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OPENSEQ.org
EMRK - Multidrug resistance protein K
UniProt: P52599 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13282
Length: 387 (336)
Sequences: 2301
Seq/Len: 6.85
EMRK
Paralog alert: 0.77 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_R 216_T 4.921 1.00
94_L 199_T 4.821 1.00
67_V 84_S 4.493 1.00
98_K 203_W 3.901 1.00
81_I 210_D 3.496 1.00
259_V 338_I 3.341 1.00
280_G 316_V 3.232 1.00
126_R 171_I 2.729 1.00
77_R 80_D 2.72 1.00
140_V 157_K 2.68 1.00
101_L 192_V 2.675 1.00
283_T 317_S 2.605 1.00
84_S 210_D 2.488 1.00
259_V 282_V 2.446 1.00
87_K 91_T 2.41 1.00
281_R 319_D 2.375 1.00
143_A 153_L 2.324 1.00
122_V 167_L 2.216 1.00
74_N 80_D 2.212 1.00
105_V 196_A 2.173 1.00
312_V 332_L 2.166 1.00
281_R 317_S 2.125 1.00
203_W 207_K 2.001 1.00
78_Q 216_T 1.993 1.00
133_L 164_K 1.992 1.00
213_S 239_V 1.979 1.00
264_S 279_H 1.94 1.00
269_S 334_M 1.884 1.00
201_E 205_A 1.876 1.00
200_K 203_W 1.868 1.00
123_A 126_R 1.866 1.00
52_G 246_W 1.863 1.00
116_K 119_S 1.841 1.00
279_H 319_D 1.817 1.00
140_V 144_K 1.787 1.00
69_N 84_S 1.769 1.00
51_T 248_N 1.768 1.00
129_Y 160_L 1.762 1.00
119_S 178_K 1.733 1.00
265_V 316_V 1.714 1.00
91_T 206_L 1.706 1.00
95_N 98_K 1.699 1.00
91_T 95_N 1.698 1.00
69_N 81_I 1.681 1.00
193_V 196_A 1.665 1.00
267_I 336_A 1.636 1.00
122_V 174_Y 1.636 1.00
83_V 211_I 1.623 1.00
204_L 208_R 1.622 1.00
265_V 336_A 1.614 1.00
251_F 259_V 1.614 1.00
251_F 338_I 1.611 1.00
137_N 140_V 1.607 1.00
94_L 203_W 1.598 1.00
267_I 318_L 1.594 1.00
136_Y 160_L 1.592 1.00
160_L 164_K 1.588 1.00
57_I 237_M 1.586 1.00
247_V 334_M 1.585 1.00
129_Y 133_L 1.572 1.00
266_N 277_V 1.536 0.99
265_V 280_G 1.519 0.99
53_N 246_W 1.51 0.99
139_R 148_I 1.496 0.99
75_Y 218_Y 1.486 0.99
81_I 212_K 1.474 0.99
133_L 137_N 1.465 0.99
101_L 199_T 1.448 0.99
90_A 209_T 1.434 0.99
60_Q 208_R 1.429 0.99
267_I 334_M 1.409 0.99
136_Y 140_V 1.4 0.99
175_K 178_K 1.397 0.99
264_S 281_R 1.375 0.98
136_Y 157_K 1.375 0.98
63_G 85_L 1.37 0.98
68_V 226_V 1.368 0.98
83_V 236_L 1.362 0.98
73_T 284_G 1.36 0.98
133_L 160_L 1.352 0.98
93_A 201_E 1.351 0.98
131_Q 135_D 1.346 0.98
51_T 292_A 1.342 0.98
251_F 336_A 1.323 0.98
205_A 208_R 1.322 0.98
247_V 267_I 1.3 0.98
65_V 224_V 1.285 0.97
96_K 198_A 1.28 0.97
98_K 199_T 1.279 0.97
157_K 161_I 1.272 0.97
100_N 194_E 1.262 0.97
43_I 259_V 1.244 0.97
125_A 170_A 1.241 0.97
266_N 279_H 1.234 0.96
126_R 130_Q 1.224 0.96
99_N 197_D 1.222 0.96
248_N 315_E 1.212 0.96
268_I 337_T 1.212 0.96
139_R 156_T 1.207 0.96
93_A 205_A 1.195 0.95
60_Q 64_S 1.168 0.95
18_S 22_V 1.165 0.95
71_K 74_N 1.164 0.95
267_I 280_G 1.162 0.94
59_A 230_V 1.161 0.94
55_D 215_V 1.16 0.94
217_G 239_V 1.157 0.94
17_F 21_A 1.152 0.94
94_L 98_K 1.149 0.94
153_L 157_K 1.142 0.94
254_T 295_L 1.135 0.94
107_Q 110_K 1.133 0.93
150_K 154_E 1.126 0.93
101_L 105_V 1.124 0.93
75_Y 242_A 1.123 0.93
102_A 105_V 1.123 0.93
136_Y 153_L 1.121 0.93
69_N 80_D 1.118 0.93
168_N 171_I 1.115 0.93
21_A 28_F 1.109 0.92
139_R 151_E 1.107 0.92
100_N 104_I 1.103 0.92
177_N 180_L 1.095 0.92
34_Y 38_E 1.095 0.92
249_A 316_V 1.095 0.92
108_T 192_V 1.088 0.92
28_F 31_A 1.085 0.91
15_K 19_L 1.085 0.91
128_Q 131_Q 1.082 0.91
219_I 237_M 1.074 0.91
130_Q 133_L 1.07 0.91
101_L 196_A 1.069 0.91
29_S 33_A 1.068 0.91
94_L 206_L 1.061 0.90
207_K 212_K 1.057 0.90
87_K 210_D 1.05 0.89
42_M 337_T 1.049 0.89
75_Y 216_T 1.038 0.89
35_W 40_E 1.035 0.89
283_T 315_E 1.034 0.89
88_T 204_L 1.034 0.89
25_F 29_S 1.031 0.88
173_A 177_N 1.031 0.88
174_Y 178_K 1.03 0.88
15_K 18_S 1.023 0.88
125_A 128_Q 1.022 0.88
230_V 236_L 1.019 0.88
180_L 183_N 1.017 0.87
66_T 84_S 1.016 0.87
148_I 153_L 1.008 0.87
67_V 226_V 1.007 0.87
119_S 174_Y 1.007 0.87
19_L 23_V 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dk0A10.84751000.555Contact Map0.613
3fppA20.80881000.559Contact Map0.731
2f1mA40.67961000.568Contact Map0.68
3lnnA20.8321000.587Contact Map0.662
4l8jA10.74421000.609Contact Map0.705
1vf7A130.76231000.611Contact Map0.744
3ne5B20.73641000.635Contact Map0.716
4kkuA40.63051000.679Contact Map0.77
2k32A10.297299.90.761Contact Map0.682
2dneA10.26199.60.814Contact Map0.612
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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