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DKGB - 2,5-diketo-D-gluconic acid reductase B
UniProt: P30863 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11648
Length: 267 (259)
Sequences: 14015
Seq/Len: 54.11
DKGB
Paralog alert: 0.86 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: DKGA DKGB GPR TAS YAJO YDBC YDHF YDJG YEAE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_T 229_E 3.063 1.00
80_K 122_L 3.022 1.00
50_A 87_R 2.735 1.00
199_H 243_D 2.628 1.00
79_L 117_A 2.485 1.00
198_K 246_A 2.402 1.00
24_T 28_L 2.373 1.00
76_I 120_Q 2.293 1.00
240_D 243_D 2.237 1.00
61_I 88_T 2.212 1.00
76_I 116_E 2.144 1.00
241_A 245_K 2.021 1.00
116_E 120_Q 2 1.00
198_K 243_D 1.999 1.00
193_A 197_A 1.997 1.00
81_E 85_K 1.967 1.00
19_I 51_E 1.966 1.00
213_G 244_K 1.956 1.00
63_T 91_V 1.95 1.00
194_R 246_A 1.915 1.00
115_L 119_K 1.891 1.00
19_I 47_Q 1.866 1.00
167_W 171_H 1.835 1.00
225_R 229_E 1.817 1.00
116_E 119_K 1.785 1.00
79_L 94_T 1.783 1.00
168_A 175_I 1.761 1.00
63_T 82_S 1.743 1.00
209_A 237_L 1.743 1.00
90_Y 124_R 1.72 1.00
174_H 217_S 1.699 1.00
7_G 32_A 1.695 1.00
43_A 85_K 1.684 1.00
202_T 230_S 1.674 1.00
28_L 232_L 1.667 1.00
201_A 237_L 1.647 1.00
28_L 229_E 1.647 1.00
55_P 58_E 1.633 1.00
24_T 225_R 1.623 1.00
214_E 248_A 1.618 1.00
91_V 123_T 1.611 1.00
19_I 48_A 1.603 1.00
72_K 76_I 1.6 1.00
137_E 167_W 1.574 1.00
24_T 27_E 1.571 1.00
245_K 249_A 1.559 1.00
95_L 150_T 1.558 1.00
95_L 176_T 1.555 1.00
37_Q 78_S 1.536 1.00
25_A 30_Y 1.536 1.00
119_K 144_G 1.521 1.00
62_T 95_L 1.507 1.00
229_E 233_K 1.486 1.00
72_K 116_E 1.485 1.00
233_K 236_N 1.478 1.00
137_E 141_A 1.476 1.00
19_I 23_I 1.47 1.00
123_T 126_I 1.444 1.00
65_I 75_L 1.441 1.00
10_T 33_I 1.434 1.00
113_A 116_E 1.422 1.00
137_E 170_Q 1.41 1.00
201_A 205_Q 1.406 0.99
79_L 91_V 1.405 0.99
23_I 27_E 1.404 0.99
33_I 45_V 1.4 0.99
26_L 59_L 1.381 0.99
166_A 170_Q 1.381 0.99
117_A 123_T 1.378 0.99
191_V 194_R 1.376 0.99
22_V 48_A 1.373 0.99
76_I 80_K 1.371 0.99
80_K 84_Q 1.355 0.99
195_I 206_V 1.349 0.99
209_A 213_G 1.341 0.99
17_V 20_S 1.332 0.99
23_I 51_E 1.327 0.99
21_S 228_L 1.321 0.99
222_S 227_N 1.297 0.99
81_E 84_Q 1.296 0.99
65_I 94_T 1.295 0.99
77_P 81_E 1.293 0.99
222_S 228_L 1.289 0.99
153_I 175_I 1.283 0.99
226_K 229_E 1.27 0.99
202_T 205_Q 1.26 0.99
194_R 197_A 1.259 0.99
246_A 249_A 1.254 0.99
47_Q 87_R 1.248 0.99
60_Y 93_L 1.245 0.98
76_I 113_A 1.245 0.98
201_A 206_V 1.238 0.98
133_I 167_W 1.237 0.98
46_G 87_R 1.234 0.98
132_T 135_L 1.233 0.98
56_R 88_T 1.233 0.98
42_E 82_S 1.227 0.98
114_L 126_I 1.226 0.98
71_S 74_K 1.224 0.98
43_A 47_Q 1.215 0.98
228_L 232_L 1.213 0.98
192_I 203_P 1.184 0.98
73_D 77_P 1.164 0.97
211_A 218_V 1.161 0.97
163_K 166_A 1.157 0.97
140_I 171_H 1.156 0.97
157_P 247_I 1.155 0.97
72_K 113_A 1.154 0.97
194_R 198_K 1.143 0.97
86_L 91_V 1.142 0.97
43_A 84_Q 1.131 0.97
191_V 246_A 1.13 0.97
56_R 90_Y 1.124 0.97
32_A 176_T 1.124 0.97
80_K 120_Q 1.118 0.96
137_E 171_H 1.115 0.96
166_A 169_K 1.108 0.96
23_I 48_A 1.107 0.96
190_E 194_R 1.103 0.96
20_S 24_T 1.095 0.96
242_E 245_K 1.093 0.96
157_P 207_I 1.092 0.96
193_A 203_P 1.092 0.96
133_I 137_E 1.088 0.96
117_A 122_L 1.087 0.96
199_H 240_D 1.078 0.95
20_S 225_R 1.072 0.95
226_K 230_S 1.061 0.95
32_A 62_T 1.053 0.95
165_V 169_K 1.053 0.95
72_K 109_E 1.053 0.95
212_M 234_A 1.048 0.94
155_L 214_E 1.047 0.94
4_P 30_Y 1.046 0.94
154_E 159_L 1.043 0.94
4_P 31_R 1.043 0.94
96_I 114_L 1.043 0.94
72_K 112_Q 1.043 0.94
49_I 59_L 1.04 0.94
15_D 47_Q 1.036 0.94
92_D 124_R 1.036 0.94
31_R 60_Y 1.023 0.93
109_E 112_Q 1.016 0.93
115_L 118_K 1.008 0.93
205_Q 230_S 1.006 0.93
169_K 215_G 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3up8A20.98881000.038Contact Map0.744
2wzmA20.9851000.07Contact Map0.698
1mi3A40.99251000.072Contact Map0.683
1hw6A10.97751000.076Contact Map0.636
1mzrA20.97381000.077Contact Map0.755
3b3eA20.97381000.08Contact Map0.806
4f40A20.9851000.081Contact Map0.718
4gieA10.9851000.082Contact Map0.719
3f7jA20.97381000.083Contact Map0.801
1vbjA20.98131000.083Contact Map0.708
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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