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OPENSEQ.org
TORA - Trimethylamine-N-oxide reductase 1
UniProt: P33225 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11814
Length: 848 (765)
Sequences: 3375
Seq/Len: 4.41
TORA
Paralog alert: 0.70 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: BISC DMSA FDHF FDNG FDOG NAPA TORA TORZ YDEP YNFE YNFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
735_I 754_A 7.605 1.00
102_Y 128_R 6.945 1.00
136_D 573_R 6.183 1.00
742_R 816_E 5.744 1.00
739_D 817_K 4.795 1.00
308_E 360_R 4.791 1.00
690_L 733_R 4.569 1.00
135_L 573_R 4.544 1.00
300_A 344_A 4.359 1.00
729_D 763_G 4.353 1.00
725_I 754_A 4.164 1.00
561_R 569_E 4.048 1.00
304_T 308_E 3.95 1.00
342_A 352_A 3.93 1.00
741_V 754_A 3.726 1.00
138_F 523_I 3.54 1.00
509_A 521_A 3.536 1.00
745_N 813_V 3.519 1.00
137_M 523_I 3.451 1.00
742_R 749_Q 3.409 1.00
565_D 569_E 3.37 1.00
141_E 144_R 3.325 1.00
129_V 523_I 3.262 1.00
552_Q 555_P 3.253 1.00
725_I 815_I 3.156 1.00
130_S 133_E 3.094 1.00
145_V 153_A 3.089 1.00
303_H 307_S 3.087 1.00
735_I 741_V 3.07 1.00
297_L 348_T 3.018 1.00
105_V 129_V 3.016 1.00
345_E 352_A 2.994 1.00
105_V 523_I 2.99 1.00
128_R 559_E 2.935 1.00
302_A 394_M 2.828 1.00
730_A 756_V 2.81 1.00
728_Q 762_P 2.78 1.00
569_E 573_R 2.77 1.00
733_R 814_E 2.768 1.00
744_F 814_E 2.737 1.00
264_E 361_Q 2.737 1.00
144_R 148_T 2.736 1.00
102_Y 559_E 2.722 1.00
222_S 225_I 2.701 1.00
138_F 508_I 2.7 1.00
313_K 317_A 2.689 1.00
135_L 569_E 2.686 1.00
304_T 341_A 2.648 1.00
228_W 298_Q 2.614 1.00
321_V 648_S 2.579 1.00
293_T 347_L 2.557 1.00
223_K 366_R 2.554 1.00
340_D 343_W 2.523 1.00
142_L 479_M 2.514 1.00
351_D 354_T 2.51 1.00
737_N 756_V 2.499 1.00
342_A 356_R 2.442 1.00
352_A 356_R 2.442 1.00
344_A 355_I 2.418 1.00
744_F 816_E 2.393 1.00
304_T 360_R 2.381 1.00
120_Q 123_D 2.358 1.00
285_K 357_G 2.348 1.00
105_V 137_M 2.342 1.00
345_E 351_D 2.34 1.00
304_T 310_L 2.331 1.00
354_T 357_G 2.33 1.00
287_I 350_I 2.325 1.00
105_V 127_V 2.295 1.00
129_V 137_M 2.262 1.00
493_Q 796_D 2.254 1.00
303_H 341_A 2.252 1.00
309_N 313_K 2.188 1.00
357_G 361_Q 2.188 1.00
723_V 765_A 2.18 1.00
648_S 652_E 2.166 1.00
137_M 141_E 2.166 1.00
101_R 558_F 2.154 1.00
302_A 326_F 2.154 1.00
723_V 741_V 2.151 1.00
311_Y 316_L 2.128 1.00
267_S 279_L 2.125 1.00
133_E 137_M 2.11 1.00
104_M 524_V 2.099 1.00
752_A 767_I 2.08 1.00
585_D 588_G 2.062 1.00
733_R 815_I 2.054 1.00
677_E 747_R 2.053 1.00
732_A 762_P 2.05 1.00
744_F 749_Q 2.028 1.00
310_L 360_R 2.01 1.00
736_R 739_D 1.997 1.00
297_L 355_I 1.992 1.00
534_N 552_Q 1.969 1.00
723_V 767_I 1.964 1.00
557_Q 560_A 1.96 1.00
482_F 507_V 1.953 1.00
725_I 735_I 1.926 1.00
133_E 523_I 1.914 1.00
224_T 266_I 1.912 1.00
509_A 518_C 1.909 1.00
506_T 523_I 1.906 1.00
103_P 131_W 1.901 1.00
720_K 753_G 1.895 1.00
289_V 350_I 1.888 1.00
270_P 286_H 1.888 1.00
224_T 361_Q 1.888 1.00
297_L 358_L 1.874 1.00
301_L 362_M 1.854 1.00
362_M 395_L 1.849 1.00
737_N 755_V 1.831 1.00
314_N 318_N 1.822 1.00
63_R 78_E 1.819 1.00
723_V 743_V 1.819 1.00
296_P 347_L 1.813 1.00
345_E 355_I 1.813 1.00
310_L 363_A 1.808 1.00
481_I 510_I 1.806 1.00
478_K 505_E 1.801 1.00
104_M 128_R 1.799 1.00
142_L 508_I 1.795 1.00
400_L 403_G 1.781 1.00
690_L 814_E 1.773 1.00
138_F 525_L 1.77 1.00
224_T 358_L 1.768 1.00
285_K 361_Q 1.766 1.00
765_A 813_V 1.765 1.00
742_R 751_L 1.764 1.00
690_L 765_A 1.756 1.00
226_V 268_I 1.755 1.00
285_K 354_T 1.749 0.99
301_L 305_L 1.743 0.99
137_M 506_T 1.733 0.99
740_V 751_L 1.733 0.99
145_V 479_M 1.733 0.99
306_Y 330_L 1.729 0.99
325_Q 328_P 1.721 0.99
724_F 757_S 1.71 0.99
308_E 356_R 1.701 0.99
71_F 94_V 1.68 0.99
499_E 502_R 1.666 0.99
306_Y 323_F 1.663 0.99
728_Q 731_S 1.66 0.99
504_L 507_V 1.65 0.99
320_C 653_I 1.637 0.99
129_V 133_E 1.637 0.99
287_I 358_L 1.634 0.99
316_L 323_F 1.623 0.99
64_A 71_F 1.623 0.99
305_L 311_Y 1.609 0.99
750_V 767_I 1.605 0.99
514_W 518_C 1.604 0.99
107_V 127_V 1.599 0.99
528_T 562_N 1.596 0.99
307_S 356_R 1.595 0.99
311_Y 323_F 1.591 0.99
740_V 753_G 1.584 0.99
221_N 401_P 1.584 0.99
143_E 147_K 1.57 0.99
268_I 297_L 1.567 0.99
226_V 358_L 1.553 0.99
362_M 367_T 1.55 0.98
687_K 746_A 1.544 0.98
267_S 276_H 1.543 0.98
345_E 350_I 1.535 0.98
101_R 128_R 1.535 0.98
569_E 572_R 1.524 0.98
145_V 505_E 1.52 0.98
498_I 502_R 1.515 0.98
107_V 125_R 1.511 0.98
304_T 356_R 1.503 0.98
127_V 133_E 1.502 0.98
55_T 59_W 1.502 0.98
561_R 565_D 1.5 0.98
306_Y 327_L 1.497 0.98
300_A 304_T 1.472 0.98
723_V 815_I 1.466 0.98
725_I 765_A 1.464 0.98
149_H 478_K 1.459 0.98
743_V 767_I 1.455 0.97
293_T 348_T 1.453 0.97
510_I 566_I 1.445 0.97
135_L 570_L 1.431 0.97
610_A 613_D 1.422 0.97
690_L 729_D 1.422 0.97
132_D 573_R 1.415 0.97
140_E 144_R 1.414 0.97
326_F 394_M 1.412 0.97
268_I 358_L 1.407 0.97
685_S 746_A 1.404 0.97
225_I 262_E 1.401 0.97
65_T 75_K 1.395 0.97
572_R 577_E 1.389 0.96
695_V 766_R 1.379 0.96
690_L 815_I 1.378 0.96
339_K 344_A 1.373 0.96
303_H 340_D 1.369 0.96
735_I 756_V 1.362 0.96
301_L 391_L 1.354 0.96
727_P 758_D 1.348 0.96
135_L 565_D 1.346 0.95
177_I 182_N 1.346 0.95
726_N 762_P 1.333 0.95
226_V 301_L 1.329 0.95
307_S 341_A 1.327 0.95
136_D 140_E 1.327 0.95
528_T 560_A 1.323 0.95
285_K 358_L 1.321 0.95
191_S 198_I 1.319 0.95
287_I 354_T 1.315 0.95
74_A 91_P 1.314 0.95
306_Y 311_Y 1.31 0.95
723_V 752_A 1.297 0.94
724_F 755_V 1.295 0.94
349_G 761_A 1.291 0.94
145_V 506_T 1.288 0.94
757_S 760_Y 1.286 0.94
613_D 618_K 1.285 0.94
188_G 197_V 1.283 0.94
397_Q 403_G 1.277 0.94
565_D 572_R 1.275 0.93
514_W 524_V 1.265 0.93
473_K 499_E 1.25 0.93
316_L 394_M 1.249 0.93
100_I 524_V 1.249 0.93
339_K 343_W 1.246 0.92
595_Q 598_V 1.242 0.92
254_L 262_E 1.238 0.92
300_A 340_D 1.237 0.92
143_E 146_Q 1.236 0.92
225_I 251_Y 1.234 0.92
255_K 280_G 1.231 0.92
343_W 346_K 1.23 0.92
272_V 277_E 1.228 0.92
255_K 278_Y 1.223 0.91
135_L 561_R 1.221 0.91
747_R 794_T 1.215 0.91
305_L 395_L 1.213 0.91
690_L 726_N 1.213 0.91
131_W 525_L 1.208 0.91
304_T 359_A 1.206 0.91
304_T 307_S 1.203 0.91
131_W 566_I 1.201 0.90
298_Q 387_M 1.196 0.90
62_I 74_A 1.193 0.90
765_A 815_I 1.191 0.90
373_W 377_R 1.189 0.90
305_L 391_L 1.188 0.90
300_A 355_I 1.187 0.90
344_A 348_T 1.185 0.90
289_V 293_T 1.184 0.90
479_M 508_I 1.184 0.90
301_L 359_A 1.182 0.90
394_M 653_I 1.179 0.89
488_F 501_L 1.177 0.89
277_E 759_R 1.177 0.89
323_F 394_M 1.175 0.89
481_I 570_L 1.174 0.89
311_Y 394_M 1.171 0.89
752_A 790_P 1.168 0.89
341_A 356_R 1.168 0.89
94_V 554_V 1.157 0.88
313_K 327_L 1.157 0.88
223_K 260_A 1.152 0.88
646_T 652_E 1.15 0.88
270_P 288_A 1.147 0.88
314_N 317_A 1.141 0.87
312_D 400_L 1.14 0.87
70_R 95_H 1.138 0.87
345_E 348_T 1.137 0.87
305_L 363_A 1.135 0.87
103_P 130_S 1.132 0.87
272_V 758_D 1.122 0.86
55_T 58_H 1.121 0.86
708_S 712_R 1.121 0.86
438_D 441_D 1.117 0.86
304_T 352_A 1.116 0.86
266_I 358_L 1.114 0.85
296_P 672_W 1.111 0.85
345_E 353_E 1.104 0.85
688_Y 745_N 1.101 0.85
223_K 365_N 1.101 0.85
142_L 574_F 1.1 0.84
150_G 153_A 1.096 0.84
512_N 529_T 1.091 0.84
518_C 524_V 1.09 0.84
561_R 566_I 1.089 0.84
176_A 567_F 1.088 0.84
64_A 74_A 1.088 0.84
308_E 341_A 1.084 0.83
141_E 145_V 1.082 0.83
591_K 612_D 1.079 0.83
730_A 735_I 1.078 0.83
305_L 362_M 1.078 0.83
584_L 592_R 1.077 0.83
644_L 651_I 1.074 0.83
353_E 356_R 1.073 0.82
80_D 83_P 1.072 0.82
224_T 362_M 1.067 0.82
459_L 496_R 1.065 0.82
66_V 69_G 1.064 0.82
482_F 517_T 1.063 0.82
66_V 554_V 1.061 0.81
142_L 481_I 1.057 0.81
66_V 72_V 1.055 0.81
591_K 595_Q 1.052 0.81
176_A 571_C 1.051 0.81
340_D 344_A 1.049 0.80
308_E 363_A 1.047 0.80
64_A 553_V 1.046 0.80
176_A 574_F 1.043 0.80
105_V 133_E 1.04 0.80
146_Q 154_L 1.04 0.80
321_V 652_E 1.038 0.79
708_S 711_L 1.037 0.79
304_T 355_I 1.031 0.79
390_V 653_I 1.031 0.79
725_I 756_V 1.029 0.79
304_T 363_A 1.028 0.79
95_H 557_Q 1.021 0.78
227_L 265_V 1.021 0.78
339_K 347_L 1.02 0.78
138_F 506_T 1.019 0.78
525_L 566_I 1.016 0.77
291_P 764_V 1.015 0.77
456_D 496_R 1.013 0.77
228_W 268_I 1.012 0.77
384_W 388_I 1.011 0.77
362_M 369_I 1.011 0.77
742_R 818_Y 1.011 0.77
154_L 180_H 1.009 0.77
587_M 591_K 1.006 0.76
554_V 557_Q 1.003 0.76
301_L 355_I 1.001 0.76
64_A 531_F 1 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tmoA10.95171000.198Contact Map0.703
1eu1A10.91271000.21Contact Map0.761
2ivfA10.87261000.307Contact Map0.772
2vpzA20.87151000.309Contact Map0.747
1kqfA10.87261000.314Contact Map0.727
1ti6A60.88211000.316Contact Map0.82
2e7zA10.80421000.337Contact Map0.762
1q16A10.93511000.343Contact Map0.733
3ml1A10.81371000.349Contact Map0.745
1h0hA20.83371000.351Contact Map0.709
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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