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LIVH - High-affinity branched-chain amino acid transport system permease protein LivH
UniProt: P0AEX7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10538
Length: 308 (297)
Sequences: 13588
Seq/Len: 45.75
LIVH
Paralog alert: 0.93 [within 20: 0.67] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
81_I 214_A 4.145 1.00
85_S 210_V 3.953 1.00
191_L 205_I 3.036 1.00
85_S 214_A 2.99 1.00
88_G 213_A 2.875 1.00
53_V 83_I 2.792 1.00
200_N 203_R 2.784 1.00
184_C 208_T 2.622 1.00
89_W 210_V 2.604 1.00
23_A 164_T 2.592 1.00
84_A 217_A 2.498 1.00
84_A 213_A 2.484 1.00
30_T 257_A 2.456 1.00
173_I 177_Y 2.326 1.00
180_M 207_L 2.262 1.00
81_I 218_V 2.24 1.00
187_C 204_V 2.2 1.00
174_F 180_M 2.192 1.00
57_I 79_G 2.182 1.00
170_A 174_F 2.153 1.00
203_R 207_L 2.15 1.00
91_I 114_M 2.15 1.00
241_K 268_E 2.121 1.00
25_I 242_A 2.056 1.00
89_W 206_A 1.977 1.00
144_G 150_S 1.943 1.00
48_M 122_V 1.887 1.00
172_T 176_R 1.884 1.00
72_L 75_A 1.864 1.00
19_G 265_G 1.84 1.00
98_P 202_D 1.837 1.00
183_A 204_V 1.831 1.00
199_I 204_V 1.798 1.00
169_L 173_I 1.798 1.00
77_F 221_V 1.783 1.00
92_E 206_A 1.747 1.00
31_M 171_L 1.73 1.00
32_V 212_G 1.703 1.00
186_A 194_A 1.674 1.00
168_M 258_M 1.672 1.00
26_A 257_A 1.66 1.00
180_M 184_C 1.65 1.00
23_A 261_G 1.648 1.00
179_R 183_A 1.645 1.00
116_I 119_Q 1.642 1.00
38_M 107_A 1.619 1.00
24_L 219_A 1.613 1.00
249_G 256_G 1.6 1.00
192_K 195_S 1.598 1.00
19_G 262_L 1.598 1.00
183_A 199_I 1.567 1.00
25_I 47_Y 1.565 1.00
49_I 87_Y 1.559 1.00
162_I 166_L 1.551 1.00
206_A 210_V 1.537 1.00
187_C 201_T 1.519 1.00
191_L 195_S 1.517 1.00
54_S 221_V 1.508 1.00
210_V 214_A 1.497 1.00
207_L 211_I 1.49 1.00
31_M 208_T 1.48 1.00
259_I 300_L 1.467 1.00
114_M 118_L 1.467 1.00
253_S 256_G 1.457 1.00
28_G 215_M 1.455 1.00
78_V 82_V 1.44 1.00
80_A 84_A 1.436 1.00
36_I 208_T 1.436 1.00
82_V 86_A 1.429 1.00
220_G 224_G 1.415 1.00
81_I 221_V 1.411 1.00
167_A 215_M 1.41 1.00
27_I 171_L 1.395 0.99
241_K 284_S 1.39 0.99
249_G 260_G 1.386 0.99
82_V 85_S 1.386 0.99
23_A 258_M 1.378 0.99
74_A 78_V 1.377 0.99
95_A 110_S 1.367 0.99
52_Y 232_P 1.363 0.99
76_G 80_A 1.363 0.99
96_Y 111_A 1.357 0.99
183_A 194_A 1.355 0.99
38_M 209_F 1.353 0.99
11_Q 269_A 1.34 0.99
45_E 119_Q 1.339 0.99
24_L 222_L 1.331 0.99
54_S 80_A 1.326 0.99
107_A 209_F 1.324 0.99
47_Y 223_L 1.321 0.99
184_C 204_V 1.314 0.99
195_S 202_D 1.313 0.99
166_L 170_A 1.3 0.99
43_H 216_A 1.285 0.99
101_N 104_R 1.253 0.99
207_L 210_V 1.25 0.99
279_Y 282_V 1.249 0.99
29_Y 43_H 1.241 0.98
171_L 211_I 1.232 0.98
29_Y 246_A 1.229 0.98
165_F 169_L 1.226 0.98
245_A 260_G 1.222 0.98
53_V 57_I 1.211 0.98
97_R 202_D 1.2 0.98
26_A 246_A 1.2 0.98
31_M 175_I 1.197 0.98
87_Y 118_L 1.194 0.98
51_S 230_I 1.193 0.98
15_G 266_I 1.189 0.98
80_A 221_V 1.184 0.98
269_A 272_S 1.179 0.98
85_S 217_A 1.178 0.98
57_I 61_L 1.162 0.97
244_T 288_L 1.158 0.97
19_G 261_G 1.157 0.97
99_V 110_S 1.156 0.97
187_C 194_A 1.145 0.97
92_E 97_R 1.145 0.97
29_Y 242_A 1.14 0.97
86_A 89_W 1.14 0.97
217_A 221_V 1.136 0.97
58_I 76_G 1.131 0.97
270_L 274_Y 1.128 0.97
41_F 243_F 1.124 0.97
86_A 90_S 1.117 0.96
255_P 259_I 1.116 0.96
119_Q 239_G 1.114 0.96
194_A 199_I 1.114 0.96
126_E 131_V 1.11 0.96
93_R 97_R 1.107 0.96
45_E 118_L 1.101 0.96
88_G 210_V 1.096 0.96
213_A 217_A 1.095 0.96
75_A 78_V 1.09 0.96
50_G 220_G 1.082 0.96
172_T 177_Y 1.081 0.95
26_A 245_A 1.079 0.95
45_E 115_S 1.068 0.95
180_M 211_I 1.059 0.95
26_A 261_G 1.055 0.95
214_A 218_V 1.052 0.95
53_V 79_G 1.045 0.94
100_R 191_L 1.043 0.94
57_I 76_G 1.038 0.94
36_I 184_C 1.036 0.94
253_S 257_A 1.032 0.94
167_A 218_V 1.025 0.93
286_A 290_L 1.025 0.93
158_A 162_I 1.023 0.93
81_I 217_A 1.022 0.93
180_M 204_V 1.02 0.93
214_A 217_A 1.016 0.93
91_I 110_S 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g1uA20.8766930.899Contact Map0.499
2qi9A20.853992.90.9Contact Map0.568
2nq2A20.866991.30.904Contact Map0.548
2ksfA10.33441.50.969Contact Map0.336
1q90R10.15261.50.969Contact Map0.497
4gh4D10.084410.972Contact Map
2rddB10.090910.972Contact Map0.543
2kluA10.12990.90.973Contact Map0
2l9xA10.06820.80.974Contact Map0.114
1meqA10.05520.80.974Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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