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DPPC - Dipeptide transport system permease protein DppC
UniProt: P0AEG1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12626
Length: 300 (275)
Sequences: 6348
Seq/Len: 23.08
DPPC
Paralog alert: 0.76 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: DDPB DDPC DPPB DPPC GSIC GSID NIKB NIKC OPPB OPPC SAPB SAPC YEJB YEJE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
234_M 250_E 3.431 1.00
98_A 251_W 3.272 1.00
119_L 134_I 3.045 1.00
131_D 181_R 2.927 1.00
126_F 203_A 2.836 1.00
251_W 279_T 2.754 1.00
191_D 194_T 2.591 1.00
81_L 94_L 2.562 1.00
61_F 64_A 2.489 1.00
46_A 98_A 2.461 1.00
84_D 88_R 2.376 1.00
201_A 205_R 2.224 1.00
77_M 80_L 2.218 1.00
56_N 59_E 2.172 1.00
187_E 192_Y 2.162 1.00
111_L 169_T 2.157 1.00
85_D 257_D 2.135 1.00
53_A 92_S 2.109 1.00
121_L 184_V 2.099 1.00
35_G 282_A 2.078 1.00
136_R 139_D 2.066 1.00
204_M 208_F 2.043 1.00
79_H 89_D 2.041 1.00
291_R 295_D 2.005 1.00
42_V 279_T 1.983 1.00
124_G 184_V 1.966 1.00
23_W 27_K 1.944 1.00
91_L 95_M 1.869 1.00
81_L 271_F 1.86 1.00
125_Y 203_A 1.809 1.00
44_F 48_F 1.804 1.00
49_A 96_Y 1.784 1.00
48_F 51_W 1.782 1.00
32_A 289_G 1.737 1.00
45_I 95_M 1.731 1.00
90_V 254_M 1.717 1.00
38_Y 282_A 1.707 1.00
54_P 92_S 1.685 1.00
39_V 282_A 1.665 1.00
187_E 211_I 1.662 1.00
94_L 275_A 1.632 1.00
184_V 211_I 1.619 1.00
107_L 165_A 1.618 1.00
183_A 186_V 1.605 1.00
176_Y 226_G 1.583 1.00
81_L 91_L 1.582 1.00
126_F 130_V 1.574 1.00
36_L 286_M 1.553 1.00
121_L 207_M 1.552 1.00
187_E 190_R 1.551 1.00
133_I 137_V 1.532 1.00
122_I 126_F 1.497 1.00
202_G 205_R 1.473 1.00
135_M 177_V 1.451 1.00
192_Y 214_N 1.444 1.00
50_N 99_R 1.423 1.00
54_P 91_L 1.422 1.00
104_V 234_M 1.413 1.00
127_G 188_V 1.411 1.00
96_Y 99_R 1.408 1.00
35_G 289_G 1.403 0.99
187_E 215_C 1.402 0.99
197_R 203_A 1.384 0.99
113_L 223_A 1.368 0.99
36_L 40_V 1.36 0.99
186_V 190_R 1.356 0.99
129_L 133_I 1.353 0.99
67_A 76_S 1.344 0.99
124_G 188_V 1.344 0.99
69_P 267_W 1.341 0.99
109_V 223_A 1.341 0.99
132_N 136_R 1.337 0.99
224_S 287_G 1.335 0.99
35_G 285_L 1.328 0.99
121_L 212_F 1.325 0.99
38_Y 278_L 1.319 0.99
251_W 275_A 1.318 0.99
64_A 67_A 1.318 0.99
55_Y 92_S 1.314 0.99
76_S 79_H 1.303 0.99
162_G 166_L 1.281 0.99
168_L 233_D 1.278 0.99
135_M 139_D 1.278 0.99
126_F 207_M 1.278 0.99
27_K 33_V 1.277 0.99
123_A 135_M 1.26 0.99
205_R 209_I 1.259 0.99
258_V 269_V 1.252 0.99
271_F 274_L 1.249 0.99
267_W 271_F 1.239 0.98
90_V 268_V 1.239 0.98
135_M 138_V 1.234 0.98
138_V 177_V 1.232 0.98
194_T 197_R 1.23 0.98
125_Y 206_Q 1.224 0.98
258_V 268_V 1.214 0.98
266_W 270_T 1.208 0.98
39_V 286_M 1.205 0.98
228_S 280_V 1.205 0.98
34_V 37_V 1.205 0.98
108_V 168_L 1.205 0.98
173_L 177_V 1.201 0.98
37_V 41_I 1.2 0.98
117_V 219_L 1.193 0.98
80_L 91_L 1.187 0.98
184_V 215_C 1.161 0.97
76_S 80_L 1.144 0.97
127_G 131_D 1.144 0.97
123_A 134_I 1.136 0.97
160_S 163_N 1.125 0.97
239_F 259_L 1.121 0.97
134_I 177_V 1.114 0.96
117_V 180_T 1.112 0.96
196_S 210_N 1.108 0.96
49_A 52_I 1.108 0.96
193_V 206_Q 1.107 0.96
103_L 107_L 1.099 0.96
270_T 274_L 1.091 0.96
115_M 118_I 1.083 0.96
55_Y 78_A 1.074 0.95
30_K 33_V 1.073 0.95
141_M 173_L 1.067 0.95
42_V 278_L 1.065 0.95
55_Y 79_H 1.065 0.95
181_R 185_L 1.064 0.95
58_A 249_P 1.054 0.95
48_F 52_I 1.05 0.94
119_L 177_V 1.049 0.94
39_V 283_F 1.048 0.94
67_A 83_T 1.047 0.94
115_M 173_L 1.046 0.94
138_V 174_P 1.042 0.94
108_V 230_A 1.041 0.94
93_R 247_P 1.034 0.94
194_T 198_V 1.026 0.94
45_I 98_A 1.024 0.93
238_G 250_E 1.017 0.93
35_G 38_Y 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.6899.90.682Contact Map0.782
3rlfG10.886799.90.69Contact Map0.55
3d31C20.913399.90.699Contact Map0.555
3rlfF10.956799.90.707Contact Map0.483
2onkC40.893399.90.72Contact Map0.56
2kncA10.153.70.973Contact Map0.473
3hd7B20.17673.40.973Contact Map0.215
2m8rA10.17673.40.973Contact Map0.088
2lcoA10.073.20.973Contact Map0.261
2kogA10.16332.30.975Contact Map0.282
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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