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OPENSEQ.org
YAJO - Uncharacterized oxidoreductase YajO
UniProt: P77735 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13611
Length: 324 (318)
Sequences: 12751
Seq/Len: 40.10
YAJO
Paralog alert: 0.85 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: DKGA DKGB GPR TAS YAJO YDBC YDHF YDJG YEAE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
46_R 293_D 3.317 1.00
110_D 150_K 3.271 1.00
37_E 72_R 2.986 1.00
75_R 117_G 2.918 1.00
261_L 307_Q 2.772 1.00
109_I 145_V 2.763 1.00
260_E 310_E 2.678 1.00
46_R 50_G 2.642 1.00
5_P 12_R 2.57 1.00
106_L 148_A 2.508 1.00
85_V 118_M 2.398 1.00
304_K 307_Q 2.331 1.00
87_T 121_V 2.318 1.00
106_L 144_D 2.195 1.00
305_P 309_A 2.118 1.00
260_E 307_Q 2.115 1.00
255_T 259_E 2.058 1.00
41_R 76_D 2.032 1.00
275_S 308_I 2.012 1.00
144_D 148_A 1.983 1.00
143_N 147_K 1.98 1.00
87_T 112_S 1.951 1.00
109_I 124_L 1.899 1.00
111_D 115_R 1.895 1.00
256_G 310_E 1.891 1.00
144_D 147_K 1.875 1.00
264_T 294_E 1.871 1.00
4_N 15_R 1.87 1.00
65_S 68_E 1.864 1.00
125_Q 181_S 1.863 1.00
271_A 301_I 1.817 1.00
120_Y 152_R 1.802 1.00
50_G 296_L 1.793 1.00
41_R 72_R 1.791 1.00
121_V 151_A 1.783 1.00
41_R 73_A 1.782 1.00
68_E 115_R 1.778 1.00
50_G 293_D 1.774 1.00
263_A 301_I 1.768 1.00
289_E 293_D 1.752 1.00
201_C 208_V 1.745 1.00
125_Q 209_I 1.719 1.00
79_R 82_D 1.718 1.00
200_L 204_E 1.713 1.00
17_C 54_F 1.708 1.00
36_P 39_S 1.68 1.00
309_A 313_T 1.655 1.00
276_K 312_E 1.646 1.00
46_R 49_E 1.641 1.00
109_I 121_V 1.635 1.00
3_Y 12_R 1.628 1.00
102_R 106_L 1.619 1.00
55_F 70_V 1.619 1.00
102_R 144_D 1.618 1.00
59_N 108_S 1.616 1.00
89_V 105_I 1.576 1.00
86_A 125_Q 1.568 1.00
46_R 289_E 1.566 1.00
257_V 268_V 1.56 1.00
207_A 281_A 1.549 1.00
165_A 203_Q 1.545 1.00
165_A 169_E 1.54 1.00
293_D 297_N 1.53 1.00
20_C 55_F 1.514 1.00
47_A 52_I 1.511 1.00
11_L 153_Y 1.506 1.00
41_R 45_K 1.501 1.00
106_L 141_A 1.493 1.00
48_L 83_V 1.492 1.00
263_A 267_Q 1.487 1.00
145_V 151_A 1.486 1.00
151_A 154_I 1.472 1.00
297_N 300_D 1.463 1.00
141_A 144_D 1.452 1.00
165_A 200_L 1.439 1.00
253_R 256_G 1.438 1.00
106_L 110_D 1.427 1.00
39_S 42_P 1.422 1.00
44_I 73_A 1.42 1.00
111_D 114_R 1.405 0.99
196_E 199_P 1.388 0.99
89_V 124_L 1.383 0.99
45_K 49_E 1.365 0.99
43_I 292_L 1.364 0.99
290_E 293_D 1.353 0.99
310_E 313_T 1.352 0.99
202_Y 277_P 1.345 0.99
168_L 204_E 1.338 0.99
110_D 114_R 1.331 0.99
184_D 208_V 1.331 0.99
72_R 117_G 1.329 0.99
286_T 292_L 1.327 0.99
292_L 296_L 1.323 0.99
264_T 267_Q 1.319 0.99
153_Y 180_V 1.318 0.99
107_R 111_D 1.317 0.99
37_E 41_R 1.316 0.99
199_P 203_Q 1.316 0.99
142_L 154_I 1.313 0.99
45_K 76_D 1.312 0.99
11_L 84_V 1.299 0.99
68_E 114_R 1.295 0.99
80_R 118_M 1.293 0.99
256_G 259_E 1.289 0.99
68_E 72_R 1.281 0.99
160_H 163_Q 1.273 0.99
263_A 268_V 1.271 0.99
271_A 275_S 1.257 0.99
84_V 123_I 1.256 0.99
67_E 112_S 1.249 0.99
71_G 117_G 1.227 0.98
254_L 265_R 1.22 0.98
110_D 148_A 1.217 0.98
188_L 311_L 1.21 0.98
273_L 282_P 1.208 0.98
103_A 107_R 1.205 0.98
2_Q 15_R 1.204 0.98
168_L 200_L 1.2 0.98
286_T 291_Q 1.198 0.98
256_G 260_E 1.198 0.98
102_R 140_E 1.195 0.98
254_L 311_L 1.188 0.98
45_K 73_A 1.172 0.98
102_R 137_E 1.17 0.97
306_E 309_A 1.167 0.97
54_F 209_I 1.166 0.97
172_K 178_Q 1.164 0.97
74_L 83_V 1.162 0.97
261_L 304_K 1.161 0.97
116_L 121_V 1.161 0.97
38_E 42_P 1.16 0.97
102_R 141_A 1.156 0.97
42_P 289_E 1.152 0.97
80_R 120_Y 1.151 0.97
146_V 180_V 1.144 0.97
193_E 208_V 1.143 0.97
161_A 200_L 1.126 0.97
145_V 150_K 1.124 0.97
271_A 298_A 1.115 0.96
20_C 70_V 1.115 0.96
188_L 269_A 1.109 0.96
123_I 181_S 1.107 0.96
165_A 204_E 1.106 0.96
253_R 310_E 1.097 0.96
101_S 104_Q 1.094 0.96
185_H 190_Y 1.094 0.96
14_S 52_I 1.093 0.96
255_T 265_R 1.093 0.96
191_R 194_E 1.092 0.96
42_P 46_R 1.089 0.96
53_N 84_V 1.086 0.96
268_V 301_I 1.086 0.96
143_N 177_A 1.082 0.96
54_F 86_A 1.078 0.95
267_Q 294_E 1.071 0.95
290_E 294_E 1.067 0.95
138_T 141_A 1.065 0.95
252_E 256_G 1.062 0.95
122_D 152_R 1.059 0.95
267_Q 297_N 1.059 0.95
186_Y 276_K 1.057 0.95
126_I 142_L 1.054 0.95
104_Q 107_R 1.053 0.95
137_E 140_E 1.05 0.94
45_K 77_F 1.05 0.94
309_A 312_E 1.046 0.94
113_L 150_K 1.042 0.94
294_E 297_N 1.038 0.94
274_L 298_A 1.036 0.94
14_S 53_N 1.031 0.94
202_Y 278_G 1.027 0.94
145_V 148_A 1.026 0.94
44_I 55_F 1.022 0.93
9_T 153_Y 1.021 0.93
59_N 104_Q 1.009 0.93
156_A 164_F 1.008 0.93
146_V 177_A 1.006 0.93
199_P 202_Y 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pyfA10.94751000.099Contact Map0.749
1pz1A20.9661000.102Contact Map0.737
3v0sA10.9631000.103Contact Map0.8
3n2tA10.95681000.11Contact Map0.728
1lqaA20.96911000.112Contact Map0.766
3lutA10.9661000.112Contact Map0.762
3eauA10.95991000.114Contact Map0.776
3erpA20.94751000.12Contact Map0.782
3n6qA80.9661000.126Contact Map0.788
1ur3M10.88891000.134Contact Map0.729
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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