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MGLC - Galactoside transport system permease protein MglC
UniProt: P23200 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10594
Length: 336 (311)
Sequences: 12938
Seq/Len: 41.60
MGLC
Paralog alert: 0.92 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
113_C 240_V 4.17 1.00
117_A 236_A 3.919 1.00
217_P 231_L 3.082 1.00
117_A 240_V 2.845 1.00
226_N 229_L 2.806 1.00
120_G 239_G 2.804 1.00
82_V 115_I 2.733 1.00
116_G 239_G 2.674 1.00
210_I 234_I 2.525 1.00
53_I 190_A 2.462 1.00
116_G 243_A 2.429 1.00
121_L 236_A 2.415 1.00
60_A 289_V 2.357 1.00
213_I 230_N 2.263 1.00
113_C 244_F 2.252 1.00
229_L 233_M 2.25 1.00
200_L 206_F 2.241 1.00
129_Y 228_G 2.235 1.00
86_L 111_I 2.176 1.00
206_F 233_M 2.164 1.00
199_V 203_K 2.164 1.00
196_F 200_L 2.127 1.00
123_N 141_T 2.074 1.00
104_P 107_L 2.067 1.00
55_I 268_A 2.041 1.00
267_D 300_N 2 1.00
121_L 232_L 1.941 1.00
225_V 230_N 1.895 1.00
49_S 297_T 1.854 1.00
206_F 210_I 1.839 1.00
198_W 202_N 1.808 1.00
209_N 230_N 1.796 1.00
212_A 220_A 1.793 1.00
275_G 288_G 1.75 1.00
124_G 232_L 1.743 1.00
194_V 290_V 1.723 1.00
77_G 149_N 1.719 1.00
54_I 245_G 1.695 1.00
195_A 199_V 1.676 1.00
61_G 197_V 1.655 1.00
67_G 134_P 1.648 1.00
109_I 247_M 1.645 1.00
53_I 293_V 1.634 1.00
65_T 234_I 1.628 1.00
62_L 238_S 1.617 1.00
205_R 209_N 1.615 1.00
218_E 221_K 1.599 1.00
29_I 302_G 1.591 1.00
110_L 114_A 1.557 1.00
55_I 76_V 1.555 1.00
213_I 227_V 1.55 1.00
124_G 128_A 1.536 1.00
106_A 110_L 1.533 1.00
209_N 225_V 1.528 1.00
56_A 289_V 1.523 1.00
61_G 234_I 1.518 1.00
233_M 237_L 1.516 1.00
285_T 288_G 1.514 1.00
232_L 236_A 1.495 1.00
192_I 196_F 1.49 1.00
49_S 294_I 1.487 1.00
217_P 221_K 1.479 1.00
236_A 240_V 1.465 1.00
57_L 197_V 1.463 1.00
64_V 284_G 1.454 1.00
67_G 235_Y 1.448 1.00
64_V 211_F 1.434 1.00
188_F 192_I 1.431 1.00
141_T 145_V 1.428 1.00
76_V 249_E 1.427 1.00
128_A 228_G 1.427 1.00
60_A 277_V 1.425 1.00
209_N 220_A 1.424 1.00
143_I 146_Y 1.419 1.00
246_G 250_A 1.411 1.00
78_L 119_I 1.4 0.99
114_A 117_A 1.397 0.99
41_N 301_Y 1.392 0.99
277_V 289_V 1.378 0.99
83_A 112_V 1.377 0.99
114_A 118_V 1.37 0.99
273_V 279_F 1.366 0.99
83_A 247_M 1.366 0.99
81_V 258_N 1.362 0.99
125_L 129_Y 1.361 0.99
221_K 228_G 1.345 0.99
113_C 247_M 1.337 0.99
58_G 241_F 1.337 0.99
267_D 317_K 1.334 0.99
210_I 230_N 1.316 0.99
108_V 112_V 1.313 0.99
59_V 72_A 1.311 0.99
126_I 137_T 1.31 0.99
54_I 248_L 1.309 0.99
103_M 111_I 1.298 0.99
74_R 146_Y 1.298 0.99
134_P 235_Y 1.296 0.99
53_I 290_V 1.295 0.99
59_V 272_C 1.281 0.99
233_M 236_A 1.268 0.99
129_Y 232_L 1.26 0.99
191_L 195_A 1.248 0.99
220_A 225_V 1.246 0.98
56_A 272_C 1.243 0.98
270_A 321_I 1.239 0.98
103_M 107_L 1.234 0.98
72_A 242_Y 1.233 0.98
70_L 269_I 1.223 0.98
112_V 116_G 1.219 0.98
80_A 256_A 1.214 0.98
117_A 243_A 1.213 0.98
275_G 292_G 1.212 0.98
118_V 122_I 1.206 0.98
146_Y 265_E 1.201 0.98
197_V 237_L 1.197 0.98
80_A 260_L 1.195 0.98
28_I 32_Q 1.195 0.98
82_V 86_L 1.192 0.98
86_L 103_M 1.19 0.98
131_N 217_P 1.189 0.98
301_Y 304_T 1.181 0.98
239_G 243_A 1.173 0.98
206_F 237_L 1.169 0.97
243_A 247_M 1.154 0.97
119_I 145_V 1.154 0.97
118_V 121_L 1.148 0.97
61_G 201_W 1.144 0.97
113_C 243_A 1.129 0.97
276_G 282_G 1.129 0.97
213_I 220_A 1.128 0.97
107_L 110_L 1.123 0.97
67_G 231_L 1.12 0.96
79_A 246_G 1.119 0.96
59_V 268_A 1.116 0.96
287_I 291_T 1.094 0.96
57_L 193_A 1.093 0.96
49_S 293_V 1.083 0.96
56_A 271_A 1.081 0.95
63_I 272_C 1.081 0.95
240_V 244_F 1.073 0.95
112_V 247_M 1.072 0.95
312_W 315_I 1.068 0.95
193_A 241_F 1.065 0.95
148_I 152_Y 1.061 0.95
152_Y 155_F 1.06 0.95
271_A 292_G 1.059 0.95
82_V 111_I 1.048 0.94
87_L 108_V 1.045 0.94
123_N 137_T 1.03 0.94
120_G 236_A 1.03 0.94
130_L 137_T 1.029 0.94
86_L 89_S 1.024 0.93
242_Y 246_G 1.024 0.93
18_I 22_L 1.019 0.93
319_A 323_F 1.016 0.93
73_G 265_E 1.015 0.93
74_R 142_M 1.012 0.93
76_V 264_Y 1.008 0.93
240_V 243_A 1.006 0.93
206_F 230_N 1.003 0.93
83_A 251_G 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nq2A20.863196.50.886Contact Map0.557
2qi9A20.863195.40.896Contact Map0.601
4g1uA20.88195.30.897Contact Map0.552
2l2tA20.11940.964Contact Map0.427
2rddB10.08043.60.965Contact Map0.574
2ksfA10.29763.30.966Contact Map0.38
2kluA10.1222.50.968Contact Map0
3hd7B20.11012.50.968Contact Map0.275
2m8rA10.11012.50.968Contact Map0.222
2ks1B10.1222.40.968Contact Map0.142
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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