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OPENSEQ.org
TORZ - Trimethylamine-N-oxide reductase 2
UniProt: P46923 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13276
Length: 809 (746)
Sequences: 3915
Seq/Len: 5.25
TORZ
Paralog alert: 0.78 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: BISC DMSA FDHF FDNG FDOG NAPA TORA TORZ YDEP YNFE YNFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
714_I 733_A 6.859 1.00
87_H 112_Q 6.786 1.00
120_K 551_L 5.863 1.00
721_R 790_E 5.514 1.00
280_G 324_A 4.553 1.00
288_Q 340_E 4.388 1.00
718_D 791_K 4.321 1.00
708_D 742_G 4.312 1.00
119_L 551_L 4.199 1.00
670_L 712_F 4.191 1.00
284_T 288_Q 4.021 1.00
539_R 547_D 3.902 1.00
704_I 733_A 3.78 1.00
322_V 332_E 3.735 1.00
487_V 499_A 3.528 1.00
721_R 728_Q 3.505 1.00
121_L 501_I 3.488 1.00
720_V 733_A 3.471 1.00
543_D 547_D 3.434 1.00
724_N 787_V 3.429 1.00
122_I 501_I 3.406 1.00
113_V 501_I 3.327 1.00
125_Q 128_R 3.287 1.00
530_Q 533_A 3.266 1.00
129_I 137_A 3.155 1.00
90_V 501_I 3.114 1.00
283_H 287_T 3.087 1.00
90_V 113_V 3.055 1.00
714_I 720_V 3.014 1.00
325_A 332_E 2.995 1.00
277_L 328_T 2.988 1.00
704_I 789_I 2.914 1.00
282_A 374_M 2.907 1.00
293_K 297_E 2.886 1.00
112_Q 537_E 2.876 1.00
707_E 741_K 2.843 1.00
114_S 117_Q 2.816 1.00
213_W 278_M 2.813 1.00
128_R 132_A 2.799 1.00
709_A 735_V 2.735 1.00
301_T 631_S 2.671 1.00
723_W 788_Y 2.647 1.00
87_H 537_E 2.641 1.00
712_F 788_Y 2.632 1.00
547_D 551_L 2.621 1.00
208_Q 346_R 2.616 1.00
245_P 341_L 2.583 1.00
122_I 486_V 2.578 1.00
119_L 547_D 2.53 1.00
282_A 306_F 2.486 1.00
284_T 321_A 2.485 1.00
471_D 770_D 2.459 1.00
332_E 336_V 2.457 1.00
320_S 323_W 2.416 1.00
126_H 457_M 2.406 1.00
334_Q 337_K 2.401 1.00
716_N 735_V 2.398 1.00
284_T 340_E 2.389 1.00
723_W 790_E 2.383 1.00
90_V 121_L 2.378 1.00
207_S 210_V 2.374 1.00
273_T 327_I 2.349 1.00
337_K 341_L 2.341 1.00
283_H 321_A 2.34 1.00
702_I 744_V 2.33 1.00
331_P 334_Q 2.315 1.00
631_S 635_E 2.295 1.00
113_V 121_L 2.278 1.00
324_A 335_I 2.274 1.00
248_A 260_F 2.268 1.00
322_V 336_V 2.227 1.00
121_L 125_Q 2.215 1.00
90_V 111_V 2.194 1.00
291_H 296_L 2.163 1.00
731_T 746_V 2.124 1.00
284_T 290_K 2.12 1.00
265_T 337_K 2.107 1.00
289_G 293_K 2.101 1.00
325_A 331_P 2.072 1.00
267_I 330_V 2.055 1.00
104_G 107_E 2.052 1.00
711_R 741_K 2.037 1.00
702_I 720_V 2.035 1.00
86_Q 536_F 2.033 1.00
723_W 728_Q 2.026 1.00
117_Q 121_L 2.016 1.00
89_M 502_V 2.01 1.00
290_K 343_A 1.997 1.00
535_Q 538_A 1.987 1.00
565_D 568_A 1.985 1.00
209_V 247_I 1.963 1.00
380_T 383_G 1.955 1.00
290_K 340_E 1.954 1.00
512_N 530_Q 1.937 1.00
267_I 338_L 1.935 1.00
92_K 111_V 1.931 1.00
484_M 501_I 1.918 1.00
294_V 298_K 1.916 1.00
300_T 636_I 1.912 1.00
269_P 330_V 1.911 1.00
276_A 327_I 1.905 1.00
286_M 310_L 1.904 1.00
492_W 496_A 1.904 1.00
209_V 341_L 1.903 1.00
288_Q 336_V 1.897 1.00
296_L 303_Y 1.893 1.00
712_F 789_I 1.867 1.00
265_T 341_L 1.862 1.00
281_I 342_M 1.862 1.00
129_I 457_M 1.858 1.00
704_I 714_I 1.853 1.00
744_V 787_V 1.845 1.00
702_I 746_V 1.842 1.00
342_M 375_L 1.837 1.00
456_K 483_E 1.821 1.00
660_E 726_R 1.816 1.00
665_A 725_K 1.815 1.00
286_M 303_Y 1.805 1.00
56_I 79_V 1.804 1.00
719_L 730_L 1.796 1.00
716_N 734_V 1.793 1.00
117_Q 501_I 1.79 1.00
206_N 381_P 1.79 1.00
487_V 496_A 1.79 1.00
702_I 722_V 1.788 1.00
459_W 488_S 1.785 1.00
325_A 335_I 1.779 1.00
211_V 249_I 1.777 1.00
265_T 334_Q 1.774 1.00
715_A 718_D 1.773 1.00
277_L 335_I 1.771 1.00
251_P 266_W 1.77 1.00
670_L 744_V 1.754 1.00
277_L 338_L 1.753 1.00
88_P 115_W 1.741 1.00
670_L 788_Y 1.727 1.00
460_W 485_I 1.723 1.00
719_L 732_G 1.699 1.00
126_H 486_V 1.693 1.00
48_N 63_L 1.683 1.00
287_T 336_V 1.682 1.00
285_L 291_H 1.678 1.00
291_H 303_Y 1.678 1.00
209_V 338_L 1.67 0.99
703_T 736_T 1.67 0.99
721_R 730_L 1.669 0.99
122_I 503_L 1.667 0.99
482_P 485_I 1.657 0.99
342_M 347_T 1.633 0.99
547_D 550_E 1.63 0.99
49_V 56_I 1.625 0.99
121_L 484_M 1.598 0.99
539_R 543_D 1.589 0.99
506_T 540_N 1.588 0.99
89_M 112_Q 1.587 0.99
249_I 277_L 1.577 0.99
675_A 745_C 1.564 0.99
284_T 336_V 1.559 0.99
50_E 60_T 1.556 0.99
286_M 307_E 1.554 0.99
729_I 746_V 1.55 0.99
374_M 636_I 1.548 0.99
305_Q 308_E 1.542 0.99
704_I 744_V 1.539 0.99
476_I 480_Q 1.538 0.99
133_N 456_K 1.536 0.99
477_K 480_Q 1.534 0.99
319_K 324_A 1.523 0.99
273_T 328_T 1.516 0.99
699_R 732_G 1.516 0.99
670_L 708_D 1.515 0.99
281_I 285_L 1.513 0.99
248_A 257_I 1.495 0.99
129_I 483_E 1.493 0.99
722_V 746_V 1.486 0.99
667_E 725_K 1.485 0.99
211_V 338_L 1.484 0.99
707_E 710_A 1.474 0.98
488_S 544_V 1.468 0.98
113_V 117_Q 1.464 0.98
325_A 330_V 1.459 0.98
239_L 244_K 1.456 0.98
111_V 117_Q 1.45 0.98
86_Q 112_Q 1.441 0.98
353_W 357_R 1.435 0.98
59_S 76_A 1.434 0.98
127_D 131_K 1.431 0.98
85_I 502_V 1.431 0.98
280_G 335_I 1.428 0.98
736_T 739_I 1.423 0.98
283_H 320_S 1.419 0.98
267_I 334_Q 1.419 0.98
92_K 109_T 1.411 0.98
590_M 593_A 1.408 0.98
116_E 551_L 1.401 0.98
119_L 543_D 1.392 0.98
134_G 137_A 1.39 0.97
286_M 291_H 1.378 0.97
120_K 124_E 1.377 0.97
265_T 338_L 1.375 0.97
49_V 59_S 1.368 0.97
211_V 281_I 1.365 0.97
571_K 575_D 1.36 0.97
319_K 323_W 1.347 0.97
325_A 333_A 1.335 0.97
702_I 789_I 1.33 0.96
575_D 578_Q 1.323 0.96
543_D 550_E 1.318 0.96
702_I 731_T 1.315 0.96
124_E 128_R 1.315 0.96
210_V 236_F 1.314 0.96
253_R 258_E 1.31 0.96
296_L 374_M 1.303 0.96
249_I 338_L 1.302 0.96
323_W 326_E 1.298 0.96
129_I 484_M 1.297 0.96
492_W 502_V 1.289 0.96
119_L 539_R 1.289 0.96
115_W 503_L 1.286 0.96
306_F 374_M 1.284 0.95
329_G 740_K 1.283 0.95
703_T 734_V 1.282 0.95
550_E 557_K 1.281 0.95
629_T 635_E 1.276 0.95
284_T 287_T 1.273 0.95
280_G 284_T 1.273 0.95
377_Q 383_G 1.266 0.95
506_T 538_A 1.262 0.95
670_L 789_I 1.258 0.95
247_I 338_L 1.255 0.95
714_I 735_V 1.241 0.94
278_M 368_L 1.24 0.94
269_P 273_T 1.237 0.94
503_L 544_V 1.228 0.94
287_T 321_A 1.222 0.94
210_V 244_K 1.222 0.94
162_M 167_G 1.218 0.94
606_S 610_E 1.217 0.93
51_V 57_V 1.216 0.93
161_Y 552_L 1.215 0.93
55_K 80_H 1.214 0.93
726_R 768_T 1.213 0.93
705_H 741_K 1.21 0.93
126_H 552_L 1.209 0.93
706_T 737_D 1.207 0.93
294_V 297_E 1.206 0.93
115_W 544_V 1.204 0.93
564_K 572_F 1.203 0.93
731_T 764_A 1.194 0.93
212_L 246_V 1.193 0.93
451_T 477_K 1.192 0.93
127_D 130_R 1.191 0.92
333_A 336_V 1.191 0.92
261_D 264_A 1.19 0.92
79_V 532_V 1.188 0.92
319_K 327_I 1.187 0.92
240_K 261_D 1.182 0.92
283_H 310_L 1.175 0.92
176_S 183_I 1.168 0.92
324_A 328_T 1.167 0.91
325_A 328_T 1.163 0.91
490_C 507_T 1.157 0.91
240_K 259_F 1.153 0.91
321_A 336_V 1.147 0.91
457_M 486_V 1.143 0.90
284_T 339_A 1.142 0.90
119_L 548_L 1.14 0.90
670_L 705_H 1.135 0.90
285_L 343_A 1.131 0.90
512_N 527_P 1.128 0.90
284_T 332_E 1.127 0.89
213_W 249_I 1.122 0.89
258_E 738_G 1.112 0.89
660_E 725_K 1.111 0.89
293_K 307_E 1.106 0.88
278_M 367_M 1.105 0.88
593_A 598_N 1.103 0.88
285_L 375_L 1.096 0.88
303_Y 374_M 1.091 0.87
125_Q 129_I 1.09 0.87
320_S 324_A 1.088 0.87
270_N 740_K 1.088 0.87
91_R 110_Y 1.088 0.87
417_E 420_D 1.087 0.87
210_V 239_L 1.084 0.87
466_F 479_W 1.084 0.87
332_E 335_I 1.083 0.87
80_H 535_Q 1.083 0.87
291_H 374_M 1.082 0.87
110_Y 502_V 1.081 0.87
247_I 265_T 1.077 0.86
540_N 543_D 1.075 0.86
268_A 740_K 1.074 0.86
208_Q 242_S 1.069 0.86
271_M 743_V 1.068 0.86
284_T 335_I 1.068 0.86
506_T 534_P 1.063 0.85
459_W 548_L 1.061 0.85
373_A 634_I 1.06 0.85
281_I 371_L 1.06 0.85
280_G 320_S 1.059 0.85
668_K 724_N 1.059 0.85
746_V 764_A 1.052 0.85
253_R 737_D 1.049 0.84
292_D 380_T 1.048 0.84
364_K 368_L 1.047 0.84
280_G 323_W 1.046 0.84
51_V 54_G 1.039 0.84
54_G 57_V 1.039 0.84
457_M 484_M 1.038 0.84
370_T 636_I 1.035 0.83
466_F 476_I 1.03 0.83
285_L 342_M 1.03 0.83
126_H 459_W 1.022 0.82
321_A 332_E 1.021 0.82
529_K 595_W 1.018 0.82
471_D 474_R 1.018 0.82
541_D 544_V 1.017 0.82
49_V 509_F 1.013 0.81
488_S 505_I 1.008 0.81
284_T 343_A 1.007 0.81
532_V 535_Q 1.005 0.81
137_A 456_K 1.005 0.81
208_Q 345_N 1.004 0.81
212_L 215_M 1.002 0.80
744_V 789_I 1.001 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tmoA10.98151000.204Contact Map0.71
1eu1A10.95181000.212Contact Map0.771
1kqfA10.90361000.289Contact Map0.735
2vpzA20.89121000.294Contact Map0.755
2ivfA10.90111000.295Contact Map0.768
1ti6A60.91841000.306Contact Map0.824
2e7zA10.82451000.327Contact Map0.77
3ml1A10.85661000.327Contact Map0.754
1h0hA20.87521000.328Contact Map0.717
1q16A10.95551000.328Contact Map0.723
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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