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OPENSEQ.org
YNFE - Putative dimethyl sulfoxide reductase chain YnfE
UniProt: P77374 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13843
Length: 808 (795)
Sequences: 4053
Seq/Len: 5.10
YNFE
Paralog alert: 0.78 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: BISC DMSA FDHF FDNG FDOG NAPA TORA TORZ YDEP YNFE YNFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
728_I 747_A 7.07 1.00
114_Y 129_R 6.935 1.00
137_D 566_R 6.087 1.00
289_G 346_A 4.866 1.00
297_E 362_R 4.558 1.00
722_D 756_G 4.537 1.00
687_L 726_R 4.372 1.00
136_L 566_R 4.247 1.00
293_V 297_E 4.171 1.00
554_K 562_E 4.088 1.00
718_I 747_A 4.022 1.00
344_Q 354_E 3.839 1.00
501_V 513_A 3.8 1.00
138_T 515_I 3.698 1.00
735_R 742_E 3.664 1.00
734_V 747_A 3.558 1.00
558_W 562_E 3.55 1.00
223_K 369_P 3.49 1.00
142_S 145_K 3.482 1.00
139_I 515_I 3.477 1.00
545_P 548_S 3.443 1.00
130_I 515_I 3.392 1.00
117_K 515_I 3.261 1.00
347_S 354_E 3.231 1.00
146_T 154_A 3.231 1.00
286_L 350_T 3.197 1.00
292_W 296_N 3.191 1.00
735_R 806_E 3.165 1.00
291_A 397_L 3.157 1.00
117_K 130_I 3.111 1.00
728_I 734_V 3.019 1.00
129_R 552_E 2.968 1.00
721_I 755_P 2.964 1.00
228_F 287_V 2.957 1.00
131_S 134_E 2.915 1.00
302_Q 306_D 2.901 1.00
145_K 149_Q 2.875 1.00
723_A 749_V 2.854 1.00
310_V 639_S 2.85 1.00
259_V 272_E 2.718 1.00
143_L 467_F 2.702 1.00
114_Y 552_E 2.69 1.00
136_L 562_E 2.679 1.00
716_V 758_S 2.62 1.00
256_K 363_E 2.616 1.00
139_I 500_V 2.608 1.00
291_A 327_Y 2.6 1.00
293_V 343_P 2.563 1.00
732_D 807_K 2.559 1.00
580_T 583_Q 2.553 1.00
562_E 566_R 2.533 1.00
292_W 343_P 2.522 1.00
354_E 358_I 2.482 1.00
356_R 359_K 2.477 1.00
222_S 225_V 2.474 1.00
117_K 138_T 2.469 1.00
353_P 356_R 2.467 1.00
293_V 362_R 2.467 1.00
342_T 345_W 2.454 1.00
274_E 359_K 2.436 1.00
130_I 138_T 2.425 1.00
121_K 124_E 2.412 1.00
282_T 349_I 2.388 1.00
716_V 734_V 2.384 1.00
730_N 749_V 2.373 1.00
346_A 357_I 2.357 1.00
117_K 128_E 2.35 1.00
726_R 804_E 2.349 1.00
67_R 82_N 2.333 1.00
639_S 643_E 2.322 1.00
347_S 353_P 2.315 1.00
737_F 742_E 2.307 1.00
293_V 299_L 2.299 1.00
344_Q 358_I 2.264 1.00
300_V 305_L 2.256 1.00
498_M 515_I 2.239 1.00
297_E 358_I 2.238 1.00
359_K 363_E 2.238 1.00
745_L 760_M 2.225 1.00
303_P 307_K 2.175 1.00
482_D 787_L 2.174 1.00
113_N 551_F 2.162 1.00
134_E 138_T 2.162 1.00
276_L 352_I 2.161 1.00
725_K 755_P 2.131 1.00
224_L 258_I 2.124 1.00
364_I 398_T 2.119 1.00
299_L 365_G 2.113 1.00
290_I 364_I 2.105 1.00
550_K 553_R 2.079 1.00
138_T 142_S 2.067 1.00
506_M 510_A 2.06 1.00
716_V 760_M 2.06 1.00
466_K 497_E 2.058 1.00
298_N 302_Q 2.057 1.00
276_L 360_L 2.055 1.00
526_E 545_P 2.054 1.00
299_L 362_R 2.054 1.00
397_L 644_I 2.007 1.00
134_E 515_I 1.999 1.00
116_M 516_L 1.991 1.00
224_L 363_E 1.971 1.00
730_N 748_K 1.958 1.00
278_I 352_I 1.952 1.00
403_I 406_G 1.942 1.00
262_P 275_W 1.939 1.00
347_S 357_I 1.931 1.00
295_I 312_Y 1.925 1.00
469_W 502_I 1.925 1.00
286_L 357_I 1.923 1.00
274_E 356_R 1.919 1.00
295_I 331_I 1.916 1.00
364_I 370_A 1.897 1.00
274_E 363_E 1.881 1.00
294_L 300_V 1.879 1.00
718_I 728_I 1.877 1.00
226_V 260_I 1.865 1.00
496_C 499_I 1.861 1.00
733_M 746_P 1.861 1.00
75_V 106_I 1.857 1.00
138_T 498_M 1.844 1.00
501_V 510_A 1.843 1.00
285_A 349_I 1.843 1.00
733_M 744_R 1.827 1.00
224_L 360_L 1.826 1.00
146_T 467_F 1.824 1.00
290_I 294_L 1.816 1.00
296_N 358_I 1.809 1.00
717_W 750_T 1.806 1.00
139_I 517_L 1.802 1.00
716_V 736_V 1.797 1.00
729_A 732_D 1.786 1.00
286_L 360_L 1.77 1.00
735_R 744_R 1.76 1.00
687_L 758_S 1.759 1.00
218_D 221_N 1.756 1.00
488_E 491_Q 1.749 1.00
502_I 559_I 1.743 1.00
116_M 129_R 1.742 1.00
743_V 760_M 1.735 1.00
115_P 132_W 1.732 1.00
221_N 404_S 1.722 1.00
718_I 805_I 1.714 1.00
305_L 312_Y 1.71 1.00
68_L 75_V 1.705 1.00
562_E 565_K 1.703 1.00
718_I 758_S 1.701 1.00
554_K 558_W 1.69 1.00
684_T 739_H 1.687 1.00
260_I 286_L 1.673 0.99
300_V 312_Y 1.658 0.99
721_I 724_Q 1.648 0.99
225_V 255_A 1.645 0.99
601_S 604_E 1.641 0.99
150_Y 466_K 1.626 0.99
293_V 358_I 1.625 0.99
119_V 128_E 1.619 0.99
69_H 79_E 1.618 0.99
226_V 360_L 1.601 0.99
470_N 499_I 1.599 0.99
687_L 722_D 1.582 0.99
146_T 497_E 1.582 0.99
130_I 134_E 1.573 0.99
225_V 246_L 1.568 0.99
250_R 273_D 1.553 0.99
276_L 356_R 1.549 0.99
675_E 740_R 1.544 0.99
282_T 350_T 1.537 0.99
604_E 608_M 1.529 0.99
341_K 346_A 1.505 0.99
737_F 804_E 1.5 0.99
329_A 332_L 1.493 0.99
289_G 357_I 1.492 0.98
143_L 500_V 1.489 0.98
736_V 760_M 1.483 0.98
78_V 103_R 1.481 0.98
520_L 555_P 1.481 0.98
292_W 342_T 1.47 0.98
367_A 370_A 1.467 0.98
113_N 129_R 1.466 0.98
136_L 558_W 1.465 0.98
682_R 739_H 1.45 0.98
750_T 753_I 1.448 0.98
687_L 804_E 1.446 0.98
274_E 360_L 1.442 0.98
119_V 126_K 1.436 0.98
128_E 134_E 1.434 0.98
590_A 593_L 1.432 0.98
345_W 348_Q 1.427 0.98
740_R 785_T 1.424 0.98
487_H 491_Q 1.423 0.98
137_D 141_S 1.413 0.98
347_S 352_I 1.411 0.98
719_N 755_P 1.411 0.98
376_W 380_R 1.407 0.98
136_L 563_V 1.406 0.98
68_L 78_V 1.403 0.98
341_K 349_I 1.4 0.97
720_P 751_P 1.4 0.97
728_I 749_V 1.392 0.97
60_C 64_C 1.389 0.97
520_L 553_R 1.387 0.97
506_M 516_L 1.38 0.97
218_D 405_G 1.378 0.97
139_I 498_M 1.378 0.97
112_L 516_L 1.378 0.97
144_K 148_E 1.378 0.97
226_V 290_I 1.375 0.97
295_I 300_V 1.362 0.97
351_G 754_L 1.36 0.97
309_C 644_I 1.36 0.97
287_V 391_I 1.359 0.97
104_R 707_L 1.354 0.97
258_I 360_L 1.345 0.97
136_L 554_K 1.345 0.97
249_A 255_A 1.342 0.97
223_K 367_A 1.339 0.96
132_W 517_L 1.338 0.96
364_I 372_I 1.325 0.96
296_N 343_P 1.323 0.96
141_S 145_K 1.314 0.96
314_E 329_A 1.314 0.96
144_K 147_V 1.314 0.96
341_K 345_W 1.302 0.96
289_G 293_V 1.3 0.96
259_V 268_A 1.298 0.96
56_C 60_C 1.291 0.95
68_L 523_V 1.286 0.95
717_W 748_K 1.283 0.95
146_T 498_M 1.283 0.95
558_W 565_K 1.279 0.95
151_G 154_A 1.277 0.95
293_V 296_N 1.27 0.95
295_I 328_K 1.267 0.95
278_I 282_T 1.263 0.95
106_I 547_T 1.262 0.95
400_N 406_G 1.26 0.95
687_L 719_N 1.26 0.95
133_D 566_R 1.259 0.95
74_E 107_N 1.256 0.94
517_L 559_I 1.255 0.94
305_L 397_L 1.245 0.94
67_R 81_D 1.243 0.94
132_W 559_I 1.24 0.94
737_F 806_E 1.232 0.94
303_P 306_D 1.229 0.94
504_N 521_M 1.228 0.94
260_I 360_L 1.226 0.93
347_S 350_T 1.224 0.93
716_V 805_I 1.224 0.93
716_V 745_L 1.221 0.93
155_V 467_F 1.217 0.93
223_K 368_K 1.215 0.93
469_W 563_V 1.208 0.93
637_T 643_E 1.207 0.93
565_K 572_Y 1.201 0.93
290_I 394_L 1.199 0.92
370_A 400_N 1.198 0.92
181_L 567_L 1.197 0.92
790_S 793_A 1.197 0.92
289_G 345_W 1.197 0.92
586_Q 603_D 1.196 0.92
579_R 587_H 1.194 0.92
223_K 253_S 1.193 0.92
70_V 547_T 1.192 0.92
293_V 354_E 1.192 0.92
293_V 357_I 1.191 0.92
300_V 397_L 1.19 0.92
290_I 361_A 1.189 0.92
277_P 754_L 1.187 0.92
292_W 331_I 1.185 0.92
647_S 651_E 1.184 0.92
294_L 365_G 1.183 0.92
227_M 257_M 1.183 0.92
147_V 155_V 1.181 0.92
343_P 358_I 1.181 0.92
718_I 749_V 1.181 0.92
387_T 391_I 1.18 0.92
312_Y 397_L 1.176 0.91
555_P 558_W 1.174 0.91
346_A 350_T 1.171 0.91
228_F 260_I 1.166 0.91
294_L 397_L 1.164 0.91
738_N 803_V 1.162 0.91
143_L 567_L 1.161 0.91
143_L 469_W 1.16 0.91
342_T 346_A 1.157 0.91
80_T 93_V 1.154 0.90
127_F 516_L 1.152 0.90
347_S 355_D 1.151 0.90
482_D 485_K 1.15 0.90
355_D 358_I 1.147 0.90
358_I 362_R 1.147 0.90
142_S 146_T 1.147 0.90
526_E 542_F 1.146 0.90
250_R 257_M 1.146 0.90
287_V 390_A 1.145 0.90
393_M 644_I 1.142 0.90
115_P 131_S 1.135 0.89
70_V 76_T 1.132 0.89
645_Y 666_P 1.131 0.89
250_R 271_R 1.13 0.89
293_V 361_A 1.13 0.89
554_K 559_I 1.129 0.89
258_I 274_E 1.129 0.89
760_M 781_V 1.124 0.89
262_P 277_P 1.12 0.89
196_S 199_Q 1.116 0.88
289_G 342_T 1.115 0.88
256_K 273_D 1.112 0.88
467_F 498_M 1.105 0.88
362_R 366_T 1.103 0.88
219_I 371_Y 1.102 0.88
73_N 76_T 1.102 0.88
547_T 550_K 1.102 0.88
294_L 364_I 1.101 0.87
378_P 391_I 1.097 0.87
521_M 550_K 1.096 0.87
294_L 398_T 1.092 0.87
311_G 314_E 1.088 0.87
343_P 354_E 1.087 0.87
520_L 549_E 1.087 0.87
264_Y 269_A 1.087 0.87
181_L 560_L 1.086 0.86
502_I 519_D 1.085 0.86
118_R 127_F 1.083 0.86
64_C 96_C 1.083 0.86
327_Y 397_L 1.083 0.86
745_L 781_V 1.082 0.86
113_N 550_K 1.081 0.86
342_T 347_S 1.073 0.86
224_L 367_A 1.067 0.85
108_H 505_F 1.066 0.85
470_N 509_S 1.065 0.85
468_I 496_C 1.065 0.85
279_R 754_L 1.064 0.85
310_V 643_E 1.064 0.85
55_A 541_I 1.063 0.85
203_A 392_A 1.063 0.85
224_L 256_K 1.06 0.85
299_L 366_T 1.059 0.85
467_F 500_V 1.059 0.85
396_I 642_I 1.056 0.84
758_S 803_V 1.056 0.84
715_E 748_K 1.055 0.84
132_W 554_K 1.051 0.84
293_V 365_G 1.048 0.84
302_Q 328_K 1.048 0.84
227_M 230_N 1.046 0.84
294_L 394_L 1.046 0.84
264_Y 751_P 1.042 0.83
154_A 466_K 1.042 0.83
224_L 364_I 1.04 0.83
12_R 15_L 1.038 0.83
107_N 550_K 1.034 0.83
343_P 347_S 1.033 0.83
312_Y 328_K 1.03 0.82
54_G 543_L 1.03 0.82
692_F 759_A 1.028 0.82
117_K 134_E 1.023 0.82
280_P 757_V 1.023 0.82
117_K 139_I 1.019 0.81
638_P 643_E 1.016 0.81
719_N 749_V 1.011 0.81
261_D 265_T 1.011 0.81
66_L 95_A 1.008 0.80
52_V 70_V 1.007 0.80
68_L 546_V 1.006 0.80
156_Y 465_I 1.005 0.80
354_E 357_I 1.005 0.80
121_K 126_K 1.005 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vpzA20.88991000.226Contact Map0.74
2ivfA10.93321000.231Contact Map0.75
1kqfA10.92451000.243Contact Map0.724
1tmoA10.91961000.256Contact Map0.692
2e7zA10.84031000.266Contact Map0.757
1ti6A60.89231000.276Contact Map0.802
1eu1A10.87871000.279Contact Map0.749
1h0hA20.88371000.282Contact Map0.708
1q16A10.95171000.282Contact Map0.727
3ml1A10.84411000.292Contact Map0.739
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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