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YJFF - Inner membrane ABC transporter permease protein YjfF
UniProt: P37772 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12439
Length: 331 (297)
Sequences: 13017
Seq/Len: 43.83
YJFF
Paralog alert: 0.92 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
95_L 219_G 4.108 1.00
99_C 215_M 3.819 1.00
196_A 210_T 3.034 1.00
99_C 219_G 2.842 1.00
102_G 218_T 2.8 1.00
205_S 208_S 2.767 1.00
75_F 97_M 2.73 1.00
98_G 218_T 2.605 1.00
189_V 213_I 2.546 1.00
103_A 215_M 2.514 1.00
46_G 169_M 2.422 1.00
98_G 222_T 2.395 1.00
53_T 268_T 2.293 1.00
192_I 209_T 2.227 1.00
185_F 212_R 2.214 1.00
111_A 207_R 2.209 1.00
79_V 93_L 2.206 1.00
208_S 212_R 2.171 1.00
179_L 185_F 2.144 1.00
86_S 89_L 2.1 1.00
95_L 223_L 2.099 1.00
175_I 179_L 2.096 1.00
178_F 182_R 2.091 1.00
105_M 123_G 2.041 1.00
246_D 279_Q 2.012 1.00
103_A 211_I 1.931 1.00
48_I 247_A 1.923 1.00
185_F 189_V 1.878 1.00
42_N 276_G 1.862 1.00
188_Q 209_T 1.8 1.00
177_I 181_H 1.786 1.00
204_I 209_T 1.775 1.00
91_F 226_I 1.743 1.00
191_A 199_A 1.723 1.00
54_F 176_G 1.696 1.00
174_V 178_F 1.691 1.00
70_A 131_S 1.679 1.00
106_G 211_I 1.679 1.00
254_G 267_G 1.648 1.00
60_G 116_A 1.642 1.00
47_I 224_A 1.635 1.00
173_V 269_L 1.602 1.00
88_L 92_P 1.57 1.00
192_I 206_T 1.555 1.00
55_V 217_S 1.555 1.00
184_R 188_Q 1.543 1.00
188_Q 204_I 1.532 1.00
49_A 268_T 1.531 1.00
46_G 272_V 1.524 1.00
92_P 96_V 1.523 1.00
58_S 213_I 1.521 1.00
171_A 175_I 1.52 1.00
197_T 200_N 1.518 1.00
48_I 69_I 1.499 1.00
188_Q 199_A 1.49 1.00
42_N 273_A 1.479 1.00
54_F 213_I 1.476 1.00
196_A 200_N 1.475 1.00
106_G 110_D 1.47 1.00
264_T 267_G 1.466 1.00
215_M 219_G 1.465 1.00
125_F 128_R 1.451 1.00
211_I 215_M 1.45 1.00
60_G 214_Y 1.445 1.00
123_G 127_L 1.414 1.00
57_L 263_G 1.414 1.00
167_L 171_A 1.406 0.99
212_R 216_L 1.406 0.99
69_I 228_F 1.399 0.99
50_V 176_G 1.396 0.99
51_G 220_L 1.391 0.99
225_G 229_S 1.388 0.99
107_L 111_A 1.383 0.99
110_D 207_R 1.378 0.99
252_V 258_L 1.375 0.99
53_T 256_T 1.369 0.99
255_G 261_G 1.368 0.99
34_V 280_T 1.367 0.99
96_V 100_A 1.367 0.99
47_I 227_V 1.362 0.99
76_L 226_I 1.361 0.99
71_F 101_F 1.36 0.99
246_D 297_I 1.347 0.99
256_T 268_T 1.347 0.99
74_V 237_A 1.342 0.99
57_L 190_Y 1.332 0.99
90_A 94_V 1.326 0.99
189_V 209_T 1.32 0.99
96_V 99_C 1.313 0.99
20_L 24_T 1.312 0.99
212_R 215_M 1.308 0.99
111_A 211_I 1.303 0.99
95_L 226_I 1.297 0.99
67_S 128_R 1.296 0.99
85_L 93_L 1.288 0.99
46_G 269_L 1.279 0.99
52_M 65_V 1.27 0.99
76_L 94_V 1.264 0.99
85_L 89_L 1.263 0.99
200_N 207_R 1.256 0.99
199_A 204_I 1.252 0.99
108_L 119_I 1.24 0.98
254_G 271_G 1.236 0.98
94_V 98_G 1.228 0.98
116_A 214_Y 1.223 0.98
52_M 251_V 1.222 0.98
65_V 221_A 1.219 0.98
128_R 244_E 1.21 0.98
113_K 196_A 1.204 0.98
73_G 235_G 1.197 0.98
21_Y 281_Y 1.196 0.98
49_A 251_V 1.186 0.98
63_L 248_I 1.181 0.98
249_A 301_L 1.164 0.97
100_A 103_A 1.163 0.97
101_F 127_L 1.161 0.97
170_L 174_V 1.158 0.97
75_F 79_V 1.156 0.97
79_V 85_L 1.153 0.97
192_I 199_A 1.149 0.97
222_T 226_I 1.135 0.97
218_T 222_T 1.133 0.97
99_C 222_T 1.128 0.97
280_T 283_N 1.126 0.97
73_G 239_A 1.117 0.96
100_A 104_F 1.098 0.96
72_T 225_G 1.097 0.96
60_G 210_T 1.096 0.96
185_F 216_L 1.094 0.96
299_I 303_I 1.094 0.96
79_V 83_F 1.093 0.96
176_G 216_L 1.092 0.96
54_F 180_A 1.084 0.96
89_L 92_P 1.062 0.95
52_M 247_A 1.056 0.95
94_V 226_I 1.056 0.95
49_A 250_S 1.055 0.95
80_I 90_A 1.053 0.95
219_G 223_L 1.052 0.95
266_L 270_F 1.047 0.94
250_S 271_G 1.045 0.94
102_G 215_M 1.045 0.94
95_L 222_T 1.041 0.94
42_N 272_V 1.038 0.94
172_V 220_L 1.03 0.94
219_G 222_T 1.023 0.93
56_I 251_V 1.022 0.93
292_W 295_I 1.022 0.93
78_K 135_S 1.02 0.93
50_V 172_V 1.012 0.93
75_F 93_L 1.011 0.93
185_F 209_T 1.01 0.93
221_A 225_G 1.006 0.93
67_S 124_M 1.003 0.93
177_I 182_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nq2A20.879296.30.896Contact Map0.508
4g1uA20.882295.90.9Contact Map0.51
2qi9A20.870195.30.903Contact Map0.565
1u7gA10.5559120.958Contact Map0.349
2l2tA20.13295.90.964Contact Map0.361
2gfpA20.59214.90.965Contact Map0.131
2ksfA10.31124.80.965Contact Map0.387
2ks1B10.13294.20.966Contact Map0.116
2kncA10.15414.10.966Contact Map0.245
2rddB10.10272.70.969Contact Map0.552
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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