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OPENSEQ.org
XYLH - Xylose transport system permease protein XylH
UniProt: P0AGI4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12276
Length: 393 (333)
Sequences: 3218
Seq/Len: 9.66
XYLH
Paralog alert: 0.72 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
68_G 248_L 4.143 1.00
275_L 289_K 3.381 1.00
133_Y 286_E 3.191 1.00
43_F 360_G 2.96 1.00
121_L 298_L 2.889 1.00
121_L 294_A 2.82 1.00
120_G 301_A 2.82 1.00
120_G 297_G 2.812 1.00
56_N 359_N 2.777 1.00
72_V 251_L 2.773 1.00
268_I 292_V 2.762 1.00
117_L 298_L 2.711 1.00
138_S 293_F 2.695 1.00
64_T 355_A 2.688 1.00
75_V 347_A 2.633 1.00
264_F 291_A 2.629 1.00
82_E 293_F 2.607 1.00
82_E 138_S 2.541 1.00
69_I 306_I 2.392 1.00
144_A 380_L 2.375 1.00
72_V 255_G 2.32 1.00
246_L 250_L 2.317 1.00
127_N 145_G 2.284 1.00
70_L 326_A 2.227 1.00
79_I 269_Y 2.19 1.00
145_G 149_F 2.19 1.00
325_D 375_K 2.184 1.00
264_F 268_I 2.102 1.00
98_A 116_T 2.068 1.00
331_V 337_L 2.057 1.00
125_A 290_L 2.054 1.00
42_F 46_T 1.992 1.00
75_V 335_T 1.992 1.00
271_I 288_T 1.975 1.00
125_A 294_A 1.956 1.00
76_F 255_G 1.956 1.00
254_G 258_M 1.946 1.00
150_R 323_E 1.916 1.00
276_E 279_R 1.915 1.00
335_T 347_A 1.913 1.00
80_S 293_F 1.901 1.00
252_L 348_V 1.898 1.00
82_E 289_K 1.877 1.00
73_G 299_M 1.875 1.00
123_L 149_F 1.855 1.00
130_W 136_V 1.825 1.00
131_V 293_F 1.771 1.00
79_I 342_G 1.729 1.00
258_M 264_F 1.712 1.00
78_I 330_C 1.7 1.00
263_A 267_R 1.692 1.00
287_R 291_A 1.68 1.00
40_M 356_S 1.668 1.00
76_F 259_A 1.649 1.00
108_P 111_L 1.612 1.00
239_R 246_L 1.605 1.00
169_M 308_S 1.58 1.00
100_I 156_I 1.576 1.00
151_G 373_I 1.574 1.00
359_N 363_M 1.573 1.00
290_L 294_A 1.57 1.00
89_S 150_R 1.568 1.00
253_L 257_F 1.564 1.00
68_G 351_A 1.539 1.00
74_M 87_V 1.525 1.00
358_D 375_K 1.517 1.00
132_A 286_E 1.517 1.00
72_V 252_L 1.481 1.00
80_S 292_V 1.476 1.00
155_G 370_W 1.464 1.00
357_L 378_I 1.447 1.00
257_F 261_R 1.426 1.00
304_G 308_S 1.423 1.00
298_L 301_A 1.419 0.99
267_R 288_T 1.419 0.99
74_M 326_A 1.417 0.99
136_V 141_V 1.412 0.99
256_M 260_T 1.411 0.99
89_S 146_M 1.408 0.99
113_I 305_L 1.407 0.99
129_W 290_L 1.405 0.99
128_G 290_L 1.401 0.99
334_G 339_G 1.401 0.99
284_N 287_R 1.394 0.99
96_G 157_T 1.377 0.99
296_N 300_V 1.369 0.99
90_M 149_F 1.364 0.99
294_A 297_G 1.362 0.99
249_T 253_L 1.353 0.99
133_Y 290_L 1.351 0.99
90_M 123_L 1.33 0.99
294_A 298_L 1.322 0.99
126_W 145_G 1.32 0.99
118_V 122_L 1.316 0.99
135_K 286_E 1.315 0.99
114_I 118_V 1.315 0.99
269_Y 342_G 1.31 0.99
107_W 115_V 1.307 0.99
271_I 285_V 1.305 0.99
129_W 133_Y 1.301 0.99
122_L 126_W 1.298 0.99
159_G 369_F 1.297 0.99
69_I 251_L 1.276 0.99
336_S 386_D 1.275 0.99
70_L 87_V 1.275 0.99
130_W 141_V 1.274 0.99
60_L 356_S 1.269 0.99
71_A 347_A 1.269 0.99
81_A 275_L 1.263 0.99
88_G 319_G 1.262 0.99
57_V 61_L 1.257 0.98
283_I 288_T 1.255 0.98
152_I 373_I 1.251 0.98
300_V 304_G 1.237 0.98
251_L 302_I 1.233 0.98
94_L 304_G 1.224 0.98
258_M 295_I 1.221 0.98
134_R 384_W 1.22 0.98
44_T 52_L 1.215 0.98
117_L 302_I 1.213 0.98
244_P 306_I 1.213 0.98
95_G 314_G 1.208 0.98
328_A 379_L 1.205 0.98
32_M 36_I 1.201 0.98
330_C 347_A 1.195 0.98
251_L 299_M 1.19 0.98
334_G 342_G 1.187 0.98
76_F 268_I 1.18 0.97
96_G 153_L 1.176 0.97
175_S 243_T 1.171 0.97
92_G 150_R 1.171 0.97
93_L 149_F 1.168 0.97
97_V 119_L 1.15 0.97
264_F 295_I 1.147 0.97
70_L 91_M 1.144 0.97
324_L 328_A 1.136 0.97
85_L 139_F 1.136 0.97
90_M 300_V 1.135 0.97
297_G 301_A 1.125 0.96
339_G 342_G 1.121 0.96
99_A 314_G 1.114 0.96
214_S 218_V 1.107 0.96
250_L 254_G 1.105 0.96
129_W 134_R 1.104 0.96
95_G 308_S 1.102 0.96
77_V 296_N 1.096 0.96
291_A 294_A 1.091 0.95
361_M 366_V 1.085 0.95
270_A 278_A 1.082 0.95
118_V 121_L 1.072 0.95
268_I 288_T 1.071 0.95
129_W 132_A 1.07 0.95
68_G 348_V 1.065 0.95
121_L 301_A 1.059 0.94
131_V 138_S 1.059 0.94
95_G 318_A 1.044 0.94
91_M 322_A 1.043 0.94
86_S 127_N 1.043 0.94
279_R 286_E 1.037 0.94
101_C 112_T 1.031 0.93
101_C 115_V 1.025 0.93
88_G 323_E 1.021 0.93
102_D 112_T 1.02 0.93
37_I 40_M 1.018 0.93
56_N 363_M 1.015 0.93
128_G 132_A 1.01 0.92
169_M 172_I 1.005 0.92
80_S 289_K 1.005 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g1uA20.8372880.951Contact Map0.484
2nq2A20.8015790.956Contact Map0.385
2qi9A20.778671.70.959Contact Map0.449
2kogA10.12984.10.979Contact Map0.253
3dh4A40.147640.979Contact Map0.22
4gipD30.16283.50.979Contact Map0.005
1u7gA10.52423.20.98Contact Map0.288
2zy9A20.27482.50.981Contact Map0.189
3hd7A20.12981.70.983Contact Map0.795
1m56D20.1121.60.983Contact Map1
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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