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OPENSEQ.org
YHII - Uncharacterized protein YhiI
UniProt: P37626 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12224
Length: 355 (322)
Sequences: 5771
Seq/Len: 17.92
YHII
Paralog alert: 0.79 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_R 219_D 4.231 1.00
60_T 77_K 3.962 1.00
74_V 213_E 3.499 1.00
282_A 313_A 3.427 1.00
87_R 202_E 3.142 1.00
140_R 157_R 3.102 1.00
91_I 206_A 2.9 1.00
267_E 281_P 2.721 1.00
140_R 144_Q 2.693 1.00
70_R 73_E 2.65 1.00
98_Q 199_Q 2.627 1.00
126_Q 171_K 2.517 1.00
80_T 84_Q 2.43 1.00
133_A 137_T 2.425 1.00
285_S 314_R 2.377 1.00
94_I 195_V 2.367 1.00
77_K 213_E 2.302 1.00
122_V 167_L 2.228 1.00
267_E 283_T 2.211 1.00
139_S 148_I 2.21 1.00
129_L 160_A 2.197 1.00
133_A 164_R 2.157 1.00
74_V 215_K 2.151 1.00
283_T 314_R 2.151 1.00
283_T 316_P 2.124 1.00
62_L 77_K 2.121 1.00
143_A 153_L 2.113 1.00
87_R 206_A 2.02 1.00
139_S 156_D 2.019 1.00
157_R 161_E 2.006 1.00
71_E 219_D 1.984 1.00
84_Q 209_I 1.964 1.00
43_I 250_M 1.952 1.00
152_Q 155_D 1.896 1.00
262_L 284_I 1.888 1.00
196_E 199_Q 1.883 1.00
136_H 160_A 1.878 1.00
262_L 337_V 1.863 1.00
136_H 140_R 1.847 1.00
62_L 74_V 1.825 1.00
269_R 279_R 1.825 1.00
254_L 262_L 1.785 1.00
67_K 73_E 1.776 1.00
53_K 211_D 1.759 1.00
123_N 126_Q 1.755 1.00
44_E 251_T 1.727 1.00
133_A 160_A 1.719 1.00
119_Q 178_K 1.718 1.00
105_Q 192_Q 1.717 1.00
88_L 91_I 1.713 1.00
94_I 202_E 1.691 1.00
116_R 119_Q 1.674 1.00
136_H 153_L 1.674 1.00
216_A 242_M 1.666 1.00
68_F 221_R 1.664 1.00
122_V 174_V 1.661 1.00
206_A 210_D 1.66 1.00
203_R 206_A 1.633 1.00
220_G 242_M 1.621 1.00
268_A 313_A 1.62 1.00
281_P 316_P 1.617 1.00
87_R 91_I 1.608 1.00
83_L 212_S 1.599 1.00
269_R 281_P 1.595 1.00
58_I 76_A 1.595 1.00
87_R 209_I 1.589 1.00
129_L 133_A 1.586 1.00
168_E 171_K 1.562 1.00
143_A 150_A 1.562 1.00
91_I 202_E 1.562 1.00
136_H 157_R 1.55 1.00
250_M 333_G 1.55 1.00
160_A 164_R 1.527 1.00
249_Y 312_K 1.525 1.00
68_F 245_L 1.51 1.00
153_L 157_R 1.507 1.00
131_S 135_R 1.474 1.00
60_T 229_P 1.466 1.00
56_G 78_M 1.448 1.00
75_L 240_L 1.447 1.00
64_K 67_K 1.44 1.00
84_Q 88_L 1.44 1.00
126_Q 130_D 1.436 1.00
234_A 237_G 1.431 1.00
164_R 168_E 1.423 1.00
126_Q 167_L 1.421 1.00
122_V 171_K 1.406 0.99
86_Q 204_R 1.393 0.99
101_V 192_Q 1.392 0.99
252_F 335_A 1.388 0.99
105_Q 188_I 1.378 0.99
89_E 201_T 1.359 0.99
129_L 164_R 1.358 0.99
137_T 140_R 1.355 0.99
94_I 98_Q 1.335 0.99
59_D 79_D 1.33 0.99
76_A 214_L 1.319 0.99
130_D 134_K 1.306 0.99
111_R 114_E 1.304 0.99
94_I 199_Q 1.301 0.99
61_I 229_P 1.297 0.99
286_F 312_K 1.296 0.99
252_F 313_A 1.295 0.99
284_I 311_V 1.293 0.99
119_Q 174_V 1.282 0.99
59_D 77_K 1.278 0.99
150_A 154_D 1.262 0.99
251_T 310_R 1.259 0.99
255_P 258_Q 1.252 0.99
161_E 164_R 1.251 0.99
175_S 178_K 1.246 0.98
95_K 98_Q 1.243 0.98
272_L 333_G 1.238 0.98
93_Q 194_R 1.234 0.98
101_V 195_V 1.231 0.98
90_A 198_A 1.228 0.98
50_I 240_L 1.223 0.98
189_I 192_Q 1.222 0.98
58_I 227_A 1.221 0.98
270_L 333_G 1.221 0.98
167_L 171_K 1.215 0.98
216_A 219_D 1.196 0.98
222_V 240_L 1.193 0.98
268_A 282_A 1.182 0.98
102_A 105_Q 1.179 0.98
86_Q 208_D 1.177 0.98
207_A 211_D 1.176 0.98
138_R 154_D 1.172 0.98
130_D 133_A 1.167 0.97
98_Q 195_V 1.166 0.97
233_L 239_V 1.164 0.97
122_V 126_Q 1.159 0.97
199_Q 203_R 1.159 0.97
100_A 194_R 1.153 0.97
103_A 187_N 1.141 0.97
69_V 75_L 1.14 0.97
80_T 212_S 1.129 0.97
135_R 155_D 1.129 0.97
92_A 200_A 1.126 0.97
204_R 208_D 1.124 0.97
254_L 337_V 1.12 0.96
129_L 167_L 1.12 0.96
140_R 153_L 1.106 0.96
125_R 163_A 1.104 0.96
101_V 105_Q 1.083 0.96
155_D 159_A 1.082 0.96
93_Q 197_A 1.081 0.95
269_R 338_R 1.075 0.95
74_V 77_K 1.07 0.95
58_I 61_I 1.063 0.95
76_A 239_V 1.062 0.95
154_D 157_R 1.051 0.94
86_Q 89_E 1.05 0.94
251_T 312_K 1.047 0.94
83_L 208_D 1.047 0.94
88_L 203_R 1.045 0.94
125_R 170_A 1.043 0.94
134_K 154_D 1.031 0.94
210_D 215_K 1.027 0.94
159_A 162_S 1.026 0.94
137_T 141_S 1.019 0.93
52_S 214_L 1.016 0.93
124_Q 166_A 1.012 0.93
86_Q 205_I 1.007 0.93
247_D 314_R 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dk0A10.81411000.471Contact Map0.651
3fppA20.78591000.473Contact Map0.746
2f1mA40.72391000.497Contact Map0.734
3lnnA20.78871000.518Contact Map0.739
4l8jA10.72681000.539Contact Map0.792
1vf7A130.73241000.54Contact Map0.78
3ne5B20.71551000.564Contact Map0.774
4kkuA40.56061000.627Contact Map0.81
2k32A10.323999.80.714Contact Map0.687
2dneA10.284599.50.781Contact Map0.675
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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