.069 0.95
114_R 258_G 1.065 0.95
115_H 262_E 1.063 0.95
111_F 114_R 1.062 0.95
2_K 27_T 1.06 0.95
46_V 59_F 1.058 0.95
16_A 40_E 1.054 0.95
399_K 403_A 1.047 0.94
54_P 58_D 1.045 0.94
219_G 334_V 1.045 0.94
131_A 186_I 1.044 0.94
389_A 401_A 1.044 0.94
53_I 57_L 1.044 0.94
406_T 417_K 1.043 0.94
162_E 166_A 1.039 0.94
201_V 256_V 1.038 0.94
166_A 170_D 1.038 0.94
305_S 310_L 1.036 0.94
156_I 174_G 1.033 0.94
190_L 285_I 1.032 0.94
126_T 183_R 1.029 0.94
396_E 399_K 1.027 0.94
81_V 91_I 1.026 0.94
24_L 312_L 1.024 0.93
17_W 365_F 1.019 0.93
115_H 258_G 1.012 0.93
199_V 252_I 1.009 0.93
295_E 298_P 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lp8A10.9791000.215Contact Map0.619
2yw2A20.9861000.22Contact Map0.712
3mjfA10.9931000.228Contact Map0.638
2qk4A20.98141000.229Contact Map0.644
2yrxA10.97671000.239Contact Map0.606
2xclA10.97671000.242Contact Map0.659
2ip4A20.96741000.246Contact Map0.618
1vkzA20.92071000.292Contact Map0.6
4dimA10.89281000.373Contact Map0.604
2dwcA20.91611000.379Contact Map0.722
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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