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OPENSEQ.org
YEAE - Uncharacterized protein YeaE
UniProt: P76234 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13491
Length: 284 (272)
Sequences: 14107
Seq/Len: 51.86
YEAE
Paralog alert: 0.86 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: DKGA DKGB GPR TAS YAJO YDBC YDHF YDJG YEAE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_A 250_Q 3.129 1.00
96_E 135_K 3.049 1.00
69_T 103_N 2.648 1.00
219_H 264_E 2.646 1.00
95_C 130_L 2.539 1.00
218_A 267_M 2.452 1.00
40_A 44_L 2.349 1.00
92_I 133_Q 2.346 1.00
31_R 66_E 2.309 1.00
77_L 104_T 2.276 1.00
261_S 264_E 2.22 1.00
92_I 129_K 2.153 1.00
79_S 107_L 2.104 1.00
218_A 264_E 2.087 1.00
7_Q 13_S 2.049 1.00
262_S 266_A 2.011 1.00
213_N 217_H 1.977 1.00
129_K 133_Q 1.975 1.00
97_A 101_R 1.974 1.00
128_E 132_A 1.866 1.00
214_E 267_M 1.849 1.00
233_S 265_L 1.818 1.00
79_S 98_S 1.807 1.00
182_W 186_Q 1.804 1.00
246_I 250_Q 1.804 1.00
129_K 132_A 1.787 1.00
189_P 238_M 1.785 1.00
222_S 251_Q 1.77 1.00
95_C 110_Y 1.766 1.00
183_C 190_V 1.759 1.00
229_A 258_V 1.756 1.00
62_K 101_R 1.718 1.00
106_Y 137_R 1.704 1.00
221_I 258_V 1.7 1.00
44_L 253_A 1.696 1.00
107_L 136_I 1.695 1.00
35_V 66_E 1.677 1.00
111_L 163_T 1.656 1.00
44_L 250_Q 1.646 1.00
40_A 43_E 1.639 1.00
59_G 62_K 1.626 1.00
40_A 246_I 1.599 1.00
150_Q 154_Q 1.594 1.00
18_G 48_L 1.587 1.00
111_L 191_M 1.584 1.00
35_V 67_A 1.568 1.00
53_E 94_A 1.568 1.00
71_L 74_K 1.548 1.00
266_A 270_K 1.54 1.00
250_Q 254_A 1.518 1.00
88_G 92_I 1.515 1.00
41_G 46_L 1.507 1.00
78_V 111_L 1.495 1.00
88_G 129_K 1.495 1.00
254_A 257_E 1.481 1.00
150_Q 182_W 1.479 1.00
81_V 91_A 1.469 1.00
35_V 70_G 1.461 1.00
49_I 64_V 1.458 1.00
95_C 107_L 1.453 1.00
126_A 129_K 1.438 1.00
130_L 136_I 1.422 1.00
136_I 139_W 1.418 1.00
12_V 138_R 1.413 1.00
215_I 226_V 1.408 1.00
150_Q 185_Q 1.403 0.99
38_L 67_A 1.398 0.99
37_A 249_V 1.388 0.99
92_I 96_E 1.386 0.99
221_I 225_Q 1.386 0.99
39_R 43_E 1.383 0.99
35_V 39_R 1.38 0.99
181_P 185_Q 1.379 0.99
42_I 75_V 1.363 0.99
96_E 100_R 1.36 0.99
21_T 49_I 1.329 0.99
97_A 100_R 1.314 0.99
81_V 110_Y 1.309 0.99
92_I 126_A 1.304 0.99
178_D 181_P 1.291 0.99
93_N 97_A 1.291 0.99
211_V 214_E 1.29 0.99
247_A 250_Q 1.279 0.99
12_V 76_F 1.279 0.99
243_A 249_V 1.276 0.99
214_E 217_H 1.274 0.99
72_R 104_T 1.271 0.99
5_M 13_S 1.268 0.99
222_S 225_Q 1.268 0.99
166_V 190_V 1.266 0.99
221_I 226_V 1.259 0.99
62_K 66_E 1.256 0.99
249_V 253_A 1.251 0.99
66_E 103_N 1.25 0.99
243_A 248_H 1.24 0.98
33_T 36_A 1.236 0.98
132_A 158_G 1.235 0.98
61_E 98_S 1.235 0.98
267_M 270_K 1.232 0.98
127_M 139_W 1.227 0.98
65_G 103_N 1.219 0.98
229_A 233_S 1.217 0.98
145_D 148_D 1.214 0.98
138_R 162_A 1.21 0.98
76_F 109_L 1.207 0.98
10_G 138_R 1.2 0.98
6_I 16_A 1.194 0.98
184_Q 236_G 1.18 0.98
89_Q 93_N 1.177 0.98
153_W 186_Q 1.166 0.97
128_E 159_N 1.161 0.97
146_Y 182_W 1.16 0.97
102_L 107_L 1.156 0.97
88_G 126_A 1.152 0.97
62_K 100_R 1.148 0.97
39_R 67_A 1.145 0.97
214_E 218_A 1.143 0.97
96_E 133_Q 1.14 0.97
72_R 106_Y 1.138 0.97
212_V 223_A 1.136 0.97
146_Y 150_Q 1.127 0.97
39_R 70_G 1.127 0.97
48_L 191_M 1.12 0.96
234_H 269_D 1.114 0.96
263_A 266_A 1.113 0.96
219_H 261_S 1.109 0.96
9_S 162_A 1.1 0.96
130_L 135_K 1.092 0.96
181_P 184_Q 1.081 0.95
68_L 75_V 1.078 0.95
180_L 184_Q 1.076 0.95
247_A 251_Q 1.073 0.95
48_L 78_V 1.072 0.95
150_Q 186_Q 1.071 0.95
213_N 223_A 1.068 0.95
30_Q 33_T 1.067 0.95
36_A 246_I 1.064 0.95
112_L 127_M 1.056 0.95
232_I 255_V 1.053 0.95
87_G 90_K 1.053 0.95
122_E 125_A 1.046 0.94
108_D 137_R 1.043 0.94
175_I 190_V 1.039 0.94
88_G 125_A 1.037 0.94
36_A 40_A 1.032 0.94
218_A 261_S 1.032 0.94
131_I 159_N 1.032 0.94
167_L 172_S 1.031 0.94
229_A 255_V 1.027 0.94
211_V 267_M 1.024 0.93
47_T 76_F 1.022 0.93
212_V 268_L 1.021 0.93
90_K 93_N 1.016 0.93
266_A 269_D 1.006 0.93
15_P 46_L 1.005 0.93
210_A 214_E 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pyfA10.95071000.112Contact Map0.746
3n2tA10.98591000.113Contact Map0.703
1pz1A20.98241000.123Contact Map0.71
1ur3M10.97181000.125Contact Map0.704
3eauA10.97541000.128Contact Map0.777
3v0sA10.97891000.131Contact Map0.792
1lqaA20.97181000.132Contact Map0.764
3lutA10.98941000.142Contact Map0.768
2bp1A40.98941000.143Contact Map0.732
3erpA20.96481000.147Contact Map0.776
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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