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OPENSEQ.org
TAS - Protein tas
UniProt: P0A9T4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13093
Length: 346 (329)
Sequences: 11002
Seq/Len: 33.44
TAS
Paralog alert: 0.83 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: DKGA DKGB GPR TAS YAJO YDBC YDHF YDJG YEAE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_Y 316_K 3.624 1.00
115_H 172_K 3.348 1.00
29_E 71_N 3.273 1.00
74_A 122_Q 3.113 1.00
283_R 333_E 3.071 1.00
284_H 330_V 2.995 1.00
38_Y 42_Q 2.841 1.00
5_R 12_E 2.682 1.00
114_L 167_Y 2.679 1.00
86_S 126_L 2.628 1.00
111_R 170_A 2.602 1.00
327_S 330_V 2.485 1.00
84_I 123_T 2.438 1.00
328_E 332_A 2.167 1.00
111_R 166_E 2.146 1.00
165_A 169_R 2.127 1.00
278_V 282_R 2.097 1.00
64_L 67_T 2.068 1.00
114_L 126_L 2.068 1.00
4_H 15_T 2.06 1.00
114_L 129_Y 2.053 1.00
283_R 330_V 2.048 1.00
130_Q 203_T 2.037 1.00
166_E 169_R 1.981 1.00
86_S 117_S 1.945 1.00
42_Q 319_I 1.92 1.00
42_Q 316_K 1.911 1.00
130_Q 231_L 1.907 1.00
279_D 333_E 1.902 1.00
125_Y 174_R 1.893 1.00
166_E 170_A 1.881 1.00
298_R 331_L 1.878 1.00
17_G 46_L 1.867 1.00
332_A 336_A 1.825 1.00
28_S 31_D 1.825 1.00
33_H 72_W 1.822 1.00
287_D 317_T 1.809 1.00
78_S 81_K 1.807 1.00
88_V 110_I 1.799 1.00
20_T 47_I 1.794 1.00
294_A 324_L 1.789 1.00
286_L 324_L 1.745 1.00
126_L 173_I 1.739 1.00
67_T 120_R 1.728 1.00
33_H 75_K 1.697 1.00
47_I 69_V 1.697 1.00
116_D 120_R 1.678 1.00
51_E 113_A 1.674 1.00
280_I 291_M 1.66 1.00
312_M 316_K 1.655 1.00
39_A 44_I 1.653 1.00
107_R 111_R 1.652 1.00
222_V 226_E 1.651 1.00
107_R 166_E 1.635 1.00
173_I 176_I 1.608 1.00
286_L 290_Q 1.596 1.00
163_A 166_E 1.589 1.00
33_H 71_N 1.584 1.00
36_L 72_W 1.575 1.00
3_Y 12_E 1.575 1.00
320_E 323_H 1.572 1.00
276_A 279_D 1.571 1.00
85_A 130_Q 1.564 1.00
112_E 116_D 1.559 1.00
223_S 230_L 1.547 1.00
187_M 191_H 1.54 1.00
11_L 175_Y 1.538 1.00
218_G 221_E 1.52 1.00
167_Y 173_I 1.514 1.00
187_M 225_Y 1.514 1.00
31_D 34_A 1.505 1.00
313_D 316_K 1.499 1.00
35_Q 315_L 1.492 1.00
111_R 163_A 1.491 1.00
299_Q 335_E 1.489 1.00
38_Y 312_M 1.475 1.00
38_Y 41_A 1.468 1.00
33_H 37_D 1.467 1.00
111_R 115_H 1.454 1.00
116_D 119_K 1.448 1.00
287_D 290_Q 1.444 1.00
210_L 334_I 1.423 1.00
316_K 320_E 1.422 1.00
37_D 41_A 1.42 1.00
333_E 336_A 1.41 1.00
70_G 122_Q 1.399 0.99
29_E 33_H 1.399 0.99
40_V 82_L 1.394 0.99
67_T 119_K 1.39 0.99
296_V 305_T 1.374 0.99
107_R 159_D 1.37 0.99
315_L 319_I 1.355 0.99
67_T 71_N 1.35 0.99
286_L 291_M 1.348 0.99
88_V 129_Y 1.345 0.99
164_L 176_I 1.344 0.99
71_N 122_Q 1.331 0.99
11_L 83_I 1.328 0.99
229_E 304_S 1.309 0.99
224_Q 300_P 1.308 0.99
279_D 283_R 1.298 0.99
115_H 170_A 1.297 0.99
2_Q 15_T 1.291 0.99
115_H 119_K 1.287 0.99
206_N 230_L 1.28 0.99
79_R 123_T 1.279 0.99
277_Y 288_P 1.278 0.99
194_D 200_R 1.276 0.99
279_D 282_R 1.267 0.99
277_Y 334_I 1.264 0.99
215_F 230_L 1.261 0.99
329_D 332_A 1.258 0.99
51_E 109_N 1.256 0.99
221_E 225_Y 1.245 0.98
66_E 117_S 1.243 0.98
73_L 82_L 1.239 0.98
37_D 75_K 1.232 0.98
131_V 164_L 1.222 0.98
207_P 212_N 1.218 0.98
309_A 315_L 1.218 0.98
284_H 327_S 1.206 0.98
182_T 185_G 1.204 0.98
290_Q 320_E 1.203 0.98
299_Q 331_L 1.194 0.98
79_R 125_Y 1.193 0.98
128_L 203_T 1.186 0.98
290_Q 317_T 1.184 0.98
45_N 83_I 1.182 0.98
175_Y 202_V 1.176 0.98
294_A 298_R 1.176 0.98
291_M 324_L 1.174 0.98
37_D 72_W 1.172 0.98
34_A 312_M 1.171 0.98
108_K 112_E 1.171 0.98
36_L 47_I 1.168 0.97
276_A 333_E 1.167 0.97
14_S 44_I 1.155 0.97
278_V 288_P 1.155 0.97
183_A 222_V 1.155 0.97
224_Q 301_F 1.15 0.97
37_D 76_H 1.145 0.97
107_R 162_D 1.141 0.97
275_A 279_D 1.134 0.97
213_R 216_E 1.129 0.97
167_Y 172_K 1.124 0.97
180_N 233_Y 1.12 0.96
83_I 128_L 1.115 0.96
187_M 222_V 1.11 0.96
165_A 199_P 1.108 0.96
210_L 292_A 1.106 0.96
275_A 278_V 1.104 0.96
188_R 191_H 1.101 0.96
220_A 230_L 1.099 0.96
30_A 34_A 1.096 0.96
313_D 317_T 1.086 0.96
121_L 126_L 1.082 0.96
9_S 202_V 1.081 0.95
46_L 231_L 1.077 0.95
309_A 314_Q 1.068 0.95
17_G 307_L 1.068 0.95
46_L 85_A 1.067 0.95
113_A 116_D 1.067 0.95
127_D 174_R 1.065 0.95
160_T 163_A 1.052 0.95
20_T 69_V 1.05 0.94
109_N 112_E 1.047 0.94
190_L 226_E 1.039 0.94
14_S 45_N 1.038 0.94
203_T 231_L 1.031 0.94
317_T 320_E 1.018 0.93
176_I 201_I 1.016 0.93
190_L 222_V 1.015 0.93
159_D 162_D 1.01 0.93
134_P 185_G 1.01 0.93
332_A 335_E 1.009 0.93
118_L 172_K 1.007 0.93
229_E 303_A 1.005 0.93
15_T 297_R 1.002 0.92
169_R 194_D 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1lqaA211000.076Contact Map0.766
1pz1A20.90171000.141Contact Map0.749
1pyfA10.88441000.143Contact Map0.741
3n2tA10.90171000.146Contact Map0.72
3eauA10.90751000.147Contact Map0.778
3v0sA10.90171000.148Contact Map0.803
3erpA20.89881000.149Contact Map0.794
3lutA10.91041000.15Contact Map0.766
2bp1A40.90461000.157Contact Map0.712
3n6qA80.91041000.159Contact Map0.797
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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