May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YIBH - Inner membrane protein YibH
UniProt: P0AFV0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11764
Length: 378 (332)
Sequences: 3784
Seq/Len: 11.40
YIBH
Paralog alert: 0.75 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
86_Q 227_N 4.921 1.00
76_E 93_K 4.315 1.00
103_V 210_L 4.147 1.00
292_G 328_I 3.917 1.00
90_V 221_V 3.748 1.00
149_L 168_R 3.486 1.00
107_Q 214_K 3.239 1.00
86_Q 89_E 3.022 1.00
110_L 203_I 2.857 1.00
295_T 329_E 2.759 1.00
277_D 291_H 2.69 1.00
96_P 100_Q 2.689 1.00
114_T 207_R 2.664 1.00
293_K 331_D 2.575 1.00
272_L 349_V 2.555 1.00
131_T 178_V 2.497 1.00
135_S 182_V 2.447 1.00
149_L 155_A 2.439 1.00
272_L 294_L 2.412 1.00
93_K 221_V 2.365 1.00
142_F 175_D 2.304 1.00
293_K 329_E 2.282 1.00
78_T 93_K 2.247 1.00
83_Q 89_E 2.169 1.00
142_F 146_Q 2.14 1.00
264_F 272_L 2.12 1.00
87_K 227_N 2.093 1.00
214_K 218_E 2.057 1.00
154_A 164_I 2.045 1.00
291_H 331_D 2.039 1.00
90_V 223_R 2.037 1.00
103_V 214_K 2.028 1.00
145_Y 149_L 1.998 1.00
277_D 293_K 1.992 1.00
145_Y 171_F 1.984 1.00
78_T 90_V 1.982 1.00
204_V 207_R 1.977 1.00
121_R 200_Q 1.908 1.00
104_D 107_Q 1.902 1.00
125_T 128_Q 1.87 1.00
100_Q 217_L 1.855 1.00
211_T 214_K 1.848 1.00
148_Y 159_F 1.813 1.00
279_E 291_H 1.793 1.00
228_G 252_F 1.776 1.00
132_T 135_S 1.754 1.00
148_Y 167_A 1.738 1.00
138_R 142_F 1.73 1.00
131_T 185_Q 1.729 1.00
224_A 252_F 1.719 1.00
171_F 175_D 1.701 1.00
260_I 345_A 1.687 1.00
168_R 172_L 1.682 1.00
110_L 210_L 1.682 1.00
138_R 171_F 1.678 1.00
128_Q 189_Q 1.668 1.00
84_L 255_E 1.663 1.00
163_D 166_D 1.657 1.00
278_A 328_I 1.654 1.00
66_I 250_M 1.65 1.00
92_F 222_I 1.634 1.00
142_F 171_F 1.616 1.00
135_S 139_D 1.605 1.00
111_M 114_T 1.604 1.00
282_F 345_A 1.592 1.00
324_V 343_I 1.561 1.00
100_Q 104_D 1.545 1.00
164_I 168_R 1.54 1.00
72_G 94_L 1.532 1.00
121_R 196_V 1.517 1.00
84_L 229_Y 1.516 1.00
146_Q 149_L 1.516 1.00
103_V 107_Q 1.509 1.00
279_E 289_V 1.489 1.00
145_Y 168_R 1.485 1.00
69_Q 219_Q 1.484 1.00
91_L 250_M 1.471 1.00
75_T 93_K 1.467 1.00
74_V 92_F 1.467 1.00
179_K 182_V 1.465 1.00
128_Q 185_Q 1.463 1.00
261_V 327_T 1.459 1.00
280_V 345_A 1.456 1.00
262_A 328_I 1.448 1.00
140_R 144_N 1.44 1.00
145_Y 164_I 1.436 1.00
242_A 247_R 1.426 1.00
175_D 179_K 1.422 1.00
102_R 212_E 1.41 1.00
212_E 216_N 1.409 1.00
264_F 349_V 1.381 0.99
99_Y 220_T 1.373 0.99
75_T 95_D 1.371 0.99
105_R 209_Q 1.362 0.99
215_Y 219_Q 1.353 0.99
103_V 217_L 1.342 0.99
107_Q 210_L 1.329 0.99
76_E 237_P 1.322 0.99
60_A 261_V 1.32 0.99
186_A 189_Q 1.318 0.99
278_A 347_V 1.313 0.99
117_I 203_I 1.301 0.99
280_V 330_L 1.288 0.99
80_K 83_Q 1.285 0.99
280_V 347_V 1.279 0.99
294_L 326_G 1.26 0.99
110_L 114_T 1.256 0.99
281_V 348_A 1.242 0.98
62_I 259_Q 1.185 0.98
154_A 161_E 1.185 0.98
139_D 142_F 1.182 0.98
139_D 143_K 1.177 0.98
117_I 200_Q 1.168 0.97
74_V 77_V 1.166 0.97
241_A 249_V 1.157 0.97
138_R 175_D 1.154 0.97
92_F 249_V 1.149 0.97
131_T 135_S 1.147 0.97
109_D 202_Q 1.145 0.97
59_K 260_I 1.137 0.97
104_D 211_T 1.129 0.97
109_D 205_S 1.129 0.97
207_R 211_T 1.126 0.97
106_L 206_L 1.124 0.97
161_E 165_D 1.117 0.96
110_L 207_R 1.115 0.96
265_R 268_S 1.114 0.96
61_V 259_Q 1.113 0.96
77_V 237_P 1.108 0.96
313_Q 316_T 1.104 0.96
197_N 200_Q 1.097 0.96
115_H 201_S 1.092 0.96
178_V 182_V 1.089 0.96
85_I 91_L 1.081 0.95
148_Y 162_R 1.071 0.95
117_I 121_R 1.07 0.95
108_A 208_A 1.068 0.95
69_Q 73_I 1.067 0.95
118_K 121_R 1.066 0.95
144_N 166_D 1.062 0.95
114_T 203_I 1.062 0.95
278_A 292_G 1.06 0.95
44_I 49_Y 1.06 0.95
172_L 175_D 1.055 0.95
57_A 61_V 1.052 0.95
64_I 226_S 1.028 0.94
99_Y 213_A 1.015 0.93
308_A 313_Q 1.015 0.93
82_N 296_S 1.014 0.93
141_L 174_Q 1.013 0.93
270_L 286_P 1.011 0.93
119_T 195_M 1.009 0.93
113_A 117_I 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dk0A10.81221000.48Contact Map0.635
3fppA20.77511000.484Contact Map0.738
3lnnA20.78841000.517Contact Map0.717
2f1mA40.69051000.525Contact Map0.688
1vf7A130.72751000.543Contact Map0.756
4l8jA10.70631000.543Contact Map0.735
3ne5B20.75661000.581Contact Map0.779
4kkuA40.59521000.626Contact Map0.784
2k32A10.304299.90.733Contact Map0.697
2dneA10.267299.50.8Contact Map0.648
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 1.3031 seconds.